Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ tumors in vitro and in vivo

Neoplasia (United States)

Volumn 14, Issue 10, 2012, Pages 952-963

  Jensen, Martin Blomberg ^a   Jørgensen, Anne ^a   Nielsen, John Erik ^a   Steinmeyer, Andreas ^b   Leffers, Henrik ^a   Juul, Anders ^a   Meyts, Ewa Rajpert De ^a  

^a Rigshospitalet   (Denmark)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CISPLATIN; COLECALCIFEROL; FIBROBLAST GROWTH FACTOR 23; MELANOMA ANTIGEN 4; OCTAMER TRANSCRIPTION FACTOR 4; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR RUNX2; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOMA IN SITU; CELL DIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYONAL CARCINOMA; FETUS; GENE EXPRESSION; GERM CELL TUMOR; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINOMA; TESTIS NONSEMINOMA CANCER; TUMOR GROWTH; TUMOR VOLUME; VITAMIN D METABOLISM; YOLK SAC TUMOR;

EID: 84867753586     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.121164     Document Type: Article

References (47)

1. Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L, Harrison NJ, Schwager C, Abdollahi A, Huber PE, et al. (2009). Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res 69, 5241-5250.
2. Kristensen DM, Sonne SB, Ottesen AM, Perrett RM, Nielsen JE, Almstrup K, Skakkebaek NE, Leffers H, and Rajpert-De Meyts E (2008). Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development. Mol Cell Endocrinol 288, 111-118.
3. Skakkebaek NE, Berthelsen JG, and Muller J (1982). Carcinoma-in-situ of the undescended testis. Urol Clin North Am 9, 377-385.
4. Ulbright TM (1993). Germ cell neoplasms of the testis. Am J Surg Pathol 17, 1075-1091.
5. Chaganti RS and Houldsworth J (2000). Genetics and biology of adult human male germ cell tumors. Cancer Res 60, 1475-1482.
6. Looijenga LH, Gillis AJ, Stoop H, Biermann K, and Oosterhuis JW (2011). Dissecting the molecular pathways of (testicular) germ cell tumour pathogenesis; from initiation to treatment-resistance. Int J Androl 34, e234-e251.
7. Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fossa SD, Duale N, Brunborg G, Kallioniemi O, Andrews PW, et al. (2005). Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. Cancer Res 65, 5588-5598.
8. Looijenga LH, Gillis AJ, Stoop HJ, Hersmus R, and Oosterhuis JW (2007). Chromosomes and expression in human testicular germ-cell tumors: insight into their cell of origin and pathogenesis. Ann N Y Acad Sci 1120, 187-214.
9. Gocek E and Studzinski GP (2009). Vitamin D and differentiation in cancer. Crit Rev Clin Lab Sci 46, 190-209.
10. Bouillon R, Eelen G, Verlinden L, Mathieu C, Carmeliet G, and Verstuyf A (2006). Vitamin D and cancer. J Steroid Biochem Mol Biol 102, 156-162.
11. Blomberg Jensen M (2012). Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction 144, 135-152.
12. Blomberg Jensen M and Dissing S (2012). Non-genomic effects of vitamin D in human spermatozoa. Steroids 77, 903-909.
13. Krishnan AV and Feldman D (2011). Mechanisms of the anti-cancer and antiinflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol 51, 311-336.
14. Blomberg Jensen M, Andersen CB, Nielsen JE, Bagi P, Jorgensen A, Juul A, and Leffers H (2010). Expression of the vitamin D receptor, 25-hydroxylases, 1α-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. J Steroid Biochem Mol Biol 121, 376-382.
15. Blomberg Jensen M, Nielsen JE, Jorgensen A, Rajpert-De Meyts E, Kristensen DM, Jorgensen N, Skakkebaek NE, Juul A, and Leffers H (2010). Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod 25, 1303-1311.
16. Deeb KK, Trump DL, and Johnson CS (2007). Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 7, 684-700.
17. Healy KD, Frahm MA, and DeLuca HF (2005). 1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization. Arch Biochem Biophys 433, 466-473.
18. Ebert R, Schutze N, Adamski J, and Jakob F (2006). Vitamin D signaling is modulated on multiple levels in health and disease. Mol Cell Endocrinol 248, 149-159.
19. Chung I, Karpf AR, Muindi JR, Conroy JM, Nowak NJ, Johnson CS, and Trump DL (2007). Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol. J Biol Chem 282, 8704-8714.
20. Haussler MR, Jurutka PW, Mizwicki M, and Norman AW (2011). Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2 vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 25, 543-559.
21. Nangia AK, Hill O, Waterman MD, Schwender CE, and Memoli V (2007). Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. J Urol 178, 1092-1096.
