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Volumn 83, Issue 4, 2012, Pages 443-451

Thymoquinone: Potential cure for inflammatory disorders and cancer

Author keywords

Apoptosis; Cancer; Drug toxicity; Inflammatory disorders; Thymoquinone

Indexed keywords

BORTEZOMIB; CASPASE 3; CATALASE; CISPLATIN; DOXORUBICIN; FREE RADICAL; GEMCITABINE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NIGELLA SATIVA EXTRACT; OXALIPLATIN; PACLITAXEL; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; SUPEROXIDE; THYMOQUINONE;

EID: 84855810908     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.09.029     Document Type: Note
Times cited : (433)

References (89)
  • 1
    • 78650162192 scopus 로고    scopus 로고
    • Triphala, Ayurvedic formulation for treating and preventing cancer: A review
    • M.S. Baliga Triphala, Ayurvedic formulation for treating and preventing cancer: a review J Altern Complement Med 16 2010 1301 1308
    • (2010) J Altern Complement Med , vol.16 , pp. 1301-1308
    • Baliga, M.S.1
  • 2
    • 0036488643 scopus 로고    scopus 로고
    • Natural products in cancer chemotherapy: Past, present and future
    • J. Mann Natural products in cancer chemotherapy: past, present and future Nat Rev Cancer 2 2002 143 148 (Pubitemid 37328801)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.2 , pp. 143-148
    • Mann, J.1
  • 3
    • 0031595885 scopus 로고    scopus 로고
    • Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and development
    • DOI 10.1002/(SICI)1098-1128(199809)18:5<315::AID-MED3>3.0.CO;2-W
    • G.M. Cragg Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development Med Res Rev 18 1998 315 331 (Pubitemid 28419084)
    • (1998) Medicinal Research Reviews , vol.18 , Issue.5 , pp. 315-331
    • Cragg, G.M.1
  • 5
    • 58149186496 scopus 로고    scopus 로고
    • In vitro toxicological properties of thymoquinone
    • M. Khader, N. Bresgen, and P.M. Eckl In vitro toxicological properties of thymoquinone Food Chem Toxicol 47 2009 129 133
    • (2009) Food Chem Toxicol , vol.47 , pp. 129-133
    • Khader, M.1    Bresgen, N.2    Eckl, P.M.3
  • 6
    • 2342626583 scopus 로고    scopus 로고
    • Black Cumin Seed Essential Oil, as a Potent Analgesic and Antiinflammatory Drug
    • DOI 10.1002/ptr.1390
    • V. Hajhashemi, A. Ghannadi, and H. Jafarabadi Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug Phytother Res 18 2004 195 199 (Pubitemid 38568744)
    • (2004) Phytotherapy Research , vol.18 , Issue.3 , pp. 195-199
    • Hajhashemi, V.1    Ghannadi, A.2    Jafarabadi, H.3
  • 7
    • 0033837710 scopus 로고    scopus 로고
    • Antioxidant activity of Nigella sativa essential oil
    • DOI 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q
    • M. Burits, and F. Bucar Antioxidant activity of Nigella sativa essential oil Phytother Res 14 2000 323 328 (Pubitemid 30655515)
    • (2000) Phytotherapy Research , vol.14 , Issue.5 , pp. 323-328
    • Burits, M.1    Bucar, F.2
  • 8
    • 0000988920 scopus 로고
    • Studies on the chemical constitution of Egyptian N. sativa L. seeds
    • M. El-Dakhakhany Studies on the chemical constitution of Egyptian N. sativa L. seeds Planta Med 11 1963 465 470
    • (1963) Planta Med , vol.11 , pp. 465-470
    • El-Dakhakhany, M.1
  • 11
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 12
    • 10344235988 scopus 로고    scopus 로고
    • Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism
    • DOI 10.1016/j.intimp.2004.09.001, PII S1567576904002772, New Trends in Immunosuppression
    • A. El-Mahmoudy, Y. Shimizu, T. Shiina, H. Matsuyama, M. El-Sayed, and T. Takewaki Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism Int Immunopharmacol 5 2005 195 207 (Pubitemid 39626705)
