메뉴 건너뛰기




Volumn 62, Issue 7, 2010, Pages 938-946

Review on molecular and therapeutic potential of thymoquinone in cancer

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOXORUBICIN; GEMCITABINE; IFOSFAMIDE; MERCURIC CHLORIDE; OXALIPLATIN; THYMOQUINONE;

EID: 77958014176     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635581.2010.509832     Document Type: Review
Times cited : (214)

References (62)
  • 1
    • 62549153670 scopus 로고    scopus 로고
    • From here to eternity-the secret of pharaohs: Therapeutic potential of black cumin seeds and beyond
    • Padhye S, Banerjee S, Ahmad A, Mohammad R, and Sarkar FH: From here to eternity-the secret of pharaohs: therapeutic potential of black cumin seeds and beyond. Cancer Ther 6, 495-510, 2008.
    • (2008) Cancer Ther. , vol.6 , pp. 495-510
    • Padhye, S.1    Banerjee, S.2    Ahmad, A.3    Mohammad, R.4    Sarkar, F.H.5
  • 2
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, et al.: Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res 69, 5575-5583, 2009.
    • (2009) Cancer Res. , vol.69 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5
  • 3
    • 21344452084 scopus 로고    scopus 로고
    • Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines
    • Rooney S and Ryan MF: Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res 25, 2199-2204, 2005.
    • (2005) Anticancer Res. , vol.25 , pp. 2199-2204
    • Rooney, S.1    Ryan, M.F.2
  • 4
    • 0012980550 scopus 로고    scopus 로고
    • In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone
    • Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, and Tithof PK: In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 22, 107-113, 2003.
    • (2003) Int. J. Oncol. , vol.22 , pp. 107-113
    • Shoieb, A.M.1    Elgayyar, M.2    Dudrick, P.S.3    Bell, J.L.4    Tithof, P.K.5
  • 5
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    • Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, et al.: Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 25, 857-866, 2004.
    • (2004) Int. J. Oncol. , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5
  • 6
    • 34247362432 scopus 로고    scopus 로고
    • Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells
    • Roepke M, Diestel A, Bajbouj K, Walluscheek D, Schonfeld P, et al.: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther 6, 160-169, 2007.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 160-169
    • Roepke, M.1    Diestel, A.2    Bajbouj, K.3    Walluscheek, D.4    Schonfeld, P.5
  • 7
    • 34247624462 scopus 로고    scopus 로고
    • Physiological responses of ES-2 ovarian cell line following administration of epigallocatechin-3-gallate (EGCG), thymoquinone (TQ), and selenium (SE)
    • Wilson-Simpson F, Vance S, and Benghuzzi H: Physiological responses of ES-2 ovarian cell line following administration of epigallocatechin-3-gallate (EGCG), thymoquinone (TQ), and selenium (SE). Biomed Sci Instrum 43, 378-383, 2007.
    • (2007) Biomed. Sci. Instrum. , vol.43 , pp. 378-383
    • Wilson-Simpson, F.1    Vance, S.2    Benghuzzi, H.3
  • 8
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • El-Mahdy MA, Zhu Q, Wang QE, Wani G, and Wani AA: Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Cancer 117, 409-417, 2005.
    • (2005) Int. J. Cancer , vol.117 , pp. 409-417
    • El-Mahdy, M.A.1    Zhu, Q.2    Wang, Q.E.3    Wani, G.4    Wani, A.A.5
  • 9
    • 34548015409 scopus 로고    scopus 로고
    • Androgen receptor and E2F-1 targeted thymoquinone therapy for hormonerefractory prostate cancer
    • Kaseb AO, Chinnakannu K, Chen D, Sivanandam A, Tejwari S, et al.: Androgen receptor and E2F-1 targeted thymoquinone therapy for hormonerefractory prostate cancer. Cancer Res 67, 7782-7788, 2007.
    • (2007) Cancer Res. , vol.67 , pp. 7782-7788
    • Kaseb, A.O.1    Chinnakannu, K.2    Chen, D.3    Sivanandam, A.4    Tejwari, S.5
  • 10
    • 70349528180 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
    • Chehl N, Chipitsyna G, Gong Q, Yeo CJ, and Arafat HA: Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford) 11, 373-381, 2009.
