메뉴 건너뛰기




Volumn 95, Issue 1, 1998, Pages 23-29

Hepatoprotective activity of thymoquinone in isolated rat hepatocytes

Author keywords

Hepatoprotective agent; Rat hepatocytes; Thymoquinone

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; PLANT EXTRACT; SILIBININ; TERT BUTYL HYDROPEROXIDE; THYMOQUINONE; UNCLASSIFIED DRUG;

EID: 0032584004     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00012-5     Document Type: Article
Times cited : (253)

References (32)
  • 2
    • 3142536289 scopus 로고
    • Regu-lation of intracellular calcium compartmentation: Studies with isolated hepatocytes and t-butyl hydroperoxide
    • Bellamo, G., Jewell, S.A., Thor, H., Omenius, S., 1982. Regu-lation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide. Proc. Natl. Acad. Sci. USA 79, 6842-6846.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 6842-6846
    • Bellamo, G.1    Jewell, S.A.2    Thor, H.3    Omenius, S.4
  • 3
    • 0014645531 scopus 로고
    • High yield preparation of isolated rat liver parenchymal cells
    • Berry, M.N., Friend, D.S., 1969. High yield preparation of isolated rat liver parenchymal cells. J. Cell Biol. 43, 506-520.
    • (1969) J. Cell Biol. , vol.43 , pp. 506-520
    • Berry, M.N.1    Friend, D.S.2
  • 4
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • Beutler, E., Duran, O., Kelly, B.M., 1963. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61, 882-888.
    • (1963) J. Lab. Clin. Med. , vol.61 , pp. 882-888
    • Beutler, E.1    Duran, O.2    Kelly, B.M.3
  • 5
    • 0017747605 scopus 로고
    • Inhibitory action of silymarin on lipid peroxide formation in rat liver mitochondria and microsomes
    • Bindoli, A., Cavallini, L., Siliprandi, N., 1977. Inhibitory action of silymarin on lipid peroxide formation in rat liver mitochondria and microsomes. Biochem. Pharmacol. 26, 2405-2409.
    • (1977) Biochem. Pharmacol. , vol.26 , pp. 2405-2409
    • Bindoli, A.1    Cavallini, L.2    Siliprandi, N.3
  • 6
    • 0026532350 scopus 로고
    • Effect of flavonolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes
    • Bosisio, E., Benelli, C., Pirola, O., 1992. Effect of flavonolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol. Res. 25 (2), 147-154.
    • (1992) Pharmacol. Res. , vol.25 , Issue.2 , pp. 147-154
    • Bosisio, E.1    Benelli, C.2    Pirola, O.3
  • 8
    • 0024452911 scopus 로고
    • Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver
    • Campos, R., Garrido, A., Guerra, R., Valenzuela, A., 1989. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 55, 417-419.
    • (1989) Planta Med. , vol.55 , pp. 417-419
    • Campos, R.1    Garrido, A.2    Guerra, R.3    Valenzuela, A.4
  • 9
    • 0027528479 scopus 로고
    • Inhibition of histamine release from mast cells by nigellone
    • Chakravarty, N., 1993. Inhibition of histamine release from mast cells by nigellone. Ann. Allergy 70 (3), 237-242.
    • (1993) Ann. Allergy , vol.70 , Issue.3 , pp. 237-242
    • Chakravarty, N.1
  • 10
    • 0021130228 scopus 로고
    • The protection from hepatotoxicity of some compounds by the synthetic immunomodulator muramyl dipeptide in rat hepatocytes and in vivo
