메뉴 건너뛰기




Volumn 6, Issue 1, 2014, Pages 1-27

The molecular crosstalk between the MET receptor tyrosine kinase and the DNA damage response-biological and clinical aspects

Author keywords

DNA damage response; Ionizing radiation; MET; Radioresistance; Radiotherapy

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; ORANTINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SEMAXANIB; SOMATOMEDIN C RECEPTOR; VASCULOTROPIN RECEPTOR;

EID: 84891319812     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6010001     Document Type: Review
Times cited : (29)

References (157)
  • 4
    • 0242331653 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
    • Zhang, Y.W.; Su, Y.; Volpert, O.V.; vande Woude, G.F. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc. Natl. Acad. Sci. USA 2003, 100, 12718-12723.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12718-12723
    • Zhang, Y.W.1    Su, Y.2    Volpert, O.V.3    vande Woude, G.F.4
  • 7
    • 0035067626 scopus 로고    scopus 로고
    • c-MET expression in myofibroblasts: Role in autocrine activation and prognostic significance in lung adenocarcinoma
    • Tokunou, M.; Niki, T.; Eguchi, K.; Iba, S.; Tsuda, H.; Yamada, T.; Matsuno, Y.; Kondo, H.; Saitoh, Y.; Imamura, H.; et al. c-MET expression in myofibroblasts: Role in autocrine activation and prognostic significance in lung adenocarcinoma. Am. J. Pathol. 2001, 158, 1451-1463.
    • (2001) Am. J. Pathol. , vol.158 , pp. 1451-1463
    • Tokunou, M.1    Niki, T.2    Eguchi, K.3    Iba, S.4    Tsuda, H.5    Yamada, T.6    Matsuno, Y.7    Kondo, H.8    Saitoh, Y.9    Imamura, H.10
  • 8
    • 0033731007 scopus 로고    scopus 로고
    • Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma
    • Ramirez, R.; Hsu, D.; Patel, A.; Fenton, C.; Dinauer, C.; Tuttle, R.M.; Francis, G.L. Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clin. Endocrinol. (Oxf.) 2000, 53, 635-644.
    • (2000) Clin. Endocrinol. (Oxf.) , vol.53 , pp. 635-644
    • Ramirez, R.1    Hsu, D.2    Patel, A.3    Fenton, C.4    Dinauer, C.5    Tuttle, R.M.6    Francis, G.L.7
  • 10
    • 0028941747 scopus 로고
    • Expression of the MET/hepatocyte growth factor receptor in human pancreatic cancer
    • Di Renzo, M.F.; Poulsom, R.; Olivero, M.; Comoglio, P.M.; Lemoine, N.R. Expression of the MET/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res. 1995, 55, 1129-1138.
    • (1995) Cancer Res. , vol.55 , pp. 1129-1138
    • Di Renzo, M.F.1    Poulsom, R.2    Olivero, M.3    Comoglio, P.M.4    Lemoine, N.R.5
  • 11
    • 0026595807 scopus 로고
    • Overexpression of c-MET proto-oncogene but not epidermal growth factor receptor or c-ERBB-2 in primary human colorectal carcinomas
    • Liu, C.; Park, M.; Tsao, M.S. Overexpression of c-MET proto-oncogene but not epidermal growth factor receptor or c-ERBB-2 in primary human colorectal carcinomas. Oncogene 1992, 7, 181-185.
    • (1992) Oncogene , vol.7 , pp. 181-185
    • Liu, C.1    Park, M.2    Tsao, M.S.3
  • 20
    • 38549115197 scopus 로고    scopus 로고
    • The MET tyrosine kinase receptor in development and cancer
    • Gentile, A.; Trusolino, L.; Comoglio, P.M. The MET tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev. 2008, 27, 85-94.
