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Volumn 13, Issue 9, 2011, Pages 806-821

Activation of Pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 112; PLASMIN; PROUROKINASE; UNCLASSIFIED DRUG; UROKINASE;

EID: 80053458622     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.11704     Document Type: Article
Times cited : (43)

References (54)
  • 1
    • 38949143636 scopus 로고    scopus 로고
    • Cancer invasion and metastasis: Changing views
    • Duffy MJ, McGowan PM, and Gallagher WM (2008). Cancer invasion and metastasis: changing views. J Pathol 214, 283-293.
    • (2008) J Pathol , vol.214 , pp. 283-293
    • Duffy, M.J.1    McGowan, P.M.2    Gallagher, W.M.3
  • 2
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, and Werb Z (2010). Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141, 52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 4
    • 33750073572 scopus 로고    scopus 로고
    • Evaluation of urokinase plasminogen activator and its receptor in different grades of human prostate cancer
    • Cozzi PJ, Wang J, Delprado W, Madigan MC, Fairy S, Russell PJ, and Li Y (2006). Evaluation of urokinase plasminogen activator and its receptor in different grades of human prostate cancer. Hum Pathol 37, 1442-1451.
    • (2006) Hum Pathol , vol.37 , pp. 1442-1451
    • Cozzi, P.J.1    Wang, J.2    Delprado, W.3    Madigan, M.C.4    Fairy, S.5    Russell, P.J.6    Li, Y.7
  • 5
    • 33846978442 scopus 로고    scopus 로고
    • Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis
    • Shariat SF, Roehrborn CG, McConnell JD, Park S, Alam N, Wheeler TM, and Slawin KM (2007). Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis. J Clin Oncol 25, 349-355.
    • (2007) J Clin Oncol , vol.25 , pp. 349-355
    • Shariat, S.F.1    Roehrborn, C.G.2    McConnell, J.D.3    Park, S.4    Alam, N.5    Wheeler, T.M.6    Slawin, K.M.7
  • 6
    • 34548414532 scopus 로고    scopus 로고
    • Targeting uPA/uPAR in prostate cancer
    • Li Y and Cozzi PJ (2007). Targeting uPA/uPAR in prostate cancer. Cancer Treat Rev 33, 521-527.
    • (2007) Cancer Treat Rev , vol.33 , pp. 521-527
    • Li, Y.1    Cozzi, P.J.2
  • 7
    • 0033981473 scopus 로고    scopus 로고
    • The plasminogen activation system in tumor growth, invasion, and metastasis
    • Andreasen PA, Egelund R, and Petersen HH (2000). The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57, 25-40.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 25-40
    • Andreasen, P.A.1    Egelund, R.2    Petersen, H.H.3
  • 8
    • 0037965779 scopus 로고    scopus 로고
    • The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: Rescue of activity through reciprocal pro-enzyme activation
    • Behrendt N, List K, Andreasen PA, and Dano K (2003). The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation. Biochem J 371, 277-287.
    • (2003) Biochem J , vol.371 , pp. 277-287
    • Behrendt, N.1    List, K.2    Andreasen, P.A.3    Dano, K.4
  • 11
    • 0036906177 scopus 로고    scopus 로고
    • uPAR: A versatile signalling orchestrator
    • Blasi F and Carmeliet P (2002). uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 3, 932-943.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 12
    • 33947321575 scopus 로고    scopus 로고
    • uPAR-uPA-PAI-1 interactions and signaling: A vascular biologist's view
    • Binder BR, Mihaly J, and Prager GW (2007). uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view. Thromb Haemost 97, 336-342.
    • (2007) Thromb Haemost , vol.97 , pp. 336-342
    • Binder, B.R.1    Mihaly, J.2    Prager, G.W.3
  • 13
    • 0025883277 scopus 로고
    • Plasminogen activation by receptorbound urokinase. A kinetic study with both cell-associated and isolated receptor
    • Ellis V, Behrendt N, and Dano K (1991). Plasminogen activation by receptorbound urokinase. A kinetic study with both cell-associated and isolated receptor. J Biol Chem 266, 12752-12758.
    • (1991) J Biol Chem , vol.266 , pp. 12752-12758
    • Ellis, V.1    Behrendt, N.2    Dano, K.3
  • 14
    • 0028023538 scopus 로고
    • An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II
    • Hajjar KA, Jacovina AT, and Chacko J (1994). An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. J Biol Chem 269, 21191-21197.
    • (1994) J Biol Chem , vol.269 , pp. 21191-21197
    • Hajjar, K.A.1    Jacovina, A.T.2    Chacko, J.3
  • 15
    • 77949897126 scopus 로고    scopus 로고
    • Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
    • Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Kiosses WB, Kamps MP, Yates JR III, Parmer RJ, and Miles LA (2010). Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood 115, 1319-1330.
