-
1
-
-
33646577163
-
Genetics and biology of pancreatic ductal adenocarcinoma
-
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, and DePinho RA (2006). Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 20, 1218-1249.
-
(2006)
Genes Dev
, vol.20
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
Bardeesy, N.4
DePinho, R.A.5
-
2
-
-
84055193971
-
Pancreatic ductal cells in development, regeneration, and neoplasia
-
Reichert M and Rustgi A (2011). Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest 121, 4572-4578.
-
(2011)
J Clin Invest
, vol.121
, pp. 4572-4578
-
-
Reichert, M.1
Rustgi, A.2
-
3
-
-
34447260549
-
Stromal biology of pancreatic cancer
-
Chu GC, Kimmelman AC, Hezel AF, and DePinho RA (2007). Stromal biology of pancreatic cancer. J Cell Biochem 101, 887-907.
-
(2007)
J Cell Biochem
, vol.101
, pp. 887-907
-
-
Chu, G.C.1
Kimmelman, A.C.2
Hezel, A.F.3
DePinho, R.A.4
-
4
-
-
28844507883
-
Mutant KRAS in the initiation of pancreatic cancer
-
Deramaudt T and Rustgi AK (2005). Mutant KRAS in the initiation of pancreatic cancer. Biochim Biophys Acta 1756, 97-101.
-
(2005)
Biochim Biophys Acta
, vol.1756
, pp. 97-101
-
-
Deramaudt, T.1
Rustgi, A.K.2
-
5
-
-
9144241047
-
Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
-
Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, et al. (2003). Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 63, 8614-8622.
-
(2003)
Cancer Res
, vol.63
, pp. 8614-8622
-
-
Iacobuzio-Donahue, C.A.1
Ashfaq, R.2
Maitra, A.3
Adsay, N.V.4
Shen-ong, G.L.5
Berg, K.6
Hollingsworth, M.A.7
Cameron, J.L.8
Yeo, C.J.9
Kern, S.E.10
-
6
-
-
77949568748
-
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
-
Drosten M, Dhawahir A, Sum EYM, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, and Barbacid M (2010). Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J 29, 1091-1104.
-
(2010)
EMBO J
, vol.29
, pp. 1091-1104
-
-
Drosten, M.1
Dhawahir, A.2
Sum, E.Y.M.3
Urosevic, J.4
Lechuga, C.G.5
Esteban, L.M.6
Castellano, E.7
Guerra, C.8
Santos, E.9
Barbacid, M.10
-
7
-
-
84857223882
-
Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1
-
Botta GP, Reginato MJ, Reichert M, Rustgi AK, and Lelkes PI (2012). Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1. Mol Cancer Res 10, 183-196.
-
(2012)
Mol Cancer Res
, vol.10
, pp. 183-196
-
-
Botta, G.P.1
Reginato, M.J.2
Reichert, M.3
Rustgi, A.K.4
Lelkes, P.I.5
-
8
-
-
0037192635
-
Complex roles of tissue inhibitors of metalloproteinases in cancer
-
Jiang Y, Goldberg ID, and Shi YE (2002). Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene 21, 2245-2252.
-
(2002)
Oncogene
, vol.21
, pp. 2245-2252
-
-
Jiang, Y.1
Goldberg, I.D.2
Shi, Y.E.3
-
9
-
-
0030801093
-
Imbalance ofexpression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
-
Bramhall SR, Neoptolemos JP, Stamp GW, and Lemoine NR (1997). Imbalance ofexpression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. J Pathol 182, 347-355.
-
(1997)
J Pathol
, vol.182
, pp. 347-355
-
-
Bramhall, S.R.1
Neoptolemos, J.P.2
Stamp, G.W.3
Lemoine, N.R.4
-
10
-
-
0036350763
-
MMP-2 and TIMP-1 are derived from, not in response to, pancreatic cancer
-
Bloomston M, Shafii A, Zervos EE, Rojiani A, and Rosemurgy AS (2002). MMP-2 and TIMP-1 are derived from, not in response to, pancreatic cancer. J Surg Res 102, 35-38.
-
(2002)
J Surg Res
, vol.102
, pp. 35-38
-
-
Bloomston, M.1
Shafii, A.2
Zervos, E.E.3
Rojiani, A.4
Rosemurgy, A.S.5
-
11
-
-
77956301181
-
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
-
Bourboulia D and Stetler-Stevenson WG (2010). Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 20, 161-168.
