Cancer subclonal genetic architecture as a key to personalized medicine

Neoplasia (United States)

Volumn 15, Issue 12, 2013, Pages 1410-1420

  Rehemtulla, Alnawaz ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CANCER GROWTH; CANCER PATIENT; CANCER RESEARCH; ECONOMIC ASPECT; EVIDENCE BASED MEDICINE; GENE MUTATION; GENETIC HETEROGENEITY; HUMAN; LEUKEMIA; NEOPLASM; NONHUMAN; PATIENT CARE; PERSONALIZED MEDICINE; PRIORITY JOURNAL; QUALITY OF LIFE; TUMOR IMMUNOLOGY;

EVIDENCE-BASED MEDICINE; HUMANS; INDIVIDUALIZED MEDICINE; MOLECULAR DIAGNOSTIC TECHNIQUES; NEOPLASMS;

EID: 84891588807     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.131972     Document Type: Article

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107. Yori JL, Seachrist DD, Johnson E, Lozada KL, Abdul-Karim FW, Chodosh LA, Schiemann WP, and Keri RA (2011). Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia 13, 601-610.
108. Zhang J, Sud S, Mizutani K, Gyetko MR, and Pienta KJ (2011). Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model. Neoplasia 13, 23-30.
109. Zhang M, Herion TW, Timke C, Han N, Hauser K, Weber KJ, Peschke P, Wirkner U, Lahn M, and Huber PE (2011). Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761. Neoplasia 13, 537-549.
110. Zhou L, Ercolano E, Ammoun S, Schmid MC, Barczyk MA, and Hanemann CO (2011). Merlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways. Neoplasia 13, 1101-1112.
111. Adamcic U, Skowronski K, Peters C, Morrison J, and Coomber BL (2012). The effect of bevacizumab on human malignant melanoma cells with functional VEGF/VEGFR2 autocrine and intracrine signaling loops. Neoplasia 14, 612-623.
112. Ahsan A, Ramanand SG, Whitehead C, Hiniker SM, Rehemtulla A, Pratt WB, Jolly S, Gouveia C, Truong K, Van Waes C, et al. (2012). Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia 14, 670-677.
113. Al Nakouzi N, Bawa O, Le Pape A, Lerondel S, Gaudin C, Opolon P, Gonin P, Fizazi K, and Chauchereau A (2012). The IGR-CaP1 xenograft model recapitulates mixed osteolytic/blastic bone lesions observed in metastatic prostate cancer. Neoplasia 14, 376-387.
114. Al-Ansari MM, Hendrayani SF, Tulbah A, Al-Tweigeri T, Shehata AI, and Aboussekhra A (2012). p16INK4A represses breast stromal fibroblasts migration/ invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition. Neoplasia 14, 1269-1277.
115. Al-Hassan NN, Behzadian A, Caldwell R, Ivanova VS, Syed V, Motamed K, and Said NA (2012). Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia 14, 259-270.
116. Aschacher T, Sampl S, Käser L, Bernhard D, Spittler A, Holzmann K, and Bergmann M (2012). The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations. Neoplasia 14, 44-53.
117. Beghini A, Corlazzoli F, Del Giacco L, Re M, Lazzaroni F, Brioschi M, Valentini G, Ferrazzi F, Ghilardi A, Righi M, et al. (2012). Regenerationassociated WNT signaling is activated in long-term reconstituting AC133bright acute myeloid leukemia cells. Neoplasia 14, 1236-1248.
118. Benezra M, Hambardzumyan D, Penate-Medina O, Veach DR, Pillarsetty N, Smith-Jones P, Phillips E, Ozawa T, Zanzonico PB, Longo V, et al. (2012). Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-drivenmurine glioblastomamodel. Neoplasia 14, 1132-1143.
119. Blomberg Jensen M, Jørgensen A, Nielsen JE, Steinmeyer A, Leffers H, Juul A, and Rajpert-De Meyts E (2012). Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo. Neoplasia 14, 952-963.
120. Bocci G, Fioravanti A, Orlandi P, Di Desidero T, Natale G, Fanelli G, Viacava P, Naccarato AG, Francia G, and Danesi R (2012). Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1. Neoplasia 14, 833-845.
121. Bonezzi K, Belotti D, North BJ, Ghilardi C, Borsotti P, Resovi A, Ubezio P, Riva A, Giavazzi R, Verdin E, et al. (2012). Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. Neoplasia 14, 846-854.
122. Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, et al. (2012). Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia 14, 535-546.
123. Briggs JW, Ren L, Nguyen R, Chakrabarti K, Cassavaugh J, Rahim S, Bulut G, Zhou M, Veenstra TD, Chen Q, et al. (2012). The Ezrin metastatic phenotype is associated with the initiation of protein translation. Neoplasia 14, 297-310.
124. Buoncervello M, Borghi P, Romagnoli G, Spadaro F, Belardelli F, Toschi E, and Gabriele L (2012). Apicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast cancer cells. Neoplasia 14, 855-867.
125. Candolfi M, King GD, Yagiz K, Curtin JF, Mineharu Y, Muhammad AK, Foulad D, Kroeger KM, Barnett N, Josien R, et al. (2012). Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics. Neoplasia 14, 757-770.
126. Cassell A, Freilino ML, Lee J, Barr S, Wang L, Panahandeh MC, Thomas SM, and Grandis JR (2012). Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models. Neoplasia 14, 1005-1014.
127. Cattelani S, Ferrari-Amorotti G, Galavotti S, Defferrari R, Tanno B, Cialfi S, Vergalli J, Fragliasso V, Guerzoni C, Manzotti G, et al. (2012). The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform. Neoplasia 14, 634-643.
128. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, et al. (2012). MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia 14, 868-879.
129. Cerny-Reiterer S, Ghanim V, Hoermann G, Aichberger KJ, Herrmann H, Muellauer L, Repa A, Sillaber C, Walls AF, Mayerhofer M, et al. (2012). Identification of basophils as a major source of hepatocyte growth factor in chronic myeloid leukemia: a novel mechanism of BCR-ABL1-independent disease progression. Neoplasia 14, 572-584.
