메뉴 건너뛰기




Volumn 25, Issue 3, 2011, Pages 135-142

Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats

Author keywords

Adenosine Triphosphate; Cardiotoxicity; Cyclophosphamide; Nitrosative Stress; Oxidative Stress; Thymoquinone

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATALASE; CHOLESTEROL; CREATINE KINASE; CREATININE; CYCLOPHOSPHAMIDE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; NITRATE; NITRITE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID; THYMOQUINONE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UREA;

EID: 79958783302     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20369     Document Type: Article
Times cited : (100)

References (59)
  • 1
    • 0035950826 scopus 로고    scopus 로고
    • Cyclophosphamide and related anticancer drugs
    • Baumann F, Preiss R. Cyclophosphamide and related anticancer drugs. J Chromatogr B: Biomed Sci Appl 2001;764(1-2):173-192.
    • (2001) J Chromatogr B: Biomed Sci Appl , vol.764 , Issue.1-2 , pp. 173-192
    • Baumann, F.1    Preiss, R.2
  • 2
    • 0022905604 scopus 로고
    • Results of treatment of advanced-stage Burkitt's lymphoma and B cell (SIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated high-dose methotrexate and cytarabine
    • Murphy SB, Bowman WP, Abromowitch M, Mirro J, Ochs J, Rivera G, Pui CH, Fairclough D, Berard CW. Results of treatment of advanced-stage Burkitt's lymphoma and B cell (SIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated high-dose methotrexate and cytarabine. J Clin Oncol 1986;4(12):1732-1739.
    • (1986) J Clin Oncol , vol.4 , Issue.12 , pp. 1732-1739
    • Murphy, S.B.1    Bowman, W.P.2    Abromowitch, M.3    Mirro, J.4    Ochs, J.5    Rivera, G.6    Pui, C.H.7    Fairclough, D.8    Berard, C.W.9
  • 3
    • 33845367644 scopus 로고    scopus 로고
    • Principles of cancer treatment by chemotherapy
    • Bhosle JaH. Principles of cancer treatment by chemotherapy. Surgery 2006;24(2):66-69.
    • (2006) Surgery , vol.24 , Issue.2 , pp. 66-69
    • Bhosle, J.1
  • 4
    • 0020406634 scopus 로고
    • Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention-III, profile of action of sodium 2-mercaptoethane sulfonate (mesna)
    • Brock N, Pohl J, Stekar J, Scheef W. Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention-III, profile of action of sodium 2-mercaptoethane sulfonate (mesna). Eur J Cancer Clin Oncol 1982;18(12):1377-1387.
    • (1982) Eur J Cancer Clin Oncol , vol.18 , Issue.12 , pp. 1377-1387
    • Brock, N.1    Pohl, J.2    Stekar, J.3    Scheef, W.4
  • 5
    • 0032826199 scopus 로고    scopus 로고
    • An overview of cyclophosphamide development and clinical applications
    • Colvin OM. An overview of cyclophosphamide development and clinical applications. Curr Pharm Des 1999;5(8):555-560.
    • (1999) Curr Pharm Des , vol.5 , Issue.8 , pp. 555-560
    • Colvin, O.M.1
  • 6
    • 0032849465 scopus 로고    scopus 로고
    • The chemistry of the metabolites of cyclophosphamide
    • Ludeman SM. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des 1999;5(8):627-643.
    • (1999) Curr Pharm Des , vol.5 , Issue.8 , pp. 627-643
    • Ludeman, S.M.1
  • 7
    • 0034888045 scopus 로고    scopus 로고
    • Acute life-threatening toxicity of cancer treatment
    • Shanholtz C. Acute life-threatening toxicity of cancer treatment. Crit Care Clin 2001;17(3):483-502.
    • (2001) Crit Care Clin , vol.17 , Issue.3 , pp. 483-502
    • Shanholtz, C.1
  • 8
    • 0018646130 scopus 로고
    • Cyclophosphamide-induced cardiomyopathy: A report of two cases and review of the English literature
    • Mills BA, Roberts RW. Cyclophosphamide-induced cardiomyopathy: A report of two cases and review of the English literature. Cancer 1979;43(6):2223-2226.
