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Volumn 15, Issue 1, 2013, Pages 11-22

WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; COMPLEMENTARY DNA; DOXYCYCLINE; GEMCITABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NFAT; WNT5A PROTEIN;

EID: 84873042539     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.121312     Document Type: Article
Times cited : (67)

References (49)
  • 1
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY and Nusse R (2004). The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20, 781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 2
    • 0037066744 scopus 로고    scopus 로고
    • Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum
    • Tanaka K, Kitagawa Y, and Kadowaki T (2002). Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum. J Biol Chem 277(15), 12816-12823.
    • (2002) J Biol Chem , vol.277 , Issue.15 , pp. 12816-12823
    • Tanaka, K.1    Kitagawa, Y.2    Kadowaki, T.3
  • 3
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • McDonald SL and Silver A (2009). The opposing roles of Wnt-5a in cancer. Br J Cancer 101(2), 209-214.
    • (2009) Br J Cancer , vol.101 , Issue.2 , pp. 209-214
    • McDonald, S.L.1    Silver, A.2
  • 5
    • 0027965236 scopus 로고
    • Differential transformation of mammary epithelial cells by Wnt genes
    • Wong GT, Gavin BJ, and McMahon AP (1994). Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol 14(9), 6278-6286.
    • (1994) Mol Cell Biol , vol.14 , Issue.9 , pp. 6278-6286
    • Wong, G.T.1    Gavin, B.J.2    McMahon, A.P.3
  • 6
    • 0031846665 scopus 로고
    • Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation
    • Olson DJ and Gibo DM (1989). Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation. Exp Cell Res 241(1), 134-141.
    • (1989) Exp Cell Res , vol.241 , Issue.1 , pp. 134-141
    • Olson, D.J.1    Gibo, D.M.2
  • 7
    • 0031821881 scopus 로고    scopus 로고
    • Ectopic expression of wnt-5a in human renal cell carcinoma cells suppresses in vitro growth and telomerase activity
    • Olson DJ, Oshimura M, Otte AP, and Kumar R (1998). Ectopic expression of wnt-5a in human renal cell carcinoma cells suppresses in vitro growth and telomerase activity. Tumour Biol 19(4), 244-252.
    • (1998) Tumour Biol , vol.19 , Issue.4 , pp. 244-252
    • Olson, D.J.1    Oshimura, M.2    Otte, A.P.3    Kumar, R.4
  • 9
    • 33746990262 scopus 로고    scopus 로고
    • Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1α signaling in human mammary epithelial cells
    • Dejmek J, Safholm A, Kamp NC, Andersson T, and Leandersson K (2006). Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1α signaling in human mammary epithelial cells. Mol Cell Biol 26(16), 6024-6036.
    • (2006) Mol Cell Biol , vol.26 , Issue.16 , pp. 6024-6036
    • Dejmek, J.1    Safholm, A.2    Kamp, N.C.3    Andersson, T.4    Leandersson, K.5
  • 11
    • 0029096787 scopus 로고
    • Aberrant expression of the growth factor Wnt-5A in human malignancy
    • Iozzo RV, Eichstetter I, and Danielson KG (1995). Aberrant expression of the growth factor Wnt-5A in human malignancy. Cancer Res 55(16), 3495-3499.
    • (1995) Cancer Res , vol.55 , Issue.16 , pp. 3495-3499
    • Iozzo, R.V.1    Eichstetter, I.2    Danielson, K.G.3
  • 12
    • 0028902359 scopus 로고
    • Wnt5a cloning, expression, and up-regulation in human primary breast cancers
    • Lejeune S, Huguet EL, Hamby A, Poulsom R, and Harris AL (1995). Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin Cancer Res 1(2), 215-222.
    • (1995) Clin Cancer Res , vol.1 , Issue.2 , pp. 215-222
    • Lejeune, S.1    Huguet, E.L.2    Hamby, A.3    Poulsom, R.4    Harris, A.L.5
  • 13
    • 0036583231 scopus 로고    scopus 로고
    • Frequent up-regulation of WNT5A mRNA in primary gastric cancer
    • Saitoh T, Mine T, and Katoh M (2002). Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Int J Mol Med 9(5), 515-519.
