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Volumn 14, Issue 8, 2012, Pages 670-677

Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors

Author keywords

[No Author keywords available]

Indexed keywords

AT 13387; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; UNCLASSIFIED DRUG;

EID: 84865263433     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.12986     Document Type: Article
Times cited : (70)

References (37)
  • 2
    • 39049150922 scopus 로고    scopus 로고
    • Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel
    • Sawai A, Chandarlapaty S, Greulich H, Gonen M, Ye Q, Arteaga CL, Sellers W, Rosen N, and Solit DB (2008). Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel. Cancer Res 68, 589-596.
    • (2008) Cancer Res , vol.68 , pp. 589-596
    • Sawai, A.1    Chandarlapaty, S.2    Greulich, H.3    Gonen, M.4    Ye, Q.5    Arteaga, C.L.6    Sellers, W.7    Rosen, N.8    Solit, D.B.9
  • 3
    • 23844498514 scopus 로고    scopus 로고
    • The role of cetuximab in the treatment of squamous cell cancer of the head and neck
    • Burtness B (2005). The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert Opin Biol Ther 5, 1085-1093.
    • (2005) Expert Opin Biol Ther , vol.5 , pp. 1085-1093
    • Burtness, B.1
  • 7
    • 67449127097 scopus 로고    scopus 로고
    • Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitiza-tion
    • Ahsan A, Hiniker SM, Davis MA, Lawrence TS, and Nyati MK (2009). Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitiza-tion. Cancer Res 69, 5108-5114.
    • (2009) Cancer Res , vol.69 , pp. 5108-5114
    • Ahsan, A.1    Hiniker, S.M.2    Davis, M.A.3    Lawrence, T.S.4    Nyati, M.K.5
  • 8
    • 34247877768 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor inhibitor class in the treatment of head and neck cancer with concurrent radio-chemotherapy in vivo
    • Feng FY, Lopez CA, Normolle DP, Varambally S, Li X, Chun PY, Davis MA, Lawrence TS, and Nyati MK (2007). Effect of epidermal growth factor receptor inhibitor class in the treatment of head and neck cancer with concurrent radio-chemotherapy in vivo. Clin Cancer Res 13, 2512-2518.
    • (2007) Clin Cancer Res , vol.13 , pp. 2512-2518
    • Feng, F.Y.1    Lopez, C.A.2    Normolle, D.P.3    Varambally, S.4    Li, X.5    Chun, P.Y.6    Davis, M.A.7    Lawrence, T.S.8    Nyati, M.K.9
  • 12
    • 0037805620 scopus 로고    scopus 로고
    • Growth hormone-induced phos-phorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling
    • Huang Y, Kim SO, Jiang J, and Frank SJ (2003). Growth hormone-induced phos-phorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling. J Biol Chem 278, 18902-18913.
    • (2003) J Biol Chem , vol.278 , pp. 18902-18913
    • Huang, Y.1    Kim, S.O.2    Jiang, J.3    Frank, S.J.4
  • 13
    • 65549138976 scopus 로고    scopus 로고
    • The complex dance of the molecular chaperone Hsp90
    • Neckers L, Mollapour M, and Tsutsumi S (2009). The complex dance of the molecular chaperone Hsp90. Trends Biochem Sci 34, 223-226.
    • (2009) Trends Biochem Sci , vol.34 , pp. 223-226
    • Neckers, L.1    Mollapour, M.2    Tsutsumi, S.3
  • 14
    • 1142273472 scopus 로고    scopus 로고
    • Altered states: Selectively drugging the Hsp90 cancer chap-erone
    • Workman P (2004). Altered states: selectively drugging the Hsp90 cancer chap-erone. Trends Mol Med 10, 47-51.
    • (2004) Trends Mol Med , vol.10 , pp. 47-51
    • Workman, P.1
  • 15
    • 33746899628 scopus 로고    scopus 로고
    • Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors
    • Yang S, Qu S, Perez-Tores M, Sawai A, Rosen N, Solit DB, and Arteaga CL (2006). Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors. Cancer Res 66, 6990-6997.