130. Ceteci F, Ceteci S, Zanucco E, Thakur C, Becker M, El-Nikhely N, Fink L, Seeger W, Savai R, and Rapp UR (2012). E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice. Neoplasia 14, 1164-1177.
131. Cho HS, Hayami S, Toyokawa G, Maejima K, Yamane Y, Suzuki T, Dohmae N, Kogure M, Kang D, Neal DE, et al. (2012). RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia 14, 476-486.
132. Clark PA, Iida M, Treisman DM, Kalluri H, Ezhilan S, Zorniak M, Wheeler DL, and Kuo JS (2012). Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia 14, 420-428.
133. Couture F, D'Anjou F, Desjardins R, Boudreau F, and Day R (2012). Role of proprotein convertases in prostate cancer progression. Neoplasia 14, 1032-1042.
134. Deng X, Li Q, Hoff J, Novak M, Yang H, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, et al. (2012). Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia 14, 678-689.
135. Derer S, Berger S, Schlaeth M, Schneider-Merck T, Klausz K, Lohse S, Overdijk MB, Dechant M, Kellner C, Nagelmeier I, et al. (2012). Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression. Neoplasia 14, 190-205.
136. Diaz RJ, Guduk M, Romagnuolo R, Smith CA, Northcott P, Shih D, Berisha F, Flanagan A, Munoz DG, Cusimano MD, et al. (2012). High-resolution whole-genome analysis of skull base chordomas implicatesFHIT loss in chordoma pathogenesis. Neoplasia 14, 788-798.
137. Domanska UM, Timmer-Bosscha H, Nagengast WB, Oude Munnink TH, Kruizinga RC, Ananias HJ, Kliphuis NM, Huls G, De Vries EG, de Jong IJ, et al. (2012). CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapy. Neoplasia 14, 709-718.
138. Elguero B, Gueron G, Giudice J, Toscani MA, De Luca P, Zalazar F, Coluccio-Leskow F, Meiss R, Navone N, De Siervi A, et al. (2012). Unveiling the association of STAT3 and HO-1 in prostate cancer: role beyond heme degradation. Neoplasia 14, 1043-1056.
139. Fu J, Bassi DE, Zhang J, Li T, Nicolas E, and Klein-Szanto AJ (2012). Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Neoplasia 14, 271-282.
140. Fung AS, Jonkman J, and Tannock IF (2012). Quantitative immunohistochemistry for evaluating the distribution of Ki67 and other biomarkers in tumor sections and use of the method to study repopulation in xenografts after treatment with paclitaxel. Neoplasia 14, 324-334.
141. Gadd S, Huff V, Huang CC, Ruteshouser EC, Dome JS, Grundy PE, Breslow N, Jennings L, Green DM, Beckwith JB, et al. (2012). Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study. Neoplasia 14, 742-756.
142. Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, and Primo L (2012). 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner. Neoplasia 14, 719-731.
143. Galleu A, Fozza C, Simula MP, Contini S, Virdis P, Corda G, Pardini S, Cottoni F, Pruneddu S, Angeloni A, et al. (2012). CD4+ and CD8+ T-cell skewness in classic Kaposi sarcoma. Neoplasia 14, 487-494.
144. Gámez-Pozo A, Antón-Aparicio LM, Bayona C, Borrega P, Gallegos Sancho MI, García-Domínguez R, de Portugal T, Ramos-Vázquez M, Pérez-Carrión R, Bolós MV, et al. (2012). MicroRNA expression profiling of peripheral blood samples predicts resistance to first-line sunitinib in advanced renal cell carcinoma patients. Neoplasia 14, 1144-1152.
145. Ghazani AA, Castro CM, Gorbatov R, Lee H, and Weissleder R (2012). Sensitive and direct detection of circulating tumor cells by multimarker micronuclear magnetic resonance. Neoplasia 14, 388-395.
146. Glinskii OV, Sud S, Mossine VV, Mawhinney TP, Anthony DC, Glinsky GV, Pienta KJ, and Glinsky VV (2012). Inhibition of prostate cancer bone metastasis by synthetic TF antigen mimic/galectin-3 inhibitor lactulose-L-leucine. Neoplasia 14, 65-73.
147. Glogowska A, Stetefeld J, Weber E, Ghavami S, Hoang-Vu C, and Klonisch T (2012). Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells. Neoplasia 14, 396-409.
148. Grund SE, Polycarpou-Schwarz M, Luo C, Eichmüller SB, and Diederichs S (2012). Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells. Neoplasia 14, 238-248.
149. Guan B, Gao M, Wu CH, Wang TL, and Shih Ie M (2012). Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Neoplasia 14, 986-993.
150. Haeberle H, Dudley JT, Liu JT, Butte AJ, and Contag CH (2012). Identification of cell surface targets through meta-analysis of microarray data. Neoplasia 14, 666-669.
151. Hasenstein JR, Kasmerchak K, Buehler D, Hafez GR, Cleary K, Moody JS, and Kozak KR (2012). Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia 14, 131-140.
152. Haupenthal J, Bihrer V, Korkusuz H, Kollmar O, Schmithals C, Kriener S, Engels K, Pleli T, Benz A, Canamero M, et al. (2012). Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels. Neoplasia 14, 410-419.
153. Hensley HH, Roder NA, O'Brien SW, Bickel LE, Xiao F, Litwin S, and Connolly DC (2012). Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 14, 451-462.
154. Hong SH, Ren L, Mendoza A, Eleswarapu A, and Khanna C (2012). Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells. Neoplasia 14, 249-258.
155. Hu Y, Ylivinkka I, Chen P, Li L, Hautaniemi S, Nyman TA, Keski-Oja J, and Hyytiainen M (2012). Netrin-4 promotes glioblastoma cell proliferation through integrin β4 signaling. Neoplasia 14, 219-227.