    • (2005) International Immunopharmacology , vol.5 , Issue.1 , pp. 195-207
    • El-Mahmoudy, A.1    Shimizu, Y.2    Shiina, T.3    Matsuyama, H.4    El-Sayed, M.5    Takewaki, T.6
  • 13
    • 36949037103 scopus 로고    scopus 로고
    • Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy
    • DOI 10.1007/s11064-007-9419-5
    • M. Kanter Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy Neurochem Res 33 2008 87 96 (Pubitemid 350242795)
    • (2008) Neurochemical Research , vol.33 , Issue.1 , pp. 87-96
    • Kanter, M.1
  • 14
    • 70649088771 scopus 로고    scopus 로고
    • Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats
    • L. Pari, and C. Sankaranarayanan Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats Life Sci 85 2009 830 834
    • (2009) Life Sci , vol.85 , pp. 830-834
    • Pari, L.1    Sankaranarayanan, C.2
  • 15
    • 78649673581 scopus 로고    scopus 로고
    • Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats
    • N.E. Abdelmeguid, R. Fakhoury, S.M. Kamal, and R.J. Al Wafai Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats J Diabetes 2 2010 256 266
    • (2010) J Diabetes , vol.2 , pp. 256-266
    • Abdelmeguid, N.E.1    Fakhoury, R.2    Kamal, S.M.3    Al Wafai, R.J.4
  • 16
    • 67651202351 scopus 로고    scopus 로고
    • Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy
    • M. Kanter Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy J Mol Histol 40 2009 107 115
    • (2009) J Mol Histol , vol.40 , pp. 107-115
    • Kanter, M.1
  • 17
    • 33751437702 scopus 로고    scopus 로고
    • Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis
    • DOI 10.1007/s00204-006-0094-0
    • M. Budancamanak, M. Kanter, A. Demirel, A. Ocakci, H. Uysal, and C. Karakaya Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis Arch Toxicol 80 2006 768 776 (Pubitemid 44817816)
    • (2006) Archives of Toxicology , vol.80 , Issue.11 , pp. 768-776
    • Budancamanak, M.1    Kanter, M.2    Demirel, A.3    Ocakci, A.4    Uysal, H.5    Karakaya, C.6
  • 18
    • 33750200100 scopus 로고    scopus 로고
    • Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models
    • DOI 10.1002/ptr.1964
    • I. Tekeoglu, A. Dogan, and L. Demiralp Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models Phytother Res 20 2006 869 871 (Pubitemid 44606483)
    • (2006) Phytotherapy Research , vol.20 , Issue.10 , pp. 869-871
    • Tekeoglu, I.1    Dogan, A.2    Demiralp, L.3
  • 19
    • 78651296775 scopus 로고    scopus 로고
    • Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis
    • F. Vaillancourt, P. Silva, Q. Shi, H. Fahmi, J.C. Fernandes, and M. Benderdour Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis J Cell Biochem 112 2011 107 117
    • (2011) J Cell Biochem , vol.112 , pp. 107-117
    • Vaillancourt, F.1    Silva, P.2    Shi, Q.3    Fahmi, H.4    Fernandes, J.C.5    Benderdour, M.6
  • 20
    • 0029875804 scopus 로고    scopus 로고
    • Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra
    • L.A. Joosten, M.M. Helsen, F.A. van de Loo, and W.B. van den Berg Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra Arthritis Rheum 39 1996 797 809
    • (1996) Arthritis Rheum , vol.39 , pp. 797-809
    • Joosten, L.A.1    Helsen, M.M.2    Van De Loo, F.A.3    Van Den Berg, W.B.4
  • 22
    • 0036090986 scopus 로고    scopus 로고
    • Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action
    • M.A. Mansour, M.N. Nagi, A.S. El-Khatib, and A.M. Al-Bekairi Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action Cell Biochem Funct 20 2002 143 151
    • (2002) Cell Biochem Funct , vol.20 , pp. 143-151
    • Mansour, M.A.1    Nagi, M.N.2    El-Khatib, A.S.3    Al-Bekairi, A.M.4
  • 24
    • 79955483122 scopus 로고    scopus 로고
    • Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats
