The calcium-sensing receptor is necessary for the rapid development of hypercalcemia in human lung squamous cell carcinoma

Neoplasia

Volumn 13, Issue 5, 2011, Pages 428-438

  Lorch, Gwendolen ^a   Viatchenko Karpinski, Serge ^b   Ho, Hsiang Ting ^b   Dirksen, Wessel P ^a   Toribio, Ramiro E ^a   Foley, John ^c   Györke, Sandor ^b   Rosol, Thomas J ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SENSING RECEPTOR; JANUS KINASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARATHYROID HORMONE RELATED PROTEIN; SHORT HAIRPIN RNA;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CANCER CELL CULTURE; CELL VIABILITY; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; EXON; FEMALE; GENE EXPRESSION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCALCEMIA; HYPERCALCEMIA OF MALIGNANCY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; LUNG SQUAMOUS CELL CARCINOMA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING;

EID: 79955837919     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.101620     Document Type: Article

References (29)

1. Lazaretti-Castro M, Kayath M, Jamnik S, Santoro IL, Tadokoru H, and Vieira JG (1993). Prevalence of hypercalcemia in patients with lung cancer. Rev Assoc Med Bras 39(2), 83-87.
2. Gilmore JL, Gonterman RM, Menon K, Lorch G, Riese DJ, Robling A, and Foley J (2009). Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone. Mol Cancer Res 7(10), 1714-1728.
3. Lorch G, Gilmore JL, Koltz PF, Gonterman RM, Laughner R, Lewis DA, Konger RL, Nadella KS, Toribio RE, Rosol TJ, et al. (2007). Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice. Br J Cancer 97(2), 183-193.
4. Berridge MJ, Bootman MD, and Roderick HL (2003). Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4(7), 517-529.
5. Davies SL, Ozawa A, McCormick WD, Dvorak MM, and Ward DT (2007). Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity. J Biol Chem 282(20), 15048-15056.
6. Bai M, Trivedi S, and Brown EM (1998). Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells. J Biol Chem 273(36), 23605-23610.
7. Pollak MR, Brown EM, Chou YH, Hebert SC, Marx SJ, Steinmann B, Levi T, Seidman CE, and Seidman JG (1993). Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 75(7), 1297-1303.
8. VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, and Wysolmerski JJ (2004). The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest 113(4), 598-608.
9. Kohn EC and Liotta LA (1995). Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res 55(9), 1856-1862.
10. Milara J, Mata M, Serrano A, Peiro T, Morcillo EJ, and Cortijo J (2010). Extracellular calcium-sensing receptor mediates human bronchial epithelial wound repair. Biochem Pharmacol 80(2), 236-246.
11. Ellison M, Woodhouse D, Hillyard C, Dowsett M, Coombes RC, Gilby ED, Greenberg PB, and Neville AM (1975). Immunoreactive calcitonin production by human lung carcinoma cells in culture. Br J Cancer 32(3), 373-379.
12. Hussain SR, Lucas DM, Johnson AJ, Lin TS, Bakaletz AP, Dang VX, Viatchenko- Karpinski S, Ruppert AS, Byrd JC, Kuppusamy P, et al. (2008). Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. Blood 111(6), 3190-3199.
13. Guise TA, Chirgwin JM, Taylor S, Boyce BF, Dunstan CR, and Mundy GR (1993). Deletions of C-terminal end of parathyroid hormone-related protein (Pthrp) have equivalent effects on bone and calcium homeostasis in-vivo. J Bone Miner Res 8, S174.
14. Iguchi H, Tanaka S, Ozawa Y, Kashiwakuma T, Kimura T, Hiraga T, Ozawa H, and Kono A (1996). An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis. Cancer Res 56(17), 4040-4043.
15. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD, et al. (1987). Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 84(14), 5048-5052.
16. Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, and Brown EM (2000). Extracellular calcium-sensing receptor expression and its potentialrole in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 141(12), 4357-4364.
17. Dolmetsch RE, Xu K, and Lewis RS (1998). Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392(6679), 933-936.
18. Li W, Llopis J, Whitney M, Zlokarnik G, and Tsien RY (1998). Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature 392(6679), 936-941.
19. Hastings RH, Summerstorres D, Ditmer LS, Burton DW, Cheung TC, Spragg RG, Brown EM, and Deftos LJ (1995). Pulmonary alveolar epithelial-cells express a functional Pthrp-calcium-surfactant regulatory loop. J Bone Miner Res 10, S382.
20. Hastings RH, Duong HS, Burton DW, and Deftos LJ (1994). Alveolar epithelialcells express and secrete parathyroid hormone-related protein. Am J Resp Cell Mol 11(6), 701-706.
21. Li X and Drucker DJ (1994). Parathyroid hormone-related peptide is a downstream target for Ras and Src activation. J Biol Chem 269(9), 6263-6266.
22. Aklilu F, Park M, Goltzman D, and Rabbani SA (1997). Induction of parathyroid hormone-related peptide by the Ras oncogene: role of Ras farnesylation inhibitors as potential therapeutic agents for hypercalcemia of malignancy. Cancer Res 57(20), 4517-4522.
23. Aklilu F, Gladu J, Goltzman D, and Rabbani SA (2000). Role of mitogenactivated protein kinases in the induction of parathyroid hormone-related peptide. Cancer Res 60(6), 1753-1760.
24. Tfelt-Hansen J, Yano S, John Macleod R, Smajilovic S, Chattopadhyay N, and Brown EM (2005). High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors 23(2), 117-123.
25. Yano S, Macleod RJ, Chattopadhyay N, Tfelt-Hansen J, Kifor O, Butters RR, and Brown EM (2004). Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation. Bone 35(3), 664-672.
26. Vezzoli G, Terranegra A, Arcidiacono T, Biasion R, Coviello D, Syren ML, Paloschi V, Giannini S, Mignogna G, Rubinacci A, et al. (2007). R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria. Kidney Int 71(11), 1155-1162.
27. Vezzoli G, Tanini A, Ferrucci L, Soldati L, Bianchin C, Franceschelli F, Malentacchi C, Porfirio B, Adamo D, Terranegra A, et al. (2002). Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J Am Soc Nephrol 13(10), 2517-2523.
28. Vargas-Poussou R, Huang C, Hulin P, Houillier P, Jeunemaitre X, Paillard M, Planelles G, Dechaux M, Miller RT, and Antignac C (2002). Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome. J Am Soc Nephrol 13(9), 2259-2266.
29. Dirksen WP, Mohamed SA, and Fisher SA (2003). Splicing of a myosin phosphatase targeting subunit 1 alternative exon is regulated by intronic cis-elements and a novel bipartite exonic enhancer/silencer element. J Biol Chem 278(11), 9722-9732.