    • (2009) HPB (Oxford) , vol.11 , pp. 373-381
    • Chehl, N.1    Chipitsyna, G.2    Gong, Q.3    Yeo, C.J.4    Arafat, H.A.5
  • 11
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    • Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, et al.: Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther 7, 1789-1796, 2008.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1789-1796
    • Yi, T.1    Cho, S.G.2    Yi, Z.3    Pang, X.4    Rodriguez, M.5
  • 12
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • Sethi G, Ahn KS, and Aggarwal BB: Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res 6, 1059-1070, 2008.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 13
  • 14
    • 48649088554 scopus 로고    scopus 로고
    • Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
    • Gali-Muhtasib H, Kuester D, Mawrin C, et al.: Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer Res 68, 5609-5618, 2008.
    • (2008) Cancer Res. , vol.68 , pp. 5609-5618
    • Gali-Muhtasib, H.1    Kuester, D.2    Mawrin, C.3
  • 15
    • 4644335311 scopus 로고    scopus 로고
    • Cancer: An inflammatory link
    • Balkwill F and Coussens LM: Cancer: an inflammatory link. Nature 431, 405-406, 2004.
    • (2004) Nature , vol.431 , pp. 405-406
    • Balkwill, F.1    Coussens, L.M.2
  • 16
    • 0036090986 scopus 로고    scopus 로고
    • Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action
    • Mansour MA, Nagi MN, El-Khatib AS, and Al-Bekairi AM: Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 20, 143-151, 2002.
    • (2002) Cell. Biochem. Funct , vol.20 , pp. 143-151
    • Mansour, M.A.1    Nagi, M.N.2    El-Khatib, A.S.3    Al-Bekairi, A.M.4
  • 17
    • 68549098103 scopus 로고    scopus 로고
    • Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats
    • Hamdy NM and Taha RA: Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacology 84, 127-134, 2009.
    • (2009) Pharmacology , vol.84 , pp. 127-134
    • Hamdy, N.M.1    Taha, R.A.2
  • 18
    • 0031431309 scopus 로고    scopus 로고
    • Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity
    • Badary OA, Nagi MN, al-Shabanah OA, al-Sawaf HA, al-Sohaibani MO, et al.: Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol 75, 1356-1361, 1997.
    • (1997) Can. J. Physiol. Pharmacol. , vol.75 , pp. 1356-1361
    • Badary, O.A.1    Nagi, M.N.2    Al-Shabanah, O.A.3    Al-Sawaf, H.A.4    Al-Sohaibani, M.O.5
  • 19
    • 0032876393 scopus 로고    scopus 로고
    • Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    • Badary OA: Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol 67, 135-142, 1999.
    • (1999) J. Ethnopharmacol. , vol.67 , pp. 135-142
    • Badary, O.A.1
  • 20
    • 47649095969 scopus 로고    scopus 로고
    • Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats
    • Fouda AM, Daba MH, Dahab GM, and Sharaf El-Din OA: Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol 103, 109-118, 2008.
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.103 , pp. 109-118
    • Fouda, A.M.1    Daba, M.H.2    Dahab, G.M.3    Sharaf El-Din, O.A.4
  • 21
    • 55449095062 scopus 로고    scopus 로고
    • Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats
    • Al-Johar D, Shinwari N, Arif J, Al-Sanea N, Jabbar AA, et al.: Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats. Phytother Res 22, 1311-1323, 2008.
    • (2008) Phytother. Res. , vol.22 , pp. 1311-1323
    • Al-Johar, D.1    Shinwari, N.2    Arif, J.3    Al-Sanea, N.4    Jabbar, A.A.5
  • 22
    • 0034686073 scopus 로고    scopus 로고
    • Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice
    • Mansour MA: Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci 66, 2583-2591, 2000.
    • (2000) Life Sci. , vol.66 , pp. 2583-2591
    • Mansour, M.A.1
  • 23
    • 0038637860 scopus 로고    scopus 로고
    • Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: Evidence for antioxidant effects of thymoquinone
    • Mansour MA, Ginawi OT, El-Hadiyah T, El-Khatib AS, Al-Shabanah OA, et al.: Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res Commun Mol Pathol Pharmacol 110, 239-251, 2001.
    • (2001) Res. Commun. Mol. Pathol. Pharmacol. , vol.110 , pp. 239-251
    • Mansour, M.A.1    Ginawi, O.T.2    El-Hadiyah, T.3    El-Khatib, A.S.4    Al-Shabanah, O.A.5
  • 24
    • 0033065662 scopus 로고    scopus 로고
    • Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism
    • Nagi MN, Alam K, Badary OA, al-Shabanah OA, al-Sawaf HA, et al.: Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem Mol Biol Int 47, 153-159, 1999.