    • C. Sankaranarayanan, and L. Pari Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats Chem Biol Interact 190 2011 148 154
    • (2011) Chem Biol Interact , vol.190 , pp. 148-154
    • Sankaranarayanan, C.1    Pari, L.2
  • 26
    • 0642283965 scopus 로고    scopus 로고
    • The changing faces of glutathione, a cellular protagonist
    • DOI 10.1016/S0006-2952(03)00504-5, PII S0006295203005045
    • A. Pompella, A. Visvikis, A. Paolicchi, V. De Tata, and A.F. Casini The changing faces of glutathione, a cellular protagonist Biochem Pharmacol 66 2003 1499 1503 (Pubitemid 38373339)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.8 , pp. 1499-1503
    • Pompella, A.1    Visvikis, A.2    Paolicchi, A.3    De Tata, V.4    Casini, A.F.5
  • 28
    • 33947638565 scopus 로고    scopus 로고
    • Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    • DOI 10.1111/j.1440-1681.2007.04560.x
    • M.M. Sayed-Ahmed, and M.N. Nagi Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats Clin Exp Pharmacol Physiol 34 2007 399 405 (Pubitemid 46494460)
    • (2007) Clinical and Experimental Pharmacology and Physiology , vol.34 , Issue.5-6 , pp. 399-405
    • Sayed-Ahmed, M.M.1    Nagi, M.N.2
  • 29
    • 29744443925 scopus 로고    scopus 로고
    • Transcription factor NF-κB: A sensor for smoke and stress signals
    • DOI 10.1196/annals.1352.026
    • K.S. Ahn, and B.B. Aggarwal Transcription factor NF-kappaB: a sensor for smoke and stress signals Ann NY Acad Sci 1056 2005 218 233 (Pubitemid 43030980)
    • (2005) Annals of the New York Academy of Sciences , vol.1056 , pp. 218-233
    • Ahn, K.S.1    Aggarwal, B.B.2
  • 30
    • 70349528180 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
    • N. Chehl, G. Chipitsyna, Q. Gong, C.J. Yeo, and H.A. Arafat Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells HPB (Oxford) 11 2009 373 381
    • (2009) HPB (Oxford) , vol.11 , pp. 373-381
    • Chehl, N.1    Chipitsyna, G.2    Gong, Q.3    Yeo, C.J.4    Arafat, H.A.5
  • 31
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • G. Sethi, K.S. Ahn, and B.B. Aggarwal Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis Mol Cancer Res 6 2008 1059 1070
    • (2008) Mol Cancer Res , vol.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 32
    • 79960598135 scopus 로고    scopus 로고
    • Role of plant-derived antioxidants on NF-kb expression in LPS-stimulated macrophages
    • R. Wilkins, M. Tucci, and H. Benghuzzi Role of plant-derived antioxidants on NF-kb expression in LPS-stimulated macrophages Biomed Sci Instrum 47 2011 222 227
    • (2011) Biomed Sci Instrum , vol.47 , pp. 222-227
    • Wilkins, R.1    Tucci, M.2    Benghuzzi, H.3
  • 33
    • 33847104142 scopus 로고    scopus 로고
    • Thymoquinone attenuates proinflammatory responses in lipopolysaccharide- activated mast cells by modulating NF-kappaB nuclear transactivation
    • DOI 10.1016/j.bbagen.2007.01.002, PII S0304416507000049
    • M.A. El Gazzar, R. El Mezayen, M.R. Nicolls, and S.C. Dreskin Thymoquinone attenuates proinflammatory responses in lipopolysaccharide- activated mast cells by modulating NF-kappaB nuclear transactivation Biochim Biophys Acta 1770 2007 556 564 (Pubitemid 46281476)
    • (2007) Biochimica et Biophysica Acta - General Subjects , vol.1770 , Issue.4 , pp. 556-564
    • El Gazzar, M.A.1    El Mezayen, R.2    Nicolls, M.R.3    Dreskin, S.C.4
  • 34
    • 17044423457 scopus 로고    scopus 로고
    • Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis
    • A. Mohamed, D.M. Afridi, O. Garani, and M. Tucci Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis Biomed Sci Instrum 41 2005 388 393
    • (2005) Biomed Sci Instrum , vol.41 , pp. 388-393
    • Mohamed, A.1    Afridi, D.M.2    Garani, O.3    Tucci, M.4
  • 35
