Inhibitory effects of thymoquinone on human pancreatic carcinoma orthotopically implanted in nude mice

National Medical Journal of China

Volumn 91, Issue 44, 2011, Pages 3111-3114

  Wang, Yong Mei ^a  

^a Dezhou Municipal Hospital   (China)

Author keywords

Matrix metalloproteinase 9; Metastasis; Pancreatic neoplasms; Thymoquinone; X linked inhibitor of apoptosis protein

Indexed keywords

ALCOHOL; GELATINASE B; GEMCITABINE; KI 67 ANTIGEN; THYMOQUINONE; X LINKED INHIBITOR OF APOPTOSIS; BENZOQUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG MEGADOSE; HUMAN; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; METABOLISM; NUDE MOUSE; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; BENZOQUINONES; CELL LINE, TUMOR; HUMANS; KI-67 ANTIGEN; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84871475402     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2011.44.05     Document Type: Article

References (11)

1. Norwood AA, Tan M, May M, et al. Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells. Biomed Sci Instrum, 2006, 42:350-356.
2. El-Mahdy MA, Zhu Q, Wang QE, et al. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myelo-blastic leukemia HL-60 cells. Int J Cancer, 2005, 117: 409-417.
3. Jafri SH, Glass J, Shi R, et al. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: in vitro and in vivo. J Exp Clin Cancer Res, 2010, 29:87.
4. Guo Q, Chen Y, Zhang B, et al. Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition. Biochem Pharmacol, 2009, 77:1674-1683.
5. Lillemoe KD. Current management of bile duct injury. Br J Surg, 2008, 95:403-405.
6. Rivera F, López-Tarruella S, Vega-Villegas ME, et al. Treatment of advanced pancreatic cancer; from gemcitabine single agent to combinations and targeted therapy. Cancer Treat Rev, 2009, 35: 335-339.
7. 2002, 8:557-559.
8. Jost PJ, Grabow S, Gray D, et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature, 2009, 460: 1035-1039.
9. Banerjee S, Kaseb AO, Wang Z, et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res, 2009, 69: 5575-5583.
10. 2009, 89: 2381-2385.
11. 2009, 89: 2391-2394.