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Volumn 15, Issue 12, 2013, Pages 1391-1399

Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD31 ANTIGEN; COLLAGEN TYPE 1; EVEROLIMUS; IMATINIB; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; NILOTINIB; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; S6 KINASE;

EID: 84891607843     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.131668     Document Type: Article
Times cited : (32)

References (42)
  • 3
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL (2008). The tumor microenvironment and its role in promoting tumor growth. Oncogene 27, 5904-5912.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 4
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes-bipolar effects of the tumour stroma in cancer
    • Mueller MM and Fusenig NE (2004). Friends or foes-bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4, 839-849.
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 5
    • 78649642473 scopus 로고    scopus 로고
    • Cancer-stromal cell interaction and tumor angiogenesis in gastric cancer
    • Kitadai Y (2010). Cancer-stromal cell interaction and tumor angiogenesis in gastric cancer. Cancer Microenviron 3, 109-116.
    • (2010) Cancer Microenviron , vol.3 , pp. 109-116
    • Kitadai, Y.1
  • 7
    • 0026594044 scopus 로고
    • Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products
    • Antoniades HN, Galanopoulos T, Neville-Golden J, and O'Hara CJ (1992). Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc Natl Acad Sci USA 89, 3942-3946.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3942-3946
    • Antoniades, H.N.1    Galanopoulos, T.2    Neville-Golden, J.3    O'Hara, C.J.4
  • 8
    • 0027723524 scopus 로고
    • Stromal expression of platelet-derived growth factor beta-receptor and platelet-derived growth factor B-chain in colorectal cancer
    • Lindmark G, Sundberg C, Glimelius B, Påhlman L, Rubin K, and Gerdin B (1993). Stromal expression of platelet-derived growth factor beta-receptor and platelet-derived growth factor B-chain in colorectal cancer. Lab Invest 69, 682-689.
    • (1993) Lab Invest , vol.69 , pp. 682-689
    • Lindmark, G.1    Sundberg, C.2    Glimelius, B.3    Påhlman, L.4    Rubin, K.5    Gerdin, B.6
  • 9
    • 0027488086 scopus 로고
    • Tissue platelet derived-growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer
    • Seymour L, Dajee D, and Bezwoda WR (1993). Tissue platelet derived-growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer. Breast Cancer Res Treat 26, 247-252.
    • (1993) Breast Cancer Res Treat , vol.26 , pp. 247-252
    • Seymour, L.1    Dajee, D.2    Bezwoda, W.R.3
  • 10
    • 0036468926 scopus 로고    scopus 로고
    • Tumorderived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer
    • Yi B, Williams PJ, Niewolna M, Wang Y, and Yoneda T (2002). Tumorderived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res 62, 917-923.
    • (2002) Cancer Res , vol.62 , pp. 917-923
    • Yi, B.1    Williams, P.J.2    Niewolna, M.3    Wang, Y.4    Yoneda, T.5
  • 12
    • 77955950139 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma
    • Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W, and Chayama K (2010). Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma. Cancer Sci 101, 1984-1989.
    • (2010) Cancer Sci , vol.101 , pp. 1984-1989
    • Kodama, M.1    Kitadai, Y.2    Sumida, T.3    Ohnishi, M.4    Ohara, E.5    Tanaka, M.6    Shinagawa, K.7    Tanaka, S.8    Yasui, W.9    Chayama, K.10
  • 13
    • 2942670180 scopus 로고    scopus 로고
    • PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
    • Ostman A (2004). PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 15, 275-286.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 275-286
    • Ostman, A.1
  • 15
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, and Hanahan D (2003). Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111, 1287-1295.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 16
    • 3042714173 scopus 로고    scopus 로고
    • Increasing tumor uptake of anticancer drugs with imatinib
    • Pietras K (2004). Increasing tumor uptake of anticancer drugs with imatinib. Semin Oncol 31, 18-23.
    • (2004) Semin Oncol , vol.31 , pp. 18-23
    • Pietras, K.1
  • 17
    • 0033987746 scopus 로고    scopus 로고
    • Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
    • Druker BJ and Lydon NB (2000). Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 105, 3-7.
    • (2000) J Clin Invest , vol.105 , pp. 3-7
    • Druker, B.J.1    Lydon, N.B.2
  • 18
    • 3042711783 scopus 로고    scopus 로고
    • Role of KIT and platelet-derived growth factor receptors as oncoproteins
    • Fletcher JA (2004). Role of KIT and platelet-derived growth factor receptors as oncoproteins. Semin Oncol 31, 4-11.
    • (2004) Semin Oncol , vol.31 , pp. 4-11
    • Fletcher, J.A.1
  • 19
    • 55049111858 scopus 로고    scopus 로고
    • Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib
    • Day E, Waters B, Spiegel K, Alnadaf T, Manley PW, Buchdunger E, Walker C, and Jarai G (2008). Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib. Eur J Pharmacol 599, 44-53.
    • (2008) Eur J Pharmacol , vol.599 , pp. 44-53
    • Day, E.1    Waters, B.2    Spiegel, K.3    Alnadaf, T.4    Manley, P.W.5    Buchdunger, E.6    Walker, C.7    Jarai, G.8
  • 23
    • 77952975814 scopus 로고    scopus 로고
    • Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway
    • Wen YG, Wang Q, Zhou CZ, Qiu GQ, Peng ZH, and Tang HM (2010). Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. Oncol Rep 24, 89-95.
    • (2010) Oncol Rep , vol.24 , pp. 89-95
    • Wen, Y.G.1    Wang, Q.2    Zhou, C.Z.3    Qiu, G.Q.4    Peng, Z.H.5    Tang, H.M.6
  • 25
    • 77951908414 scopus 로고    scopus 로고
    • Prognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer
    • An JY, Kim KM, Choi MG, Noh JH, Sohn TS, Bae JM, and Kim S (2010). Prognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer. Int J Cancer 126, 2904-2913.
    • (2010) Int J Cancer , vol.126 , pp. 2904-2913
    • An, J.Y.1    Kim, K.M.2    Choi, M.G.3    Noh, J.H.4    Sohn, T.S.5    Bae, J.M.6    Kim, S.7
  • 27
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA and Sabatini DM (2007). Defining the role of mTOR in cancer. Cancer Cell 12, 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 29
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • Wan X, Mendoza A, Khanna C, and Helman LJ (2005). Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 65, 2406-2411.
    • (2005) Cancer Res , vol.65 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 30
    • 1042301958 scopus 로고    scopus 로고
    • Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma
    • Apte SM, Fan D, Killion JJ, and Fidler IJ (2004). Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma. Clin Cancer Res 10, 897-908.
    • (2004) Clin Cancer Res , vol.10 , pp. 897-908
    • Apte, S.M.1    Fan, D.2    Killion, J.J.3    Fidler, I.J.4
  • 31
    • 33846804532 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor imatinib [STI571] induces regression of xenografted canine mast cell tumors in SCID mice
    • Kobie K, Kawabata M, Hioki K, Tanaka A, Matsuda H, Mori T, and Maruo K (2007). The tyrosine kinase inhibitor imatinib [STI571] induces regression of xenografted canine mast cell tumors in SCID mice. Res Vet Sci 82, 239-241.
    • (2007) Res Vet Sci , vol.82 , pp. 239-241
    • Kobie, K.1    Kawabata, M.2    Hioki, K.3    Tanaka, A.4    Matsuda, H.5    Mori, T.6    Maruo, K.7
  • 32
    • 18544366598 scopus 로고    scopus 로고
    • PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia
    • Wolff NC, Veach DR, Tong WP, Bornmann WG, Clarkson B, and Ilaria RL Jr (2005). PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia. Blood 105, 3995-4003.
    • (2005) Blood , vol.105 , pp. 3995-4003
    • Wolff, N.C.1    Veach, D.R.2    Tong, W.P.3    Bornmann, W.G.4    Clarkson, B.5    Ilaria Jr., R.L.6
  • 33
    • 28544451083 scopus 로고    scopus 로고
    • Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model
    • Yokoi K, Sasaki T, Bucana CD, Fan D, Baker CH, Kitadai Y, Kuwai T, Abbruzzese JL, and Fidler IJ (2005). Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. Cancer Res 65, 10371-10380.
    • (2005) Cancer Res , vol.65 , pp. 10371-10380
    • Yokoi, K.1    Sasaki, T.2    Bucana, C.D.3    Fan, D.4    Baker, C.H.5    Kitadai, Y.6    Kuwai, T.7    Abbruzzese, J.L.8    Fidler, I.J.9
  • 36
    • 84885182576 scopus 로고    scopus 로고
    • RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine
    • Saunders PO, Weiss J, Welschinger R, Baraz R, Bradstock KF, and Bendall LJ (2013). RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine. Oncogene 32, 4789-4797.
    • (2013) Oncogene , vol.32 , pp. 4789-4797
    • Saunders, P.O.1    Weiss, J.2    Welschinger, R.3    Baraz, R.4    Bradstock, K.F.5    Bendall, L.J.6
  • 40
    • 34147121375 scopus 로고    scopus 로고
    • Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
    • Kobayashi S, Kishimoto T, Kamata S, Otsuka M, Miyazaki M, and Ishikura H (2007). Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci 98, 726-733.
    • (2007) Cancer Sci , vol.98 , pp. 726-733
    • Kobayashi, S.1    Kishimoto, T.2    Kamata, S.3    Otsuka, M.4    Miyazaki, M.5    Ishikura, H.6
  • 41
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, and Alitalo K (2002). Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94, 819-825.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3    Koshikawa, K.4    Yla-Herttuala, S.5    Takahashi, T.6    Alitalo, K.7
  • 42
    • 84862912936 scopus 로고    scopus 로고
    • Current development of the second generation of mTOR inhibitors as anticancer agents
    • Zhou HY and Huang SL (2012). Current development of the second generation of mTOR inhibitors as anticancer agents. Chin J Cancer 31, 8-18.
    • (2012) Chin J Cancer , vol.31 , pp. 8-18
    • Zhou, H.Y.1    Huang, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.