Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia

Circulation Research

Volumn 111, Issue 2, 2012, Pages 170-179

  Schober, Tilmann ^a,c   Huke, Sabine ^a   Venkataraman, Raghav ^b   Gryshchenko, Oleksiy ^a   Kryshtal, Dmytro ^a   Hwang, Hyun Seok ^a   Baudenbacher, Franz J ^b   Knollmann, Björn C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

arrhythmia; Ca buffering; early afterdepolarizations; familial hypertrophic cardiomyopathy; myofilament Ca sensitivity

Indexed keywords

CALCIUM; CALMODULIN; CALSEQUESTRIN; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TROPONIN T;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL ISOLATION; CONTROLLED STUDY; CYTOSOL; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART PACING; HEART VENTRICLE TACHYCARDIA; MOUSE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SENSITIZATION;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM SIGNALING; CYTOSOL; HOMEOSTASIS; HUMANS; INTRACELLULAR FLUID; MICE; MICE, TRANSGENIC; MUTATION; MYOFIBRILS; PROTEIN BINDING; UP-REGULATION;

EID: 84863723103     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.270041     Document Type: Article

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