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 85-94
    • Gentile, A.1    Trusolino, L.2    Comoglio, P.M.3
  • 23
    • 0028276786 scopus 로고
    • Invasiveness and metastasis of NIH 3T3 cells induced by MET-hepatocyte growth factor/scatter factor autocrine stimulation
    • Rong, S.; Segal, S.; Anver, M.; Resau, J.H.; vande Woude, G.F. Invasiveness and metastasis of NIH 3T3 cells induced by MET-hepatocyte growth factor/scatter factor autocrine stimulation. Proc. Natl. Acad. Sci. USA 1994, 91, 4731-4735.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4731-4735
    • Rong, S.1    Segal, S.2    Anver, M.3    Resau, J.H.4    vande Woude, G.F.5
  • 25
    • 34249984736 scopus 로고    scopus 로고
    • HER3 and mutant EGFR meet MET
    • Arteaga, C.L. HER3 and mutant EGFR meet MET. Nat. Med. 2007, 13, 675-677.
    • (2007) Nat. Med. , vol.13 , pp. 675-677
    • Arteaga, C.L.1
  • 26
    • 84879636711 scopus 로고    scopus 로고
    • Strategies for optimizing the response of cancer and normal tissues to radiation
    • Moding, E.J.; Kastan, M.B.; Kirsch, D.G. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat. Rev. Drug Discov. 2013, 12, 526-542.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 526-542
    • Moding, E.J.1    Kastan, M.B.2    Kirsch, D.G.3
  • 27
    • 34547548651 scopus 로고    scopus 로고
    • New technologies for the radiotherapy of prostate cancer. A discussion of clinical treatment programs
    • Meyer, J.L.; Leibel, S.; Roach, M.; Vijayakumar, S. New technologies for the radiotherapy of prostate cancer. A discussion of clinical treatment programs. Front. Radiat. Ther. Oncol. 2007, 40, 315-337.
    • (2007) Front. Radiat. Ther. Oncol. , vol.40 , pp. 315-337
    • Meyer, J.L.1    Leibel, S.2    Roach, M.3    Vijayakumar, S.4
  • 28
    • 84870218588 scopus 로고    scopus 로고
    • DNA repair dysregulation from cancer driver to therapeutic target
    • Curtin, N.J. DNA repair dysregulation from cancer driver to therapeutic target. Nat. Rev. Cancer 2012, 12, 801-817.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 801-817
    • Curtin, N.J.1
  • 29
    • 33749050567 scopus 로고    scopus 로고
    • Keynote comment: Radiotherapy in the age of molecular oncology
    • Baumann, M. Keynote comment: Radiotherapy in the age of molecular oncology. Lancet Oncol. 2006, 7, 786-787.
    • (2006) Lancet Oncol. , vol.7 , pp. 786-787
    • Baumann, M.1
  • 30
    • 84866307717 scopus 로고    scopus 로고
    • Age and comorbidity considerations related to radiotherapy and chemotherapy administration
    • Rodrigues, G.; Sanatani, M. Age and comorbidity considerations related to radiotherapy and chemotherapy administration. Semin. Radiat. Oncol. 2012, 22, 277-283.
    • (2012) Semin. Radiat. Oncol. , vol.22 , pp. 277-283
    • Rodrigues, G.1    Sanatani, M.2
  • 31
    • 84891323358 scopus 로고    scopus 로고
    • Radio-chemotherapy for bladder cancer: Contribution of chemotherapy on local control
    • Plataniotis, G.A.; Dale, R.G. Radio-chemotherapy for bladder cancer: Contribution of chemotherapy on local control. World J. Radiol. 2013, 5, 267-274.
    • (2013) World J. Radiol. , vol.5 , pp. 267-274
    • Plataniotis, G.A.1    Dale, R.G.2
  • 32
    • 84879427246 scopus 로고    scopus 로고
    • Multimodality therapy for patients with high-risk prostate cancer: Current status and future directions
    • Zaorsky, N.G.; Trabulsi, E.J.; Lin, J.; Den, R.B. Multimodality therapy for patients with high-risk prostate cancer: Current status and future directions. Semin. Oncol. 2013, 40, 308-321.
