Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: An integrative in silico/in vitro approach

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14515-14523

  Manning, Edward P ^a   Guinto, Pia J ^a   Tardiff, Jil C ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FUNCTIONS; BENDING COORDINATES; BENDING FORCE; CALCIUM ACTIVATION; CARDIAC TROPONIN; COOPERATIVITY; EXPERIMENTAL APPROACHES; FAMILIAL HYPERTROPHIC CARDIOMYOPATHIES; FUNCTIONAL CHANGES; FUNCTIONAL DOMAINS; FUNCTIONAL PROPERTIES; HIGH-RESOLUTION STRUCTURES; HIGH-THROUGHPUT; IN-SILICO; IN-VITRO; PRIMARY SEQUENCES; SLIDING SPEED; STRUCTURE-FUNCTION ANALYSIS; THIN FILAMENTS;

BIOCHEMISTRY; BIOLOGY;

CALCIUM;

ARGININE; CALCIUM; LEUCINE; TROPONIN T; TRYPTOPHAN;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; FORCE; GENE MUTATION; HINGE REGION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RABBIT;

AMINO ACID SUBSTITUTION; ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; CHICKENS; HUMANS; MICE; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TROPONIN T;

EID: 84860371801     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.257436     Document Type: Article

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