156. Jackson JB and Pallas DC (2012). Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner. Neoplasia 14, 585-599.
157. Jackson RS II, Placzek W, Fernandez A, Ziaee S, Chu CY, Wei J, Stebbins J, Kitada S, Fritz G, Reed JC, et al. (2012). Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia 14, 656-665.
158. Jain G, Voogdt C, Tobias A, Spindler KD, Möller P, Cronauer MV, and Marienfeld RB (2012). IκB kinases modulate the activity of the androgen receptor in prostate carcinoma cell lines. Neoplasia 14, 178-189.
159. Jaiswal AS, Armas ML, Izumi T, Strauss PR, and Narayan S (2012). Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function. Neoplasia 14, 495-508.
160. Jamal M, Rath BH, Tsang PS, Camphausen K, and Tofilon PJ (2012). The brain microenvironment preferentially enhances the radioresistance of CD133+ glioblastoma stem-like cells. Neoplasia 14, 150-158.
161. Janakiram NB, Mohammed A, Qian L, Choi CI, Steele VE, and Rao CV (2012). Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of ApcMin/+ mice. Neoplasia 14, 159-168.
162. Jarzyna PA, Deddens LH, Kann BH, Ramachandran S, Calcagno C, Chen W, Gianella A, Dijkhuizen RM, Griffioen AW, Fayad ZA, et al. (2012). Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging. Neoplasia 14, 964-973.
163. Jiang L, Greenwood TR, Artemov D, Raman V, Winnard PT Jr, Heeren RM, Bhujwalla ZM, and Glunde K (2012). Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models. Neoplasia 14, 732-741.
164. Judy BF, Aliperti LA, Predina JD, Levine D, Kapoor V, Thorpe PE, Albelda SM, and Singhal S (2012). Vascular endothelial-targeted therapy combined with cytotoxic chemotherapy induces inflammatory intratumoral infiltrates and inhibits tumor relapses after surgery. Neoplasia 14, 352-359.
165. Jung Y, Shiozawa Y, Wang J, McGregor N, Dai J, Park SI, Berry JE, Havens AM, Joseph J, Kim JK, et al. (2012). Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. Neoplasia 14, 429-439.
166. Kalyana-Sundaram S, Shankar S, Deroo S, Iyer MK, Palanisamy N, Chinnaiyan AM, and Kumar-Sinha C (2012). Gene fusions associated with recurrent amplicons represent a class of passenger aberrations in breast cancer. Neoplasia 14, 702-708.
167. Katoh H, Yamashita K, Waraya M, Margalit O, Ooki A, Tamaki H, Sakagami H, Kokubo K, Sidransky D, and Watanabe M (2012). Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer. Neoplasia 14, 559-571.
168. Klingelhöfer J, Grum-Schwensen B, Beck MK, Knudsen RS, Grigorian M, Lukanidin E, and Ambartsumian N (2012). Anti-S100A4 antibody suppresses metastasis formation by blocking stroma cell invasion. Neoplasia 14, 1260-1268.
169. Korzeniewski N, Hohenfellner M, and Duensing S (2012). CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. Neoplasia 14, 799-806.
170. Kumbrink J and Kirsch KH (2012). Regulation of p130Cas/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2. Neoplasia 14, 108-120.
171. Kuzyk A and Mai S (2012). Selected telomere length changes and aberrant three-dimensional nuclear telomere organization during fast-onset mouse plasmacytomas. Neoplasia 14, 344-351.
172. Larbouret C, Gaborit N, Chardès T, Coelho M, Campigna E, Bascoul-Mollevi C, Mach JP, Azria D, Robert B, and Pèlegrin A (2012). In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' down-regulation and dimers' disruption. Neoplasia 14, 121-130.
173. Lecomte J, Masset A, Blacher S, Maertens L, Gothot A, Delgaudine M, Bruyère F, Carnet O, Paupert J, Illemann M, et al. (2012). Bone marrow-derived myofibroblasts are the providers of pro-invasive matrix metalloproteinase 13 in primary tumor. Neoplasia 14, 943-951.
174. Lee HJ, Yu HK, Papadopoulos JN, Kim SW, He J, Park YK, Yoon Y, Kim JS, and Kim SJ (2012). Targeted antivascular therapy with the apolipoprotein(a) kringle V, rhLK8, inhibits the growth and metastasis of human prostate cancer in an orthotopic nude mouse model. Neoplasia 14, 335-343.
175. Li J, O'Malley M, Sampath P, Kalinski P, Bartlett DL, and Thorne SH (2012). Expression of CCL19 from oncolytic vaccinia enhances immunotherapeutic potential while maintaining oncolytic activity. Neoplasia 14, 1115-1121.
176. ] Li Z, Owonikoko TK, Sun SY, Ramalingam SS, Doetsch PW, Xiao ZQ, Khuri FR, Curran WJ, and Deng X (2012). c-Myc suppression of DNA double-strand break repair. Neoplasia 14, 1190-1202.
177. Lin YC, Wu MH, Wei TT, Chuang SH, Chen KF, Cheng AL, and Chen CC (2012). Degradation of epidermal growth factor receptor mediates dasatinibinduced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia 14, 463-475.
178. Loveless ME, Lawson D, Collins M, Nadella MV, Reimer C, Huszar D, Halliday J, Waterton JC, Gore JC, and Yankeelov TE (2012). Comparisons of the efficacy of a Jak1/2 inhibitor (AZD1480) with a VEGF signaling inhibitor (cediranib) and sham treatments in mouse tumors using DCE-MRI, DW-MRI, and histology. Neoplasia 14, 54-64.
179. Luo Y, Liu L, Rogers D, Su W, Odaka Y, Zhou H, Chen W, Shen T, Alexander JS, and Huang S (2012). Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression. Neoplasia 14, 228-237.
180. Malenda A, Skrobanska A, Issat T, Winiarska M, Bil J, Oleszczak B, Sinski M, Firczuk M, Bujnicki JM, Chlebowska J, et al. (2012). Statins impair glucose uptake in tumor cells. Neoplasia 14, 311-323.
