c-Myc suppression of DNA double-strand break repair

Neoplasia (United States)

Volumn 14, Issue 12, 2012, Pages 1190-1202

  Li, Zhaozhong ^a   Owonikoko, Taofeek K ^a   Sun, Shi Yong ^a   Ramalingam, Suresh S ^a   Doetsch, Paul W ^a   Xiao, Zhi Qiang ^b   Khuri, Fadlo R ^a   Curran, Walter J ^a   Deng, Xingming ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; KU ANTIGEN; MYC PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; FLUORESCENCE IN SITU HYBRIDIZATION; GEL MOBILITY SHIFT ASSAY; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INFRARED RADIATION; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PULSED FIELD GEL ELECTROPHORESIS; RNA INTERFERENCE; TELOMERE; VDJ RECOMBINATION; WESTERN BLOTTING;

EID: 84871602994     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.121258     Document Type: Article

References (61)

1. Kinner A, Wu W, Staudt C, and Iliakis G (2008). γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 36, 5678-5694.
2. Richardson C and Jasin M (2000). Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 405, 697-700.
3. Rothkamm K, Kuhne M, Jeggo PA, and Lobrich M (2001). Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res 61, 3886-3893.
4. Bunting SF, Callen E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, et al. (2010). 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141, 243-254.
5. Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, and Nussenzweig A (2003). Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol 5, 675-679.
6. Fillingham J, Keogh MC, and Krogan NJ (2006). γH2AX and its role in DNA double-strand break repair. Biochem Cell Biol 84, 568-577.
7. Rogakou EP, Boon C, Redon C, and Bonner WM (1999). Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146, 905-916.
8. Falck J, Coates J, and Jackson SP (2005). Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434, 605-611.
9. Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, and Jeggo PA (2004). ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 64, 2390-2396.
10. Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche MC, Sanal O, Plebani A, Stéphan JL, Hufnagel M, le Deist F, et al. (2006). Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124, 287-299.
11. Gostissa M, Alt FW, and Chiarle R (2011). Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol 29, 319-350.
12. Fugmann SD, Lee AI, Shockett PE, Villey IJ, and Schatz DG (2000). The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol 18, 495-527.
13. Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, et al. (1995). Defective DNAdependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
14. Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, et al. (2002). Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell 10, 1379-1390.
15. Pelengaris S, Khan M, and Evan GI (2002). Suppression of Myc-induced apoptosis in β cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109, 321-334.
16. Klapproth K and Wirth T (2010). Advances in the understanding of MYCinduced lymphomagenesis. Br J Haematol 149, 484-497.
17. Blackwood EM and Eisenman RN (1991). Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251, 1211-1217.
18. Felsher DW and Bishop JM (1999). Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci USA 96, 3940-3944.
19. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, and Brinster RL (1985). The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318, 533-538.
20. Potter M and Wiener F (1992). Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 13, 1681-1697.
21. Felsher DW and Bishop JM (1999). Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4, 199-207.
22. Hironaka K, Factor VM, Calvisi DF, Conner EA, and Thorgeirsson SS (2003). Dysregulation of DNA repair pathways in a transforming growth factor alpha/ c-myc transgenic mouse model of accelerated hepatocarcinogenesis. Lab Invest 83, 643-654.
23. Karlsson A, Deb-Basu D, Cherry A, Turner S, Ford J, and Felsher DW (2003). Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression. Proc Natl Acad Sci USA 100, 9974-9979.
24. Louis SF, Vermolen BJ, Garini Y, Young IT, Guffei A, Lichtensztejn Z, Kuttler F, Chuang TC, Moshir S, Mougey V, et al. (2005). c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus. Proc Natl Acad Sci USA 102, 9613-9618.
25. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, and Wahl GM (2002). c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 9, 1031-1044.
26. Ray S, Atkuri KR, Deb-Basu D, Adler AS, Chang HY, Herzenberg LA, and Felsher DW (2006). MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. Cancer Res 66, 6598-6605.
27. Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR III, Menssen A, and Hermeking H (2007). Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle 6, 205-217.
28. Mateyak MK, Obaya AJ, Adachi S, and Sedivy JM (1997). Phenotypes of c-Mycdeficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 8, 1039-1048.