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: Anticancer strategies and challenges
    • P.A. Johnston, and J.R. Grandis STAT3 signaling: anticancer strategies and challenges Mol Interventions 11 2011 18 26
    • (2011) Mol Interventions , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2
  • 36
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • DOI 10.1038/nrc906
    • J.E. Darnell Jr. Transcription factors as targets for cancer therapy Nat Rev Cancer 2 2002 740 749 (Pubitemid 37328909)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 740-749
    • Darnell Jr., J.E.1
  • 37
    • 77956325713 scopus 로고    scopus 로고
    • Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
    • F. Li, P. Rajendran, and G. Sethi Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway Br J Pharmacol 161 2010 541 554
    • (2010) Br J Pharmacol , vol.161 , pp. 541-554
    • Li, F.1    Rajendran, P.2    Sethi, G.3
  • 38
    • 51349098155 scopus 로고    scopus 로고
    • Cytokines as a key component of cancer-related inflammation
    • G. Germano, P. Allavena, and A. Mantovani Cytokines as a key component of cancer-related inflammation Cytokine 43 2008 374 379
    • (2008) Cytokine , vol.43 , pp. 374-379
    • Germano, G.1    Allavena, P.2    Mantovani, A.3
  • 39
    • 34547744423 scopus 로고    scopus 로고
    • Thymoquinone suppresses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation
    • M.A. El-Gazzar Thymoquinone suppresses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation Inflamm Res 56 2007 345 351
    • (2007) Inflamm Res , vol.56 , pp. 345-351
    • El-Gazzar, M.A.1
  • 40
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • S. Banerjee, A.O. Kaseb, Z. Wang, D. Kong, M. Mohammad, and S. Padhye Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer Cancer Res 69 2009 5575 5583
    • (2009) Cancer Res , vol.69 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5    Padhye, S.6
  • 41
    • 33746225596 scopus 로고    scopus 로고
    • Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    • DOI 10.1016/j.imlet.2006.04.012, PII S0165247806001234
    • R. El Mezayen, M. El Gazzar, M.R. Nicolls, J.C. Marecki, S.C. Dreskin, and H. Nomiyama Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation Immunol Lett 106 2006 72 81 (Pubitemid 44093055)
    • (2006) Immunology Letters , vol.106 , Issue.1 , pp. 72-81
    • El Mezayen, R.1    El Gazzar, M.2    Nicolls, M.R.3    Marecki, J.C.4    Dreskin, S.C.5    Nomiyama, H.6
  • 42
    • 33745007923 scopus 로고    scopus 로고
    • Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
    • DOI 10.1016/j.bbagen.2006.03.006, PII S0304416506000729
    • M. El Gazzar, R. El Mezayen, M.R. Nicolls, J.C. Marecki, and S.C. Dreskin Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma Biochim Biophys Acta 1760 2006 1088 1095 (Pubitemid 43867923)
    • (2006) Biochimica et Biophysica Acta - General Subjects , vol.1760 , Issue.7 , pp. 1088-1095
    • El Gazzar, M.1    El Mezayen, R.2    Nicolls, M.R.3    Marecki, J.C.4    Dreskin, S.C.5
  • 43
    • 11044232238 scopus 로고    scopus 로고
    • 4 synthase in human blood cells by thymoquinone
    • DOI 10.1080/14756360400002072
    • M. Mansour, and S. Tornhamre Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone J Enzyme Inhib Med Chem 19 2004 431 436 (Pubitemid 40045504)
    • (2004) Journal of Enzyme Inhibition and Medicinal Chemistry , vol.19 , Issue.5 , pp. 431-436
    • Mansour, M.1    Tornhamre, S.2
  • 44
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • D.M. Parkin Global cancer statistics in the year 2000 Lancet Oncol 2 2000 533 543
    • (2000) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 45
    • 77958014176 scopus 로고    scopus 로고
    • Review on molecular and therapeutic potential of thymoquinone in cancer