181. Mankame TP and Lingen MW (2012). The RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7. Neoplasia 14, 1213-1222.
182. Maret D, Sadr MS, Sadr ES, Colman DR, Del Maestro RF, and Seidah NG (2012). Opposite roles of furin and PC5A in N-cadherin processing. Neoplasia 14, 880-892.
183. Martin-Padura I, Marighetti P, Gregato G, Agliano A, Malazzi O, Mancuso P, Pruneri G, Viale A, and Bertolini F (2012). Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential. Neoplasia 14, 1057-1066.
184. Mattei F, Schiavoni G, Sestili P, Spadaro F, Fragale A, Sistigu A, Lucarini V, Spada M, Sanchez M, Scala S, et al. (2012). IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment. Neoplasia 14, 1223-1235.
185. Mohammed A, Janakiram NB, Brewer M, Duff A, Lightfoot S, Brush RS, Anderson RE, and Rao CV (2012). Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48Cre/+-LSL-KrasG12D/+ mice. Neoplasia 14, 1249-1259.
186. Moser C, Ruemmele P, Gehmert S, Schenk H, Kreutz MP, Mycielska ME, Hackl C, Kroemer A, Schnitzbauer AA, Stoeltzing O, et al. (2012). STAT5b as molecular target in pancreatic cancer-inhibition of tumor growth, angiogenesis, and metastases. Neoplasia 14, 915-925.
187. Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N, and Burma S (2012). The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia 14, 34-43.
188. Murphy AJ, de Caestecker C, Pierce J, Boyle SC, Ayers GD, Zhao Z, Libes JM, Correa H, Walter T, Huppert SS, et al. (2012). CITED1 expression in liver development and hepatoblastoma. Neoplasia 14, 1153-1163.
189. Naderi A, Meyer M, and Dowhan DH (2012). Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer. Neoplasia 14, 283-296.
190. Ngora H, Galli UM, Miyazaki K, and Zoller M (2012). Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α6β4 integrin and MT1-MMP. Neoplasia 14, 95-107.
191. Nord KH, Paulsson K, Veerla S, Wejde J, Brosjö O, Mandahl N, and Mertens F (2012). Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. Neoplasia 14, 807-812.
192. Nunez-Cruz S, Gimotty PA, Guerra MW, Connolly DC, Wu YQ, DeAngelis RA, Lambris JD, Coukos G, and Scholler N (2012). Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization. Neoplasia 14, 994-1004.
193. Olszewski U, Deally A, Tacke M, and Hamilton G (2012). Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y. Neoplasia 14, 813-822.
194. Pal A, Huang W, Toy KA, and Kleer CG (2012). CCN6 knockdown disrupts acinar organization of breast cells in three-dimensional cultures through upregulation of type III TGF-β receptor. Neoplasia 14, 1067-1074.
195. Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, et al. (2012). Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements. Neoplasia 14, 600-611.
196. Plebani R, Oliver GR, Trerotola M, Guerra E, Cantanelli P, Apicella L, Emerson A, Albiero A, Harkin PD, Kennedy RD, et al. (2012). Long-range transcriptome sequencing reveals cancer cell growth regulatory chimeric mRNA. Neoplasia 14, 1087-1096.
197. Qiu X, Guo G, Chen K, Kashiwada M, Druker BJ, Rothman PB, and Chen JL (2012). A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr- Abl-induced tumorigenesis. Neoplasia 14, 547-558.
198. Rahman M, Selvarajan K, Hasan MR, Chan AP, Jin C, Kim J, Chan SK, Le ND, Kim YB, and Tai IT (2012). Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivo. Neoplasia 14, 624-633.
199. Rao CV, Mohammed A, Janakiram NB, Li Q, Ritchie RL, Lightfoot S, Vibhudutta A, and Steele VE (2012). Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48Cre/+-LSL-KrasG12D/+ mice. Neoplasia 14, 778-787.
200. Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH, Vinegoni C, and Weissleder R (2012). Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents. Neoplasia 14, 169-177.
201. Ronchi CL, Leich E, Sbiera S, Weismann D, Rosenwald A, Allolio B, and Fassnacht M (2012). Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways. Neoplasia 14, 206-218.
202. Samanta D, Kaufman J, Carbone DP, and Datta PK (2012). Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer. Neoplasia 14, 644-655.
203. Shang X, Lin X, Alvarez E, Manorek G, and Howell SB (2012). Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases. Neoplasia 14, 974-985.
204. Soria G, Lebel-Haziv Y, Ehrlich M, Meshel T, Suez A, Avezov E, Rozenberg P, and Ben-Baruch A (2012). Mechanisms regulating the secretion of the promalignancy chemokine CCL5 by breast tumor cells: CCL5's 40s loop and intracellular glycosaminoglycans. Neoplasia 14, 1-19.
205. Stead LF, Berri S, Wood HM, Egan P, Conway C, Daly C, Papagiannopoulos K, and Rabbitts P (2012). The transcriptional consequences of somatic amplifications, deletions, and rearrangements in a human lung squamous cell carcinoma. Neoplasia 14, 1075-1086.
206. Stigliani S, Coco S, Moretti S, Oberthuer A, Fischer M, Theissen J, Gallo F, Garavent A, Berthold F, Bonassi S, et al. (2012). High genomic instability predicts survival in metastatic high-risk neuroblastoma. Neoplasia 14, 823-832.
207. Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, and Prat A (2012). Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. Neoplasia 14, 1122-1131.
208. Tanikawa C, Nakagawa H, Furukawa Y, Nakamura Y, and Matsuda K (2012). CLCA2 as a p53-inducible senescence mediator. Neoplasia 14, 141-149.
209. Taniuchi K, Yokotani K, and Saibara T (2012). BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1. Neoplasia 14, 440-450.
210. Thomasova D, Mulay SR, Bruns H, and Anders HJ (2012). p53-independent roles of MDM2 in NF-κB signaling: implications for cancer therapy, wound healing, and autoimmune diseases. Neoplasia 14, 1097-1101.