-
(2010)
Semin Cancer Biol
, vol.20
, pp. 161-168
-
-
Bourboulia, D.1
Stetler-Stevenson, W.G.2
-
12
-
-
0034693233
-
The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1
-
Dean G, Young DA, Edwards DR, and Clark IM (2000). The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1. J Biol Chem 275, 32664-32671.
-
(2000)
J Biol Chem
, vol.275
, pp. 32664-32671
-
-
Dean, G.1
Young, D.A.2
Edwards, D.R.3
Clark, I.M.4
-
13
-
-
0033566049
-
Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development
-
Fata JE, Leco KJ, Moorehead RA, Martin DC, and Khokha R (1999). Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Dev Biol 211, 238-254.
-
(1999)
Dev Biol
, vol.211
, pp. 238-254
-
-
Fata, J.E.1
Leco, K.J.2
Moorehead, R.A.3
Martin, D.C.4
Khokha, R.5
-
14
-
-
0038532305
-
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1
-
Hall M-C, Young DA, Waters JG, Rowan AD, Chantry A, Edwards DR, and Clark IM (2003). The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1. J Biol Chem 278, 10304-10313.
-
(2003)
J Biol Chem
, vol.278
, pp. 10304-10313
-
-
Hall, M.-C.1
Young, D.A.2
Waters, J.G.3
Rowan, A.D.4
Chantry, A.5
Edwards, D.R.6
Clark, I.M.7
-
15
-
-
0029979467
-
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease
-
Bramhall SR, Stamp GW, Dunn J, Lemoine NR, and Neoptolemos JP (1996). Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. Br J Cancer 73, 972-978.
-
(1996)
Br J Cancer
, vol.73
, pp. 972-978
-
-
Bramhall, S.R.1
Stamp, G.W.2
Dunn, J.3
Lemoine, N.R.4
Neoptolemos, J.P.5
-
16
-
-
0036065691
-
Enhanced mRNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in breast carcinomas is correlated with adverse prognosis
-
Nakopoulou L, Giannopoulou I, Stefanaki K, Panayotopoulou E, Tsirmpa I, Alexandrou P, Mavrommatis J, Katsarou S, and Davaris P (2002). Enhanced mRNA expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in breast carcinomas is correlated with adverse prognosis. J Pathol 197, 307-313.
-
(2002)
J Pathol
, vol.197
, pp. 307-313
-
-
Nakopoulou, L.1
Giannopoulou, I.2
Stefanaki, K.3
Panayotopoulou, E.4
Tsirmpa, I.5
Alexandrou, P.6
Mavrommatis, J.7
Katsarou, S.8
Davaris, P.9
-
17
-
-
0036350926
-
TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis
-
Bloomston M, Shafii A, Zervos EE, and Rosemurgy AS (2002). TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis. J Surg Res 102, 39-44.
-
(2002)
J Surg Res
, vol.102
, pp. 39-44
-
-
Bloomston, M.1
Shafii, A.2
Zervos, E.E.3
Rosemurgy, A.S.4
-
18
-
-
69049097423
-
TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro
-
Bigelow RLH, Williams BJ, Carroll JL, Daves LK, and Cardelli JA (2009). TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro. Breast Cancer Res Treat 117, 31-44.
-
(2009)
Breast Cancer Res Treat
, vol.117
, pp. 31-44
-
-
Bigelow, R.L.H.1
Williams, B.J.2
Carroll, J.L.3
Daves, L.K.4
Cardelli, J.A.5
-
19
-
-
79959266553
-
TIMP-1 deficiency subverts cellcycle dynamics in murine long-term HSCs
-
Rossi L, Ergen AV, and Goodell MA (2011). TIMP-1 deficiency subverts cellcycle dynamics in murine long-term HSCs. Blood 117, 6479-6488.
-
(2011)
Blood
, vol.117
, pp. 6479-6488
-
-
Rossi, L.1
Ergen, A.V.2
Goodell, M.A.3
-
20
-
-
0026568011
-
Growthpromoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum
-
Hayakawa T, Yamashita K, Tanzawa K, Uchijima E, and Iwata K (1992). Growthpromoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum. FEBS Lett 298, 29-32.
