메뉴 건너뛰기




Volumn 30, Issue 8, 2011, Pages 897-903

Protective effects of thymoquinone against methotrexate-induced testicular injury

Author keywords

methotrexate; oxidative stress; testes; thymoquinone

Indexed keywords

ANTIOXIDANT; METHOTREXATE; MYELOPEROXIDASE; THYMOQUINONE;

EID: 79960759529     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110382564     Document Type: Article
Times cited : (81)

References (39)
  • 1
    • 27644478718 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance- associated protein 2 (rMrp2)
    • DOI 10.1016/j.ejps.2005.07.008, PII S0928098705002241
    • Ng C., Xiao YD, Lum BL, and Han YH Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance-associated protein 2 (rMrp2). Eur J Pharm Sci 2005 ; 26: 405-413. (Pubitemid 41554153)
    • (2005) European Journal of Pharmaceutical Sciences , vol.26 , Issue.5 , pp. 405-413
    • Ng, C.1    Xiao, Y.-D.2    Lum, B.L.3    Han, Y.-H.4
  • 2
    • 33745647522 scopus 로고    scopus 로고
    • Understanding and managing methotrexate nephrotoxicity
    • DOI 10.1634/theoncologist.11-6-694
    • Widemann BC, Adamson PC Understanding and managing methotrexate nephrotoxicity. Oncologist 2006 ; 11: 694-703. (Pubitemid 43967624)
    • (2006) Oncologist , vol.11 , Issue.6 , pp. 694-703
    • Widemann, B.C.1    Adamson, P.C.2
  • 3
    • 70749083504 scopus 로고    scopus 로고
    • Antiapoptotic and antioxidant effects of beta-carotene against methotrexate-induced testicular injury
    • Vardi N., Parlakpinar H., Ates B., Cetin A., and Otlu A. Antiapoptotic and antioxidant effects of beta-carotene against methotrexate-induced testicular injury. Fertil Steril 2009 ; 92: 2028-2033.
    • (2009) Fertil Steril , vol.92 , pp. 2028-2033
    • Vardi, N.1    Parlakpinar, H.2    Ates, B.3    Cetin, A.4    Otlu, A.5
  • 5
    • 0018876017 scopus 로고
    • Psoriasis, methotrexate, and oligospermia
    • DOI 10.1001/archderm.116.2.215
    • Sussman A., Leonard JM Psoriasis, methotrexate, and oligospermia. Arch Dermatol 1980 ; 116: 215-217. (Pubitemid 10176570)
    • (1980) Archives of Dermatology , vol.116 , Issue.2 , pp. 215-217
    • Sussman, A.1    Leonard, J.M.2
  • 7
    • 0034286955 scopus 로고    scopus 로고
    • Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection
    • DOI 10.1016/S0192-0561(00)00036-9, PII S0192056100000369
    • Salem ML, Hossain MS Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol 2000 ; 22: 729-740. (Pubitemid 30407026)
    • (2000) International Journal of Immunopharmacology , vol.22 , Issue.9 , pp. 729-740
    • Salem, M.L.1    Hossain, M.S.2
  • 8
    • 0028852880 scopus 로고
    • Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation
    • Houghton PJ, Zarka R., de las Heras B., and Hoult JR Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995 ; 61: 33-36.
    • (1995) Planta Med , vol.61 , pp. 33-36
    • Houghton, P.J.1    Zarka, R.2    De Las Heras, B.3    Hoult, J.R.4
  • 9
    • 0031863041 scopus 로고    scopus 로고
    • Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats
    • el Daly ES Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J Pharm Belg 1998 ; 53: 87-93.
    • (1998) J Pharm Belg , vol.53 , pp. 87-93
    • El Daly, E.S.1
  • 10
    • 0028015961 scopus 로고
    • Hyperglycemic and insulin release inhibitory effects of Rosmarinus officinalis
    • DOI 10.1016/0378-8741(94)90046-9
    • al-Hader AA, Hasan ZA, and Aqel MB Hyperglycemic and insulin release inhibitory effects of Rosmarinus officinalis. J Ethnopharmacol 1994 ; 43: 217-221. (Pubitemid 24232190)
    • (1994) Journal of Ethnopharmacology , vol.43 , Issue.3 , pp. 217-221
    • Al-Hader, A.A.1    Hasan, Z.A.2    Aqel, M.B.3
  • 11
    • 1642544733 scopus 로고    scopus 로고
    • Partial regeneration/proliferation of the β-cells in the Islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats
    • DOI 10.1620/tjem.201.213
    • Kanter M., Meral I., Yener Z., Ozbek H., and Demir H. Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J Exp Med 2003 ; 201: 213-219. (Pubitemid 38128805)
    • (2003) Tohoku Journal of Experimental Medicine , vol.201 , Issue.4 , pp. 213-219
    • Kanter, M.1    Meral, I.2    Yener, Z.3    Ozbek, H.4    Demir, H.5
  • 12
    • 0036273437 scopus 로고    scopus 로고
    • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions
    • DOI 10.1055/s-2002-32084
    • El-Dakhakhny M., Mady N., Lembert N., and Ammon HP The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 2002 ; 68: 465-466. (Pubitemid 34606696)
    • (2002) Planta Medica , vol.68 , Issue.5 , pp. 465-466
    • El-Dakhakhny, M.1    Mady, N.2    Lembert, N.3    Ammon, H.P.T.4
  • 13
    • 30444452089 scopus 로고    scopus 로고
    • Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats
    • Kanter M., Coskun O., and Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol 2005 ; 11: 6684-6688. (Pubitemid 43072712)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.42 , pp. 6684-6688
    • Kanter, M.1    Coskun, O.2    Budancamanak, M.3
  • 15
    • 47649095969 scopus 로고    scopus 로고
    • Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats
    • DOI 10.1111/j.1742-7843.2008.00260.x
    • Fouda AM, Daba MH, Dahab GM, and Sharaf El-Din OA Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol 2008 ; 103: 109-118. (Pubitemid 352019726)
    • (2008) Basic and Clinical Pharmacology and Toxicology , vol.103 , Issue.2 , pp. 109-118
    • Fouda, A.-M.M.1    Daba, M.-H.Y.2    Dahab, G.M.3    Sharaf El-Din, O.A.4
  • 18
    • 33750911068 scopus 로고    scopus 로고
    • The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: Protective effect of caffeic acid phenethyl ester
    • DOI 10.1007/s11010-006-9196-5
    • Uzar E., Koyuncuoglu HR, Uz E., et al. The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Mol Cell Biochem 2006 ; 291: 63-68. (Pubitemid 44725303)
    • (2006) Molecular and Cellular Biochemistry , vol.291 , Issue.1-2 , pp. 63-68
    • Uzar, E.1    Koyuncuoglu, H.R.2    Uz, E.3    Yilmaz, H.R.4    Kutluhan, S.5    Kilbas, S.6    Gultekin, F.7
  • 19
    • 8844234253 scopus 로고    scopus 로고
    • Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
    • DOI 10.1080/00365520410003605
    • Miyazono Y., Gao F., and Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand J Gastroenterol 2004 ; 39: 1119-1127. (Pubitemid 39536402)
    • (2004) Scandinavian Journal of Gastroenterology , vol.39 , Issue.11 , pp. 1119-1127
    • Miyazono, Y.1    Gao, F.2    Horie, T.3
  • 21
    • 0025127633 scopus 로고
    • Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
    • DOI 10.1016/0076-6879(90)86134-H
    • Esterbauer H., Cheeseman KH Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990 ; 186: 407-421. (Pubitemid 20279982)
    • (1990) Methods in Enzymology , vol.186 , pp. 407-421
    • Esterbauer, H.1    Cheeseman, K.H.2
  • 22
    • 0025941759 scopus 로고
    • Vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin
    • Wei H., Frenkel K. In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin. Cancer Res 1991 ; 51: 4443-4449.
    • (1991) Cancer Res , vol.51 , pp. 4443-4449
    • Wei, H.1    Frenkel, K.2
  • 23
    • 1542316295 scopus 로고    scopus 로고
    • A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation
    • DOI 10.1016/j.clinbiochem.2003.11.015, PII S0009912003002315
    • Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004 ; 37: 277-285. (Pubitemid 38314881)
    • (2004) Clinical Biochemistry , vol.37 , Issue.4 , pp. 277-285
    • Erel, O.1
  • 24
    • 29144527533 scopus 로고    scopus 로고
    • A new automated colorimetric method for measuring total oxidant status
    • Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005 ; 38: 1103-1111.
    • (2005) Clin Biochem , vol.38 , pp. 1103-1111
    • Erel, O.1
  • 25
    • 29244482766 scopus 로고    scopus 로고
    • The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: Protective effect of caffeic acid phenethyl ester
    • DOI 10.1016/j.tox.2005.10.014, PII S0300483X05005081
    • Uzar E., Sahin O., Koyuncuoglu HR, et al. The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: protective effect of caffeic acid phenethyl ester. Toxicology 2006 ; 218: 125-133. (Pubitemid 41821344)
    • (2006) Toxicology , vol.218 , Issue.2-3 , pp. 125-133
    • Uzar, E.1    Sahin, O.2    Koyuncuoglu, H.R.3    Uz, E.4    Bas, O.5    Kilbas, S.6    Yilmaz, H.R.7    Yurekli, V.A.8    Kucuker, H.9    Songur, A.10
  • 27
    • 50249176999 scopus 로고    scopus 로고