    • (1979) Cancer , vol.43 , Issue.6 , pp. 2223-2226
    • Mills, B.A.1    Roberts, R.W.2
  • 10
    • 0022806838 scopus 로고
    • Cyclophosphamide cardiotoxicity: An analysis of dosing as a risk factor
    • Goldberg MA, Antin JH, Guinan EC, Rappeport JM. Cyclophosphamide cardiotoxicity: An analysis of dosing as a risk factor. Blood 1986;68(5):1114-1118.
    • (1986) Blood , vol.68 , Issue.5 , pp. 1114-1118
    • Goldberg, M.A.1    Antin, J.H.2    Guinan, E.C.3    Rappeport, J.M.4
  • 12
    • 10644259704 scopus 로고    scopus 로고
    • Protective effect of dl-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury
    • Mythili Y, Sudharsan PT, Selvakumar E, Varalakshmi P. Protective effect of dl-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury. Chem Biol Interact 2004;151(1):13-19.
    • (2004) Chem Biol Interact , vol.151 , Issue.1 , pp. 13-19
    • Mythili, Y.1    Sudharsan, P.T.2    Selvakumar, E.3    Varalakshmi, P.4
  • 13
    • 0021203817 scopus 로고
    • Effects of an antimitotic agent (cyclophosphamide) on plasma lipoproteins
    • Loudet AM, Dousset N, Carton M, Douste-Blazy L. Effects of an antimitotic agent (cyclophosphamide) on plasma lipoproteins. Biochem Pharmacol 1984;33(19):2961-2965.
    • (1984) Biochem Pharmacol , vol.33 , Issue.19 , pp. 2961-2965
    • Loudet, A.M.1    Dousset, N.2    Carton, M.3    Douste-Blazy, L.4
  • 14
    • 0031562440 scopus 로고    scopus 로고
    • Impaired secretion of heart lipoprotein lipase in cyclophosphamide-treated rabbit
    • Lespine A, Chap H, Perret B. Impaired secretion of heart lipoprotein lipase in cyclophosphamide-treated rabbit. Biochim Biophys Acta 1997;1345(1):77-85.
    • (1997) Biochim Biophys Acta , vol.1345 , Issue.1 , pp. 77-85
    • Lespine, A.1    Chap, H.2    Perret, B.3
  • 15
    • 0032436596 scopus 로고    scopus 로고
    • 2+ dependent damage of rat heart and liver mitochondria by cyclosporin A
    • 2+ dependent damage of rat heart and liver mitochondria by cyclosporin A. Comp Biochem Physiol A: Mol Integr Physiol 1998;121(3):209-214.
    • (1998) Comp Biochem Physiol A: Mol Integr Physiol , vol.121 , Issue.3 , pp. 209-214
    • Al-Nasser, I.A.1
  • 16
    • 26444605469 scopus 로고    scopus 로고
    • dl-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury
    • Mythili Y, Sudharsan PT, Varalakshmi P. dl-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury. Toxicology 2005;215(1-2):108-114.
    • (2005) Toxicology , vol.215 , Issue.1-2 , pp. 108-114
    • Mythili, Y.1    Sudharsan, P.T.2    Varalakshmi, P.3
  • 17
    • 0028852880 scopus 로고
    • Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation
    • Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995;61(1):33-36.
    • (1995) Planta Med , vol.61 , Issue.1 , pp. 33-36
    • Houghton, P.J.1    Zarka, R.2    de las Heras, B.3    Hoult, J.R.4
  • 18
    • 0033836675 scopus 로고    scopus 로고
    • Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection
    • Nagi MN, Mansour MA. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res 2000;41(3):283-289.
    • (2000) Pharmacol Res , vol.41 , Issue.3 , pp. 283-289
    • Nagi, M.N.1    Mansour, M.A.2
  • 21
  • 22
    • 17044423457 scopus 로고    scopus 로고
    • Thymoquinone inhibits the activation of NF-kB in the brain and spinal cord of experimental autoimmune encephalomyelitis
    • Mohamed A, Afridi DM, Garani O, Tucci M. Thymoquinone inhibits the activation of NF-kB in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed Sci Instrum 2005;41:388-393.
    • (2005) Biomed Sci Instrum , vol.41 , pp. 388-393
    • Mohamed, A.1    Afridi, D.M.2    Garani, O.3    Tucci, M.4
  • 23
    • 0037298005 scopus 로고    scopus 로고
    • Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats
    • El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol 2003;84(2-3):251-258.