    • (1999) Biochem. Mol. Biol. Int. , vol.47 , pp. 153-159
    • Nagi, M.N.1    Alam, K.2    Badary, O.A.3    Al-Shabanah, O.A.4    Al-Sawaf, H.A.5
  • 25
    • 34248165186 scopus 로고    scopus 로고
    • Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
    • Khattab MM and Nagi MN: Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res 21, 410-414, 2007.
    • (2007) Phytother. Res. , vol.21 , pp. 410-414
    • Khattab, M.M.1    Nagi, M.N.2
  • 26
    • 69749091547 scopus 로고    scopus 로고
    • Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: Possible role in protection against chemical carcinogenesis and toxicity
    • Nagi MN and Almakki HA: Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity. Phytother Res 23, 1295-1298, 2009.
    • (2009) Phytother. Res. , vol.23 , pp. 1295-1298
    • Nagi, M.N.1    Almakki, H.A.2
  • 27
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis
    • Badary OA and Gamal El-Din AM: Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detect Prev 25, 362-368, 2001.
    • (2001) Cancer Detect Prev. , vol.25 , pp. 362-368
    • Badary, O.A.1    Gamal El-Din, A.M.2
  • 28
    • 77956268772 scopus 로고    scopus 로고
    • Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death
    • Mousavi SH, Tayarani-Najaran Z, Asghari M, and Sadeghnia HR: protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol.
    • Cell. Mol. Neurobiol.
    • Mousavi, S.H.1    Tayarani-Najaran, Z.2    Asghari, M.3    Sadeghnia, H.R.4
  • 29
    • 30344474930 scopus 로고    scopus 로고
    • Connecting COX-2 and Wnt in cancer
    • Buchanan FG and DuBois RN: Connecting COX-2 and Wnt in cancer. Cancer Cell 9, 6-8, 2006.
    • (2006) Cancer Cell. , vol.9 , pp. 6-8
    • Buchanan, F.G.1    DuBois, R.N.2
  • 30
    • 44649115954 scopus 로고    scopus 로고
    • Pro-inflammatory prostaglandins and progression of colorectal cancer
    • Wang D and DuBois RN: Pro-inflammatory prostaglandins and progression of colorectal cancer. Cancer Lett 267, 197-203, 2008.
    • (2008) Cancer Lett. , vol.267 , pp. 197-203
    • Wang, D.1    DuBois, R.N.2
  • 31
    • 33746225596 scopus 로고    scopus 로고
    • Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    • DOI 10.1016/j.imlet.2006.04.012, PII S0165247806001234
    • El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, et al.: Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett 106, 72-81, 2006. (Pubitemid 44093055)
    • (2006) Immunology Letters , vol.106 , Issue.1 , pp. 72-81
    • El Mezayen, R.1    El Gazzar, M.2    Nicolls, M.R.3    Marecki, J.C.4    Dreskin, S.C.5    Nomiyama, H.6
  • 32
    • 11044232238 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone
    • Mansour M and Tornhamre S: Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. J Enzyme Inhib Med Chem 19, 431-436, 2004.
    • (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , pp. 431-436
    • Mansour, M.1    Tornhamre, S.2
  • 33
    • 0036277862 scopus 로고    scopus 로고
    • Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesisof5-lipoxygenase products in polymorphonuclear leukocytes from rats
    • El-Dakhakhny M, Madi NJ, Lembert N, and Ammon HP: Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesisof5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol 81, 161-164, 2002.
    • (2002) J. Ethnopharmacol. , vol.81 , pp. 161-164
    • El-Dakhakhny, M.1    Madi, N.J.2    Lembert, N.3    Ammon, H.P.4
  • 34
    • 34547744423 scopus 로고    scopus 로고
    • Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation
    • El Gazzar MA: Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. Inflamm Res 56, 345-351, 2007.
    • (2007) Inflamm. Res. , vol.56 , pp. 345-351
    • El Gazzar, M.A.1
  • 35
    • 33644663877 scopus 로고    scopus 로고
    • Comparison of the amelioration effects of two enzyme inducers on the inflammatory process of experimental allergic encephalitis (EAE) using immunohistochemical technique
    • El-Gouhary I, Mohamed A, Suleiman S, and Benghuzzi H: Comparison of the amelioration effects of two enzyme inducers on the inflammatory process of experimental allergic encephalitis (EAE) using immunohistochemical technique. Biomed Sci Instrum 41, 376-381, 2005.