    • (2010) Blood , vol.115 , pp. 1319-1330
    • Andronicos, N.M.1    Chen, E.I.2    Baik, N.3    Bai, H.4    Parmer, C.M.5    Kiosses, W.B.6    Kamps, M.P.7    Yates III, J.R.8    Parmer, R.J.9    Miles, L.A.10
  • 16
    • 11244271736 scopus 로고    scopus 로고
    • Regulation and interactions in the activation of cell-associated plasminogen
    • Myohanen H and Vaheri A (2004). Regulation and interactions in the activation of cell-associated plasminogen. Cell Mol Life Sci 61, 2840-2858.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2840-2858
    • Myohanen, H.1    Vaheri, A.2
  • 17
    • 0010469194 scopus 로고
    • Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells
    • Quigley JP, Gold LI, Schwimmer R, and Sullivan LM (1987). Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells. Proc Natl Acad Sci USA 84, 2776-2780.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2776-2780
    • Quigley, J.P.1    Gold, L.I.2    Schwimmer, R.3    Sullivan, L.M.4
  • 18
    • 0032489876 scopus 로고    scopus 로고
    • Processing of laminin-5 and its functional consequences: Role of plasmin and tissue-type plasminogen activator
    • Goldfinger LE, Stack MS, and Jones JC (1998). Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator. J Cell Biol 141, 255-265.
    • (1998) J Cell Biol , vol.141 , pp. 255-265
    • Goldfinger, L.E.1    Stack, M.S.2    Jones, J.C.3
  • 19
    • 0037107551 scopus 로고    scopus 로고
    • Fibronectin at a glance
    • Pankov R and Yamada KM (2002). Fibronectin at a glance. J Cell Sci 115, 3861-3863.
    • (2002) J Cell Sci , vol.115 , pp. 3861-3863
    • Pankov, R.1    Yamada, K.M.2
  • 21
    • 0033532205 scopus 로고    scopus 로고
    • Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion
    • Ramos-DeSimone N, Hahn-Dantona E, Sipley J, Nagase H, French DL, and Quigley JP (1999). Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 274, 13066-13076.
    • (1999) J Biol Chem , vol.274 , pp. 13066-13076
    • Ramos-Desimone, N.1    Hahn-Dantona, E.2    Sipley, J.3    Nagase, H.4    French, D.L.5    Quigley, J.P.6
  • 22
    • 0035740252 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in prostate cancer metastasis
    • Sheng S (2001). The urokinase-type plasminogen activator system in prostate cancer metastasis. Cancer Metastasis Rev 20, 287-296.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 287-296
    • Sheng, S.1
  • 23
    • 0038364216 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy
    • Sidenius N and Blasi F (2003). The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev 22, 205-222.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 205-222
    • Sidenius, N.1    Blasi, F.2
  • 24
    • 0036431989 scopus 로고    scopus 로고
    • Inhibitors of the protease domain of urokinase-type plasminogen activator
    • Rockway TW, Nienaber V, and Giranda VL (2002). Inhibitors of the protease domain of urokinase-type plasminogen activator. Curr Pharm Des 8, 2541-2558.
    • (2002) Curr Pharm Des , vol.8 , pp. 2541-2558
    • Rockway, T.W.1    Nienaber, V.2    Giranda, V.L.3
  • 25
    • 27744435789 scopus 로고    scopus 로고
    • RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo
    • Pulukuri SM, Gondi CS, Lakka SS, Jutla A, Estes N, Gujrati M, and Rao JS (2005). RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. J Biol Chem 280, 36529-36540.
    • (2005) J Biol Chem , vol.280 , pp. 36529-36540
    • Pulukuri, S.M.1    Gondi, C.S.2    Lakka, S.S.3    Jutla, A.4    Estes, N.5    Gujrati, M.6    Rao, J.S.7
  • 26
    • 33847034860 scopus 로고    scopus 로고
    • Demethylation-linked activation of urokinase plasminogen activator is involved in progression of prostate cancer
    • Pulukuri SM, Estes N, Patel J, and Rao JS (2007). Demethylation-linked activation of urokinase plasminogen activator is involved in progression of prostate cancer. Cancer Res 67, 930-939.
    • (2007) Cancer Res , vol.67 , pp. 930-939
    • Pulukuri, S.M.1    Estes, N.2    Patel, J.3    Rao, J.S.4
  • 27
    • 43249124467 scopus 로고    scopus 로고
    • Prostate cancer cell-derived urokinase-type plasminogen activator contributes to intraosseous tumor growth and bone turnover
    • Dong Z, Saliganan AD, Meng H, Nabha SM, Sabbota AL, Sheng S, Bonfil RD, and Cher ML (2008). Prostate cancer cell-derived urokinase-type plasminogen activator contributes to intraosseous tumor growth and bone turnover. Neoplasia 10, 439-449.