    • Farghali, H., Machkova, Z., Kamemikova, L., Jankn, J., Masek, K., 1984. The protection from hepatotoxicity of some compounds by the synthetic immunomodulator muramyl dipeptide in rat hepatocytes and in vivo. Methods Find. Exp. Clin. Pharmacol. 6, 449-454.
    • (1984) Methods Find. Exp. Clin. Pharmacol. , vol.6 , pp. 449-454
    • Farghali, H.1    Machkova, Z.2    Kamemikova, L.3    Jankn, J.4    Masek, K.5
  • 11
    • 0029620247 scopus 로고
    • Hepatoprotective activity of xanthones and xanthonolignoids against tertbutylhydroperoxide induced toxicity in isolated hepatocytes - Comparison with silybin
    • Fernandez, E.R., Carvalho, F.D., Remiao, F.G., Bastos, M.L., Pinto, M.M., Gottlieb, O.R., 1995. Hepatoprotective activity of xanthones and xanthonolignoids against tertbutylhydroperoxide induced toxicity in isolated hepatocytes - comparison with silybin. Pharmacol. Res. 12 (11), 1756-1760.
    • (1995) Pharmacol. Res. , vol.12 , Issue.11 , pp. 1756-1760
    • Fernandez, E.R.1    Carvalho, F.D.2    Remiao, F.G.3    Bastos, M.L.4    Pinto, M.M.5    Gottlieb, O.R.6
  • 12
    • 0026583939 scopus 로고
    • Ruthenium red delays the onset of cell death during oxidative stress of rat hepatocytes
    • Gartskreutz, J.L., Bronk, S.F., Gores, G.J., 1992. Ruthenium red delays the onset of cell death during oxidative stress of rat hepatocytes. Gastroenterology 102, 1030-1038.
    • (1992) Gastroenterology , vol.102 , pp. 1030-1038
    • Gartskreutz, J.L.1    Bronk, S.F.2    Gores, G.J.3
  • 13
    • 0025305313 scopus 로고
    • Plasma membrane bleb formation and rupture: A common feature of hepatocellular injury
    • Gores, G.J., Herman, B., Lemasters, J.J., 1990. Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury. Hepatology 11, 690-698.
    • (1990) Hepatology , vol.11 , pp. 690-698
    • Gores, G.J.1    Herman, B.2    Lemasters, J.J.3
  • 14
    • 0029100394 scopus 로고
    • Nigella sativa: Effect on human lymphocytes and polymorphonuclear leucocyte phagocytic activity
    • Haq, A., Adbullatif, M., Labo, P., Khabar, K., Sheth, K., AlSedairy, S., 1995. Nigella sativa: effect on human lymphocytes and polymorphonuclear leucocyte phagocytic activity. Immunopharmacology 30, 147-155.
    • (1995) Immunopharmacology , vol.30 , pp. 147-155
    • Haq, A.1    Adbullatif, M.2    Labo, P.3    Khabar, K.4    Sheth, K.5    Alsedairy, S.6
  • 15
    • 0025128542 scopus 로고
    • 2 induced hepatocyte plasma membrane bleb formation by certain eicosanoid inhibitors
    • 2 induced hepatocyte plasma membrane bleb formation by certain eicosanoid inhibitors. Biochim. Biophys. Acta 1022 (30), 319-324.
    • (1990) Biochim. Biophys. Acta , vol.1022 , Issue.30 , pp. 319-324
    • Horton, A.A.1    Wood, J.M.2
  • 16
    • 0025914692 scopus 로고
    • Prevention of paracetamol hepatotoxicity by thromboxane receptor antagonist
    • Horton, A.A., Wood, J.M., 1991. Prevention of paracetamol hepatotoxicity by thromboxane receptor antagonist. J. Lipid Mediators 4 (2), 245-247.
    • (1991) J. Lipid Mediators , vol.4 , Issue.2 , pp. 245-247
    • Horton, A.A.1    Wood, J.M.2
  • 17
    • 0028852880 scopus 로고
    • Fixed oil of Nigella saliva and derived thymoquinone inhibit eicosanoid generation in leucocytes and membrane lipid peroxidation