    • (2013) Semin. Oncol. , vol.40 , pp. 308-321
    • Zaorsky, N.G.1    Trabulsi, E.J.2    Lin, J.3    Den, R.B.4
  • 36
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001, 15, 2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 37
    • 3242882820 scopus 로고    scopus 로고
    • PI 3-kinase related kinases: Big' players in stress-induced signaling pathways
    • Abraham, R.T. PI 3-kinase related kinases: Big' players in stress-induced signaling pathways. DNA Repair (Amst.) 2004, 3, 883-887.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 883-887
    • Abraham, R.T.1
  • 38
    • 0035253615 scopus 로고    scopus 로고
    • ATM and ATR: Networking cellular responses to DNA damage
    • Shiloh, Y. ATM and ATR: Networking cellular responses to DNA damage. Curr. Opin. Genet. Dev. 2001, 11, 71-77.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 71-77
    • Shiloh, Y.1
  • 39
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek, J.; Bartkova, J.; Lukas, J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26, 7773-7779.
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 41
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411, 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 42
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin, M.F.; Kozlov, S. ATM activation and DNA damage response. Cell Cycle 2007, 6, 931-942.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 43
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L.; Elledge, S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 44
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper, J.W.; Elledge, S.J. The DNA damage response: Ten years after. Mol. Cell 2007, 28, 739-745.
    • (2007) Mol. Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 45
    • 33646183367 scopus 로고    scopus 로고
    • DNA damage responses and their many interactions with the replication fork
    • Andreassen, P.R.; Ho, G.P.; D'Andrea, A.D. DNA damage responses and their many interactions with the replication fork. Carcinogenesis 2006, 27, 883-892.
    • (2006) Carcinogenesis , vol.27 , pp. 883-892
    • Andreassen, P.R.1    Ho, G.P.2    D'Andrea, A.D.3
  • 46
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: Chemosensitization versus chemoprotection
    • Zhou, B.B.; Bartek, J. Targeting the checkpoint kinases: Chemosensitization versus chemoprotection. Nat. Rev. Cancer 2004, 4, 216-225.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1    Bartek, J.2
  • 47
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.B.; Elledge, S.J. The DNA damage response: Putting checkpoints in perspective. Nature 2000, 408, 433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 49
    • 41149094512 scopus 로고    scopus 로고
    • Regulation of DNA repair throughout the cell cycle
    • Branzei, D.; Foiani, M. Regulation of DNA repair throughout the cell cycle. Nat. Rev. Mol. Cell Biol. 2008, 9, 297-308.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 297-308
    • Branzei, D.1    Foiani, M.2
  • 50
    • 33745001764 scopus 로고    scopus 로고
    • CDC25: Mechanisms of checkpoint inhibition and recovery
    • Karlsson-Rosenthal, C.; Millar, J.B. CDC25: Mechanisms of checkpoint inhibition and recovery. Trends Cell Biol. 2006, 16, 285-292.
    • (2006) Trends Cell Biol. , vol.16 , pp. 285-292
    • Karlsson-Rosenthal, C.1    Millar, J.B.2
  • 51
    • 36448973875 scopus 로고    scopus 로고
    • CHK2 kinase: Cancer susceptibility and cancer therapy-Two sides of the same coin?
    • Antoni, L.; Sodha, N.; Collins, I.; Garrett, M.D. CHK2 kinase: Cancer susceptibility and cancer therapy-Two sides of the same coin? Nat. Rev. Cancer 2007, 7, 925-936.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4
  • 54
    • 48249092713 scopus 로고    scopus 로고
    • DNA damage detection and repair pathways-Recent advances with inhibitors of checkpoint kinases in cancer therapy
    • Ashwell, S.; Zabludoff, S. DNA damage detection and repair pathways-Recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin. Cancer Res. 2008, 14, 4032-4037.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4032-4037
    • Ashwell, S.1    Zabludoff, S.2
  • 55
    • 52949145309 scopus 로고    scopus 로고
    • Keeping checkpoint kinases in line: New selective inhibitors in clinical trials
    • Ashwell, S.; Janetka, J.W.; Zabludoff, S. Keeping checkpoint kinases in line: New selective inhibitors in clinical trials. Expert Opin. Investig. Drugs 2008, 17, 1331-1340.