211. Treviño JG, Pillai S, Kunigal S, Singh S, Fulp WJ, Centeno BA, and Chellappan SP (2012). Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia 14, 1102-1114.
212. Trivigno D, Essmann F, Huber SM, and Rudner J (2012). Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1. Neoplasia 14, 893-904.
213. Venkatesha VA, Parsels LA, Parsels JD, Zhao L, Zabludoff SD, Simeone DM, Maybaum J, Lawrence TS, and Morgan MA (2012). Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition. Neoplasia 14, 519-525.
214. Voigt M, Braig F, Göthel M, Schulte A, Lamszus K, Bokemeyer C, and Binder M (2012). Functional dissection of the epidermal growth factor receptor epitopes targeted by panitumumab and cetuximab. Neoplasia 14, 1023-1031.
215. Volk-Draper LD, Rajput S, Hall KL, Wilber A, and Ran S (2012). Novel model for basaloid triple-negative breast cancer: behavior in vivo and response to therapy. Neoplasia 14, 926-942.
216. von dem Knesebeck A, Felsberg J, Waha A, Hartmann W, Scheffler B, Glas M, Hammes J, Mikeska T, Yan PS, Endl E, et al. (2012). RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas. Neoplasia 14, 526-534.
217. Wang R, Asangani IA, Chakravarthi BV, Ateeq B, Lonigro RJ, Cao Q, Mani RS, Camacho DF, McGregor N, Schumann TE, et al. (2012). Role of transcriptional corepressor CtBP1 in prostate cancer progression. Neoplasia 14, 905-914.
218. Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, and Wei W (2012). An evolving role for DEPTOR in tumor development and progression. Neoplasia 14, 368-375.
219. Weekes CD, Song D, Arcaroli J, Wilson LA, Rubio-Viqueira B, Cusatis G, Garrett-Mayer E, Messersmith WA, Winn RA, and Hidalgo M (2012). Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer. Neoplasia 14, 690-701.
220. Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, and McMahon JB (2012). Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A. Neoplasia 14, 771-777.
221. Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, and Jain RK (2012). Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia 14, 84-94.
222. Wu X, Tao Y, Hou J, Meng X, and Shi J (2012). Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma. Neoplasia 14, 1178-1189.
223. Xu Y, Zhou J, Carey TE, McHugh JB, Voorhees JJ, and Fisher GJ (2012). Receptor-type protein tyrosine phosphatase β regulates Met phosphorylation and function in head and neck squamous cell carcinoma. Neoplasia 14, 1015-1022.
224. Yamashita S, Lai KP, Chuang KL, Xu D, Miyamoto H, Tochigi T, Pang ST, Li L, Arai Y, Kung HJ, et al. (2012). ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia 14, 74-83.
225. Yang HW, Kim TM, Song SS, Shrinath N, Park R, Kalamarides M, Park PJ, Black PM, Carroll RS, and Johnson MD (2012). Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma. Neoplasia 14, 20-28.
226. Yang Y, Jiang H, Gao H, Kong J, Zhang P, Hu S, Shi B, Zhang P, Yao M, and Li Z (2012). The monoclonal antibody CH12 enhances the sorafenibmediated growth inhibition of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III. Neoplasia 14, 509-518.
227. Yu L, Tumati V, Tseng SF, Hsu FM, Kim DN, Hong D, Hsieh JT, Jacobs C, Kapur P, and Saha D (2012). DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor. Neoplasia 14, 1203-1212.
228. Zhai R, Zhao Y, Su L, Cassidy L, Liu G, and Christiani DC (2012). Genomewide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus. Neoplasia 14, 29-33.
229. Zhao Y and Sun Y (2012). Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application. Neoplasia 14, 360-367.
230. Arias-González L, Moreno-Gimeno I, del Campo AR, Serrano-Oviedo L, Valero ML, Esparís-Ogando A, de la Cruz-Morcillo MÁ, Melgar-Rojas P, García-Cano J, Cimas FJ, et al. (2013). ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma. Neoplasia 15, 649-659.
231. Armstrong MB, Mody RE, Hill AB, Erichsen DA, and Wechsler DS (2013). N-Myc differentially regulates expression of MXI1 isoforms in neuroblastoma. Neoplasia 15, 1363-1370.
232. Baiz D, Hassan S, Choi YA, Flores A, Karpova Y, Yancey D, Pullikuth A, Sui G, Sadelain M, Debinski W, et al. (2013). Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. Neoplasia 15, 1172-1183.
233. Barros-Silva JD, Paulo P, Bakken AC, Cerveira N, Løvf M, Henrique R, Jerónimo C, Lothe RA, Skotheim RI, and Teixeira MR (2013). Novel 5′ fusion partners of ETV1 and ETV4 in prostate cancer. Neoplasia 15, 720-726.
234. Boedigheimer MJ, Freeman DJ, Kiaei P, Damore MA, and Radinsky R (2013). Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models. Neoplasia 15, 125-132.
235. Boissonnas A, Licata F, Poupel L, Jacquelin S, Fetler L, Krumeich S, Théry C, Amigorena S, and Combadière C (2013). CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network. Neoplasia 15, 85-94.
236. Botta GP, Reichert M, Reginato MJ, Heeg S, Rustgi AK, and Lelkes PI (2013). ERK2-regulated TIMP1 induces hyperproliferation of K-RasG12D-transformed pancreatic ductal cells. Neoplasia 15, 359-372.
237. Brunetto E, Ferrara AM, Rampoldi F, Talarico A, Cin ED, Grassini G, Spagnuolo L, Sassi I, Ferro A, Cuorvo LV, et al. (2013). CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment. Neoplasia 15, 579-590.
238. Bruno A, Focaccetti C, Pagani A, Imperatori AS, Spagnoletti M, Rotolo N, Cantelmo AR, Franzi F, Capella C, Ferlazzo G, et al. (2013). The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer. Neoplasia 15, 133-142.