    • S. Banerjee, S. Padhye, A. Azmi, Z. Wang, P.A. Philip, and O. Kucuk Review on molecular and therapeutic potential of thymoquinone in cancer Nutr Cancer 62 2010 938 946
    • (2010) Nutr Cancer , vol.62 , pp. 938-946
    • Banerjee, S.1    Padhye, S.2    Azmi, A.3    Wang, Z.4    Philip, P.A.5    Kucuk, O.6
  • 47
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis
    • O.A. Badary, and A.M. Gamal El-Din Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis Cancer Detect Prev 25 2001 362 368
    • (2001) Cancer Detect Prev , vol.25 , pp. 362-368
    • Badary, O.A.1    Gamal El-Din, A.M.2
  • 48
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • S. Lapenna, and A. Giordano Cell cycle kinases as therapeutic targets for cancer Nat Rev Drug Discov 8 2009 547 566
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 49
    • 1942485326 scopus 로고    scopus 로고
    • Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
    • DOI 10.1097/00001813-200404000-00012
    • H.U. Gali-Muhtasib, W.G. Abou Kheir, L.A. Kheir, N. Darwiche, and P.A. Crooks Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes Anticancer Drugs 15 2004 389 399 (Pubitemid 38526764)
    • (2004) Anti-Cancer Drugs , vol.15 , Issue.4 , pp. 389-399
    • Gali-Muhtasib, H.U.1    Abou Kheir, W.G.2    Kheir, L.A.3    Darwiche, N.4    Crooks, P.A.5
  • 51
    • 77957913537 scopus 로고    scopus 로고
    • Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells
    • R.L. Gurung, S.N. Lim, A.K. Khaw, J.F. Soon, K. Shenoy, and S. Mohamed Ali Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells PLoS One 5 2010 e12124
    • (2010) PLoS One , vol.5 , pp. 12124
    • Gurung, R.L.1    Lim, S.N.2    Khaw, A.K.3    Soon, J.F.4    Shenoy, K.5    Mohamed Ali, S.6
  • 52
    • 79954440155 scopus 로고    scopus 로고
    • Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin
    • K. Effenberger-Neidnicht, and R. Schobert Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin Cancer Chemother Pharmacol 67 2011 867 874
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 867-874
    • Effenberger-Neidnicht, K.1    Schobert, R.2
  • 53
    • 79960929095 scopus 로고    scopus 로고
    • Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway
    • C.C. Woo, S.Y. Loo, G. Veronica, C.W. Yap, G. Sethi, and A.P. Kumar Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway Biochem Pharmacol 82 2011 464 475
    • (2011) Biochem Pharmacol , vol.82 , pp. 464-475
    • Woo, C.C.1    Loo, S.Y.2    Veronica, G.3    Yap, C.W.4    Sethi, G.5    Kumar, A.P.6
  • 54
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • DOI 10.1002/ijc.21205
    • M.A. El-Mahdy, Q. Zhu, Q.E. Wang, G. Wani, and A.A. Wani Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myoloblastic leukemia HL-60 cells Int J Cancer 117 2005 409 417 (Pubitemid 41429564)
    • (2005) International Journal of Cancer , vol.117 , Issue.3 , pp. 409-417
    • El-Mahdy, M.A.1    Zhu, Q.2    Wang, Q.-E.3    Wani, G.4    Wani, A.A.5
  • 55
    • 77649191011 scopus 로고    scopus 로고
    • Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1
    • M. Alhosin, A. Abusnina, M. Achour, T. Sharif, C. Muller, and J. Peluso Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1 Biochem Pharmacol 79 2010 1251 1260
    • (2010) Biochem Pharmacol , vol.79 , pp. 1251-1260
    • Alhosin, M.1    Abusnina, A.2    Achour, M.3    Sharif, T.4    Muller, C.5    Peluso, J.6
  • 57
    • 21344452084 scopus 로고    scopus 로고
    • Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines
    • S. Rooney, and M.F. Ryan Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines Anticancer Res 25 2010 2199 2204 (Pubitemid 40904623)
    • (2005) Anticancer Research , vol.25 , Issue.B , pp. 2199-2204