-
(1992)
FEBS Lett
, vol.298
, pp. 29-32
-
-
Hayakawa, T.1
Yamashita, K.2
Tanzawa, K.3
Uchijima, E.4
Iwata, K.5
-
21
-
-
0033551186
-
Tissue inhibitor of metalloproteinases-1 (TIMP-1) binds to the cell surface and translocates to the nucleus of human MCF-7 breast carcinoma cells
-
Ritter LM, Garfield SH, and Thorgeirsson UP (1999). Tissue inhibitor of metalloproteinases-1 (TIMP-1) binds to the cell surface and translocates to the nucleus of human MCF-7 breast carcinoma cells. Biochem Biophys Res Commun 257, 494-499.
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 494-499
-
-
Ritter, L.M.1
Garfield, S.H.2
Thorgeirsson, U.P.3
-
22
-
-
33750218032
-
TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis
-
Davidsen ML, Würtz S, Rømer MU, Sørensen NM, Johansen SK, Christensen IJ, Larsen JK, Offenberg H, Brünner N, and Lademann U (2006). TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis. Br J Cancer 95, 1114-1120.
-
(2006)
Br J Cancer
, vol.95
, pp. 1114-1120
-
-
Davidsen, M.L.1
Würtz, S.2
Rømer, M.U.3
Sørensen, N.M.4
Johansen, S.K.5
Christensen, I.J.6
Larsen, J.K.7
Offenberg, H.8
Brünner, N.9
Lademann, U.10
-
23
-
-
33947199328
-
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling
-
Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, and Der CJ (2007). K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res 67, 2098-2106.
-
(2007)
Cancer Res
, vol.67
, pp. 2098-2106
-
-
Campbell, P.M.1
Groehler, A.L.2
Lee, K.M.3
Ouellette, M.M.4
Khazak, V.5
Der, C.J.6
-
24
-
-
3242697219
-
Successful growth and characterization of mouse pancreatic ductal cells: Functional properties of the Ki-RAS(G12V) oncogene
-
Schreiber FS, Deramaudt TB, Brunner TB, Boretti MI, Gooch KJ, Stoffers DA, Bernhard EJ, and Rustgi AK (2004). Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene. Gastroenterology 127, 250-260.
-
(2004)
Gastroenterology
, vol.127
, pp. 250-260
-
-
Schreiber, F.S.1
Deramaudt, T.B.2
Brunner, T.B.3
Boretti, M.I.4
Gooch, K.J.5
Stoffers, D.A.6
Bernhard, E.J.7
Rustgi, A.K.8
-
25
-
-
84873488509
-
The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis
-
Reichert M, Takano S, Von Burstin J, Kim S-B, Lee J-S, Ihida-Stansbury K, Hahn C, Heeg S, Schneider G, Rhim AD, et al. (2013). The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev 27, 288-300.
-
(2013)
Genes Dev
, vol.27
, pp. 288-300
-
-
Reichert, M.1
Takano, S.2
Von Burstin, J.3
Kim, S.-B.4
Lee, J.-S.5
Ihida-Stansbury, K.6
Hahn, C.7
Heeg, S.8
Schneider, G.9
Rhim, A.D.10
-
26
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
Gu G, Dubauskaite J, and Melton DA (2002). Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457.
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
27
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, and Tuveson DA (2001). Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15, 3243-3248.
-
(2001)
Genes Dev
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
28
-
-
33750826362
-
Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure
-
Chen F, Hancock C, Macias A, Joh J, Still K, Zhong S, Mackerell AD, and Shapiro P (2007). Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. J Biol Chem16, 6281-6287.
-
(2007)
J Biol Chem
, vol.16
, pp. 6281-6287
-
-
Chen, F.1
Hancock, C.2
Macias, A.3
Joh, J.4
Still, K.5
Zhong, S.6
Mackerell, A.D.7
Shapiro, P.8
-
29
-
-
46349104324
-
Mouse to human search for plasma proteome changes associated with pancreatic tumor development
-
Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, et al. (2008). Mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med 5, e123.