    • (2002) Int J Mol Med , vol.9 , Issue.5 , pp. 515-519
    • Saitoh, T.1    Mine, T.2    Katoh, M.3
  • 14
    • 77953539908 scopus 로고    scopus 로고
    • Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells
    • Nishita M, Enomoto M, Yamagata K, and Minami Y (2010). Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells. Trends Cell Biol 20(6), 346-354.
    • (2010) Trends Cell Biol , vol.20 , Issue.6 , pp. 346-354
    • Nishita, M.1    Enomoto, M.2    Yamagata, K.3    Minami, Y.4
  • 15
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
    • Gordon MD and Nusse R (2006). Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281(32), 22429-22433.
    • (2006) J Biol Chem , vol.281 , Issue.32 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 17
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context
    • Mikels AJ and Nusse R (2006). Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. PLoS Biol 4(4), e115.
    • (2006) PLoS Biol , vol.4 , Issue.4
    • Mikels, A.J.1    Nusse, R.2
  • 18
    • 77957141708 scopus 로고    scopus 로고
    • WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma
    • Li J, Ying J, Fan Y, Wu L, Ying Y, Chan AT, Srivastava G, and Tao Q (2010). WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Cancer Biol Ther 10(6), 617-624.
    • (2010) Cancer Biol Ther , vol.10 , Issue.6 , pp. 617-624
    • Li, J.1    Ying, J.2    Fan, Y.3    Wu, L.4    Ying, Y.5    Chan, A.T.6    Srivastava, G.7    Tao, Q.8
  • 19
    • 0036784634 scopus 로고    scopus 로고
    • Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: Involvement of the wnt/glycogen synthase kinase-3β pathway
    • Murphy LL and Hughes CC (2002). Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3β pathway. J Immunol 169(7), 3717-3725.
    • (2002) J Immunol , vol.169 , Issue.7 , pp. 3717-3725
    • Murphy, L.L.1    Hughes, C.C.2
  • 20
    • 77955501594 scopus 로고    scopus 로고
    • Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate
    • Fromigue O, Hay E, Barbara A, and Marie PJ (2010). Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem 285(33), 25251-25258.
    • (2010) J Biol Chem , vol.285 , Issue.33 , pp. 25251-25258
    • Fromigue, O.1    Hay, E.2    Barbara, A.3    Marie, P.J.4
  • 21
    • 70350514636 scopus 로고    scopus 로고
    • NFAT proteins: Emerging roles in cancer progression
    • Mancini M and Toker A (2009). NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer 9(11), 810-820.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 810-820
    • Mancini, M.1    Toker, A.2
  • 22
    • 77958514637 scopus 로고    scopus 로고
    • NFAT transcription factors, the potion mediating "Dr. Jekill-Mr. Hyde" transformation of the TGFβ pathway in cancer cells
    • Fernandez-Zapico ME and Ellenrieder V (2010). NFAT transcription factors, the potion mediating "Dr. Jekill-Mr. Hyde" transformation of the TGFβ pathway in cancer cells. Cell Cycle 9(19), 3838-3839.
    • (2010) Cell Cycle , vol.9 , Issue.19 , pp. 3838-3839
    • Fernandez-Zapico, M.E.1    Ellenrieder, V.2
  • 25
    • 0028986091 scopus 로고
    • New pancreas cancers cell lines that represent distinct stages of ductal differentiation
    • Vila MR, Lloreta J, Schussler MH, Berrozpe G, Welt S, and Real FX (1995). New pancreas cancers cell lines that represent distinct stages of ductal differentiation. Lab Invest 72(4), 395-404.