    • (2003) J Ethnopharmacol , vol.84 , Issue.2-3 , pp. 251-258
    • El-Abhar, H.S.1    Abdallah, D.M.2    Saleh, S.3
  • 24
    • 0032876393 scopus 로고    scopus 로고
    • Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    • Badary OA. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol 1999;67(2):135-142.
    • (1999) J Ethnopharmacol , vol.67 , Issue.2 , pp. 135-142
    • Badary, O.A.1
  • 25
    • 77951556746 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide
    • Alenzi FQ, El-Bolkiny Yel S, Salem ML. Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. Br J Biomed Sci 2010;67(1):20-28.
    • (2010) Br J Biomed Sci , vol.67 , Issue.1 , pp. 20-28
    • Alenzi, F.Q.1    El-Bolkiny Yel, S.2    Salem, M.L.3
  • 26
    • 0017816152 scopus 로고
    • Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 °C
    • Buhl SN, Jackson KY. Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 °C. Clin Chem 1978;24(5):828-831.
    • (1978) Clin Chem , vol.24 , Issue.5 , pp. 828-831
    • Buhl, S.N.1    Jackson, K.Y.2
  • 27
    • 0019958463 scopus 로고
    • Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals
    • Wu AH, Bowers GN Jr. Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals. Clin Chem 1982;28(10):2017-2021.
    • (1982) Clin Chem , vol.28 , Issue.10 , pp. 2017-2021
    • Wu, A.H.1    Bowers Jr, G.N.2
  • 29
    • 0015591066 scopus 로고
    • Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method
    • Foster LB, Dunn RT. Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chem 1973;19(3):338-340.
    • (1973) Clin Chem , vol.19 , Issue.3 , pp. 338-340
    • Foster, L.B.1    Dunn, R.T.2
  • 30
    • 0018403650 scopus 로고
    • Simplified enzymic/colorimetric serum urea nitrogen determination
    • Tabacco A, Meiattini F, Moda E, Tarli P. Simplified enzymic/colorimetric serum urea nitrogen determination. Clin Chem 1979;25(2):336-337.
    • (1979) Clin Chem , vol.25 , Issue.2 , pp. 336-337
    • Tabacco, A.1    Meiattini, F.2    Moda, E.3    Tarli, P.4
  • 31
    • 0015109591 scopus 로고
    • Automated reaction-rate method for determination of serum creatinine with the CentrifiChem
    • Fabiny DL, Ertingshausen G. Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin Chem 1971;17(8):696-700.
    • (1971) Clin Chem , vol.17 , Issue.8 , pp. 696-700
    • Fabiny, D.L.1    Ertingshausen, G.2
  • 32
    • 0017666831 scopus 로고
    • Enzyme-linked immunosorbent assay for hepatitis B surface antigen
    • Wolters G, Kuijpers LP, Kacaki J, Schuurs AH. Enzyme-linked immunosorbent assay for hepatitis B surface antigen. J Infect Dis 1977;136(Suppl.):S311- S317.
    • (1977) J Infect Dis , vol.136 , Issue.SUPPL.
    • Wolters, G.1    Kuijpers, L.P.2    Kacaki, J.3    Schuurs, A.H.4
  • 33
    • 0021689574 scopus 로고
    • Direct enzymatic assay for reduced and oxidized glutathione
    • Davies MH, Birt DF, Schnell RC. Direct enzymatic assay for reduced and oxidized glutathione. J Pharmacol Methods 1984;12(3):191-194.
    • (1984) J Pharmacol Methods , vol.12 , Issue.3 , pp. 191-194
    • Davies, M.H.1    Birt, D.F.2    Schnell, R.C.3
  • 34
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95(2):351-358.
    • (1979) Anal Biochem , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 35
    • 0035709008 scopus 로고    scopus 로고
    • A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
    • Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001;5(1):62-71.
    • (2001) Nitric Oxide , vol.5 , Issue.1 , pp. 62-71
    • Miranda, K.M.1    Espey, M.G.2    Wink, D.A.3
  • 36
    • 0014691242 scopus 로고
    • Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
    • McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244(22):6049-6055.