    • (2006) Cancer Res , vol.66 , pp. 6990-6997
    • Yang, S.1    Qu, S.2    Perez-Tores, M.3    Sawai, A.4    Rosen, N.5    Solit, D.B.6    Arteaga, C.L.7
  • 17
    • 0012999148 scopus 로고    scopus 로고
    • Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII
    • Lavictoire SJ, Parolin DAE, Klimowicz AC, Kelly JF, and Lorimer IAJ (2003). Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem 278, 5292-5299.
    • (2003) J Biol Chem , vol.278 , pp. 5292-5299
    • Lavictoire, S.J.1    Parolin, D.A.E.2    Klimowicz, A.C.3    Kelly, J.F.4    Lorimer, I.A.J.5
  • 19
    • 84859729014 scopus 로고    scopus 로고
    • The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer
    • Graham B, Curry J, Smyth T, Fazal L, Feltell R, Harada I, Coyle J, Williams B, Reule M, Angove H, et al. (2012). The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer. Cancer Sci 103, 522-527.
    • (2012) Cancer Sci , vol.103 , pp. 522-527
    • Graham, B.1    Curry, J.2    Smyth, T.3    Fazal, L.4    Feltell, R.5    Harada, I.6    Coyle, J.7    Williams, B.8    Reule, M.9    Angove, H.10
  • 20
    • 77955873344 scopus 로고    scopus 로고
    • Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydrois oindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design
    • Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, et al. (2010). Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydrois oindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. J Med Chem 53, 5956-5969.
    • (2010) J Med Chem , vol.53 , pp. 5956-5969
    • Woodhead, A.J.1    Angove, H.2    Carr, M.G.3    Chessari, G.4    Congreve, M.5    Coyle, J.E.6    Cosme, J.7    Graham, B.8    Day, P.J.9    Downham, R.10
  • 21
    • 0035793546 scopus 로고    scopus 로고
    • Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
    • Xu WP, Mimnaugh E, Rosser MFN, Nicchitta C, Marcu M, Yarden Y, and Neckers L (2001). Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 276, 3702-3708.
    • (2001) J Biol Chem , vol.276 , pp. 3702-3708
    • Xu, W.P.1    Mimnaugh, E.2    Rosser, M.F.N.3    Nicchitta, C.4    Marcu, M.5    Yarden, Y.6    Neckers, L.7
  • 22
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt WB and Toft DO (1997). Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 18, 306-360.
    • (1997) Endocr Rev , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 23
    • 15544372341 scopus 로고    scopus 로고
    • Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex
    • Xu WP, Yuan XT, Xiang ZX, Mimnaugh E, Marcu M, and Neckers L (2005). Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. Nat Struct Mol Biol 12, 120-126.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 120-126
    • Xu, W.P.1    Yuan, X.T.2    Xiang, Z.X.3    Mimnaugh, E.4    Marcu, M.5    Neckers, L.6
  • 24
    • 0025194462 scopus 로고
    • Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function
    • Wada T, Qian XL, and Greene MI (1990). Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function. Cell 61, 1339-1347.
    • (1990) Cell , vol.61 , pp. 1339-1347
    • Wada, T.1    Qian, X.L.2    Greene, M.I.3
  • 25
    • 1942431966 scopus 로고    scopus 로고
    • The Achilles heel of ErbB-2/ HER2-regulation by the Hsp90 chaperone machine and potential for pharmacological intervention
    • Citri A, Kochupurakkal BS, and Yarden Y (2004). The Achilles heel of ErbB-2/ HER2-regulation by the Hsp90 chaperone machine and potential for pharmacological intervention. Cell Cycle 3, 51-60.
    • (2004) Cell Cycle , vol.3 , pp. 51-60
    • Citri, A.1    Kochupurakkal, B.S.2    Yarden, Y.3
  • 26
    • 0035363805 scopus 로고    scopus 로고
    • Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
