Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats

Human and Experimental Toxicology

Volumn 31, Issue 7, 2012, Pages 726-733

  Basarslan, F ^a   Yilmaz, N ^a   Ates, S ^a   Ozgur, T ^a   Tutanc, M ^a   Motor, V K ^a   Arica, V ^a   Yilmaz, C ^a   Inci, M ^a   Buyukbas, S ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

Author keywords

nephrotoxicity; oxidative stress; thymoquinone; vancomycin

Indexed keywords

CREATININE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; THYMOQUINONE; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; HISTOLOGY; KIDNEY DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTI-BACTERIAL AGENTS; BENZOQUINONES; BLOOD UREA NITROGEN; CREATININE; GLUTATHIONE PEROXIDASE; KIDNEY; MALE; MALONDIALDEHYDE; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; VANCOMYCIN;

ANIMALIA; RATTUS;

EID: 84864120336     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111433185     Document Type: Article

References (39)

1. Wood CA, Kohlhepp SJ, Kohnen PW, et al. Vancomycin enhancement of experimental tobramycin nephrotoxicity. Antimicrob Agents Chemother. 1986 ; 30: 20-24
2. Iwamoto T, Kagawa Y, Kojima M. Clinical efficacy of therapeutic drug monitoring in patients receiving vancomycin. Biol Pharm Bull. 2003 ; 26: 876-879
3. Nishino Y, Takemura S, Minamiyama Y, et al. Targeting superoxide dismutase to renal proximal tubule cells attenuates vancomycin-induced nephrotoxicity in rats. Free Radic Res. 2003 ; 37: 373-379
4. Dean RT, Hunt JV, Grant AJ, et al. Free radical damage to proteins: the influence of the relative localization of radical generation, antioxidants, and target proteins. Free Radic Biol Med. 1991 ; 11: 161-168
5. Cunha BA. Vancomycin. Med Clin North Am. 1995 ; 79: 817-831
6. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995 ; 61: 33-36
7. Khan N, Sharma S, Sultana S. Nigella sativa ameliorates potassium bromate induced early events of carcinogenesis: diminution of oxidative stress. Hum Exp Toxicol. 2003 ; 22: 193-203
8. Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol. 2003 ; 26: 87-98
9. Sayed AA. Thymoquinone protects renal tubular cells against tubular injury. Cell Biochem Funct. 2008 ; 26: 374-380
10. Badary OA, Nagi MN, al-Shabanah OA, et al. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol. 1997 ; 75: 1356-1361
11. Nagi MN, Mansour MA. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res. 2000 ; 41: 283-289
12. Nagi MN, Alam K, Badary OA, et al. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem Mol Biol Int. 1999 ; 47: 153-159
13. Badary OA. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol. 1999 ; 67: 135-142
14. Nishino Y, Takemura S, Minamiyama Y, et al. Inhibition of vancomycin-induced nephrotoxicity by targeting superoxide dismutase to renal proximal tubule cells in the rat. Redox Rep. 2002 ; 7: 317-319
15. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 1990 ; 186: 407-421
16. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988 ; 34: 497-500
17. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967 ; 70: 158-169
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 ; 193: 265-275
19. Oktem F, Arslan MK, Ozguner F, et al. In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycininduced nephrotoxicity: protection by erdosteine. Toxicology. 2005 ; 215: 227-233
20. Wilhelm MP.. Vancomycin. Review. Mayo Clin Proc. 1991 ; 66: 1165-1170
21. Celik I, Cihangiroglu M, Ilhan N, et al. Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity. Basic Clin Pharmacol Toxicol. 2005 ; 97: 325-332
22. Wood MJ. The comparative efficacy and safety of teicoplanin and vancomycin. J Antimicrob Chemother. 1996 ; 37: 209-222
23. Parlakpinar H, Tasdemir S, Polat A, et al. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology. 2005 ; 207: 169-177
24. Inoue M, Nishikawa M, Sato E, et al. Synthesis of superoxide dismutase derivative that specifically accumulates in renal proximal tubule cells. Arch Biochem Biophys. 1999 ; 368: 354-360
25. Toyoguchi T, Takahashi S, Hosoya J, et al. Nephrotoxicity of vancomycin and drug interaction study with cilastatin in rabbits. Antimicrob Agents Chemother. 1997 ; 41: 1985-1990
26. Erdem A, Gündoan NU, Usubütün A, et al. The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol Dial Transplant. 2000 ; 15: 1175-1182
27. Sies H.. Strategies of antioxidant defense. Review. Eur J Biochem. 1993 ; 215: 213-219
28. King DW, Smith MA. Proliferative responses observed following vancomycin treatment in renal proximal tubule epithelial cells. Toxicol In Vitro. 2004 ; 18: 797-803
29. Vardi N, Parlakpinar H, Ozturk F, Acet A. Gentamicin-induced nephrotoxicity and protective effect of caffeic acid phenethyl ester in rats. Fundam Clin Pharmacol. 2005 ; 19: 173-177
30. Nielsen F, Mikkelsen BB, Nielsen JB, et al. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem. 1997 ; 47: 1209-1214
31. Cetin H, Olgar S, Oktem F, et al. Novel evidence suggesting an anti-oxidant property for erythropoietin on vancomycin-induced nephrotoxicity in a rat model. Clin Exp Pharmacol Physiol. 2007 ; 34: 1181-1185
32. Reiter RJ, Poeggeler B, Tan DX, et al. Antioxidant capacity of melatonin: a novel action not requiring a receptor. Neuroendocrinol Lett. 1993 ; 15: 103-116
33. El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol. 2003 ; 84: 251-258
34. Al-Majed AA, Al-Omar FA, Nagi MN. Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur J Pharmacol. 2006 ; 14: 40-47
35. Fouda AM, Daba MH, Dahab GM, Sharaf El-Din OA. Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol. 2008 ; 103: 109-118
36. Sayed-Ahmed MM, Nagi MN. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol. 2007 ; 34: 399-405
37. Oncu M, Gultekin F, Karaöz E, et al. Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants. Hum Exp Toxicol. 2002 ; 21: 223-230
38. Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hamada FM. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology. 2000 ; 143: 219-226
39. Beauchamp D, Pellerin M, Gourde P, et al. Effects of daptomycin and vancomycin on tobramycin nephrotoxicity in rats. Antimicrob Agents Chemother. 1990 ; 34: 139-147