    • (2008) Neoplasia , vol.10 , pp. 439-449
    • Dong, Z.1    Saliganan, A.D.2    Meng, H.3    Nabha, S.M.4    Sabbota, A.L.5    Sheng, S.6    Bonfil, R.D.7    Cher, M.L.8
  • 28
    • 34547095270 scopus 로고    scopus 로고
    • Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis
    • Pulukuri SM and Rao JS (2007). Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis. Cancer Res 67, 6637-6646.
    • (2007) Cancer Res , vol.67 , pp. 6637-6646
    • Pulukuri, S.M.1    Rao, J.S.2
  • 29
    • 0030584083 scopus 로고    scopus 로고
    • Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency
    • Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJ, and Degen JL (1996). Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. Cell 87, 709-719.
    • (1996) Cell , vol.87 , pp. 709-719
    • Bugge, T.H.1    Kombrinck, K.W.2    Flick, M.J.3    Daugherty, C.C.4    Danton, M.J.5    Degen, J.L.6
  • 32
    • 33744933988 scopus 로고    scopus 로고
    • Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation
    • Madsen MA, Deryugina EI, Niessen S, Cravatt BF, and Quigley JP (2006). Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation. J Biol Chem 281, 15997-16005.
    • (2006) J Biol Chem , vol.281 , pp. 15997-16005
    • Madsen, M.A.1    Deryugina, E.I.2    Niessen, S.3    Cravatt, B.F.4    Quigley, J.P.5
  • 34
    • 71849098077 scopus 로고    scopus 로고
    • Comparative analysis of metastasis variants derived from human prostate carcinoma cells: Roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion
    • Conn EM, Botkjaer KA, Kupriyanova TA, Andreasen PA, Deryugina EI, and Quigley JP (2009). Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion. Am J Pathol 175, 1638-1652.
    • (2009) Am J Pathol , vol.175 , pp. 1638-1652
    • Conn, E.M.1    Botkjaer, K.A.2    Kupriyanova, T.A.3    Andreasen, P.A.4    Deryugina, E.I.5    Quigley, J.P.6
  • 35
    • 28244495575 scopus 로고    scopus 로고
    • Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination
    • Deryugina EI, Zijlstra A, Partridge JJ, Kupriyanova TA, Madsen MA, Papagiannakopoulos T, and Quigley JP (2005). Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. Cancer Res 65, 10959-10969.
    • (2005) Cancer Res , vol.65 , pp. 10959-10969
    • Deryugina, E.I.1    Zijlstra, A.2    Partridge, J.J.3    Kupriyanova, T.A.4    Madsen, M.A.5    Papagiannakopoulos, T.6    Quigley, J.P.7
  • 36
    • 0036894603 scopus 로고    scopus 로고
    • A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction
    • Zijlstra A, Mellor R, Panzarella G, Aimes RT, Hooper JD, Marchenko ND, and Quigley JP (2002). A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res 62, 7083-7092.
    • (2002) Cancer Res , vol.62 , pp. 7083-7092
    • Zijlstra, A.1    Mellor, R.2    Panzarella, G.3    Aimes, R.T.4    Hooper, J.D.5    Marchenko, N.D.6    Quigley, J.P.7
  • 37
    • 33750156940 scopus 로고    scopus 로고
    • Pro-urokinase-type plasminogen activator is a substrate for hepsin
    • Moran P, Li W, Fan B, Vij R, Eigenbrot C, and Kirchhofer D (2006). Pro-urokinase-type plasminogen activator is a substrate for hepsin. J Biol Chem 281, 30439-30446.
    • (2006) J Biol Chem , vol.281 , pp. 30439-30446
    • Moran, P.1    Li, W.2    Fan, B.3    Vij, R.4    Eigenbrot, C.5    Kirchhofer, D.6
  • 38
    • 0034711244 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease
    • Lee SL, Dickson RB, and Lin CY (2000). Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J Biol Chem 275, 36720-36725.
    • (2000) J Biol Chem , vol.275 , pp. 36720-36725
    • Lee, S.L.1    Dickson, R.B.2    Lin, C.Y.3
  • 39
    • 0034714379 scopus 로고    scopus 로고
    • Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates
    • Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, and Craik CS (2000). Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem 275, 26333-26342.