    • (1995) Lab Invest , vol.72 , Issue.4 , pp. 395-404
    • Vila, M.R.1    Lloreta, J.2    Schussler, M.H.3    Berrozpe, G.4    Welt, S.5    Real, F.X.6
  • 26
    • 0033580422 scopus 로고    scopus 로고
    • Efficient control of tetracyclineresponsive gene expression from an autoregulated bi-directional expression vector
    • Strathdee CA, McLeod MR, and Hall JR (1999). Efficient control of tetracyclineresponsive gene expression from an autoregulated bi-directional expression vector. Gene 229(1-2), 21-29.
    • (1999) Gene , vol.229 , Issue.1-2 , pp. 21-29
    • Strathdee, C.A.1    McLeod, M.R.2    Hall, J.R.3
  • 27
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, and Riccardi C (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139(2), 271-279.
    • (1991) J Immunol Methods , vol.139 , Issue.2 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 28
    • 33747616250 scopus 로고    scopus 로고
    • Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
    • Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM, and Ellenrieder V (2006). Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 25(15), 3714-3724.
    • (2006) EMBO J , vol.25 , Issue.15 , pp. 3714-3724
    • Buchholz, M.1    Schatz, A.2    Wagner, M.3    Michl, P.4    Linhart, T.5    Adler, G.6    Gress, T.M.7    Ellenrieder, V.8
  • 29
    • 0029939701 scopus 로고    scopus 로고
    • Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development
    • Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, and Moon RT (1996). Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol 133(5), 1123-1137.
    • (1996) J Cell Biol , vol.133 , Issue.5 , pp. 1123-1137
    • Torres, M.A.1    Yang-Snyder, J.A.2    Purcell, S.M.3    DeMarais, A.A.4    McGrew, L.L.5    Moon, R.T.6
  • 31
    • 27144450534 scopus 로고    scopus 로고
    • Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis
    • Dejmek J, Dejmek A, Safholm A, Sjolander A, and Andersson T (2005). Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 65(20), 9142-9146.
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9142-9146
    • Dejmek, J.1    Dejmek, A.2    Safholm, A.3    Sjolander, A.4    Andersson, T.5
  • 34
    • 33751295132 scopus 로고    scopus 로고
    • Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion
    • Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, Yasui W, and Kikuchi A (2006). Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 66(21), 10439-10448.
    • (2006) Cancer Res , vol.66 , Issue.21 , pp. 10439-10448
    • Kurayoshi, M.1    Oue, N.2    Yamamoto, H.3    Kishida, M.4    Inoue, A.5    Asahara, T.6    Yasui, W.7    Kikuchi, A.8
  • 35
    • 79956116022 scopus 로고    scopus 로고
    • Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer
    • Peng C, Zhang X, Yu H, Wu D, and Zheng J (2011). Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer. Int J Gynecol Cancer 21(2), 280-288.
    • (2011) Int J Gynecol Cancer , vol.21 , Issue.2 , pp. 280-288
    • Peng, C.1    Zhang, X.2    Yu, H.3    Wu, D.4    Zheng, J.5
  • 37
    • 44449090010 scopus 로고    scopus 로고
    • Effects of Wnt proteins on cell proliferation and apoptosis in HEK293 cells
    • Jia L, Miao C, Cao Y, and Duan EK (2008). Effects of Wnt proteins on cell proliferation and apoptosis in HEK293 cells. Cell Biol Int 32(7), 807-813.
    • (2008) Cell Biol Int , vol.32 , Issue.7 , pp. 807-813
    • Jia, L.1    Miao, C.2    Cao, Y.3    Duan, E.K.4
  • 38
    • 29244446792 scopus 로고    scopus 로고
    • Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
    • Almeida M, Han L, Bellido T, Manolagas SC, and Kousteni S (2005). Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem 280(50), 41342-41351.
    • (2005) J Biol Chem , vol.280 , Issue.50 , pp. 41342-41351
    • Almeida, M.1    Han, L.2    Bellido, T.3    Manolagas, S.C.4    Kousteni, S.5
  • 39
    • 37549021795 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling promotes apoptosis in thymocyte development
    • Liang H, Coles AH, Zhu Z, Zayas J, Jurecic R, Kang J, and Jones SN (2007). Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med 204(13), 3077-3084.