    • Houghton, P.J., Zarka, R., Heras, B., Hoult, R.S., 1995. Fixed oil of Nigella saliva and derived thymoquinone inhibit eicosanoid generation in leucocytes and membrane lipid peroxidation. Planta Med. 61, 33-36.
    • (1995) Planta Med. , vol.61 , pp. 33-36
    • Houghton, P.J.1    Zarka, R.2    Heras, B.3    Hoult, R.S.4
  • 18
    • 0022770070 scopus 로고
    • Tert-butyl hydroperoxide induced toxicity in isolated hepatocytes: Contribution of thiol oxidation and lipid peroxidation
    • Jewell, A., Dimonte, D., Richelmi, R., Bellomo, G., Orrenius, S., 1986. Tert-butyl hydroperoxide induced toxicity in isolated hepatocytes: contribution of thiol oxidation and lipid peroxidation. J. Biochem. Toxicol. 1, 13-22.
    • (1986) J. Biochem. Toxicol. , vol.1 , pp. 13-22
    • Jewell, A.1    Dimonte, D.2    Richelmi, R.3    Bellomo, G.4    Orrenius, S.5
  • 19
    • 0025334151 scopus 로고
    • Tert-butyl hydroperoxide induced injury in isolated rat hepatocytes: A model for studying antihepatotoxic drugs
    • Joyeux, M., Rolland, A., Fleurentin, J., Mortier, J., Dorfman, P., 1990. Tert-butyl hydroperoxide induced injury in isolated rat hepatocytes: a model for studying antihepatotoxic drugs. Planta Med. 56, 171-174.
    • (1990) Planta Med. , vol.56 , pp. 171-174
    • Joyeux, M.1    Rolland, A.2    Fleurentin, J.3    Mortier, J.4    Dorfman, P.5
  • 20
    • 0021198432 scopus 로고
    • Mechanism of antihepatotoxic activity of glycerrhizin. Effect of free radical generation and lipid peroxidation
    • Kiso, Y., Tohkin, M., Hikine, H., Hattori, M., Sakamoto, T., Namba, T., 1984. Mechanism of antihepatotoxic activity of glycerrhizin. Effect of free radical generation and lipid peroxidation. Planta Med. 50, 298-302.
    • (1984) Planta Med. , vol.50 , pp. 298-302
    • Kiso, Y.1    Tohkin, M.2    Hikine, H.3    Hattori, M.4    Sakamoto, T.5    Namba, T.6
  • 21
    • 0024503507 scopus 로고
    • Tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids
    • Masaki, N., Kyle, M.E., Farber, J.L., 1989. Tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Arch. Biochem. Biophys. 269, 390-399.
    • (1989) Arch. Biochem. Biophys. , vol.269 , pp. 390-399
    • Masaki, N.1    Kyle, M.E.2    Farber, J.L.3
  • 22
    • 0028301966 scopus 로고
    • Hepatoprotective mechanism of silymarin: No evidence for involvement of cytochrome P450 2EI
    • Miguez, M., Anundi, I., Sainz-Pardo, L., Lindros, K.O., 1994. Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2EI. Chem.-Biol. Interact. 91, 51-63.
    • (1994) Chem.-Biol. Interact. , vol.91 , pp. 51-63
    • Miguez, M.1    Anundi, I.2    Sainz-Pardo, L.3    Lindros, K.O.4
  • 23
    • 0003633755 scopus 로고
    • NIH contact No. NOI-RR-2-2135. NIH, Bethesda, MD
    • National Institute of Health, 1985. Guide for the Care and Use of Laboratory Animals. NIH contact No. NOI-RR-2-2135. NIH, Bethesda, MD, pp. 11-28.
    • (1985) Guide for the Care and Use of Laboratory Animals , pp. 11-28
  • 24
    • 0027321652 scopus 로고
    • Free radical scavenger and antihepatotoxic activity of Rosemarinus tomentosus
    • Navaro, M.C., Montilla, M.P., Martin, A., Jimenez, J., Utrilla, M.P., 1993. Free radical scavenger and antihepatotoxic activity of Rosemarinus tomentosus. Planta Med. 53, 312-314.
    • (1993) Planta Med. , vol.53 , pp. 312-314