    • Potent protective effect of apricot and beta-carotene on methotrexateinduced intestinal oxidative damage in rats
    • Vardi N., Parlakpinar H., Ozturk F., et al. Potent protective effect of apricot and beta-carotene on methotrexateinduced intestinal oxidative damage in rats. Food Chem Toxicol 2008 ; 46: 3015-3022.
    • (2008) Food Chem Toxicol , vol.46 , pp. 3015-3022
    • Vardi, N.1    Parlakpinar, H.2    Ozturk, F.3
  • 28
    • 0033840263 scopus 로고    scopus 로고
    • The role of inflammation in vascular diseases
    • Sullivan GW, Sarembock IJ, and Linden J. The role of inflammation in vascular diseases. J Leukoc Biol 2000 ; 67: 591-602.
    • (2000) J Leukoc Biol , vol.67 , pp. 591-602
    • Sullivan, G.W.1    Sarembock, I.J.2    Linden, J.3
  • 29
    • 56049119851 scopus 로고    scopus 로고
    • Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat
    • Armagan A., Uzar E., Uz E., et al. Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat. Hum Exp Toxicol 2008 ; 27: 547-552.
    • (2008) Hum Exp Toxicol , vol.27 , pp. 547-552
    • Armagan, A.1    Uzar, E.2    Uz, E.3
  • 30
    • 50349091192 scopus 로고    scopus 로고
    • Cytotoxic and genotoxic effects of methotrexate in germ cells of male Swiss mice
    • Padmanabhan S., Tripathi DN, Vikram A., Ramarao P., and Jena GB Cytotoxic and genotoxic effects of methotrexate in germ cells of male Swiss mice. Mutat Res 2008 ; 655: 59-67.
    • (2008) Mutat Res , vol.655 , pp. 59-67
    • Padmanabhan, S.1    Tripathi, D.N.2    Vikram, A.3    Ramarao, P.4    Jena, G.B.5
  • 31
    • 58649093951 scopus 로고    scopus 로고
    • Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: Intervention of folic and folinic acid
    • Padmanabhan S., Tripathi DN, Vikram A., Ramarao P., and Jena GB Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: intervention of folic and folinic acid. Mutat Res 2009 ; 673: 43-52.
    • (2009) Mutat Res , vol.673 , pp. 43-52
    • Padmanabhan, S.1    Tripathi, D.N.2    Vikram, A.3    Ramarao, P.4    Jena, G.B.5
  • 33
    • 0025142672 scopus 로고
    • Malondialdehyde determination as index of lipid peroxidation
    • DOI 10.1016/0076-6879(90)86135-I
    • Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990 ; 186: 421-431. (Pubitemid 20279983)
    • (1990) Methods in Enzymology , vol.186 , pp. 421-431
    • Draper, H.H.1    Hadley, M.2
  • 34
    • 77949567615 scopus 로고    scopus 로고
    • Antioxidant systems and oxidative stress in the testes
    • Aitken RR, Roman SD Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev 2008 ; 1: 15-24.
    • (2008) Oxid Med Cell Longev , vol.1 , pp. 15-24
    • Aitken, R.R.1    Roman, S.D.2
  • 35
    • 42449118381 scopus 로고    scopus 로고
    • Comparison between xylazine-tiletamine-zolazepam and fentanyl-tiletamine- zolazepam anaesthetic combinations on plasma oxidative status in sheep
    • DOI 10.2754/avb200776040573
    • Aydilek N. Comparison between xylazine-tiletamine-zolazepam and fentanyl-tiletamine-zolazepam anaesthetic combinations on plasma oxidative status in sheep. Acta Vet Brno 2007 ; 76: 573-578. (Pubitemid 351569937)
    • (2007) Acta Veterinaria Brno , vol.76 , Issue.4 , pp. 573-578
    • Aydilek, N.1
  • 36
    • 0022885219 scopus 로고
    • Effects of methotrexate on rabbit testes. Part 1: Morphological changes
    • Koehler M., Waldherr R., Ludwig R., Heinrich U., and Brandeis WE Effects of methotrexate on rabbit testes. Part 1: morphological changes. Pediatr Hematol Oncol 1986 ; 3: 325-334. (Pubitemid 17038733)
    • (1986) Pediatric Hematology and Oncology , vol.3 , Issue.4 , pp. 325-334
    • Koehler, M.1    Waldherr, R.2    Ludwig, R.3
  • 37
    • 65549122524 scopus 로고    scopus 로고
    • Anti-cancer properties of Nigella spp. essential oils and their major constituents, thymoquinone and beta-elemene
    • Edris AE Anti-cancer properties of Nigella spp. essential oils and their major constituents, thymoquinone and beta-elemene. Curr Clin Pharmacol 2009 ; 4: 43-46.
    • (2009) Curr Clin Pharmacol , vol.4 , pp. 43-46
    • Edris, A.E.1
  • 39
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee S., Kaseb AO, Wang Z., et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res 2009 ; 69: 5575-5583.
    • (2009) Cancer Res , vol.69 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.