    • Rooney, S.1    Ryan, M.F.2
  • 58
    • 77949263613 scopus 로고    scopus 로고
    • Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
    • N. El-Najjar, M. Chatila, H. Moukadem, H. Vuorela, M. Ocker, and M. Gandesiri Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling Apoptosis 15 2010 183 195
    • (2010) Apoptosis , vol.15 , pp. 183-195
    • El-Najjar, N.1    Chatila, M.2    Moukadem, H.3    Vuorela, H.4    Ocker, M.5    Gandesiri, M.6
  • 60
    • 33745219871 scopus 로고    scopus 로고
    • The physiological effect of conventional treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid on the LNCaP cell line
    • L.R. Richards, P. Jones, J. Hughes, H. Benghuzzi, and M. Tucci The physiological effect of conventional treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid on the LNCaP cell line Biomed Sci Instrum 42 2006 357 362
    • (2006) Biomed Sci Instrum , vol.42 , pp. 357-362
    • Richards, L.R.1    Jones, P.2    Hughes, J.3    Benghuzzi, H.4    Tucci, M.5
  • 62
    • 77953178795 scopus 로고    scopus 로고
    • Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: Role of reactive oxygen species
    • P.S. Koka, D. Mondal, M. Schultz, A.B. Abdel-Mageed, and K.C. Agrawal Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species Exp Biol Med (Maywood) 235 2010 751 760
    • (2010) Exp Biol Med (Maywood) , vol.235 , pp. 751-760
    • Koka, P.S.1    Mondal, D.2    Schultz, M.3    Abdel-Mageed, A.B.4    Agrawal, K.C.5
  • 63
    • 33750944928 scopus 로고    scopus 로고
    • The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo
    • S. Ivankovic, R. Stojkovic, M. Jukic, M. Milos, M. Milos, and M. Jurin The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo Exp Oncol 28 2006 220 224 (Pubitemid 44735913)
    • (2006) Experimental Oncology , vol.28 , Issue.3 , pp. 220-224
    • Ivankovic, S.1    Stojkovic, R.2    Jukic, M.3    Milos, M.4    Milos, M.5    Jurin, M.6
  • 64
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    • H. Gali-Muhtasib, M. Diab-Assaf, C. Boltze, J. Al-Hmaira, R. Hartig, and A. Roessner Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism Int J Oncol 25 2004 857 866
    • (2004) Int J Oncol , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5    Roessner, A.6
  • 65
    • 78650420222 scopus 로고    scopus 로고
    • Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
    • Arafa el-SA, Q. Zhu, Z.I. Shah, G. Wani, B.M. Barakat, and I. Racoma Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells Mutat Res 706 2011 28 35
    • (2011) Mutat Res , vol.706 , pp. 28-35
    • El-Sa, A.1    Zhu, Q.2    Shah, Z.I.3    Wani, G.4    Barakat, B.M.5    Racoma, I.6
  • 66
    • 47249086549 scopus 로고    scopus 로고
    • Selective anticancer strategies via intervention of the death pathways relevant to cell transformation
    • DOI 10.1038/cdd.2008.48, PII CDD200848
    • Q.X. Li, D.H. Yu, G. Liu, N. Ke, J. McKelvy, and F. Wong-Staal Selective anticancer strategies via intervention of the death pathways relevant to cell transformation Cell Death Differ 15 2008 1197 1210 (Pubitemid 351984750)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.8 , pp. 1197-1210
    • Li, Q.-X.1    Yu, D.H.2    Liu, G.3    Ke, N.4    McKelvy, J.5    Wong-Staal, F.6
  • 67
    • 48649088554 scopus 로고    scopus 로고
    • Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
    • H. Gali-Muhtasib, D. Kuester, C. Mawrin, K. Bajbouj, A. Diestel, and M. Ocker Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells Cancer Res 68 2008 5609 5618
    • (2008) Cancer Res , vol.68 , pp. 5609-5618
    • Gali-Muhtasib, H.1    Kuester, D.2    Mawrin, C.3    Bajbouj, K.4    Diestel, A.5    Ocker, M.6
  • 68
