Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy

Heart

Volumn 75, Issue 1, 1996, Pages 50-54

  Choudhury, Lubna ^a   Guzzetti, Stefano ^a   Lefroy, David C ^a   Nihoyannopoulos, Petros ^a   McKenna, William J ^b   Oakley, Celia M ^a   Camici, Paolo G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Hypertrophic cardiomyopathy; Left ventricular function; Myocardial adrenoceptors; Positron emission tomography

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; HEART RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART LEFT VENTRICLE FUNCTION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION;

EID: 0030025184     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.75.1.50     Document Type: Article

References (26)

1. Maron BJ, Bonow RO, Cannon RO, Leon MB, Epstein SE. Hypertrophic cardiomyopathy: interrelations of clinical manifestations, pathophysiology and therapy. N Engl J Med 1987;316:780-9.
2. Maron BJ, Nichols PF, Pickle LW, Wesley YE, Mulvihill JJ. Patterns of inheritance in hypertrophic cardiomyopathy: assessment by M-mode and two-dimensional echocardiography. Am J Cardiol 1984;53:1087-94.
3. Tanigawa G, Jarcho JA, Kass S, Solomon SD, Vosberg HP, Seidman JG, et al. A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. Cell 1990;62:991-8.
4. Geisterfer-Lowrence AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, et al. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain missense mutation. Cell 1990; 62:999-1006.
5. Watkins H, Rosenzweig A, Hwang DS, Levi T, McKenna W, Seidman CE, et al. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N Engl J Med 1992; 326:1108-14.
6. Schwartz K, Beckmann J, Dufour C, Faure L, Fougerousse F, Carrier L, et al. Exclusion of cardiac myosin heavy chain and actin gene involvement in hypertrophic cardiomyopathy of several French families. Circ Res 1992;71:3-8.
7. Pearse AGE. The histochemistry and electron microscopy of obstructive cardiomyopathy. In: Cardiomyopathies [Ciba Foundation Symposium No 81]. London: Churchill, 1964:132.
8. Kawai C, Yoshiki Y, Hoshino T, Sasayama S, Matsumori A. Myocardial catecholamines in hypertrophic and dilated (congestive) cardiomyopathy: a biopsy study. J Am Coll Cardiol 1983;2:834-40.
9. Brush JE, Eisenhofer G, Garty M, Stull R, Maron BJ, Cannon RO, et al. Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy. Circulation 1989;79: 836-44.
10. Lefroy DC, de Silva R, Choudhury L, Uren NG, Crake T, Rhodes CG, et al. Diffuse reduction of myocardial beta adrenoceptors in hypertrophic cardiomyopathy: a study with positron emission tomography. J Am Coll Cardiol 1993;22:1653-60.
11. Bristow MR, Minobe W, Rasmussen R, Larrabee P, Skeri L, Klein JW, et al. Beta adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest 1992;89:803-15.
12. Spirito P, Maron BJ, Bonow RO, Epstein SE. Occurrence and significance of progressive left ventricular wall thinning and relative cavity dilatation in hypertrophic cardiomyopathy. Am J Cardiol 1987;59:123-9.
13. Oakley CM. Hypertrophic obstructive cardiomyopathy. Patterns of progression. In: Wolstenholme GEW, O'Connoe M, eds. Hypertrophic obstructive cardiomyopathy [CIBA Foundation Study Group, No 31]. London: Churchill, 1971:9-29.
14. Fighali S, Krajcer Z, Edelman S, Leachman R. Progression in hypertrophic cardiomyopathy into a hypokinetic left ventricle: higher incidence in patients with midventricular obstruction. J Am Coll Cardiol 1987;9:288-94.
15. Corr LA, French J, Oakley CM, Nihoyannopoulos P. Predictors and prognosis of left ventricular dilatation in patients with hypertrophic cardiomyopathy [abstr]. J Am Coll Cardiol 1993;21:123A.
16. Tajik AJ, Seward JB, Hagler DJ, Mair DD, Lie JT. Two-dimensional real time ultrasonic imaging of the heart and great vessels. Mayo Clin Proc 1978;53:271-303.
17. Araujo LI, Lammertsma AA, Rhodes CG, McFalls EO, Iida H, Rechavia E, et al. Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation 1991;83: 875-85.
18. Delforge J, Syrota A, Lançon JP, Nakajima K, Loch C, Janier M, et al. Cardiac beta-adrenergic receptor density measured in vivo using PET, CGP 12177 and a new graphical method. J Nucl Med 1991;32:739-48.
19. Brady F, Luthra SK, Tochon-Danguy H, Steel CJ, Waters SL, Kensett MJ, et al. Asymmetric synthesis of a precursor for the automated radiosynthesis of S[11C]CGP 12177 as a preferred radioligand for the beta-adrenergic receptors. Appl Radiat Isotopes 1991;42:621-8.
20. Robb RA, Hanson DP. A software system for interactive and quantitative visualization of multidimensional biomedical images. Aust Phys Eng Sci Med 1991;14:9-30.
21. Maron BJ, Spirito P, Green KJ, Wesley YE, Bonow RO, Arce J. Noninvasive assessment of left ventricular diastolic function by pulsed Doppler echocardiography in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 1987;10:733-42.
22. Laks MM, Morardy F, Swan HJC. Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog. Chest 1973;64:75-8.
23. Bristow MR, Ginsburg R, Minobe W, Cubiciotti RS, Sageman WS, Lurie K, et al. Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts. N Engl J Med 1982;307:205-11.
24. Bristow MR. Pathophysiologic and pharmacologic rationales for clinical management of chronic heart failure with beta-blocking agents. Am J Cardiol 1993;71: 12-22C.
25. Merlet P, Delforge J, Syrota A, Angevin E, Maziere B, Crouzel C, et al. Positron emission tomography with 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation 1993;87:1169-78.
26. Law MP. Demonstration of the suitability of CGP 12177 for in vivo studies of β-adrenoceptors. Br J Pharmacol 1993;109:1101-9.