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Volumn 15, Issue 9, 2013, Pages 1009-1017

AR variant ARv567es induces carcinogenesis in a novel transgenic mouse model of prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; BETA CATENIN; KI 67 ANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN VARIANT; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTOME; UVOMORULIN; VIMENTIN; WNT11 PROTEIN; ANDROGEN BINDING PROTEIN; FOXA1 PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; ISOPROTEIN; PROBASIN;

EID: 84884377857     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.13784     Document Type: Article
Times cited : (59)

References (38)
  • 1
    • 78149435915 scopus 로고    scopus 로고
    • Bypass mechanisms of the androgen receptor pathway in therapyresistant prostate cancer cell models
    • Marques RB, Dits NF, Erkens-Schulze S, van Weerden WM, and Jenster G (2010). Bypass mechanisms of the androgen receptor pathway in therapyresistant prostate cancer cell models. PloS One 5, e13500.
    • (2010) PloS One , vol.5
    • Marques, R.B.1    Dits, N.F.2    Erkens-Schulze, S.3    van Weerden, W.M.4    Jenster, G.5
  • 2
    • 60149089419 scopus 로고    scopus 로고
    • Androgen deprivation therapy: Progress in understanding mechanisms of resistance and optimizing androgen depletion
    • Harris WP, Mostaghel EA, Nelson PS, and Montgomery B (2009). Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 6, 76-85.
    • (2009) Nat Clin Pract Urol , vol.6 , pp. 76-85
    • Harris, W.P.1    Mostaghel, E.A.2    Nelson, P.S.3    Montgomery, B.4
  • 3
    • 66149161780 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: Locking up the molecular escape routes
    • Attar RM, Takimoto CH, and Gottardis MM (2009). Castration-resistant prostate cancer: locking up the molecular escape routes. Clin Cancer Res 15, 3251-3255.
    • (2009) Clin Cancer Res , vol.15 , pp. 3251-3255
    • Attar, R.M.1    Takimoto, C.H.2    Gottardis, M.M.3
  • 4
    • 33749345244 scopus 로고    scopus 로고
    • Improving the Outcome of Patients With Castration-resistant Prostate Cancer Through Rational Drug Development
    • Attard G, Sarker D, Reid A, Molife R, Parker C, and de Bono JS (2006). Improving the outcome of patients with castration-resistant prostate cancer through rational drug development. Br J Cancer 95, 767-774.
    • (2006) Br J Cancer , vol.95 , pp. 767-774
    • Attard, G.1    Sarker, D.2    Reid, A.3    Molife, R.4    Parker, C.5    de Bono, J.S.6
  • 5
    • 61749092850 scopus 로고    scopus 로고
    • CYP17 Blockade By Abiraterone: Further Evidence For Frequent Continued Hormone-dependence In Castrationresistant Prostate Cancer
    • Ang JE, Olmos D, and de Bono JS (2009). CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castrationresistant prostate cancer. Br J Cancer 100, 671-675.
    • (2009) Br J Cancer , vol.100 , pp. 671-675
    • Ang, J.E.1    Olmos, D.2    de Bono, J.S.3
  • 7
    • 3843069106 scopus 로고    scopus 로고
    • Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence
    • Taplin ME and Balk SP (2004). Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence. J Cell Biochem 91, 483-490.
    • (2004) J Cell Biochem , vol.91 , pp. 483-490
    • Taplin, M.E.1    Balk, S.P.2
  • 8
    • 51649097710 scopus 로고    scopus 로고
    • Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins
    • Kaur R, Yuan X, Lu ML, and Balk SP (2008). Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate 68, 1510-1516.
    • (2008) Prostate , vol.68 , pp. 1510-1516
    • Kaur, R.1    Yuan, X.2    Lu, M.L.3    Balk, S.P.4
  • 9
    • 58049196759 scopus 로고    scopus 로고
    • Mechanisms mediating androgen receptor reactivation after castration
    • Yuan X and Balk SP (2009). Mechanisms mediating androgen receptor reactivation after castration. Urol Oncol 27, 36-41.
    • (2009) Urol Oncol , vol.27 , pp. 36-41
    • Yuan, X.1    Balk, S.P.2
  • 10
    • 0036219918 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: An overview
    • Heinlein CA and Chang C (2002). Androgen receptor (AR) coregulators: an overview. Endocr Rev 23, 175-200.
    • (2002) Endocr Rev , vol.23 , pp. 175-200
    • Heinlein, C.A.1    Chang, C.2
  • 13
    • 84876695259 scopus 로고    scopus 로고
    • Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression
    • Shafi AA, Cox MB, and Weigel NL (2013). Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression. Steroids 78, 548-554.
    • (2013) Steroids , vol.78 , pp. 548-554
    • Shafi, A.A.1    Cox, M.B.2    Weigel, N.L.3
  • 14
    • 80054931284 scopus 로고    scopus 로고
    • Alternatively spliced androgen receptor variants
    • Dehm SM and Tindall DJ (2011). Alternatively spliced androgen receptor variants. Endocr Relat Cancer 18, R183-R196.
    • (2011) Endocr Relat Cancer , vol.18
    • Dehm, S.M.1    Tindall, D.J.2
  • 15
    • 79961013987 scopus 로고    scopus 로고
    • A new trick of an old molecule: Androgen receptor splice variants taking the stage?!
    • Guo Z and Qiu Y (2011). A new trick of an old molecule: androgen receptor splice variants taking the stage?! Int J Biol Sci 7, 815-822.
    • (2011) Int J Biol Sci , vol.7 , pp. 815-822
    • Guo, Z.1    Qiu, Y.2
  • 16
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, and Tindall DJ (2008). Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 68, 5469-5477.