239. Buac D, Kona FR, Seth AK, and Dou QP (2013). Regulation of metformin response by breast cancer associated gene 2 (BCA2). Neoplasia 15, 1379-1390.
240. Byron SA, Chen H, Wortmann A, Loch D, Gartside MG, Dehkhoda F, Blais SP, Neubert TA, Mohammadi M, and Pollock PM (2013). The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors. Neoplasia 15, 975-988.
241. Chakraborty S, Li L, Tang H, Xie Y, Puliyappadamba VT, Raisanen J, Burma S, Boothman DA, Cochran B, Wu J, et al. (2013). Cytoplasmic TRADD confers a worse prognosis in glioblastoma. Neoplasia 15, 888-897.
242. Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, et al. (2013). The IL-6/JAK/Stat3 feedforward loop drives tumorigenesis and metastasis. Neoplasia 15, 848-862.
243. Chen Z, Sun J, Kim ST, Groskopf J, Feng J, Isaacs WB, Rittmaster RS, Condreay LD, Zheng SL, and Xu J (2013). Genome-wide association study identifies genetic determinants of urine PCA3 levels in men. Neoplasia 15, 448-453.
244. Christiansen VJ, Jackson KW, Lee KN, Downs TD, and McKee PA (2013). Targeting inhibition of fibroblast activation protein-α and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments. Neoplasia 15, 348-358.
245. Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, and Gagos S (2013). The roles of telomerase in the generation of polyploidy during neoplastic cell growth. Neoplasia 15, 156-168.
246. Colangelo T, Fucci A, Votino C, Sabatino L, Pancione M, Laudanna C, Binaschi M, Bigioni M, Maggi CA, Parente D, et al. (2013). MicroRNA- 130b promotes tumor development and is associated with poor prognosis in colorectal cancer. Neoplasia 15, 1204-1217.
247. Coppock JD, Wieking BG, Molinolo AA, Gutkind JS, Miskimins WK, and Lee JH (2013). Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia 15, 620-630.
248. Doberstein K, Steinmeyer N, Hartmetz AK, Eberhardt W, Mittelbronn M, Harter PN, Juengel E, Blaheta R, Pfeilschifter J, and Gutwein P (2013). MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients. Neoplasia 15, 218-230.
249. Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, and Tlsty TD (2013). Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia 15, 249-262.
250. Fernández-Pérez MP, Montenegro MF, Sáez-Ayala M, Sánchez-del-Campo L, Piñero-Madrona A, Cabezas-Herrera J, and Rodríguez-López JN (2013). Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma. Neoplasia 15, 826-839.
251. Freire J, Ajona D, de Biurrun G, Agorreta J, Segura V, Guruceaga E, Bleau AM, Pio R, Blanco D, and Montuenga LM (2013). Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment. Neoplasia 15, 913-924.
252. Fu J, Bassi DE, Zhang J, Li T, Cai KQ, Testa CL, Nicolas E, and Klein-Szanto AJ (2013). Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases. Neoplasia 15, 169-179.
253. Fujimura A, Michiue H, Cheng Y, Uneda A, Tani Y, Nishiki T, Ichikawa T, Wei F, Tomizawa K, and Matsui H (2013). Cyclin G2 promotes hypoxiadriven local invasion of glioblastoma by orchestrating cytoskeletal dynamics. Neoplasia 15, 1272-1281.
254. Galvani E, Giovannetti E, Saccani F, Cavazzoni A, Leon LG, Dekker H, Alfieri R, Carmi C, Mor M, Ardizzoni A, et al. (2013). Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer. Neoplasia 15, 61-72.
255. Garnett J, Chumbalkar V, Vaillant B, Gururaj AE, Hill KS, Latha K, Yao J, Priebe W, Colman H, Elferink LA, et al. (2013). Regulation of HGF expression by ΔEGFR-mediated c-Met activation in glioblastoma cells. Neoplasia 15, 73-84.
256. Ghanbari-Azarnier R, Sato S, Wei Q, Al-Jazrawe M, and Alman BA (2013). Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling. Neoplasia 15, 712-719.
257. Griesmann H, Ripka S, Pralle M, Ellenrieder V, Baumgart S, Buchholz M, Pilarsky C, Aust D, Gress TM, and Michl P (2013). WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia 15, 11-22.
258. Han S, Brenner JC, Sabolch A, Jackson W, Speers C, Wilder-Romans K, Knudsen KE, Lawrence TS, Chinnaiyan AM, and Feng FY (2013). Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition. Neoplasia 15, 1207-1217.
259. Hendrayani SF, Al-Khalaf HH, and Aboussekhra A (2013). Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effects. Neoplasia 15, 631-640.
260. Hong J and Belkhiri A (2013). AXL mediates TRAIL resistance in esophageal adenocarcinoma. Neoplasia 15, 296-304.
261. Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, Mandell J, and Abounader R (2013). A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. Neoplasia 15, 952-965.
262. Lee MT, Ho SM, Tarapore P, Chung I, and Leung YK (2013). Estrogen receptor β isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia 15, 1262-1271.
263. Iida M, Brand TM, Starr MM, Li C, Huppert EJ, Luthar N, Pedersen MW, Horak ID, Kragh M, and Wheeler DL (2013). Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab. Neoplasia 15, 1196-1206.
264. Jacob AG, O'Brien D, Singh RK, Comiskey DF Jr, Littleton RM, Mohammad F, Gladman JT, Widmann MC, Jeyaraj SC, Bolinger C, et al. (2013). Stressinduced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. Neoplasia 15, 1049-1063.
265. Jagan IC, Deevi RK, Fatehullah A, Topley R, Eves J, Stevenson M, Loughrey M, Arthur K, and Campbell FC (2013). PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system. Neoplasia 15, 1218-1230.
266. Jaiswal AS, Panda H, Pampo CA, Siemann DW, Gairola CG, Hromas R, and Narayan S (2013). Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells. Neoplasia 15, 454-460.