29. Ager DD, Dewey WC, Gardiner K, Harvey W, Johnson RT, and Waldren CA (1990). Measurement of radiation-induced DNA double-strand breaks by pulsedfield gel electrophoresis. Radiat Res 122, 181-187.
30. Zha S, Alt FW, Cheng HL, Brush JW, and Li G (2007). Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci USA 104, 4518-4523.
31. Gu Y, Jin S, Gao Y, Weaver DT, and Alt FW (1997). Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci USA 94, 8076-8081.
32. Wang Q, Gao F, May WS, Zhang Y, Flagg T, and Deng X (2008). Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathway. Mol Cell 29, 488-498.
33. Guffei A, Lichtensztejn Z, Gonçalves Dos Santos Silva A, Louis SF, Caporali A, and Mai S (2007). c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells. Neoplasia 9, 578-588.
34. Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, and Lieberman J (2005). γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 20, 801-809.
35. Modesti M and Kanaar R (2001). DNA repair: spot(light)s on chromatin. Curr Biol 11, R229-R232.
36. Hefferin ML and Tomkinson AE (2005). Mechanism of DNA doublestrand break repair by non-homologous end joining. DNA Repair (Amst) 4, 639-648.
37. Pastwa E and Blasiak J (2003). Non-homologous DNA end joining. Acta Biochim Pol 50, 891-908.
38. Burma S, Chen BP, and Chen DJ (2006). Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) 5, 1042-1048.
39. Critchlow SE and Jackson SP (1998). DNA end-joining: from yeast to man. Trends Biochem Sci 23, 394-398.
40. Pastink A, Eeken JC, and Lohman PH (2001). Genomic integrity and the repair of double-strand DNA breaks. Mutat Res 480-481, 37-50.
41. Pierce AJ, Stark JM, Araujo FD, Moynahan ME, Berwick M, and Jasin M (2001). Double-strand breaks and tumorigenesis. Trends Cell Biol 11, S52-S59.
42. Ricke RM and Bielinsky AK (2004). Mcm10 regulates the stability and chromatin association of DNA polymerase-α. Mol Cell 16, 173-185.
43. Pelengaris S, Khan M, and Evan G (2002). c-MYC: more than just a matter of life and death. Nat Rev Cancer 2, 764-776.
44. Vervoorts J, Lüscher-Firzlaff J, and Lüscher B (2006). The ins and outs of MYC regulation by posttranslational mechanisms. J Biol Chem 281, 34725-34729.
45. Luoto KR, Meng AX, Wasylishen AR, Zhao H, Coackley CL, Penn LZ, and Bristow RG (2010). Tumor cell kill by c-MYC depletion: role of MYCregulated genes that control DNA double-strand break repair. Cancer Res 70, 8748-8759.
46. Yaneva M, Kowalewski T, and Lieber MR (1997). Interaction of DNA dependent protein kinase with DNA and with Ku: biochemical and atomicforce microscopy studies. EMBO J 16, 5098-5112.
47. Yarnell Schultz H, Landree MA, Qiu JX, Kale SB, and Roth DB (2001). Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro. Mol Cell 7, 65-75.
48. Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, and Johnson DG (2006). ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci USA 103, 1446-1451.
49. Li Q and Dang CV (1999). c-Myc overexpression uncouples DNA replication from mitosis. Mol Cell Biol 19, 5339-5351.
50. Mai S, Hanley-Hyde J, and Fluri M (1996). c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines. Oncogene 12, 277-288.
51. El-Kady A, Sun Y, Li YX, and Liao DJ (2011). Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-κB and Bcl-2 families. J Carcinog 10, 24.
52. von Bueren AO, Oehler C, Shalaby T, von Hoff K, Pruschy M, Seifert B, Gerber NU, Warmuth-Metz M, Stearns D, Eberhart CG, et al. (2011). c-MYC expression sensitizes medulloblastoma cells to radio and chemotherapy and has no impact on response in medulloblastoma patients. BMC Cancer 11, 74.
53. Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, and Dalla-Favera R (2007). Non-transcriptional control of DNA replication by c-Myc. Nature 448, 445-451.
54. Cole MD and Cowling VH (2008). Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol 9, 810-815.
55. Mu ZM, Yin XY, and Prochownik EV (2002). Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression. J Biol Chem 277, 43175-43184.
56. Bassing CH, Swat W, and Alt FW (2002). The mechanism and regulation of chromosomal V(D)J recombination. Cell 109, S45-S55.
57. Johnson K, Chaumeil J, and Skok JA (2010). Epigenetic regulation of V(D)J recombination. Essays Biochem 48, 221-243.
58. Balajee AS and Geard CR (2004). Replication protein A and γ-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks. Exp Cell Res 300, 320-334.
59. Deng X, Gao F, Flagg T, Anderson J, and May WS (2006). Bcl2's flexible loop domain regulates p53 binding and survival. Mol Cell Biol 26, 4421-4434.
60. Shin KH, Kang MK, Dicterow E, Kameta A, Baluda MA, and Park NH (2004). Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clin Cancer Res 10, 2551-2560.
61. Wu X and Lieber MR (1996). Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol Cell Biol 16, 5186-5193.