Thymoquinone in liposomes: A study of loading efficiency and biological activity towards breast cancer

Drug Delivery

Volumn 19, Issue 8, 2012, Pages 371-377

  Odeh, Fadwa ^a   Ismail, Said I ^a   Abu Dahab, Rana ^a   Mahmoud, Ismail S ^a   Al Bawab, Abeer ^a  

^a UNIVERSITY OF JORDAN   (Jordan)

Author keywords

Breast cancer; Fibroblast; Liposomes; Nigella sativa; Thymoquinone

Indexed keywords

LIPOSOME; THYMOQUINONE; TRITON X 100;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; DRUG BIOAVAILABILITY; FIBROBLAST; HUMAN; HUMAN CELL; PERIODONTAL LIGAMENT; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOQUINONES; BREAST NEOPLASMS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; FEMALE; FIBROBLASTS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPOSOMES; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; OCTOXYNOL; PARTICLE SIZE; SOLUBILITY; SURFACE PROPERTIES;

EID: 84870189574     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2012.727500     Document Type: Article

References (11)

1. Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Elmazar MM. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev 1999;8:435-440. (Pubitemid 30048073)
2. Badary OA, Gamal El-Din AM. Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detect Prev 2001;25:362-368.
3. Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford) 2009;11:373-381.
4. El-Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Cancer 2005;117:409-417. (Pubitemid 41429564)
5. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004;25:857-866.
6. Kaseb AO, Chinnakannu K, Chen D, Sivanandam A, Tejwani S, Menon M et al. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. Cancer Res 2007;67:7782-7788. (Pubitemid 47281372)
7. Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 2002;20:143-151.
8. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461-477. (Pubitemid 46595760)
9. Ravindran J, Nair HB, Sung B, Prasad S, Tekmal RR, Aggarwal BB. Thymoquinone poly(lactide-co-glycolide) nanoparticles exhibit enhanced antiproliferative, anti-inflammatory, and chemosensitization potential. Biochem Pharmacol 2010;79:1640-1647.
10. Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 2003;22:107-113.
11. Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res 1998;18:1527-1532. (Pubitemid 28342555)