267. Jin G, Zheng SL, Lilja H, Kim ST, Tao S, Gao Z, Young T, Wiklund F, Feng J, Isaacs WB, et al. (2013). Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA. Neoplasia 15, 95-101.
268. Junk DJ, Cipriano R, Bryson BL, Gilmore HL, and Jackson MW (2013). Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events. Neoplasia 15, 1100-1109.
269. Kantner H, Warsch W, Delogu A, Bauer E, Esterbauer H, Casanova E, Sexl V, and Stoiber D (2013). ETV6/RUNX1 induces reactive oxygen species and drives the accumulation of DNA damage in B cells. Neoplasia 15, 1292.
270. Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, et al. (2013). Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia 15, 684-693.
271. Khan AP, Rajendiran TM, Ateeq B, Asangani IA, Athanikar JN, Yocum AK, Mehra R, Siddiqui J, Palapattu G, Wei JT, et al. (2013). The role of sarcosine metabolism in prostate cancer progression. Neoplasia 15, 491-501.
272. Kim JK, Jung Y, Wang J, Joseph J, Mishra A, Hill EE, Krebsbach PH, Pienta KJ, Shiozawa Y, and Taichman RS (2013). TBK1 regulates prostate cancer dormancy through mTOR inhibition. Neoplasia 15, 1064-1074.
273. Kimura R, Senba M, Cutler SJ, Ralph SJ, Xiao G, and Mori N (2013). Human T cell leukemia virus type I Tax-induced IκB-ζ modulates Taxdependent and Tax-independent gene expression in T cells. Neoplasia 15, 1110-1124.
274. Kogure M, Takawa M, Saloura V, Sone K, Piao L, Ueda K, Ibrahim R, Tsunoda T, Sugiyama M, Atomi Y, et al. (2013). The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination. Neoplasia 15, 1251-1261.
275. Lachmann N, Brennig S, Phaltane R, Flasshove M, Dilloo D, and Moritz T (2013). Myeloprotection by cytidine deaminase gene transfer in antileukemic therapy. Neoplasia 15, 239-248.
276. Lazrek Y, Dubreuil O, Garambois V, Gaborit N, Larbouret C, Le Clorennec C, Thomas G, Leconet W, Jarlier M, Pugnière M, et al. (2013). Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation. Neoplasia 15, 335-347.
277. Lee E, Koskimaki JE, Pandey NB, and Popel AS (2013). Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A. Neoplasia 15, 112-124.
278. Lee M, Ho S, Tarapore P, Chung I, and Leung Y (2013). Estrogen receptor β isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia 15, 1262-1271.
279. Lee SJ, Lee SH, Yoon MH, and Park BJ (2013). A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation. Neoplasia 15, 727-737.
280. Lee WJ, Lan KH, Chou CT, Yi YC, Chen WC, Pan HC, Peng YC, Wang KB, Chen YC, Chao TH, et al. (2013). Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination. Neoplasia 15, 1036-1048.
281. Leibovich-Rivkin R, Liubomirski Y, Bernstein B, Meshel T, and Ben-Baruch A (2013). Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion and collapse of normally organized breast textures. Neoplasia 15, 1330-1346.
282. Li Y, Chen X, Wang Z, Zhao D, Chen H, Chen W, Zhou Z, Zhang J, Zhang J, Li H, et al. (2013). The HECTD3 E3 ubiquitin ligase suppresses cisplatininduced apoptosis via stabilizing MALT1. Neoplasia 15, 39-48.
283. Lin PC, Giannopoulou EG, Park K, Mosquera JM, Sboner A, Tewari AK, Garraway LA, Beltran H, Rubin MA, and Elemento O (2013). Epigenomic alterations in localized and advanced prostate cancer. Neoplasia 15, 373-383.
284. Liu G, Sprenger C, Sun S, Epilepsia KS, Haugk K, Zhang X, Coleman I, Nelson PS, and Plymate S (2013). AR variant ARv567es induces carcinogenesis in a novel transgenic mouse model of prostate cancer. Neoplasia 15, 1009-1017.
285. Mackenzie GG, Bartels LE, Xie G, Papayannis I, Alston N, Vrankova K, Ouyang N, and Rigas B (2013). A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice. Neoplasia 15, 1184-1195.
286. Madka V, Zhang Y, Li Q, Mohammed A, Sindhwani P, Lightfoot S, Wu XR, Kopelovich L, and Rao CV (2013). p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPIISV40T mice. Neoplasia 15, 966-974.
287. Majumdar S, Gong EM, Di Vizio D, Dreyfuss J, Degraff DJ, Hager MH, Park PJ, Bellmunt J, Matusik RJ, Rosenberg JE, et al. (2013). Loss of Sh3gl2/ endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior. Neoplasia 15, 749-760.
288. Marshall AD, Picchione F, Geltink RI, and Grosveld GC (2013). PAX3- FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis. Neoplasia 15, 738-748.
289. Matos P, Kotelevets L, Goncalves V, Henriques A, Zerbib P, Moyer MP, Chastre E, and Jordan P (2013). Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. Neoplasia 15, 102-111.
290. Mattie M, Christensen A, Chang MS, Yeh W, Said S, Shostak Y, Capo L, Verlinsky A, An Z, Joseph I, et al. (2013). Molecular characterization of patient-derived human pancreatic tumor xenograft models for preclinical and translational development of cancer therapeutics. Neoplasia 15, 1138-1150.
291. May T, Yang J, Shoni M, Liu S, He H, Gali R, Ng SK, Crum C, Berkowitz RS, and Ng SW (2013). BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2. Neoplasia 15, 600-608.
292. Méndez-Catalá CF, Gretton S, Vostrov A, Pugacheva E, Farrar D, Ito Y, Docquier F, Kita GX, Murrell A, Lobanenkov V, et al. (2013). A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells. Neoplasia 15, 898-912.