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 1331-1340
    • Ashwell, S.1    Janetka, J.W.2    Zabludoff, S.3
  • 56
    • 34547754492 scopus 로고    scopus 로고
    • Targeting DNA repair as a promising approach in cancer therapy
    • Damia, G.; D'Incalci, M. Targeting DNA repair as a promising approach in cancer therapy. Eur. J. Cancer 2007, 43, 1791-1801.
    • (2007) Eur. J. Cancer , vol.43 , pp. 1791-1801
    • Damia, G.1    D'Incalci, M.2
  • 57
    • 67651125091 scopus 로고    scopus 로고
    • Clinical radiation sensitivity with DNA repair disorders: An overview
    • Pollard, J.M.; Gatti, R.A. Clinical radiation sensitivity with DNA repair disorders: An overview. Int. J. Radiat. Oncol. Biol. Phys. 2009, 74, 1323-1331.
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.74 , pp. 1323-1331
    • Pollard, J.M.1    Gatti, R.A.2
  • 59
    • 0030042135 scopus 로고    scopus 로고
    • Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells
    • Schmidt-Ullrich, R.K.; Valerie, K.; Fogleman, P.B.; Walters, J. Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells. Radiat. Res. 1996, 145, 81-85.
    • (1996) Radiat. Res. , vol.145 , pp. 81-85
    • Schmidt-Ullrich, R.K.1    Valerie, K.2    Fogleman, P.B.3    Walters, J.4
  • 60
    • 0033049978 scopus 로고    scopus 로고
    • The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells
    • Contessa, J.N.; Reardon, D.B.; Todd, D.; Dent, P.; Mikkelsen, R.B.; Valerie, K.; Bowers, G.D.; Schmidt-Ullrich, R.K. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin. Cancer Res. 1999, 5, 405-411.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 405-411
    • Contessa, J.N.1    Reardon, D.B.2    Todd, D.3    Dent, P.4    Mikkelsen, R.B.5    Valerie, K.6    Bowers, G.D.7    Schmidt-Ullrich, R.K.8
  • 61
    • 0032815618 scopus 로고    scopus 로고
    • Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
    • Dent, P.; Reardon, D.B.; Park, J.S.; Bowers, G.; Logsdon, C.; Valerie, K.; Schmidt-Ullrich, R. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol. Biol. Cell 1999, 10, 2493-2506.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2493-2506
    • Dent, P.1    Reardon, D.B.2    Park, J.S.3    Bowers, G.4    Logsdon, C.5    Valerie, K.6    Schmidt-Ullrich, R.7
  • 63
    • 0031891006 scopus 로고    scopus 로고
    • Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
    • Bandyopadhyay, D.; Mandal, M.; Adam, L.; Mendelsohn, J.; Kumar, R. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J. Biol. Chem. 1998, 273, 1568-1573.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1568-1573
    • Bandyopadhyay, D.1    Mandal, M.2    Adam, L.3    Mendelsohn, J.4    Kumar, R.5
  • 64
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang, S.M.; Harari, P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin. Cancer Res. 2000, 6, 2166-2174.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 65
    • 0037382902 scopus 로고    scopus 로고
    • Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling
    • Yacoub, A.; McKinstry, R.; Hinman, D.; Chung, T.; Dent, P.; Hagan, M.P. Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. Radiat. Res. 2003, 159, 439-452.
