Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels

Neoplasia (United States)

Volumn 14, Issue 5, 2012, Pages 410-419

  Haupenthal, Jörg ^a   Bihrer, Verena ^a   Korkusuz, Huedayi ^a   Kollmar, Otto ^b   Schmithals, Christian ^a   Kriener, Susanne ^a   Engels, Knut ^a   Pleli, Thomas ^a   Benz, Alexander ^a   Canamero, Marta ^c   Longerich, Thomas ^d   Kronenberger, Bernd ^a   Richter, Swantje ^a   Waidmann, Oliver ^a   Vogl, Thomas J ^a   Zeuzem, Stefan ^a   Piiper, Albrecht ^a  

^a GOETHE UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c Centro Nacional de Investigaciones Oncológicas   (Spain)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (8 CYCLOPENTYL 7 ETHYL 5, 6, 7, 8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL) BENZAMIDE; 4 (8 CYCLOPENTYL 7 ETHYL 5,6,7,8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL)BENZAMIDE; GADOXETIC ACID; KI 67 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLO LIKE KINASE 1; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ADENOVIRUS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN ELECTROPHORESIS; PROTEIN EXPRESSION; RNA INTERFERENCE; TRANSGENIC MOUSE;

EID: 84861681511     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1596/neo.111366     Document Type: Article

References (6)

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2. Haupenthal J, Baehr C, Zeuzem S, and Piiper A (2007). RNAse A-like enzymes in serum inhibit the anti-neoplastic activity of siRNA targeting Polo-like kinase 1. Int J Cancer 121, 206-210.
3. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, and Earnshaw WC (1994). Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
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6. Korkusuz H, Knau LL, Kromen W, Bihrer V, Keese D, Piiper A, and Vogl TJ (2012). Different signal intensity at Gd-EOB-DTPA compared with Gd-DTPA-enhanced MRI in hepatocellular carcinoma transgenic mouse model in delayed phase hepatobiliary imaging. J Magn Reson Imaging, doi: 10.1002/ jmri.23584.