메뉴 건너뛰기




Volumn 14, Issue 12, 2012, Pages 1269-1277

p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P16; SMALL INTERFERING RNA; VASCULOTROPIN A; ANGIOGENESIS INHIBITOR; MONOCLONAL ANTIBODY; TARGET OF RAPAMYCIN KINASE;

EID: 84871553346     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.121632     Document Type: Article
Times cited : (32)

References (41)
  • 1
    • 82555196948 scopus 로고    scopus 로고
    • Role of cancer-associated fibroblasts in breast cancer development and prognosis
    • Aboussekhra A (2011). Role of cancer-associated fibroblasts in breast cancer development and prognosis. Int J Dev Biol 55, 841-849.
    • (2011) Int J Dev Biol , vol.55 , pp. 841-849
    • Aboussekhra, A.1
  • 2
    • 75849159205 scopus 로고    scopus 로고
    • Carcinoma-associated fibro blasts are a rate-limiting determinant for tumour progression
    • Shimoda M, Mellody KT, and Orimo A (2009). Carcinoma-associated fibro blasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol 21, 19-25.
    • (2009) Semin Cell Dev Biol , vol.21 , pp. 19-25
    • Shimoda, M.1    Mellody, K.T.2    Orimo, A.3
  • 4
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, and Weinberg RA (2005). Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 5
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G and Benjamin LE (2003). Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3, 401-410.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 6
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P (2005). VEGF as a key mediator of angiogenesis in cancer. Oncology 69(suppl 3), 4-10.
    • (2005) Oncology , vol.69 , Issue.3 SUPPL. , pp. 4-10
    • Carmeliet, P.1
  • 7
    • 77950845143 scopus 로고    scopus 로고
    • Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor positive breast cancer
    • Pinto MP, Badtke MM, Dudevoir ML, Harrell JC, Jacobsen BM, and Horwitz KB (2010). Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor positive breast cancer. Cancer Res 70, 2655-2664.
    • (2010) Cancer Res , vol.70 , pp. 2655-2664
    • Pinto, M.P.1    Badtke, M.M.2    Dudevoir, M.L.3    Harrell, J.C.4    Jacobsen, B.M.5    Horwitz, K.B.6
  • 9
    • 39049112846 scopus 로고    scopus 로고
    • AKT signaling in regulating angiogenesis
    • Jiang BH and Liu LZ (2008). AKT signaling in regulating angiogenesis. Curr Cancer Drug Targets 8, 19-26.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 19-26
    • Jiang, B.H.1    Liu, L.Z.2
  • 10
    • 84862908559 scopus 로고    scopus 로고
    • Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA
    • Xin H, Brown JA, Gong C, Fan H, Brewer G, and Gnarra JR (2012). Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA. Mol Cancer Res 10, 108-120.
    • (2012) Mol Cancer Res , vol.10 , pp. 108-120
    • Xin, H.1    Brown, J.A.2    Gong, C.3    Fan, H.4    Brewer, G.5    Gnarra, J.R.6
  • 11
    • 77957596291 scopus 로고    scopus 로고
    • The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo
    • Merdzhanova G, Gout S, Keramidas M, Edmond V, Coll JL, Brambilla C, Brambilla E, Gazzeri S, and Eymin B (2010). The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo. Oncogene 29, 5392-5403.
    • (2010) Oncogene , vol.29 , pp. 5392-5403
    • Merdzhanova, G.1    Gout, S.2    Keramidas, M.3    Edmond, V.4    Coll, J.L.5    Brambilla, C.6    Brambilla, E.7    Gazzeri, S.8    Eymin, B.9
  • 12
    • 35848935012 scopus 로고    scopus 로고
    • Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation
    • Essafi-Benkhadir K, Onesto C, Stebe E, Moroni C, and Pages G (2007). Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation. Mol Biol Cell 18, 4648-4658.
    • (2007) Mol Biol Cell , vol.18 , pp. 4648-4658
    • Essafi-Benkhadir, K.1    Onesto, C.2    Stebe, E.3    Moroni, C.4    Pages, G.5
  • 13
    • 0029827632 scopus 로고    scopus 로고
    • p53-dependent association between cyclin G and the B′ subunit of protein phosphatase 2a
    • Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, and Beach D (1996). p53-dependent association between cyclin G and the B′ subunit of protein phosphatase 2a. Mol Cell Biol 16, 6593-6602.
    • (1996) Mol Cell Biol , vol.16 , pp. 6593-6602
    • Okamoto, K.1    Kamibayashi, C.2    Serrano, M.3    Prives, C.4    Mumby, M.C.5    Beach, D.6
  • 16
    • 7044231343 scopus 로고    scopus 로고
    • INK4a-RB pathway: Molecular link between cellular senescence and tumor suppression
    • INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 51, 146-153.
    • (2004) J Med Invest , vol.51 , pp. 146-153