    • (2003) Radiat. Res. , vol.159 , pp. 439-452
    • Yacoub, A.1    McKinstry, R.2    Hinman, D.3    Chung, T.4    Dent, P.5    Hagan, M.P.6
  • 66
    • 28444453967 scopus 로고    scopus 로고
    • Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
    • Dittmann, K.; Mayer, C.; Rodemann, H.P. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother. Oncol. 2005, 76, 157-161.
    • (2005) Radiother. Oncol. , vol.76 , pp. 157-161
    • Dittmann, K.1    Mayer, C.2    Rodemann, H.P.3
  • 67
  • 68
    • 56449098784 scopus 로고    scopus 로고
    • Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells
    • Li, L.; Wang, H.; Yang, E.S.; Arteaga, C.L.; Xia, F. Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells. Cancer Res. 2008, 68, 9141-9146.
    • (2008) Cancer Res. , vol.68 , pp. 9141-9146
    • Li, L.1    Wang, H.2    Yang, E.S.3    Arteaga, C.L.4    Xia, F.5
  • 72
    • 28844501639 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
    • Shigematsu, H.; Gazdar, A.F. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int. J. Cancer 2006, 118, 257-262.
    • (2006) Int. J. Cancer , vol.118 , pp. 257-262
    • Shigematsu, H.1    Gazdar, A.F.2
  • 74
    • 10844268011 scopus 로고    scopus 로고
    • Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474
    • Arao, T.; Fukumoto, H.; Takeda, M.; Tamura, T.; Saijo, N.; Nishio, K. Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474. Cancer Res. 2004, 64, 9101-9104.
    • (2004) Cancer Res. , vol.64 , pp. 9101-9104
    • Arao, T.1    Fukumoto, H.2    Takeda, M.3    Tamura, T.4    Saijo, N.5    Nishio, K.6
  • 76
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella, R.; Bell, D.W.; Haber, D.A.; Settleman, J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004, 305, 1163-1167.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 77
    • 33750339641 scopus 로고    scopus 로고
    • Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation
    • Das, A.K.; Sato, M.; Story, M.D.; Peyton, M.; Graves, R.; Redpath, S.; Girard, L.; Gazdar, A.F.; Shay, J.W.; Minna, J.D.; et al. Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res. 2006, 66, 9601-9608.
    • (2006) Cancer Res. , vol.66 , pp. 9601-9608
    • Das, A.K.1    Sato, M.2    Story, M.D.3    Peyton, M.4    Graves, R.5    Redpath, S.6    Girard, L.7    Gazdar, A.F.8    Shay, J.W.9    Minna, J.D.10
  • 78
    • 34347223656 scopus 로고    scopus 로고
    • Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma
    • Das, A.K.; Chen, B.P.; Story, M.D.; Sato, M.; Minna, J.D.; Chen, D.J.; Nirodi, C.S. Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Cancer Res. 2007, 67, 5267-5274.
    • (2007) Cancer Res. , vol.67 , pp. 5267-5274
    • Das, A.K.1    Chen, B.P.2    Story, M.D.3    Sato, M.4    Minna, J.D.5    Chen, D.J.6    Nirodi, C.S.7
  • 79
    • 28544444712 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor as a therapeutic target in cancer
    • Miller, B.S.; Yee, D. Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res. 2005, 65, 10123-10127.
    • (2005) Cancer Res. , vol.65 , pp. 10123-10127
    • Miller, B.S.1    Yee, D.2
  • 80
    • 22044434446 scopus 로고    scopus 로고
    • Role of insulin-like growth factor 1 receptor signalling in cancer
    • Larsson, O.; Girnita, A.; Girnita, L. Role of insulin-like growth factor 1 receptor signalling in cancer. Br. J. Cancer 2005, 92, 2097-2101.
    • (2005) Br. J. Cancer , vol.92 , pp. 2097-2101
    • Larsson, O.1    Girnita, A.2    Girnita, L.3
  • 82
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway-Therapeutic perspectives in cancer
    • Tao, Y.; Pinzi, V.; Bourhis, J.; Deutsch, E. Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway-Therapeutic perspectives in cancer. Nat. Clin. Pract. Oncol. 2007, 4, 591-602.