    • (2007) J Exp Med , vol.204 , Issue.13 , pp. 3077-3084
    • Liang, H.1    Coles, A.H.2    Zhu, Z.3    Zayas, J.4    Jurecic, R.5    Kang, J.6    Jones, S.N.7
  • 41
  • 42
    • 57349133026 scopus 로고    scopus 로고
    • Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors
    • Robbs BK, Cruz AL, Werneck MB, Mognol GP, and Viola JP (2008). Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Mol Cell Biol 28(23), 7168-7181.
    • (2008) Mol Cell Biol , vol.28 , Issue.23 , pp. 7168-7181
    • Robbs, B.K.1    Cruz, A.L.2    Werneck, M.B.3    Mognol, G.P.4    Viola, J.P.5
  • 43
    • 0037118064 scopus 로고    scopus 로고
    • The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
    • Saneyoshi T, Kume S, Amasaki Y, and Mikoshiba K (2002). The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 417(6886), 295-299.
    • (2002) Nature , vol.417 , Issue.6886 , pp. 295-299
    • Saneyoshi, T.1    Kume, S.2    Amasaki, Y.3    Mikoshiba, K.4
  • 44
    • 77954978666 scopus 로고    scopus 로고
    • WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-κB pathways
    • Bradley EW and Drissi MH (2010). WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-κB pathways. Mol Endocrinol 24(8), 1581-1593.
    • (2010) Mol Endocrinol , vol.24 , Issue.8 , pp. 1581-1593
    • Bradley, E.W.1    Drissi, M.H.2
  • 46
    • 77951638135 scopus 로고    scopus 로고
    • Melatonin protects CD4+ T cells from activationinduced cell death by blocking NFAT-mediated CD95 ligand upregulation
    • Pedrosa AM, Weinlich R, Mognol GP, Robbs BK, Viola JP, Campa A, and Amarante-Mendes GP (2010). Melatonin protects CD4+ T cells from activationinduced cell death by blocking NFAT-mediated CD95 ligand upregulation. J Immunol 184(7), 3487-3494.
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3487-3494
    • Pedrosa, A.M.1    Weinlich, R.2    Mognol, G.P.3    Robbs, B.K.4    Viola, J.P.5    Campa, A.6    Amarante-Mendes, G.P.7
  • 47
    • 79551529783 scopus 로고    scopus 로고
    • TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: Role of NFAT
    • Alvarez S, Blanco A, Fresno M, and Munoz-Fernandez MA (2011). TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT. PLoS One 6(1), e16100.
    • (2011) PLoS One , vol.6 , Issue.1
    • Alvarez, S.1    Blanco, A.2    Fresno, M.3    Munoz-Fernandez, M.A.4
  • 48
    • 72849145265 scopus 로고    scopus 로고
    • Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons
    • Vashishta A, Habas A, Pruunsild P, Zheng JJ, Timmusk T, and Hetman M (2009). Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci 29(48), 15331-15340.
    • (2009) J Neurosci , vol.29 , Issue.48 , pp. 15331-15340
    • Vashishta, A.1    Habas, A.2    Pruunsild, P.3    Zheng, J.J.4    Timmusk, T.5    Hetman, M.6
  • 49
    • 78149370601 scopus 로고    scopus 로고
    • Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis
    • Lin H, Sue YM, Chou Y, Cheng CF, Chang CC, Li HF, Cehn CC, and Juan SH (2010). Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis. Br J Pharmacol 161(7), 1661-1676.
    • (2010) Br J Pharmacol , vol.161 , Issue.7 , pp. 1661-1676
    • Lin, H.1    Sue, Y.M.2    Chou, Y.3    Cheng, C.F.4    Chang, C.C.5    Li, H.F.6    Cehn, C.C.7    Juan, S.H.8


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