    • Sittler A, Lurz R, Lueder G, Priller J, Hayer-Hartl MK, Hartl FU, Lehrach H, and Wanker EE (2001). Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet 10, 1307-1315.
    • (2001) Hum Mol Genet , vol.10 , pp. 1307-1315
    • Sittler, A.1    Lurz, R.2    Lueder, G.3    Priller, J.4    Hayer-Hartl, M.K.5    Hartl, F.U.6    Lehrach, H.7    Wanker, E.E.8
  • 27
    • 73349102140 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in cancer treatment: Advances, challenges and opportunities
    • Modjtahedi H and Essapen S (2009). Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities. Anticancer Drugs 20, 851-855.
    • (2009) Anticancer Drugs , vol.20 , pp. 851-855
    • Modjtahedi, H.1    Essapen, S.2
  • 28
    • 42949176742 scopus 로고    scopus 로고
    • Survival of cancer cells is maintained by EGFR independent of its kinase activity
    • Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, and Hung MC (2008). Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 13, 385-393.
    • (2008) Cancer Cell , vol.13 , pp. 385-393
    • Weihua, Z.1    Tsan, R.2    Huang, W.C.3    Wu, Q.4    Chiu, C.H.5    Fidler, I.J.6    Hung, M.C.7
  • 29
    • 0032897474 scopus 로고    scopus 로고
    • Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases
    • Sakagami M, Morrison P, and Welch WJ (1999). Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases. Cell Stress Chaperones 4, 19-28.
    • (1999) Cell Stress Chaperones , vol.4 , pp. 19-28
    • Sakagami, M.1    Morrison, P.2    Welch, W.J.3
  • 31
    • 53149118242 scopus 로고    scopus 로고
    • The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts
    • Pratt WB, Morishima Y, and Osawa Y (2008). The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem 283, 22885-22889.
    • (2008) J Biol Chem , vol.283 , pp. 22885-22889
    • Pratt, W.B.1    Morishima, Y.2    Osawa, Y.3
  • 32
    • 12144266330 scopus 로고    scopus 로고
    • Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
    • Citri A, Gan J, Mosesson Y, Vereb G, Szollosi J, and Yarden Y (2004). Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep 5, 1165-1170.
    • (2004) EMBO Rep , vol.5 , pp. 1165-1170
    • Citri, A.1    Gan, J.2    Mosesson, Y.3    Vereb, G.4    Szollosi, J.5    Yarden, Y.6
  • 33
    • 38349132541 scopus 로고    scopus 로고
    • A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2
    • Sidera K, Gaitanou M, Stellas D, Matsas R, and Patsavoudi E (2008). A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. J Biol Chem 283, 2031-2041.
    • (2008) J Biol Chem , vol.283 , pp. 2031-2041
    • Sidera, K.1    Gaitanou, M.2    Stellas, D.3    Matsas, R.4    Patsavoudi, E.5
  • 34
    • 23044480581 scopus 로고    scopus 로고
    • ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition
    • Dote H, Cerna D, Burgan WE, Camphausen K, and Tofilon PJ (2005). ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition. Cancer Res 65, 6967-6975.
    • (2005) Cancer Res , vol.65 , pp. 6967-6975
    • Dote, H.1    Cerna, D.2    Burgan, W.E.3    Camphausen, K.4    Tofilon, P.J.5
  • 35
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • Neckers L and Workman P (2012). Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 18, 64-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 36
    • 0026749295 scopus 로고
    • Unusual expression and localization of heat-shock proteins in human tumor-cells
    • Ferrarini M, Heltai S, Zocchi MR, and Rugarli C (1992). Unusual expression and localization of heat-shock proteins in human tumor-cells. Int J Cancer 51, 613-619.
    • (1992) Int J Cancer , vol.51 , pp. 613-619
    • Ferrarini, M.1    Heltai, S.2    Zocchi, M.R.3    Rugarli, C.4


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