Hypophosphorylation of the stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium

Circulation Research

Volumn 104, Issue 6, 2009, Pages 780-786

  Borbély, Attila ^a,b   Falcao Pires, Ines ^a,c   Van Heerebeek, Loek ^a   Hamdani, Nazha ^a   Édes, István ^b   Gavina, Cristina ^c   Leite Moreira, Adelino F ^c   Bronzwaer, Jean G F ^a   Papp, Zoltán ^b   Van Der Velden, Jolanda ^a   Stienen, Ger J M ^a   Paulus, Walter J ^a,d  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c University of Porto   (Portugal)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Diastole; Heart failure; Myocardium; Titin

Indexed keywords

CONNECTIN; ISOPROTEIN; MUSCLE PROTEIN; PROTEIN N2B; PROTEIN N2BA; UNCLASSIFIED DRUG; PROTEIN KINASE;

ADULT; AGED; AORTA STENOSIS; ARTICLE; CONTROLLED STUDY; GEL ELECTROPHORESIS; HEART FAILURE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MYOFILAMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SARCOMERE LENGTH; BIOPSY; ELASTICITY; FEMALE; HEART MUSCLE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; SARCOMERE;

AGED; BIOPSY; ELASTICITY; FEMALE; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; MUSCLE PROTEINS; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASES; SARCOMERES;

EID: 64249155200     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.193326     Document Type: Article

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