    • (2000) J Biol Chem , vol.275 , pp. 26333-26342
    • Takeuchi, T.1    Harris, J.L.2    Huang, W.3    Yan, K.W.4    Coughlin, S.R.5    Craik, C.S.6
  • 40
    • 0030949650 scopus 로고    scopus 로고
    • The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
    • Pilcher BK, Dumin JA, Sudbeck BD, Krane SM, Welgus HG, and Parks WC (1997). The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol 137, 1445-1457.
    • (1997) J Cell Biol , vol.137 , pp. 1445-1457
    • Pilcher, B.K.1    Dumin, J.A.2    Sudbeck, B.D.3    Krane, S.M.4    Welgus, H.G.5    Parks, W.C.6
  • 42
    • 0028057551 scopus 로고
    • High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery
    • Janssens M, Joris J, David JL, Lemaire R, and Lamy M (1994). High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery. Anesthesiology 80, 23-29.
    • (1994) Anesthesiology , vol.80 , pp. 23-29
    • Janssens, M.1    Joris, J.2    David, J.L.3    Lemaire, R.4    Lamy, M.5
  • 44
    • 67649843650 scopus 로고    scopus 로고
    • Strategies to extend plasma half-lives of recombinant antibodies
    • Kontermann RE (2009). Strategies to extend plasma half-lives of recombinant antibodies. BioDrugs 23, 93-109.
    • (2009) BioDrugs , vol.23 , pp. 93-109
    • Kontermann, R.E.1
  • 46
    • 77951708287 scopus 로고    scopus 로고
    • Deadly allies: The fatal interplay between platelets and metastasizing cancer cells
    • Erpenbeck L and Schon MP (2010). Deadly allies: the fatal interplay between platelets and metastasizing cancer cells. Blood 115, 3427-3436.
    • (2010) Blood , vol.115 , pp. 3427-3436
    • Erpenbeck, L.1    Schon, M.P.2
  • 47
    • 79251478398 scopus 로고    scopus 로고
    • Contribution of platelets to tumour metastasis
    • Gay LJ and Felding-Habermann B (2011). Contribution of platelets to tumour metastasis. Nat Rev Cancer 11, 123-134.
    • (2011) Nat Rev Cancer , vol.11 , pp. 123-134
    • Gay, L.J.1    Felding-Habermann, B.2
  • 48
    • 77954355093 scopus 로고    scopus 로고
    • Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration
    • Sabbota AL, Kim HR, Zhe X, Fridman R, Bonfil RD, and Cher ML (2010). Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration. Cancer Res 70, 5558-5566.
    • (2010) Cancer Res , vol.70 , pp. 5558-5566
    • Sabbota, A.L.1    Kim, H.R.2    Zhe, X.3    Fridman, R.4    Bonfil, R.D.5    Cher, M.L.6
  • 49
    • 69249228553 scopus 로고    scopus 로고
    • ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
    • Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massague J, and Kang Y (2009). ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev 23, 1882-1894.
    • (2009) Genes Dev , vol.23 , pp. 1882-1894
    • Lu, X.1    Wang, Q.2    Hu, G.3    van Poznak, C.4    Fleisher, M.5    Reiss, M.6    Massague, J.7    Kang, Y.8
  • 50
    • 0141993055 scopus 로고    scopus 로고
    • Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency
    • Palumbo JS, Talmage KE, Liu H, La Jeunesse CM, Witte DP, and Degen JL (2003). Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency. Blood 102, 2819-2827.
    • (2003) Blood , vol.102 , pp. 2819-2827
    • Palumbo, J.S.1    Talmage, K.E.2    Liu, H.3    la Jeunesse, C.M.4    Witte, D.P.5    Degen, J.L.6
  • 51
    • 0035095955 scopus 로고    scopus 로고
    • A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation
    • Selvarajan S, Lund LR, Takeuchi T, Craik CS, and Werb Z (2001). A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Nat Cell Biol 3, 267-275.
    • (2001) Nat Cell Biol , vol.3 , pp. 267-275
    • Selvarajan, S.1    Lund, L.R.2    Takeuchi, T.3    Craik, C.S.4    Werb, Z.5
  • 52
    • 0028808210 scopus 로고
    • Fibronectin and integrins in invasion and metastasis
    • Akiyama SK, Olden K, and Yamada KM (1995). Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev 14, 173-189.
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 173-189
    • Akiyama, S.K.1    Olden, K.2    Yamada, K.M.3
  • 54
    • 0344256437 scopus 로고    scopus 로고
    • RGD story: A personal account. A landmark essay
    • Ruoslahti E (2003). RGD story: a personal account. A landmark essay. Matrix Biol 22, 459-465.
    • (2003) Matrix Biol , vol.22 , pp. 459-465
    • Ruoslahti, E.1


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