293. Metodieva G, Nogueira-de-Souza NC, Greenwood C, Al-Janabi K, Leng L, Bucala R, and Metodiev MV (2013). CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells. Neoplasia 15, 660-668.
294. Milosevic N, Kühnemuth B, Mühlberg L, Ripka S, Griesmann H, Lölkes C, Buchholz M, Aust D, Pilarsky C, Krug S, et al. (2013). Synthetic lethality screen identifies RPS6KA2 as modifier of epidermal growth factor receptor activity in pancreatic cancer. Neoplasia 15, 1354-1362.
295. Mohammed A, Janakiram NB, Brewer M, Vedala K, Steele VE, and Rao CV (2013). Multitargeted low-dose GLAD combination chemoprevention: a novel and promising approach to combat colon carcinogenesis. Neoplasia 15, 481-490.
296. Mohlin S, Hamidian A, and Påhlman S (2013). HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 15, 328-334.
297. Moreno MJ, Ball M, Rukhlova M, Slinn J, L'Abbe D, Iqbal U, Monette R, Hagedorn M, O'Connor-McCourt MD, Durocher Y, et al. (2013). IGFBP-4 anti-angiogenic and anti-tumorigenic effects are associated with anti-cathepsin B activity. Neoplasia 15, 554-567.
298. Moreno-Smith M, Lee SJ, Lu C, Nagaraja AS, He G, Rupaimoole R, Han HD, Jennings NB, Roh JW, Nishimura M, et al. (2013). Biologic effects of dopamine on tumor vasculature in ovarian carcinoma. Neoplasia 15, 502-510.
299. Morrison LC, McClelland R, Aiken C, Bridges M, Liang L, Wang X, Di Curzio D, Del Bigio MR, Taylor MD, and Werbowetski-Ogilvie TE (2013). Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes. Neoplasia 15, 384-398.
300. Mosquera JM, Beltran H, Park K, MacDonald TY, Robinson BD, Tagawa ST, Perner S, Bismar TA, Erbersdobler A, Dhir R, et al. (2013). Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia 15, 1-10.
301. Mu W, Rana S, and Zöller M (2013). Host matrix modulation by tumor exosomes promotes motility and invasiveness. Neoplasia 15, 875-887.
302. Nagaria TS, Williams JL, Leduc C, Squire JA, Greer PA, and Sangrar W (2013). Flavopiridol synergizes with sorafenib to induce cytotoxicity and potentiate antitumorigenic activity in EGFR/HER-2 and mutant RAS/RAF breast cancer model systems. Neoplasia 15, 939-951.
303. Natarajan S, Hombach-Klonisch S, Dröge P, and Klonisch T (2013). HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells. Neoplasia 15, 263-280.
304. Nguyen AV, Wu YY, Liu Q, Wang D, Nguyen S, Loh R, Pang J, Friedman K, Orlofsky A, Augenlicht L, et al. (2013). STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon. Neoplasia 15, 998-1008.
305. O'Brien T, Oeh J, Xiao Y, Liang X, Vanderbilt A, Qin A, Yang L, Lee LB, Ly J, Cosino E, et al. (2013). Estrogen receptor β isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia 15, 1262-1271.
306. Onoyama M, Kitadai Y, Tanaka Y, Yuge R, Shinagawa K, Tanaka S, Yasui W, and Chayama K (2013). Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer. Neoplasia 15, 1391-1399.
307. Paterson EL, Kazenwadel J, Bert AG, Khew-Goodall Y, Ruszkiewicz A, and Goodall GJ (2013). Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia 15, 180-191.
308. Petrulli JR, Sullivan JM, Zheng M, Bennett DC, Charest J, Huang Y, Morris ED, and Contessa JN (2013). Quantitative analysis of [11C]-erlotinib PET demonstrates specific binding for activating mutations of the EGFR kinase domain. Neoplasia 15, 1347-1353.
309. Pflueger D, Sboner A, Storz M, Roth J, Compérat E, Bruder E, Rubin MA, Schraml P, and Moch H (2013). Identification of molecular tumor markers in renal cell carcinomas with TFE3 protein expression by RNA sequencing. Neoplasia 15, 1231-1240.
310. Piazza R, Magistroni V, Mogavero A, Andreoni F, Ambrogio C, Chiarle R, Mologni L, Bachmann PS, Lock RB, Collini P, et al. (2013). Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. Neoplasia 15, 511-522.
311. Prasad R and Katiyar SK (2013). Prostaglandin E2 promotes UV radiation-induced immune suppression through DNA hypermethylation. Neoplasia 15, 795-804.
312. Rana S, Malinowska K, and Zöller M (2013). Exosomal tumor microRNA modulates premetastatic organ cells. Neoplasia 15, 281-295.
313. Rao CV, Patlolla JM, Qian L, Zhang Y, Brewer M, Mohammed A, Desai D, Amin S, Lightfoot S, and Kopelovich L (2013). Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia 15, 1018-1027.
314. Ribatti D, Nico B, Ranieri G, Specchia G, and Vacca A (2013). The role of angiogenesis in human non-Hodgkin lymphomas. Neoplasia 15, 231-238.
315. Ricci-Vitiani L, Runci D, D'Alessandris QG, Cenci T, Martini M, Bianchi F, Maira G, Stancato L, De Maria R, Larocca LM, et al. (2013). Chemotherapy of skull base chordoma tailored on responsiveness of patient-derived tumor cells to rapamycin. Neoplasia 15, 773-782.
316. Richichi C, Brescia P, Alberizzi V, Fornasari L, and Pelicci G (2013). Markerindependent method for isolating slow-dividing cancer stem cells in human glioblastoma. Neoplasia 15, 840-847.
317. Rodero MP, Auvynet C, Poupel L, Combadière B, and Combadière C (2013). Control of both myeloid cell infiltration and angiogenesis by CCR1 promotes liver cancer metastasis development in mice. Neoplasia 15, 641-648.
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319. Sakellariou D, Chiourea M, Raftopoulou C, and Gagos S (2013). Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction. Neoplasia 15, 1301-1313.
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