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Volumn 14, Issue 12, 2012, Pages 1249-1259

Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48Cre/+-LSL-KrasG12D/+mice

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDONATE 5 LIPOXYGENASE; BETA CATENIN; CASPASE 3; CYCLIN D1; CYCLOOXYGENASE 2; FATTY ACID; K RAS PROTEIN; MESSENGER RNA; OMEGA 3 FATTY ACID; PROTEIN BCL 2; PROTEIN P21; PROTEIN P48;

EID: 84871542969     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.121508     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 84863708472 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society, Atlanta, GA
    • American Cancer Society (2012). Cancer Facts and Figures (2012). American Cancer Society, Atlanta, GA.
    • (2012) Cancer Facts and Figures (2012)
  • 3
    • 84865305372 scopus 로고    scopus 로고
    • Early detection and prevention of pancreatic cancer: Use of genetically engineered mouse models and advanced imaging technologies
    • Mohammed A, Janakiram NB, Lightfoot S, Gali H, Vibhudutta A, and Rao CV (2012). Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologies. Current Med Chem 19(22), 3701-3713.
    • (2012) Current Med Chem , vol.19 , Issue.22 , pp. 3701-3713
    • Mohammed, A.1    Janakiram, N.B.2    Lightfoot, S.3    Gali, H.4    Vibhudutta, A.5    Rao, C.V.6
  • 4
    • 1842430550 scopus 로고    scopus 로고
    • Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases
    • Ren YX, Xu GM, Li ZS, and Song YG (2004). Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases. World J Gastroenterol 10, 881-884.
    • (2004) World J Gastroenterol , vol.10 , pp. 881-884
    • Ren, Y.X.1    Xu, G.M.2    Li, Z.S.3    Song, Y.G.4
  • 6
    • 84866123428 scopus 로고    scopus 로고
    • Genetically engineered mouse models of pancreatic cancer: Unravelling tumour biology and progressing translational oncology
    • Mazur PK and Siveke JT (2011). Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology. Gut 61, 1488-1500.
    • (2011) Gut , vol.61 , pp. 1488-1500
    • Mazur, P.K.1    Siveke, J.T.2
  • 9
    • 0031867690 scopus 로고    scopus 로고
    • Diet, nutrition, and prostate cancer
    • Clinton SK and Giovannucci E (1998). Diet, nutrition, and prostate cancer. Annu Rev Nutr 18, 413-440.
    • (1998) Annu Rev Nutr , vol.18 , pp. 413-440
    • Clinton, S.K.1    Giovannucci, E.2
  • 10
    • 0030715377 scopus 로고    scopus 로고
    • Fat and cancer. The epidemiologic evidence in perspective
    • Kolonel LN (1997). Fat and cancer. The epidemiologic evidence in perspective. Adv Exp Biol Med 422, 1-19.
    • (1997) Adv Exp Biol Med , vol.422 , pp. 1-19
    • Kolonel, L.N.1
  • 11
    • 0033957165 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and inflammatory mediator production
    • James MJ, Gibson RA, and Cleland LG (2000). Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71, 343S-348S.
    • (2000) Am J Clin Nutr , vol.71
    • James, M.J.1    Gibson, R.A.2    Cleland, L.G.3
  • 12
    • 0033637473 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids
    • Rose DP and Connolly JM (2000). Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutr Cancer 37, 119-127.
    • (2000) Nutr Cancer , vol.37 , pp. 119-127
    • Rose, D.P.1    Connolly, J.M.2
  • 13
    • 0036248820 scopus 로고    scopus 로고
    • Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells
    • Ge Y, Chen ZH, Kang ZB, Brown J, Laposata M, and Kang JX (2002). Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells. Anticancer Res 22, 537-543.
    • (2002) Anticancer Res , vol.22 , pp. 537-543
    • Ge, Y.1    Chen, Z.H.2    Kang, Z.B.3    Brown, J.4    Laposata, M.5    Kang, J.X.6
  • 15
    • 0344440984 scopus 로고    scopus 로고
    • Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study
    • Gago-Dominguez M, Yuan JM, Sun CL, Lee HP, and Yu MC (2003). Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: the Singapore Chinese Health Study. Br J Cancer 89, 1686-1692.