    • (1969) J Biol Chem , vol.244 , Issue.22 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.2
  • 37
    • 0017067418 scopus 로고
    • Glutathione peroxidase activity in selenium-deficient rat liver
    • Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 1976;71(4):952-958.
    • (1976) Biochem Biophys Res Commun , vol.71 , Issue.4 , pp. 952-958
    • Lawrence, R.A.1    Burk, R.F.2
  • 39
    • 0028346882 scopus 로고
    • Analytical evaluation of high energy phosphate determination by high performance liquid chromatography in myocardial tissue
    • Botker HE, Kimose HH, Helligso P, Nielsen TT. Analytical evaluation of high energy phosphate determination by high performance liquid chromatography in myocardial tissue. J Mol Cell Cardiol 1994;26(1):41-48.
    • (1994) J Mol Cell Cardiol , vol.26 , Issue.1 , pp. 41-48
    • Botker, H.E.1    Kimose, H.H.2    Helligso, P.3    Nielsen, T.T.4
  • 40
    • 34247141068 scopus 로고    scopus 로고
    • Effect of dl-α-lipoic acid on cyclophosphamide induced lysosomal changes in oxidative cardiotoxicity
    • Mythili Y, Sudharsan PT, Amudha G, Varalakshmi P. Effect of dl-α-lipoic acid on cyclophosphamide induced lysosomal changes in oxidative cardiotoxicity. Life Sci 2007;80(21):1993-1998.
    • (2007) Life Sci , vol.80 , Issue.21 , pp. 1993-1998
    • Mythili, Y.1    Sudharsan, P.T.2    Amudha, G.3    Varalakshmi, P.4
  • 41
    • 33746411167 scopus 로고    scopus 로고
    • Lupeol and its ester exhibit protective role against cyclophosphamide-induced cardiac mitochondrial toxicity
    • Sudharsan PT, Mythili Y, Selvakumar E, Varalakshmi P. Lupeol and its ester exhibit protective role against cyclophosphamide-induced cardiac mitochondrial toxicity. J Cardiovasc Pharmacol 2006;47(2):205-210.
    • (2006) J Cardiovasc Pharmacol , vol.47 , Issue.2 , pp. 205-210
    • Sudharsan, P.T.1    Mythili, Y.2    Selvakumar, E.3    Varalakshmi, P.4
  • 43
    • 0025323320 scopus 로고
    • Leakage of cytoplasmic enzymes from rat heart by the stress of cardiac beating after increase in cell membrane fragility by anoxia
    • Takami H, Matsuda H, Kuki S, Nishimura M, Kawashima Y, Watari H, Furuya E, Tagawa K. Leakage of cytoplasmic enzymes from rat heart by the stress of cardiac beating after increase in cell membrane fragility by anoxia. Pflugers Arch 1990;416(1-2):144-150.
    • (1990) Pflugers Arch , vol.416 , Issue.1-2 , pp. 144-150
    • Takami, H.1    Matsuda, H.2    Kuki, S.3    Nishimura, M.4    Kawashima, Y.5    Watari, H.6    Furuya, E.7    Tagawa, K.8
  • 44
    • 0025837118 scopus 로고
    • Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): Lethal peroxidative membrane injury
    • Janero DR, Hreniuk D, Sharif HM. Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): Lethal peroxidative membrane injury. J Cell Physiol 1991;149(3):347-364.
    • (1991) J Cell Physiol , vol.149 , Issue.3 , pp. 347-364
    • Janero, D.R.1    Hreniuk, D.2    Sharif, H.M.3
  • 45
    • 31044456008 scopus 로고    scopus 로고
    • Effect of squalene on cyclophosphamide-induced toxicity
    • Senthilkumar S, Devaki T, Manohar BM, Babu MS. Effect of squalene on cyclophosphamide-induced toxicity. Clin Chim Acta 2006;364(1-2):335-342.
    • (2006) Clin Chim Acta , vol.364 , Issue.1-2 , pp. 335-342
    • Senthilkumar, S.1    Devaki, T.2    Manohar, B.M.3    Babu, M.S.4
  • 46
    • 67349280855 scopus 로고    scopus 로고
    • Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione
    • Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, Klimberg VS. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition 2009;25(7-8):812-817.