-
(2008)
PLoS Med
, vol.5
-
-
Faca, V.M.1
Song, K.S.2
Wang, H.3
Zhang, Q.4
Krasnoselsky, A.L.5
Newcomb, L.F.6
Plentz, R.R.7
Gurumurthy, S.8
Redston, M.S.9
Pitteri, S.J.10
-
30
-
-
34248141223
-
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
-
Mahadevan D and Von Hoff DD (2007). Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6, 1186-1197.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1186-1197
-
-
Mahadevan, D.1
Von Hoff, D.D.2
-
31
-
-
0026496059
-
Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription
-
Edwards DR, Rocheleau H, Sharma RR, Wills AJ, Cowie A, Hassell JA, and Heath JK (1992). Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription. Biochim Biophys Acta 1171, 41-55.
-
(1992)
Biochim Biophys Acta
, vol.1171
, pp. 41-55
-
-
Edwards, D.R.1
Rocheleau, H.2
Sharma, R.R.3
Wills, A.J.4
Cowie, A.5
Hassell, J.A.6
Heath, J.K.7
-
32
-
-
1342301549
-
Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase
-
Porter JF, Shen S, and DenhardtDT(2004). Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase. Br J Cancer 90, 463-470.
-
(2004)
Br J Cancer
, vol.90
, pp. 463-470
-
-
Porter, J.F.1
Shen, S.2
Denhardt, D.T.3
-
33
-
-
33845293447
-
Pubertal mammary gland development: Insights frommouse models
-
Howlin J, McBryan J, and Martin F (2006). Pubertal mammary gland development: insights frommouse models. J Mammary Gland Biol Neoplasia 11, 283-297.
-
(2006)
J Mammary Gland Biol Neoplasia
, vol.11
, pp. 283-297
-
-
Howlin, J.1
McBryan, J.2
Martin, F.3
-
34
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, et al. (2012). EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361.
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
Mirek, E.T.2
Aiello, N.M.3
Maitra, A.4
Bailey, J.M.5
McAllister, F.6
Reichert, M.7
Beatty, G.L.8
Rustgi, A.K.9
Vonderheide, R.H.10
-
35
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, and DePinho RA (2003). Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17, 3112-3126.
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
Lopez, L.4
Tuveson, D.A.5
Horner, J.6
Redston, M.S.7
DePinho, R.A.8
-
36
-
-
45449107756
-
Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells
-
Shama J, Garcia-Medina R, Pouysségur J, and Vial E (2008). Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells. Biochem Biophys Res Commun 372, 845-849.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 845-849
-
-
Shama, J.1
Garcia-Medina, R.2
Pouysségur, J.3
Vial, E.4
-
37
-
-
37549016809
-
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels
-
Lefloch R, Pouysségur J, and Lenormand P (2008). Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol 28, 511-527.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 511-527
-
-
Lefloch, R.1
Pouysségur, J.2
Lenormand, P.3
-
38
-
-
33845904217
-
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
-
Vantaggiato C, Formentini I, Bondanza A, Naldini L, Brambilla R, and Bonini C (2006). ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J Biol 5, 14.
-
(2006)
J Biol
, vol.5
, pp. 14
-
-
Vantaggiato, C.1
Formentini, I.2
Bondanza, A.3
Naldini, L.4
Brambilla, R.5
Bonini, C.6
-
39
-
-
77950353276
-
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events
-
Shin S, Dimitri CA, Yoon S-O, Dowdle W, and Blenis J (2010). ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell 38, 114-127.
-
(2010)
Mol Cell
, vol.38
, pp. 114-127
-
-
Shin, S.1
Dimitri, C.A.2
Yoon, S.-O.3
Dowdle, W.4
Blenis, J.5
-
40
-
-
34249005535
-
Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro
-
Botta GP, Manley P, Miller S, and Lelkes PI (2006). Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro. Nat Protoc 1, 2116-2127.
-
(2006)
Nat Protoc
, vol.1
, pp. 2116-2127
-
-
Botta, G.P.1
Manley, P.2
Miller, S.3
Lelkes, P.I.4
-
41
-
-
0141993985
-
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway
-
Liu X-W, Bernardo MM, Fridman R, and Kim H-RC (2003). Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway. J Biol Chem 278, 40364-40372.
-
(2003)
J Biol Chem
, vol.278
, pp. 40364-40372
-
-
Liu, X.-W.1
Bernardo, M.M.2
Fridman, R.3
Kim, H.-R.C.4
-
42
-
-
0034621967
-
Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: Implications for cell proliferation and cell migration
-
Giehl K, Skripczynski B, Mansard A, Menke A, and Gierschik P (2000). Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene 19, 2930-2942.
