Role of NF-κB in the anti-tumor effect of thymoquinone on bladder cancer

National Medical Journal of China

Volumn 92, Issue 6, 2012, Pages 392-396

  Mu, Hai Qi ^a   Yang, Sen ^a   Wang, Yi Jun ^a   Chen, Ying He ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

NF kappa B; Thymoquinone; Urinary bladder neoplasms

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SURVIVIN; THYMOQUINONE; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HISTOCHEMISTRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BENZOQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MICE, INBRED BALB C; NF-KAPPA B; URINARY BLADDER NEOPLASMS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84867845569     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2012.06.010     Document Type: Article

References (11)

1. Costantini C, Millard F. Update on chemotherapy in the treatment of urothelial carcinoma. Scientific World Journal, 2011, 11: 1981-1994.
2. Banerjee S, Padhye S, Azmi A, et al. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer, 2010, 62: 938-946.
3. Ravindran J, Nair H B, Sung B, et al. Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced antiproliferative, anti-inflammatory, and chemosensitization potential. Biochem Pharmacol, 2010, 79: 1640-1647.
4. Banerjee S, Kaseb A O, Wang Z, et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res, 2009, 69: 5575-5583.
5. Kaseb A O, Chinnakannu K, Chen D, et al. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. Cancer Res, 2007, 67: 7782-7788.
6. Su Y T, Chang H L, Shyue S K, et al. Thymoquinone induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol, 2005, 70: 229-241.
7. Jost P J, Grabow S, Gray D, et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature, 2009, 460: 1035-1039.
8. Yang L Q, Fang D C, Wang R Q, et al. Effect of NF-kappa B, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand. World J Gastroenterol, 2004, 10: 22-25.
9. Kunnumakkara A B, Guha S, Krishnan S, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res, 2007, 67: 3853-3861.
10. Kuo T C, Yang J S, Lin M W, et al. Thymoquinone has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdrla and nuclear factor kappaB in cell survival. J Pharmacol Exp Ther, 2009, 330: 736-744.
11. Kumar A, Dhawan S, Aggarwal B B. Thymoquinone (3-methyl-1, 6, 8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene, 1998, 17: 913-918.