    • (2003) Br J Cancer , vol.89 , pp. 1686-1692
    • Gago-Dominguez, M.1    Yuan, J.M.2    Sun, C.L.3    Lee, H.P.4    Yu, M.C.5
  • 17
    • 17844408164 scopus 로고    scopus 로고
    • Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes
    • Xia S, Wang JD, and Kang JX (2005). Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes. Carcinogenesis 26, 779-784.
    • (2005) Carcinogenesis , vol.26 , pp. 779-784
    • Xia, S.1    Wang, J.D.2    Kang, J.X.3
  • 19
    • 33750284280 scopus 로고    scopus 로고
    • Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: Nutritional implications for chronic diseases
    • Simopoulos AP (2006). Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 60, 502-507.
    • (2006) Biomed Pharmacother , vol.60 , pp. 502-507
    • Simopoulos, A.P.1
  • 20
    • 3042767902 scopus 로고    scopus 로고
    • Dietary long-chain n-3 fatty acids for the prevention of cancer: A review of potential mechanisms
    • Larsson SC, Kumlin M, Ingelman-Sundberg M, and Wolk A (2004). Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 79, 935-945.
    • (2004) Am J Clin Nutr , vol.79 , pp. 935-945
    • Larsson, S.C.1    Kumlin, M.2    Ingelman-Sundberg, M.3    Wolk, A.4
  • 21
    • 15044339422 scopus 로고    scopus 로고
    • Cyclooxygenases, peroxide tone and the allure of fish oil
    • Smith WL (2005). Cyclooxygenases, peroxide tone and the allure of fish oil. Curr Opin Cell Biol 17, 174-182.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 174-182
    • Smith, W.L.1
  • 22
    • 33645894682 scopus 로고    scopus 로고
    • Prostate tumor growth and recurrence can be modulated by the omega-6:Omega-3 ratio in diet: Athymic mouse xenograft model simulating radical prostatectomy
    • Kelavkar UP, Hutzley J, Dhir R, Kim P, Allen KG, and McHugh K (2006). Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy. Neoplasia 8, 112-124.
    • (2006) Neoplasia , vol.8 , pp. 112-124
    • Kelavkar, U.P.1    Hutzley, J.2    Dhir, R.3    Kim, P.4    Allen, K.G.5    McHugh, K.6
  • 24
    • 55949119550 scopus 로고    scopus 로고
    • Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids
    • Swamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, and Rao CV (2008). Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. Nutr Cancer 60(1), 81-89.
    • (2008) Nutr Cancer , vol.60 , Issue.1 , pp. 81-89
    • Swamy, M.V.1    Citineni, B.2    Patlolla, J.M.3    Mohammed, A.4    Zhang, Y.5    Rao, C.V.6
  • 25
    • 0034221273 scopus 로고    scopus 로고
    • Human requirement for N-3 polyunsaturated fatty acids
    • Simopoulos AP (2000). Human requirement for N-3 polyunsaturated fatty acids. Poultry Sci 79, 961-970.
    • (2000) Poultry Sci , vol.79 , pp. 961-970
    • Simopoulos, A.P.1
  • 26
    • 33646129206 scopus 로고    scopus 로고
    • Influence of different dietary fat intake on liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters
    • Heukamp I, Gregor JI, Kilian M, Kiewert C, Jacobi CA, Schimke I, Walz MK, Guski H, and Wenger FA (2006). Influence of different dietary fat intake on liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters. Pancreatology 6, 96-102.
    • (2006) Pancreatology , vol.6 , pp. 96-102
    • Heukamp, I.1    Gregor, J.I.2    Kilian, M.3    Kiewert, C.4    Jacobi, C.A.5    Schimke, I.6    Walz, M.K.7    Guski, H.8    Wenger, F.A.9
  • 29
    • 67649739492 scopus 로고    scopus 로고
    • High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration
    • Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, and Anderson RE (2009). High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res 50, 807-819.