22. Korkola JE, Houldsworth J, Chadalavada RS, Olshen AB, Dobrzynski D, Reuter VE, Bosl GJ, and Chaganti RS (2006). Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res 66, 820-827.
23. Oosterhuis JW and Looijenga LH (2005). Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5, 210-222.
24. Yang W, Friedman PA, Kumar R, Omdahl JL, May BK, Siu-Caldera ML, Reddy GS, and Christakos S (1999). Expression of 25(OH)D3 24-hydroxylase in distal nephron: coordinate regulation by 1,25(OH)2D3 and cAMP or PTH. Am J Physiol 276, E793-E805.
25. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, and YamashitaT(2004).FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19, 429-435.
26. Shinki T, Ueno Y, DeLuca HF, and Suda T (1999). Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1α-hydroxylase gene in normocalcemic rats. Proc Natl Acad Sci USA 96, 8253-8258.
27. Healy KD, Vanhooke JL, Prahl JM, and DeLuca HF (2005). Parathyroid hormone decreases renal vitamin D receptor expression in vivo. Proc Natl Acad Sci USA 102, 4724-4728.
28. Lanske B and Razzaque MS (2007). Vitamin D and aging: old concepts and new insights. J Nutr Biochem 18, 771-777.
29. de Frutos CA, Dacquin R, Vega S, Jurdic P, Huca-Gayet I, and Nieto MA (2009). Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J 28, 686-696.
30. Kommagani R, Caserta TM, and Kadakia MP (2006). Identification of vitamin D receptor as a target of p63. Oncogene 25, 3745-3751.
31. Clark AT (2007). The stem cell identity of testicular cancer. Stem Cell Rev 3, 49-59.
32. Rajpert-De Meyts E and Hoei-Hansen CE (2007). From gonocytes to testicular cancer: the role of impaired gonadal development. Ann N Y Acad Sci 1120, 168-180.
33. Fleet JC (2008). Molecular actions of vitamin D contributing to cancer prevention. Mol Aspects Med 29, 388-396.
34. Sonne SB, Perrett RM, Nielsen JE, Baxter MA, Kristensen DM, Leffers H, Hanley NA, and Rajpert-De-Meyts E (2010). Analysis of SOX2 expression in developing human testis and germ cell neoplasia. Int J Dev Biol 54, 755-760.
35. Haussler MR, Haussler CA, Bartik L, Whitfield GK, Hsieh JC, Slater S, and Jurutka PW (2008). Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr Rev 66, 98-112.
36. Jung C, Ou YC, Yeung F, Frierson HF Jr, and Kao C (2001). Osteocalcin is incompletely spliced in non-osseous tissues. Gene 271, 143-150.
37. zur Nieden NI, Kempka G, and Ahr HJ (2003). In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 71, 18-27.
38. Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, Zhang Z, Martin JF, Behringer RR, Nakamura T, et al. (2005). Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci USA 102, 14665-14670.
39. zur Nieden NI, Price FD, Davis LA, Everitt RE, and Rancourt DE (2007). Gene profiling on mixed embryonic stem cell populations reveals a biphasic role for β-catenin in osteogenic differentiation. Mol Endocrinol 21, 674-685.
40. Rochel N, Wurtz JM, Mitschler A, Klaholz B, and Moras D (2000). The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell 5, 173-179.
41. Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Kyba M, and Murphy KM (2011). Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs. Stem Cells 29, 764-776.
42. He B, Mirza M, and Weber GF (2006). An osteopontin splice variant induces anchorage independence in human breast cancer cells. Oncogene 25, 2192-2202.
43. Andrews PW, Gonczol E, Plotkin SA, Dignazio M, and Oosterhuis JW (1986). Differentiation of TERA-2 human embryonal carcinoma cells into neurons and HCMV permissive cells. Induction by agents other than retinoic acid. Differentiation 31, 119-126.
44. Mizuno Y, Gotoh A, Kamidono S, and Kitazawa S (1993). Establishment and characterization of a new human testicular germ cell tumor cell line (TCam-2). Nippon Hinyokika Gakkai Zasshi 84, 1211-1218.
45. Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, Carmeliet P, Bouillon R, and Carmeliet G (2006). Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 116, 3150-3159.
46. Swami S, Krishnan AV, Wang JY, Jensen K, Horst R, Albertelli MA, and Feldman D (2012). Dietary vitamin D3 and 1,25-dihydroxyvitamin D3 (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer. Endocrinology 153, 2576-2587.
47. Fleet JC, Gliniak C, Zhang Z, Xue Y, Smith KB, McCreedy R, and Adedokun SA (2008). Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice. J Nutr 138, 1114-1120.