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    • T. Yi, S.G. Cho, Z. Yi, X. Pang, M. Rodriguez, and Y. Wang Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways Mol Cancer Ther 7 2008 1789 1796
    • (2008) Mol Cancer Ther , vol.7 , pp. 1789-1796
    • Yi, T.1    Cho, S.G.2    Yi, Z.3    Pang, X.4    Rodriguez, M.5    Wang, Y.6
  • 69
    • 77952140698 scopus 로고    scopus 로고
    • Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel cancer therapies
    • M.P. Torres, M.P. Ponnusamy, S. Chakraborty, L.M. Smith, S. Das, and H.A. Arafat Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies Mol Cancer Ther 9 2010 1419 1431
    • (2010) Mol Cancer Ther , vol.9 , pp. 1419-1431
    • Torres, M.P.1    Ponnusamy, M.P.2    Chakraborty, S.3    Smith, L.M.4    Das, S.5    Arafat, H.A.6
  • 70
    • 84860390247 scopus 로고    scopus 로고
    • Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
    • W.K. Ng, L.S. Yazan, and M. Ismail Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein Toxicol In Vitro 25 2011 1392 1398
    • (2011) Toxicol in Vitro , vol.25 , pp. 1392-1398
    • Ng, W.K.1    Yazan, L.S.2    Ismail, M.3
  • 71
    • 79952446077 scopus 로고    scopus 로고
    • Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
    • A.R. Hussain, M. Ahmed, S. Ahmed, P. Manogaran, L.C. Platanias, and S.N. Alvi Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma Free Radic Biol Med 50 2011 978 987
    • (2011) Free Radic Biol Med , vol.50 , pp. 978-987
    • Hussain, A.R.1    Ahmed, M.2    Ahmed, S.3    Manogaran, P.4    Platanias, L.C.5    Alvi, S.N.6
  • 73
    • 80054968162 scopus 로고    scopus 로고
    • Radiosensitization in human breast carcinoma cells by thymoquinone: Role of cell cycle and apoptosis
    • R. Velho-Pereira, A. Kumar, B.N. Pandey, A.G. Jagtap, and K.P. Mishra Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis Cell Biol Int 2011
    • (2011) Cell Biol Int
    • Velho-Pereira, R.1    Kumar, A.2    Pandey, B.N.3    Jagtap, A.G.4    Mishra, K.P.5
  • 74
    • 41149137253 scopus 로고    scopus 로고
    • Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    • H. Gali-Muhtasib, M. Ocker, D. Kuester, S. Krueger, Z. El-Hajj, and A. Diestel Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models J Cell Mol Med 12 2008 330 342
    • (2008) J Cell Mol Med , vol.12 , pp. 330-342
    • Gali-Muhtasib, H.1    Ocker, M.2    Kuester, D.3    Krueger, S.4    El-Hajj, Z.5    Diestel, A.6
  • 75
    • 77957800149 scopus 로고    scopus 로고
    • Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis
    • A. Abusnina, M. Alhosin, T. Keravis, C.D. Muller, G. Fuhrmann, and C. Bronner Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis Cell Signal 23 2011 152 160
    • (2011) Cell Signal , vol.23 , pp. 152-160
    • Abusnina, A.1    Alhosin, M.2    Keravis, T.3    Muller, C.D.4    Fuhrmann, G.5    Bronner, C.6
  • 76
    • 70449715208 scopus 로고    scopus 로고
    • Cisplatin overdose: Toxicities and management
    • R.Y. Tsang, T. Al-Fayea, and H.J. Au Cisplatin overdose: toxicities and management Drug Saf 32 2009 1109 1122
    • (2009) Drug Saf , vol.32 , pp. 1109-1122
    • Tsang, R.Y.1    Al-Fayea, T.2    Au, H.J.3
  • 79
    • 0033965801 scopus 로고    scopus 로고
    • The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    • DOI 10.1016/S0300-483X(99)00179-1, PII S0300483X99001791
    • O.A. Badary, A.B. Abdel-Naim, M.H. Abdel-Wahab, and F.M. Hamada The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats Toxicology 143 2000 219 226 (Pubitemid 30089521)
    • (2000) Toxicology , vol.143 , Issue.3 , pp. 219-226
    • Badary, O.A.1    Abdel-Naim, A.B.2    Abdel-Wahab, M.H.3    Hamada, F.M.A.4
  • 80
    • 79958783302 scopus 로고    scopus 로고
    • Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