    • (2009) J Lipid Res , vol.50 , pp. 807-819
    • Tanito, M.1    Brush, R.S.2    Elliott, M.H.3    Wicker, L.D.4    Henry, K.R.5    Anderson, R.E.6
  • 30
    • 77956962034 scopus 로고    scopus 로고
    • High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice
    • Li F, Marchette LD, Brush RS, Elliott MH, Davis KR, Anderson AG, and Anderson RE (2010). High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. Mol Vis 16, 1669-1679.
    • (2010) Mol Vis , vol.16 , pp. 1669-1679
    • Li, F.1    Marchette, L.D.2    Brush, R.S.3    Elliott, M.H.4    Davis, K.R.5    Anderson, A.G.6    Anderson, R.E.7
  • 31
    • 79952235103 scopus 로고    scopus 로고
    • Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration
    • Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, and Anderson RE (2010). Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. Adv Exp Med Biol 664, 567-573.
    • (2010) Adv Exp Med Biol , vol.664 , pp. 567-573
    • Tanito, M.1    Brush, R.S.2    Elliott, M.H.3    Wicker, L.D.4    Henry, K.R.5    Anderson, R.E.6
  • 32
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, and Sloan-Stanley GH (1957). A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloan-Stanley, G.H.3
  • 34
    • 42449115396 scopus 로고    scopus 로고
    • Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: Alterations in docosahexaenoic acid content of phospholipid molecular species
    • Ford DA, Monda JK, Brush RS, Anderson RE, Richards MJ, and Fliesler SJ (2008). Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species. J Neurochem 105(3), 1032-1047.
    • (2008) J Neurochem , vol.105 , Issue.3 , pp. 1032-1047
    • Ford, D.A.1    Monda, J.K.2    Brush, R.S.3    Anderson, R.E.4    Richards, M.J.5    Fliesler, S.J.6
  • 36
    • 80555156793 scopus 로고    scopus 로고
    • Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer
    • Arshad A, Al-Leswas D, Stephenson J, Metcalfe M, and Dennison A (2011). Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. Br J Nutr 106, 795-800.
    • (2011) Br J Nutr , vol.106 , pp. 795-800
    • Arshad, A.1    Al-Leswas, D.2    Stephenson, J.3    Metcalfe, M.4    Dennison, A.5
  • 38
    • 0035729373 scopus 로고    scopus 로고
    • Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia
    • Barber MD, Fearon KC, Tisdale MJ, McMillan DC, and Ross JA (2011). Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. Nutr Cancer 40, 118-124.
    • (2011) Nutr Cancer , vol.40 , pp. 118-124
    • Barber, M.D.1    Fearon, K.C.2    Tisdale, M.J.3    McMillan, D.C.4    Ross, J.A.5
  • 39
    • 1942424855 scopus 로고    scopus 로고
    • Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids
    • Moses AW, Slater C, Preston T, Barber MD, and Fearson KC (2004). Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer 90, 996-1002.
    • (2004) Br J Cancer , vol.90 , pp. 996-1002
    • Moses, A.W.1    Slater, C.2    Preston, T.3    Barber, M.D.4    Fearson, K.C.5
  • 40
    • 34047146022 scopus 로고    scopus 로고
    • Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells
    • Horia E and Watkins BA (2007). Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. Carcinogenesis 28, 809-815.
    • (2007) Carcinogenesis , vol.28 , pp. 809-815
    • Horia, E.1    Watkins, B.A.2
  • 41
    • 55749110745 scopus 로고    scopus 로고
    • Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation
    • Lu Y, Nie D, Witt WT, Chen Q, Shen M, Xie H, Lai L, Dai Y, and Zhang J (2008). Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation. Mol Cancer Ther 7, 3203-3211.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3203-3211
    • Lu, Y.1    Nie, D.2    Witt, W.T.3    Chen, Q.4    Shen, M.5    Xie, H.6    Lai, L.7    Dai, Y.8    Zhang, J.9
  • 42
    • 0035866384 scopus 로고    scopus 로고
    • Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: Mediation through cyclooxygenase-independent pathways
    • Boudreau MD, Sohn KH, Rhee SH, Lee SW, Hunt JD, and Hwang DH (2001). Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. Cancer Res 61, 1386-1391.