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , pp. 591-602
    • Tao, Y.1    Pinzi, V.2    Bourhis, J.3    Deutsch, E.4
  • 83
    • 0344734066 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis
    • Werner, H.; Le Roith, D. The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Crit. Rev. Oncog. 1997, 8, 71-92.
    • (1997) Crit. Rev. Oncog. , vol.8 , pp. 71-92
    • Werner, H.1    Le Roith, D.2
  • 84
    • 16944364325 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
    • Turner, B.C.; Haffty, B.G.; Narayanan, L.; Yuan, J.; Havre, P.A.; Gumbs, A.A.; Kaplan, L.; Burgaud, J.L.; Carter, D.; Baserga, R.; et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res. 1997, 57, 3079-3083.
    • (1997) Cancer Res. , vol.57 , pp. 3079-3083
    • Turner, B.C.1    Haffty, B.G.2    Narayanan, L.3    Yuan, J.4    Havre, P.A.5    Gumbs, A.A.6    Kaplan, L.7    Burgaud, J.L.8    Carter, D.9    Baserga, R.10
  • 85
    • 0035811559 scopus 로고    scopus 로고
    • Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
    • Macaulay, V.M.; Salisbury, A.J.; Bohula, E.A.; Playford, M.P.; Smorodinsky, N.I.; Shiloh, Y. Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene 2001, 20, 4029-4040.
    • (2001) Oncogene , vol.20 , pp. 4029-4040
    • McAulay, V.M.1    Salisbury, A.J.2    Bohula, E.A.3    Playford, M.P.4    Smorodinsky, N.I.5    Shiloh, Y.6
  • 86
    • 0035852706 scopus 로고    scopus 로고
    • ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
    • Peretz, S.; Jensen, R.; Baserga, R.; Glazer, P.M. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc. Natl. Acad. Sci. USA 2001, 98, 1676-1681.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1676-1681
    • Peretz, S.1    Jensen, R.2    Baserga, R.3    Glazer, P.M.4
  • 87
    • 0033229933 scopus 로고    scopus 로고
    • ATM: A mediator of multiple responses to genotoxic stress
    • Rotman, G.; Shiloh, Y. ATM: A mediator of multiple responses to genotoxic stress. Oncogene 1999, 18, 6135-6144.
    • (1999) Oncogene , vol.18 , pp. 6135-6144
    • Rotman, G.1    Shiloh, Y.2
  • 88
    • 10744232798 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination
    • Trojanek, J.; Ho, T.; del Valle, L.; Nowicki, M.; Wang, J.Y.; Lassak, A.; Peruzzi, F.; Khalili, K.; Skorski, T.; Reiss, K. Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination. Mol. Cell Biol. 2003, 23, 7510-7524.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 7510-7524
    • Trojanek, J.1    Ho, T.2    del Valle, L.3    Nowicki, M.4    Wang, J.Y.5    Lassak, A.6    Peruzzi, F.7    Khalili, K.8    Skorski, T.9    Reiss, K.10
  • 92
    • 0037085933 scopus 로고    scopus 로고
    • Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response
    • Griffin, R.J.; Williams, B.W.; Wild, R.; Cherrington, J.M.; Park, H.; Song, C.W. Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res. 2002, 62, 1702-1706.
    • (2002) Cancer Res. , vol.62 , pp. 1702-1706
    • Griffin, R.J.1    Williams, B.W.2    Wild, R.3    Cherrington, J.M.4    Park, H.5    Song, C.W.6
  • 93
    • 0036145292 scopus 로고    scopus 로고
    • The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation
    • Ning, S.; Laird, D.; Cherrington, J.M.; Knox, S.J. The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat. Res. 2002, 157, 45-51.