    • (2005) Biomed. Sci. Instrum. , vol.41 , pp. 376-381
    • El-Gouhary, I.1    Mohamed, A.2    Suleiman, S.3    Benghuzzi, H.4
  • 36
    • 17044423457 scopus 로고    scopus 로고
    • Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis
    • Mohamed A, Afridi DM, Garani O, and Tucci M: Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed Sci Instrum 41, 388-393, 2005.
    • (2005) Biomed. Sci. Instrum. , vol.41 , pp. 388-393
    • Mohamed, A.1    Afridi, D.M.2    Garani, O.3    Tucci, M.4
  • 37
    • 34548619335 scopus 로고    scopus 로고
    • Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells
    • Sayed AA and Morcos M: Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells. Phytother Res 21, 898-899, 2007.
    • (2007) Phytother. Res. , vol.21 , pp. 898-899
    • Sayed, A.A.1    Morcos, M.2
  • 38
    • 33750944928 scopus 로고    scopus 로고
    • The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo
    • Ivankovic S, Stojkovic R, Jukic M, Milos M, and Jurin M: The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo. Exp Oncol 28, 220-224, 2006.
    • (2006) Exp. Oncol. , vol.28 , pp. 220-224
    • Ivankovic, S.1    Stojkovic, R.2    Jukic, M.3    Milos, M.4    Jurin, M.5
  • 40
    • 70449107828 scopus 로고    scopus 로고
    • Effects of (-) epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture
    • Tan M, Norwood A, May M, Tucci M, and Benghuzzi H: Effects of (-) epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture. Biomed Sci Instrum 42, 363-371, 2006.
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 363-371
    • Tan, M.1    Norwood, A.2    May, M.3    Tucci, M.4    Benghuzzi, H.5
  • 41
    • 33745219871 scopus 로고    scopus 로고
    • The physiological effect of conventional treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid on the LNCaP cell line
    • Richards LR, Jones P, Hughes J, Benghuzzi H, and Tucci M: The physiological effect of conventional treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid on the LNCaP cell line. Biomed Sci Instrum 42, 357-362, 2006.
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 357-362
    • Richards, L.R.1    Jones, P.2    Hughes, J.3    Benghuzzi, H.4    Tucci, M.5
  • 42
    • 70449100461 scopus 로고    scopus 로고
    • The effect of conventional and sustained delivery of thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells
    • Martin TM, Benghuzzi H, and Tucci M: The effect of conventional and sustained delivery of thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells. Biomed Sci Instrum 42, 332-337, 2006.
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 332-337
    • Martin, T.M.1    Benghuzzi, H.2    Tucci, M.3
  • 43
    • 41849123128 scopus 로고    scopus 로고
    • n-Hexane toxicity in Jurkat T-cells is mediated by reactive oxygen species
    • McDermott C, O'Donoghue MH, and Heffron JJ: n-Hexane toxicity in Jurkat T-cells is mediated by reactive oxygen species. Arch Toxicol 82, 165-171, 2008.
    • (2008) Arch. Toxicol. , vol.82 , pp. 165-171
    • McDermott, C.1    O'Donoghue, M.H.2    Heffron, J.J.3
  • 44
    • 41149137253 scopus 로고    scopus 로고
    • Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    • Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El-Hajj Z, et al.: Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med 12, 330-342, 2008.
    • (2008) J. Cell. Mol. Med. , vol.12 , pp. 330-342
    • Gali-Muhtasib, H.1    Ocker, M.2    Kuester, D.3    Krueger, S.4    El-Hajj, Z.5
  • 45
    • 0037659644 scopus 로고    scopus 로고
    • Role of the RB tumor suppressor in cancer
    • Yamasaki L: Role of the RB tumor suppressor in cancer. Cancer Treat Res 115, 209-239, 2003.
    • (2003) Cancer Treat Res. , vol.115 , pp. 209-239
    • Yamasaki, L.1
  • 46
    • 77649191011 scopus 로고    scopus 로고
    • Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1
    • Biochemical pharmacology
    • Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, et al.: Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. Biochem Pharmacol 79, 1251-1260, Biochemical pharmacology.
    • Biochem. Pharmacol. , vol.79 , pp. 1251-1260
    • Alhosin, M.1    Abusnina, A.2    Achour, M.3    Sharif, T.4    Muller, C.5
  • 47
    • 77952140698 scopus 로고    scopus 로고
    • Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel cancer therapies
    • Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, et al.: Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol Cancer Ther.
    • Mol. Cancer Ther.