    • Navaro, M.C.1    Montilla, M.P.2    Martin, A.3    Jimenez, J.4    Utrilla, M.P.5
  • 25
    • 0021240616 scopus 로고
    • Glutathione depletion and susceptibility
    • Reed, D.J., Fauss, M.W., 1984. Glutathione depletion and susceptibility. Pharmacol. Rev. 36 (2), 25S-33S.
    • (1984) Pharmacol. Rev. , vol.36 , Issue.2
    • Reed, D.J.1    Fauss, M.W.2
  • 26
    • 33644792713 scopus 로고
    • Tert-butyl hydroperoxide induced metabolism and stimulation of the pentose phosphate pathway in isolated rat hepatocytes
    • Rush, G.F., Alberts, D., 1986. Tert-butyl hydroperoxide induced metabolism and stimulation of the pentose phosphate pathway in isolated rat hepatocytes. Toxicologist 6, 13.
    • (1986) Toxicologist , vol.6 , pp. 13
    • Rush, G.F.1    Alberts, D.2
  • 27
    • 0028334997 scopus 로고
    • The role of thiols in mitochondrial susceptibility to iron and tert-butyl hydroperoxide mediated toxicity in cultured hepatocytes
    • Shertzer, H.G., Bannenberg, H., Zhu, R.M., Moldeus, P., 1994. The role of thiols in mitochondrial susceptibility to iron and tert-butyl hydroperoxide mediated toxicity in cultured hepatocytes. Chem. Res. Toxicol. 7, 358-366.
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 358-366
    • Shertzer, H.G.1    Bannenberg, H.2    Zhu, R.M.3    Moldeus, P.4
  • 28
    • 0020601235 scopus 로고
    • Response of isolated hepatocytes to organic and inorganic cytotoxins
    • Story, D.L., Gee, S.J., Tyson, C.A., 1983. Response of isolated hepatocytes to organic and inorganic cytotoxins. J. Toxicol. Environ. Health 11, 483-501.
    • (1983) J. Toxicol. Environ. Health , vol.11 , pp. 483-501
    • Story, D.L.1    Gee, S.J.2    Tyson, C.A.3
  • 29
    • 0029587132 scopus 로고
    • Protective effects of Osbeckia octandra against galactosamine and tert-butyl hydroperoxide induced hepatocyte damage
    • Thabrew, M.I., Gove, C.D., Hughes, R.D., McFarlane, I.G., Williams, R., 1995. Protective effects of Osbeckia octandra against galactosamine and tert-butyl hydroperoxide induced hepatocyte damage. J. Ethnopharm. 49, 69-76.
    • (1995) J. Ethnopharm. , vol.49 , pp. 69-76
    • Thabrew, M.I.1    Gove, C.D.2    Hughes, R.D.3    McFarlane, I.G.4    Williams, R.5
  • 30
    • 0022872988 scopus 로고
    • Antioxidant properties of the flavonoids sylibin and + / - Cyanidanol-3: Comparison with butylated hydroxyanisole and butylated hydroxytoluene
    • Valenzuela, A., Guera, R., Videla, L.A., 1986. Antioxidant properties of the flavonoids sylibin and + / - cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Med. 52, 438-440.
    • (1986) Planta Med. , vol.52 , pp. 438-440
    • Valenzuela, A.1    Guera, R.2    Videla, L.A.3
  • 32
    • 0012317199 scopus 로고
    • Rate of increase in plasma levels of cytoplasmic and mitochondrial enzymes in experimental carbon tetrachloride hepatotoxicity
    • Zimmerman, H.J., Kodera, Y., West, M., 1965. Rate of increase in plasma levels of cytoplasmic and mitochondrial enzymes in experimental carbon tetrachloride hepatotoxicity. J. Lab. Clin. Med. 66(2), 315-323.
    • (1965) J. Lab. Clin. Med. , vol.66 , Issue.2 , pp. 315-323
    • Zimmerman, H.J.1    Kodera, Y.2    West, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.