    • Ohtani, N.1    Yamakoshi, K.2    Takahashi, A.3    Hara, E.4
  • 17
    • 0032517341 scopus 로고    scopus 로고
    • INK4a/CDKN2A tumor suppressor and its relatives
    • INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1378, F115-F177.
    • (1998) Biochim Biophys Acta , vol.1378
    • Ruas, M.1    Peters, G.2
  • 18
    • 0035835818 scopus 로고    scopus 로고
    • p16(MTS-1/CDKN2/INK4a) in cancer progression
    • Rocco JW and Sidransky D (2001). p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res 264, 42-55.
    • (2001) Exp Cell Res , vol.264 , pp. 42
    • Rocco, J.W.1    Sidransky, D.2
  • 24
    • 84858592019 scopus 로고    scopus 로고
    • The role of stromal myofibroblast and extra cellular matrix in tumor angiogenesis
    • Vong S and Kalluri R (2011). The role of stromal myofibroblast and extra cellular matrix in tumor angiogenesis. Genes Cancer 2, 1139-1145.
    • (2011) Genes Cancer , vol.2 , pp. 1139-1145
    • Vong, S.1    Kalluri, R.2
  • 25
    • 0032981481 scopus 로고    scopus 로고
    • INK4a inhibits both CDK4 and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
    • INK4a inhibits both CDK4 and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol 19, 1981-1989.
    • (1999) Mol Cell Biol , vol.19 , pp. 1981-1989
    • McConnell, B.B.1    Gregory, F.J.2    Stott, F.J.3    Hara, E.4    Peters, G.5
  • 26
    • 27944446105 scopus 로고    scopus 로고
    • Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
    • Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, and Toker A (2005). Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 20, 539-550.
    • (2005) Mol Cell , vol.20 , pp. 539-550
    • Yoeli-Lerner, M.1    Yiu, G.K.2    Rabinovitz, I.3    Erhardt, P.4    Jauliac, S.5    Toker, A.6
  • 27
    • 8544273759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor transcriptional activation is mediated by hypoxia inducible factor 1α, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
    • Skinner HD, Zheng JZ, Fang J, Agani F, and Jiang BH (2004). Vascular endothelial growth factor transcriptional activation is mediated by hypoxia inducible factor 1α, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling. J Biol Chem 279, 45643-45651.
    • (2004) J Biol Chem , vol.279 , pp. 45643-45651
    • Skinner, H.D.1    Zheng, J.Z.2    Fang, J.3    Agani, F.4    Jiang, B.H.5
  • 28
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 29
    • 84861186736 scopus 로고    scopus 로고
    • Jekyll and Hyde: The role of the micro environment on the progression of cancer
    • Allen M and Louise Jones J (2011). Jekyll and Hyde: the role of the micro environment on the progression of cancer. J Pathol 223, 162-176.
    • (2011) J Pathol , vol.223 , pp. 162-176
    • Allen, M.1    Louise, J.J.2
  • 30
    • 33947270928 scopus 로고    scopus 로고
    • Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway
    • Li M, Zhang Z, Hill DL, Wang H, and Zhang R (2007). Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res 67, 1988-1996.
    • (2007) Cancer Res , vol.67 , pp. 1988-1996
    • Li, M.1    Zhang, Z.2    Hill, D.L.3    Wang, H.4    Zhang, R.5
  • 31
    • 0033178714 scopus 로고    scopus 로고
    • Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas
    • Harada H, Nakagawa K, Iwata S, Saito M, Kumon Y, Sakaki S, Sato K, and Hamada K (1999). Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas. Cancer Res 59, 3783-3789.
    • (1999) Cancer Res , vol.59 , pp. 3783-3789
    • Harada, H.1    Nakagawa, K.2    Iwata, S.3    Saito, M.4    Kumon, Y.5    Sakaki, S.6    Sato, K.7    Hamada, K.8
  • 32
    • 38149015503 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in tumorigenesis and angiogenesis
    • Jiang BH and Liu LZ (2008). PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta 1784, 150-158.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 150-158
    • Jiang, B.H.1    Liu, L.Z.2
  • 33
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: Upstream and downstream of cancer metabolism
    • Semenza GL (2010). HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20, 51-56.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 35
    • 79961117100 scopus 로고    scopus 로고
    • ink4a expression in tumors: Functional significance, clinical associations and future developments
    • ink4a expression in tumors: functional significance, clinical associations and future developments. Cell Cycle 10, 2497-2503.
    • (2011) Cell Cycle , vol.10 , pp. 2497-2503
    • Witkiewicz, A.K.1    Knudsen, K.E.2    Dicker, A.P.3    Knudsen, E.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.