Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

Circulation Research

Volumn 105, Issue 6, 2009, Pages 557-564

  Granzier, Henk L ^a   Radke, Michael H ^c   Peng, Jun ^d   Westermann, Dirk ^e   Nelson, O Lynne ^d   Rost, Katharina ^c   King, Nicholas M P ^a   Yu, Qianli ^b   Tschöpe, Carsten ^e   McNabb, Mark ^d   Larson, Douglas F ^b   Labeit, Siegfried ^f   Gotthardt, Michael ^c,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d WASHINGTON STATE UNIVERSITY   (United States)

^e Mannheim University ^*  (Germany)

^f UNIVERSITY OF MANNHEIM   (Germany)

Author keywords

Compliance; Connectin; Diastole; FHL; Hypertrophy

Indexed keywords

AMINO ACID DERIVATIVE; CONNECTIN; PROLINE GLUTAMATE VALINE LYSINE; UNCLASSIFIED DRUG; ISOPROTEIN; MUSCLE PROTEIN; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CARDIOMYOPATHY; DIASTOLIC DYSFUNCTION; ECHOCARDIOGRAPHY; EXON; HEART DEVELOPMENT; HEART VENTRICLE; HEART VENTRICLE HYPERTROPHY; IMMUNOELECTRON MICROSCOPY; ISOLATED HEART; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; ANIMAL; ELASTICITY; GENE DELETION; GENETICS; HYPERTROPHIC CARDIOMYOPATHY; METABOLISM; MICROFILAMENT; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SARCOMERE; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC; ELASTICITY; HEART VENTRICLES; MICE; MICE, KNOCKOUT; MICROFILAMENTS; MUSCLE PROTEINS; PROTEIN ISOFORMS; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SARCOMERES; SEQUENCE DELETION;

EID: 70349246846     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.200964     Document Type: Article

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