    • (2009) Nutrition , vol.25 , Issue.7-8 , pp. 812-817
    • Todorova, V.1    Vanderpool, D.2    Blossom, S.3    Nwokedi, E.4    Hennings, L.5    Mrak, R.6    Klimberg, V.S.7
  • 47
    • 69749091547 scopus 로고    scopus 로고
    • Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity
    • Nagi MN, Almakki HA. Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity. Phytother Res 2009;23(9):1295-1298.
    • (2009) Phytother Res , vol.23 , Issue.9 , pp. 1295-1298
    • Nagi, M.N.1    Almakki, H.A.2
  • 48
    • 33746210028 scopus 로고    scopus 로고
    • Protective effect of dl-α-lipoic acid on cyclophosphamide induced hyperlipidemic cardiomyopathy
    • Mythili Y, Sudharsan PT, Sudhahar V, Varalakshmi P. Protective effect of dl-α-lipoic acid on cyclophosphamide induced hyperlipidemic cardiomyopathy. Eur J Pharmacol 2006;543(1-3):92-96.
    • (2006) Eur J Pharmacol , vol.543 , Issue.1-3 , pp. 92-96
    • Mythili, Y.1    Sudharsan, P.T.2    Sudhahar, V.3    Varalakshmi, P.4
  • 50
    • 0033965801 scopus 로고    scopus 로고
    • The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    • Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hamada FM. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology 2000;143(3):219-226.
    • (2000) Toxicology , vol.143 , Issue.3 , pp. 219-226
    • Badary, O.A.1    Abdel-Naim, A.B.2    Abdel-Wahab, M.H.3    Hamada, F.M.4
  • 51
    • 33947638565 scopus 로고    scopus 로고
    • Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    • Sayed-Ahmed MM, Nagi MN. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol 2007;34(5-6):399-405.
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , Issue.5-6 , pp. 399-405
    • Sayed-Ahmed, M.M.1    Nagi, M.N.2
  • 53
    • 10344235988 scopus 로고    scopus 로고
    • Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism
    • El-Mahmoudy A, Shimizu Y, Shiina T, Matsuyama H, El-Sayed M, Takewaki T. Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism. Int Immunopharmacol 2005;5(1):195-207.
    • (2005) Int Immunopharmacol , vol.5 , Issue.1 , pp. 195-207
    • El-Mahmoudy, A.1    Shimizu, Y.2    Shiina, T.3    Matsuyama, H.4    El-Sayed, M.5    Takewaki, T.6
  • 54
    • 24944496400 scopus 로고    scopus 로고
    • In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses
    • Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med 2005;71(8):739-742.
    • (2005) Planta Med , vol.71 , Issue.8 , pp. 739-742
    • Marsik, P.1    Kokoska, L.2    Landa, P.3    Nepovim, A.4    Soudek, P.5    Vanek, T.6
  • 55
    • 0036277862 scopus 로고    scopus 로고
    • Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats
    • El-Dakhakhny M, Madi NJ, Lembert N, Ammon HP. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol 2002;81(2):161-164.
    • (2002) J Ethnopharmacol , vol.81 , Issue.2 , pp. 161-164
    • El-Dakhakhny, M.1    Madi, N.J.2    Lembert, N.3    Ammon, H.P.4
  • 56
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals and disease
    • Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984;219(1):1-14.
    • (1984) Biochem J , vol.219 , Issue.1 , pp. 1-14
    • Halliwell, B.1    Gutteridge, J.M.2
  • 57
  • 58
    • 0034120730 scopus 로고    scopus 로고
    • The effect of thymol and its derivatives on reactions generating reactive oxygen species
    • Kruk I, Michalska T, Lichszteld K, Kladna A, Aboul-Enein HY. The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere 2000;41(7):1059-1064.
    • (2000) Chemosphere , vol.41 , Issue.7 , pp. 1059-1064
    • Kruk, I.1    Michalska, T.2    Lichszteld, K.3    Kladna, A.4    Aboul-Enein, H.Y.5
  • 59
    • 75149187342 scopus 로고    scopus 로고
    • Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
    • Ismail M, Al-Naqeep G, Chan KW. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med 2009;48(5):664-672.
    • (2009) Free Radic Biol Med , vol.48 , Issue.5 , pp. 664-672
    • Ismail, M.1    Al-Naqeep, G.2    Chan, K.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.