    • (2002) Radiat. Res. , vol.157 , pp. 45-51
    • Ning, S.1    Laird, D.2    Cherrington, J.M.3    Knox, S.J.4
  • 94
    • 0038756364 scopus 로고    scopus 로고
    • SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro
    • Abdollahi, A.; Lipson, K.E.; Han, X.; Krempien, R.; Trinh, T.; Weber, K.J.; Hahnfeldt, P.; Hlatky, L.; Debus, J.; Howlett, A.R.; et al. SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res. 2003, 63, 3755-3763.
    • (2003) Cancer Res. , vol.63 , pp. 3755-3763
    • Abdollahi, A.1    Lipson, K.E.2    Han, X.3    Krempien, R.4    Trinh, T.5    Weber, K.J.6    Hahnfeldt, P.7    Hlatky, L.8    Debus, J.9    Howlett, A.R.10
  • 95
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong, T.A.; Shawver, L.K.; Sun, L.; Tang, C.; App, H.; Powell, T.J.; Kim, Y.H.; Schreck, R.; Wang, X.; Risau, W.; et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 1999, 59, 99-106.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10
  • 97
    • 42249115712 scopus 로고    scopus 로고
    • Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy
    • Timke, C.; Zieher, H.; Roth, A.; Hauser, K.; Lipson, K.E.; Weber, K.J.; Debus, J.; Abdollahi, A.; Huber, P.E. Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clin. Cancer Res. 2008, 14, 2210-2219.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2210-2219
    • Timke, C.1    Zieher, H.2    Roth, A.3    Hauser, K.4    Lipson, K.E.5    Weber, K.J.6    Debus, J.7    Abdollahi, A.8    Huber, P.E.9
  • 99
    • 79952819549 scopus 로고    scopus 로고
    • MET inhibition results in DNA breaks and synergistically sensitizes tumor cells to DNA-damaging agents potentially by breaching a damage-induced checkpoint arrest
    • Medova, M.; Aebersold, D.M.; Blank-Liss, W.; Streit, B.; Medo, M.; Aebi, S.; Zimmer, Y. MET inhibition results in DNA breaks and synergistically sensitizes tumor cells to DNA-damaging agents potentially by breaching a damage-induced checkpoint arrest. Genes Cancer 2010, 1, 1053-1062.
    • (2010) Genes Cancer , vol.1 , pp. 1053-1062
    • Medova, M.1    Aebersold, D.M.2    Blank-Liss, W.3    Streit, B.4    Medo, M.5    Aebi, S.6    Zimmer, Y.7
  • 101
    • 82255163062 scopus 로고    scopus 로고
    • MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks
    • Medova, M.; Aebersold, D.M.; Zimmer, Y. MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks. Int. J. Cancer 2012, 130, 728-734.
    • (2012) Int. J. Cancer , vol.130 , pp. 728-734
    • Medova, M.1    Aebersold, D.M.2    Zimmer, Y.3
  • 102
    • 74549159014 scopus 로고    scopus 로고
    • The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells
    • Welsh, J.W.; Mahadevan, D.; Ellsworth, R.; Cooke, L.; Bearss, D.; Stea, B. The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells. Radiat. Oncol. 2009, 4, 69.
    • (2009) Radiat. Oncol. , vol.4 , pp. 69
    • Welsh, J.W.1    Mahadevan, D.2    Ellsworth, R.3    Cooke, L.4    Bearss, D.5    Stea, B.6
  • 103
    • 0032537813 scopus 로고    scopus 로고
    • Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents
    • Fan, S.; Wang, J.A.; Yuan, R.Q.; Rockwell, S.; Andres, J.; Zlatapolskiy, A.; Goldberg, I.D.; Rosen, E.M. Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene 1998, 17, 131-141.