-
(2000)
Oncogene
, vol.19
, pp. 2930-2942
-
-
Giehl, K.1
Skripczynski, B.2
Mansard, A.3
Menke, A.4
Gierschik, P.5
-
43
-
-
38949172004
-
MEK1 and MEK2regulate distinct functions by sorting ERK2 to different intracellular compartments
-
Skarpen E, Flinder LI, Rosseland CM, Orstavik S, Wierød L, Oksvold MP, Skålhegg BS, and HuitfeldtHS (2008). MEK1 and MEK2regulate distinct functions by sorting ERK2 to different intracellular compartments. FASEB J 22, 466-476.
-
(2008)
FASEB J
, vol.22
, pp. 466-476
-
-
Skarpen, E.1
Flinder, L.I.2
Rosseland, C.M.3
Orstavik, S.4
Wierød, L.5
Oksvold, M.P.6
Skålhegg, B.S.7
Huitfeldt, H.S.8
-
44
-
-
79954629785
-
Distinct patterns of activationdependent changes in conformational mobility between ERK1 and ERK2
-
Ring AY, Sours KM, Lee T, and Ahn NG (2012). Distinct patterns of activationdependent changes in conformational mobility between ERK1 and ERK2. Int J Mass Spectrom 302, 101-109.
-
(2012)
Int J Mass Spectrom
, vol.302
, pp. 101-109
-
-
Ring, A.Y.1
Sours, K.M.2
Lee, T.3
Ahn, N.G.4
-
45
-
-
35948975117
-
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation
-
Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, et al. (2007). The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev 21, 2788-2803.
-
(2007)
Genes Dev
, vol.21
, pp. 2788-2803
-
-
Okawa, T.1
Michaylira, C.Z.2
Kalabis, J.3
Stairs, D.B.4
Nakagawa, H.5
Andl, C.D.6
Johnstone, C.N.7
Klein-Szanto, A.J.8
El-Deiry, W.S.9
Cukierman, E.10
-
46
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos PI, Zhang C, Bollag G, Shokat KM, and Rosen N (2010). RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464, 427-430.
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
47
-
-
79955876081
-
Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling
-
Pan S, Chen R, Crispin DA, May D, Stevens T, Mcintosh M, Bronner MP, Ziogas A, Anton-Culver H, and Brentnall TA (2011). Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling. J Proteome Res 10, 2359-2376.
-
(2011)
J Proteome Res
, vol.10
, pp. 2359-2376
-
-
Pan, S.1
Chen, R.2
Crispin, D.A.3
May, D.4
Stevens, T.5
McIntosh, M.6
Bronner, M.P.7
Ziogas, A.8
Anton-Culver, H.9
Brentnall, T.A.10
-
48
-
-
79951833553
-
Serum biomarker panels for the detection of pancreatic cancer
-
Brand RE, Nolen BM, Zeh HJ, Allen PJ, Eloubeidi MA, Goldberg M, Elton E, Arnoletti JP, Christein JD, Vickers SM, et al. (2011). Serum biomarker panels for the detection of pancreatic cancer. Clin Cancer Res 17, 805-816.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 805-816
-
-
Brand, R.E.1
Nolen, B.M.2
Zeh, H.J.3
Allen, P.J.4
Eloubeidi, M.A.5
Goldberg, M.6
Elton, E.7
Arnoletti, J.P.8
Christein, J.D.9
Vickers, S.M.10
-
49
-
-
2442691552
-
Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras
-
Chakrabarti O, Veeraraghavalu K, Tergaonkar V, Liu Y, Androphy EJ, Stanley MA, and Krishna S (2004). Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic Ras. J Virol 78, 5934-5945.
-
(2004)
J Virol
, vol.78
, pp. 5934-5945
-
-
Chakrabarti, O.1
Veeraraghavalu, K.2
Tergaonkar, V.3
Liu, Y.4
Androphy, E.J.5
Stanley, M.A.6
Krishna, S.7
-
50
-
-
16244389638
-
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration
-
Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, and Khokha R (2005). Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology 41, 857-867.