    • M.N. Nagi, O.A. Al-Shabanah, M.M. Hafez, and M.M. Sayed-Ahmed Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats J Biochem Mol Toxicol 25 2010 135 142
    • (2010) J Biochem Mol Toxicol , vol.25 , pp. 135-142
    • Nagi, M.N.1    Al-Shabanah, O.A.2    Hafez, M.M.3    Sayed-Ahmed, M.M.4
  • 81
    • 79960759529 scopus 로고    scopus 로고
    • Protective effects of thymoquinone against methotrexate-induced testicular injury
    • A. Göke, S. Oktar, A. Koc, and Z. Yonden Protective effects of thymoquinone against methotrexate-induced testicular injury Hum Exp Toxicol 30 2010 897 903
    • (2010) Hum Exp Toxicol , vol.30 , pp. 897-903
    • Göke, A.1    Oktar, S.2    Koc, A.3    Yonden, Z.4
  • 82
    • 69749091547 scopus 로고    scopus 로고
    • Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: Possible role in protection against chemical carcinogenesis and toxicity
    • M.N. Nagi, and H.A. Almakki Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity Phytother Res 23 2009 1295 1298
    • (2009) Phytother Res , vol.23 , pp. 1295-1298
    • Nagi, M.N.1    Almakki, H.A.2
  • 83
    • 67651083705 scopus 로고    scopus 로고
    • Effects of thymoquinone-fatty acid conjugates on cancer cells
    • S. Breyer, K. Effenberger, and R. Schobert Effects of thymoquinone-fatty acid conjugates on cancer cells ChemMedChem 4 2009 761 768
    • (2009) ChemMedChem , vol.4 , pp. 761-768
    • Breyer, S.1    Effenberger, K.2    Schobert, R.3
  • 84
    • 77950086914 scopus 로고    scopus 로고
    • Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential
    • J. Ravindran, H.B. Nair, B. Sung, S. Prasad, R.R. Tekmal, and B.B. Aggarwal Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential Biochem Pharmacol 79 2010 1640 1647
    • (2010) Biochem Pharmacol , vol.79 , pp. 1640-1647
    • Ravindran, J.1    Nair, H.B.2    Sung, B.3    Prasad, S.4    Tekmal, R.R.5    Aggarwal, B.B.6
  • 85
    • 77954154547 scopus 로고    scopus 로고
    • Delivery of phytochemical thymoquinone using molecular micelle modified poly(d, l lactide-co-glycolide) (PLGA) nanoparticles
    • G.M. Ganea, S.O. Fakayode, J.N. Losso, C.F. van Nostrum, C.M. Sabliov, and I.M. Warner Delivery of phytochemical thymoquinone using molecular micelle modified poly(d, l lactide-co-glycolide) (PLGA) nanoparticles Nanotechnology 21 2010 285104
    • (2010) Nanotechnology , vol.21 , pp. 285104
    • Ganea, G.M.1    Fakayode, S.O.2    Losso, J.N.3    Van Nostrum, C.F.4    Sabliov, C.M.5    Warner, I.M.6
  • 86
    • 77953180751 scopus 로고    scopus 로고
    • Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer
    • S. Banerjee, A.S. Azmi, S. Padhye, M.W. Singh, J.B. Baruah, and P.A. Philip Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer Pharm Res 27 2010 1146 1158
    • (2010) Pharm Res , vol.27 , pp. 1146-1158
    • Banerjee, S.1    Azmi, A.S.2    Padhye, S.3    Singh, M.W.4    Baruah, J.B.5    Philip, P.A.6
  • 87
    • 84855780158 scopus 로고    scopus 로고
    • Phase i safety and clinical activity study of thymoquinone in patients with advanced refractory malignant disease
    • A.M. Al-Amri, and A.O. Bamosa Phase I safety and clinical activity study of thymoquinone in patients with advanced refractory malignant disease Shiraz E-Med J 10 2009 107 111
    • (2009) Shiraz E-Med J , vol.10 , pp. 107-111
    • Al-Amri, A.M.1    Bamosa, A.O.2
  • 89
    • 0032876393 scopus 로고    scopus 로고
    • Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    • DOI 10.1016/S0378-8741(98)00242-6, PII S0378874198002426
    • O.A. Badary Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice J Ethnopharmacol 67 1999 135 142 (Pubitemid 29421667)
    • (1999) Journal of Ethnopharmacology , vol.67 , Issue.2 , pp. 135-142
    • Badary, O.A.1


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