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 17
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, Kong X, Melamed J, Tepper CG, Kung HJ, et al. (2009). A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 69, 2305-2313.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5    Chen, H.6    Kong, X.7    Melamed, J.8    Tepper, C.G.9    Kung, H.J.10
  • 19
    • 74049109753 scopus 로고    scopus 로고
    • Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line
    • Marcias G, Erdmann E, Lapouge G, Siebert C, Barthelemy P, Duclos B, Bergerat JP, Ceraline J, and Kurtz JE (2010). Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line. Hum Mutat 31, 74-80.
    • (2010) Hum Mutat , vol.31 , pp. 74-80
    • Marcias, G.1    Erdmann, E.2    Lapouge, G.3    Siebert, C.4    Barthelemy, P.5    Duclos, B.6    Bergerat, J.P.7    Ceraline, J.8    Kurtz, J.E.9
  • 21
    • 78049280194 scopus 로고    scopus 로고
    • Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    • Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, and Sawyers CL (2010). Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci USA 107, 16759-16765.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5    Viale, A.6    Kim, K.7    Sawyers, C.L.8
  • 22
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hornberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, Widmark A, Bergh A, and Wikstrom P (2011). Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PloS One 6, e19059.
    • (2011) PloS One , vol.6
    • Hornberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5    Widmark, A.6    Bergh, A.7    Wikstrom, P.8
  • 23
    • 79959312739 scopus 로고    scopus 로고
    • A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
    • Hu R, Isaacs WB, and Luo J (2011). A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. Prostate 71, 1656-1667.
    • (2011) Prostate , vol.71 , pp. 1656-1667
    • Hu, R.1    Isaacs, W.B.2    Luo, J.3
  • 25
    • 12144290810 scopus 로고    scopus 로고
    • Prostate pathology of genetically engineered mice: Definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
    • Shappell SB, Thomas GV, Roberts RL, Herbert R, Ittmann MM, Rubin MA, Humphrey PA, Sundberg JP, Rozengurt N, Barrios R, et al. (2004). Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee. Cancer Res 64, 2270-2305.
    • (2004) Cancer Res , vol.64 , pp. 2270-2305
    • Shappell, S.B.1    Thomas, G.V.2    Roberts, R.L.3    Herbert, R.4    Ittmann, M.M.5    Rubin, M.A.6    Humphrey, P.A.7    Sundberg, J.P.8    Rozengurt, N.9    Barrios, R.10
  • 26
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M and Neilson EG (2009). Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119, 1429-1437.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 27
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, and Nieto MA (2009). Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 28
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2, 442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 29
    • 84863979005 scopus 로고    scopus 로고
    • Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    • Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, Tannahill C, Edwards J, Isaacs WB, Nelson PS, Bluemn E, et al. (2012). Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res 72, 3457-3462.
    • (2012) Cancer Res , vol.72 , pp. 3457-3462
    • Hu, R.1    Lu, C.2    Mostaghel, E.A.3    Yegnasubramanian, S.4    Gurel, M.5    Tannahill, C.6    Edwards, J.7    Isaacs, W.B.8    Nelson, P.S.9    Bluemn, E.10
  • 30
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, et al. (2009). Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138, 245-256.
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6    Chen, Z.7    Beroukhim, R.8    Wang, H.9    Lupien, M.10
  • 32
    • 84859416889 scopus 로고    scopus 로고
    • Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells
    • Mulholland DJ, Kobayashi N, Ruscetti M, Zhi A, Tran LM, Huang J, Gleave M, and Wu H (2012). Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res 72, 1878-1889.
    • (2012) Cancer Res , vol.72 , pp. 1878-1889
    • Mulholland, D.J.1    Kobayashi, N.2    Ruscetti, M.3    Zhi, A.4    Tran, L.M.5    Huang, J.6    Gleave, M.7    Wu, H.8
  • 35
    • 84872529696 scopus 로고    scopus 로고
    • Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
    • Hirsch HA, Iliopoulos D, and Struhl K (2013). Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci USA 110, 972-977.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 972-977
    • Hirsch, H.A.1    Iliopoulos, D.2    Struhl, K.3
  • 36
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
    • Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I, True L, and Nelson PS (2012). Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 18, 1359-1368.
    • (2012) Nat Med , vol.18 , pp. 1359-1368
    • Sun, Y.1    Campisi, J.2    Higano, C.3    Beer, T.M.4    Porter, P.5    Coleman, I.6    True, L.7    Nelson, P.S.8
  • 37
    • 84873486287 scopus 로고    scopus 로고
    • β-Catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma
    • [Francis JC, Thomsen MK, Taketo MM, and Swain A (2013). β-Catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma. PLoS Genet 9, e1003180.
    • (2013) PLoS Genet , vol.9
    • Francis, J.C.1    Thomsen, M.K.2    Taketo, M.M.3    Swain, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.