-
(2005)
Hepatology
, vol.41
, pp. 857-867
-
-
Mohammed, F.F.1
Pennington, C.J.2
Kassiri, Z.3
Rubin, J.S.4
Soloway, P.D.5
Ruther, U.6
Edwards, D.R.7
Khokha, R.8
-
51
-
-
68949142980
-
Clinical significance of the measurements of serum matrix metalloproteinase-9 and its inhibitor (tissue inhibitor of metalloproteinase-1) in patients with pancreatic cancer: Metalloproteinase-9 as an independent prognostic factor
-
Mroczko B, Lukaszewicz-Zajac M, Wereszczynska-Siemiatkowska U, Groblewska M, Gryko M, Kedra B, Jurkowska G, and Szmitkowski M (2009). Clinical significance of the measurements of serum matrix metalloproteinase-9 and its inhibitor (tissue inhibitor of metalloproteinase-1) in patients with pancreatic cancer: metalloproteinase-9 as an independent prognostic factor. Pancreas 38, 613-618.
-
(2009)
Pancreas
, vol.38
, pp. 613-618
-
-
Mroczko, B.1
Lukaszewicz-Zajac, M.2
Wereszczynska-Siemiatkowska, U.3
Groblewska, M.4
Gryko, M.5
Kedra, B.6
Jurkowska, G.7
Szmitkowski, M.8
-
52
-
-
79955968629
-
Mechanistic rationale for inhibition of poly(ADPribose) polymerase in ETS gene fusion-positive prostate cancer
-
Brenner JC, Ateeq B, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Wang X, Liang H, Yu J, et al. (2011). Mechanistic rationale for inhibition of poly(ADPribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell 19, 664-678.
-
(2011)
Cancer Cell
, vol.19
, pp. 664-678
-
-
Brenner, J.C.1
Ateeq, B.2
Li, Y.3
Yocum, A.K.4
Cao, Q.5
Asangani, I.A.6
Patel, S.7
Wang, X.8
Liang, H.9
Yu, J.10
-
53
-
-
78650437352
-
Regulation of matrix metalloproteinase activity in health and disease
-
Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L, and Winberg J-O (2011). Regulation of matrix metalloproteinase activity in health and disease. FEBS J 278, 28-45.
-
(2011)
FEBS J
, vol.278
, pp. 28-45
-
-
Hadler-Olsen, E.1
Fadnes, B.2
Sylte, I.3
Uhlin-Hansen, L.4
Winberg, J.-O.5
-
54
-
-
0036512208
-
New functions for the matrix metalloproteinases in cancer progression
-
EgebladMand Werb Z (2002). New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2, 161-174.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 161-174
-
-
Egeblad, M.1
Werb, Z.2
-
55
-
-
33748371637
-
Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein
-
Jung K-K, Liu X-W, Chirco R, Fridman R, and Kim H-RC (2006). Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J 25, 3934-3942.
-
(2006)
EMBO J
, vol.25
, pp. 3934-3942
-
-
Jung, K.-K.1
Liu, X.-W.2
Chirco, R.3
Fridman, R.4
Kim, H.-R.C.5
-
56
-
-
42649138943
-
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
-
Pasca di Magliano M, Biankin AV, Heiser PW, Cano DA, Gutierrez PJA, Deramaudt T, Segara D, Dawson AC, Kench JG, Henshall SM, et al. (2007). Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PloS One 2, e1155.
-
(2007)
PloS One
, vol.2
-
-
di Pasca Magliano, M.1
Biankin, A.V.2
Heiser, P.W.3
Cano, D.A.4
Gutierrez, P.J.A.5
Deramaudt, T.6
Segara, D.7
Dawson, A.C.8
Kench, J.G.9
Henshall, S.M.10
-
57
-
-
53049110158
-
Stabilization of β-catenin induces pancreas tumor formation
-
Heiser P, Cano D, Landsman L, and Kim G (2008). Stabilization of β-catenin induces pancreas tumor formation. Gastroenterology 135, 1288-1300.
-
(2008)
Gastroenterology
, vol.135
, pp. 1288-1300
-
-
Heiser, P.1
Cano, D.2
Landsman, L.3
Kim, G.4
-
58
-
-
0035183055
-
Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo
-
Rigg AS and Lemoine NR (2001). Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo. Cancer Gene Ther 8, 869-878.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 869-878
-
-
Rigg, A.S.1
Lemoine, N.R.2
|