    • Torres, M.P.1    Ponnusamy, M.P.2    Chakraborty, S.3    Smith, L.M.4    Das, S.5
  • 49
    • 70350553971 scopus 로고    scopus 로고
    • Regulation of low-density lipoprotein receptor and 3-hydroxy-3- methylglutaryl coenzyme a reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells
    • Al-Naqeep G, Ismail M, and Allaudin Z: Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme a reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells. J Nutrigenetics Nutrigenomics 2, 163-172, 2009.
    • (2009) J. Nutrigenetics Nutrigenomics , vol.2 , pp. 163-172
    • Al-Naqeep, G.1    Ismail, M.2    Allaudin, Z.3
  • 50
    • 1942485326 scopus 로고    scopus 로고
    • Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
    • Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, and Crooks PA: Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 15, 389-399, 2004.
    • (2004) Anticancer Drugs , vol.15 , pp. 389-399
    • Gali-Muhtasib, H.U.1    Abou Kheir, W.G.2    Kheir, L.A.3    Darwiche, N.4    Crooks, P.A.5
  • 53
    • 0033965801 scopus 로고    scopus 로고
    • The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    • Badary OA, Abdel-Naim AB, Abdel-Wahab MH, and Hamada FM: The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology 143, 219-226, 2000.
    • (2000) Toxicology , vol.143 , pp. 219-226
    • Badary, O.A.1    Abdel-Naim, A.B.2    Abdel-Wahab, M.H.3    Hamada, F.M.4
  • 55
    • 0031455518 scopus 로고    scopus 로고
    • Modulation of chemosensitivity through altered expression of cell cycle regulatory genes in cancer
    • Hochhauser D: Modulation of chemosensitivity through altered expression of cell cycle regulatory genes in cancer. Anticancer Drugs 8, 903-910, 1997.
    • (1997) Anticancer Drugs , vol.8 , pp. 903-910
    • Hochhauser, D.1
  • 56
    • 42949175548 scopus 로고    scopus 로고
    • Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture
    • Barron J, Benghuzzi H, and Tucci M: Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture. Biomed Sci Instrum 44, 434-440, 2008.
    • (2008) Biomed. Sci. Instrum. , vol.44 , pp. 434-440
    • Barron, J.1    Benghuzzi, H.2    Tucci, M.3
  • 57
    • 0031878048 scopus 로고    scopus 로고
    • The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L
    • Worthen DR, Ghosheh OA, and Crooks PA: The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res 18, 1527-1532, 1998.
    • (1998) Anticancer Res. , vol.18 , pp. 1527-1532
    • Worthen, D.R.1    Ghosheh, O.A.2    Crooks, P.A.3
  • 58
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, et al.: Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 65, 9064-9072, 2005.
    • (2005) Cancer Res. , vol.65 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.5
  • 59
    • 33846646439 scopus 로고    scopus 로고
    • In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
    • DOI 10.1002/ijc.22332
    • Banerjee S, Zhang Y, Wang Z, Che M, Chiao PJ, et al.: In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. Int J Cancer 120, 906-917, 2007. (Pubitemid 46175414)
    • (2007) International Journal of Cancer , vol.120 , Issue.4 , pp. 906-917
    • Banerjee, S.1    Zhang, Y.2    Wang, Z.3    Che, M.4    Chiao, P.J.5    Abbruzzese, J.L.6    Sarkar, F.H.7
  • 60
    • 75449101581 scopus 로고    scopus 로고
    • Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells
    • Effenberger K, Breyer S, and Schobert R: Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells. Chem Biodivers 7, 129-139.
    • Chem. Biodivers , vol.7 , pp. 129-139
    • Effenberger, K.1    Breyer, S.2    Schobert, R.3
  • 61
    • 77953180751 scopus 로고    scopus 로고
    • Structureactivity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer
    • Banerjee S, Azmi AS, Padhye S, Singh MW, Baruah JB, et al.: Structureactivity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer. Pharm Res.
    • Pharm. Res.
    • Banerjee, S.1    Azmi, A.S.2    Padhye, S.3    Singh, M.W.4    Baruah, J.B.5
  • 62
    • 77950086914 scopus 로고    scopus 로고
    • Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced antiproliferative, anti-inflammatory, and chemosensitization potential
    • Ravindran J, Nair HB, Sung B, Prasad S, Tekmal RR, et al.: Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced antiproliferative, anti-inflammatory, and chemosensitization potential. Biochem Pharm 79, 1640-1647.
    • Biochem. Pharm. , vol.79 , pp. 1640-1647
    • Ravindran, J.1    Nair, H.B.2    Sung, B.3    Prasad, S.4    Tekmal, R.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.