    • (2001) Cancer Res , vol.61 , pp. 1386-1391
    • Boudreau, M.D.1    Sohn, K.H.2    Rhee, S.H.3    Lee, S.W.4    Hunt, J.D.5    Hwang, D.H.6
  • 43
    • 0032860560 scopus 로고    scopus 로고
    • Omega-3 fatty acids as cancer chemopreventive agents
    • Rose DP and Connolly JM (1999). Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83, 217-244.
    • (1999) Pharmacol Ther , vol.83 , pp. 217-244
    • Rose, D.P.1    Connolly, J.M.2
  • 44
    • 0024355308 scopus 로고
    • Effect of dietary omega-3 and omega-6 fatty acids on development of azaserineinduced preneoplastic lesions in rat pancreas
    • O'Connor T, Roebuck B, Peterson F, Lokesh B, Kinsella JE, and Campbell TC (1989). Effect of dietary omega-3 and omega-6 fatty acids on development of azaserineinduced preneoplastic lesions in rat pancreas. J Natl Cancer Inst 81, 858-863.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 858-863
    • O'Connor, T.1    Roebuck, B.2    Peterson, F.3    Lokesh, B.4    Kinsella, J.E.5    Campbell, T.C.6
  • 45
    • 69149087639 scopus 로고    scopus 로고
    • Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis
    • Park KS, Lim JW, and Kim H (2009). Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. Ann N Y Acad Sci 1171, 421-427.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 421-427
    • Park, K.S.1    Lim, J.W.2    Kim, H.3
  • 46
    • 32944455133 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: The Alaska Siberia project
    • Ebbesson SO, Risica PM, Ebbesson LO, Kennish JM, and Tejero ME (2005). Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: the Alaska Siberia project. Int J Circumpolar Health 64, 396-408.
    • (2005) Int J Circumpolar Health , vol.64 , pp. 396-408
    • Ebbesson, S.O.1    Risica, P.M.2    Ebbesson, L.O.3    Kennish, J.M.4    Tejero, M.E.5
  • 47
    • 33845545300 scopus 로고    scopus 로고
    • The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype
    • Browning LM, Krebs JD, Moore CS, Mishra GD, O'Connell MA, and Jebb SA (2007). The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes Obes Metab 9, 70-80.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 70-80
    • Browning, L.M.1    Krebs, J.D.2    Moore, C.S.3    Mishra, G.D.4    O'Connell, M.A.5    Jebb, S.A.6
  • 48
    • 0035025858 scopus 로고    scopus 로고
    • Tolerance and incorporation of a high-dose eicosapentaenoic acid diester emulsion by patients with pancreatic cancer cachexia
    • Barber M and Fearon K (2001). Tolerance and incorporation of a high-dose eicosapentaenoic acid diester emulsion by patients with pancreatic cancer cachexia. Lipids 36, 347-351.
    • (2001) Lipids , vol.36 , pp. 347-351
    • Barber, M.1    Fearon, K.2
  • 49
    • 70350555610 scopus 로고    scopus 로고
    • Role of lipoxins and resolvins as antiinflammatory and proresolving mediators in colon cancer
    • Janakiram NB and Rao CV (2009). Role of lipoxins and resolvins as antiinflammatory and proresolving mediators in colon cancer. Cur Mol Med 9(5), 565-579.
    • (2009) Cur Mol Med , vol.9 , Issue.5 , pp. 565-579
    • Janakiram, N.B.1    Rao, C.V.2
  • 50
    • 70949100689 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and COX-2
    • Lim K, Han C, Dai Y, Shen M, and Wu T (2009). Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and COX-2. Mol Cancer Ther 8(11), 3046-3055.
    • (2009) Mol Cancer Ther , vol.8 , Issue.11 , pp. 3046-3055
    • Lim, K.1    Han, C.2    Dai, Y.3    Shen, M.4    Wu, T.5


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