    • (1998) Oncogene , vol.17 , pp. 131-141
    • Fan, S.1    Wang, J.A.2    Yuan, R.Q.3    Rockwell, S.4    Andres, J.5    Zlatapolskiy, A.6    Goldberg, I.D.7    Rosen, E.M.8
  • 104
    • 0034720310 scopus 로고    scopus 로고
    • The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase
    • Fan, S.; Ma, Y.X.; Wang, J.A.; Yuan, R.Q.; Meng, Q.; Cao, Y.; Laterra, J.J.; Goldberg, I.D.; Rosen, E.M. The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase. Oncogene 2000, 19, 2212-2223.
    • (2000) Oncogene , vol.19 , pp. 2212-2223
    • Fan, S.1    Ma, Y.X.2    Wang, J.A.3    Yuan, R.Q.4    Meng, Q.5    Cao, Y.6    Laterra, J.J.7    Goldberg, I.D.8    Rosen, E.M.9
  • 105
    • 0034954160 scopus 로고    scopus 로고
    • The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair
    • Fan, S.; Ma, Y.X.; Gao, M.; Yuan, R.Q.; Meng, Q.; Goldberg, I.D.; Rosen, E.M. The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair. Mol. Cell Biol. 2001, 21, 4968-4984.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 4968-4984
    • Fan, S.1    Ma, Y.X.2    Gao, M.3    Yuan, R.Q.4    Meng, Q.5    Goldberg, I.D.6    Rosen, E.M.7
  • 106
    • 0033615691 scopus 로고    scopus 로고
    • A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis
    • Maroun, C.R.; Moscatello, D.K.; Naujokas, M.A.; Holgado-Madruga, M.; Wong, A.J.; Park, M. A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis. J. Biol. Chem. 1999, 274, 31719-31726.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31719-31726
    • Maroun, C.R.1    Moscatello, D.K.2    Naujokas, M.A.3    Holgado-Madruga, M.4    Wong, A.J.5    Park, M.6
  • 107
    • 0035503605 scopus 로고    scopus 로고
    • Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage
    • Yuan, R.; Fan, S.; Achary, M.; Stewart, D.M.; Goldberg, I.D.; Rosen, E.M. Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. Cancer Res. 2001, 61, 8022-8031.
    • (2001) Cancer Res. , vol.61 , pp. 8022-8031
    • Yuan, R.1    Fan, S.2    Achary, M.3    Stewart, D.M.4    Goldberg, I.D.5    Rosen, E.M.6
  • 109
    • 0037401065 scopus 로고    scopus 로고
    • Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells
    • Qian, L.W.; Mizumoto, K.; Inadome, N.; Nagai, E.; Sato, N.; Matsumoto, K.; Nakamura, T.; Tanaka, M. Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. Int. J. Cancer 2003, 104, 542-549.
    • (2003) Int. J. Cancer , vol.104 , pp. 542-549
    • Qian, L.W.1    Mizumoto, K.2    Inadome, N.3    Nagai, E.4    Sato, N.5    Matsumoto, K.6    Nakamura, T.7    Tanaka, M.8
  • 110
    • 84878239103 scopus 로고    scopus 로고
    • Biological significance and targeting of c-Met tyrosine kinase receptor in cancer
    • Goetsch, L.; Caussanel, V.; Corvaia, N. Biological significance and targeting of c-Met tyrosine kinase receptor in cancer. Front. Biosci. (Landmark Ed.) 2013, 18, 454-473.
    • (2013) Front. Biosci. (Landmark Ed.) , vol.18 , pp. 454-473
    • Goetsch, L.1    Caussanel, V.2    Corvaia, N.3
  • 111
    • 84861733799 scopus 로고    scopus 로고
    • MET: A promising anticancer therapeutic target
    • Peters, S.; Adjei, A.A. MET: A promising anticancer therapeutic target. Nat. Rev. Clin. Oncol. 2012, 9, 314-326.
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 314-326
    • Peters, S.1    Adjei, A.A.2
  • 112
    • 0035916363 scopus 로고    scopus 로고
    • Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation
    • Aebersold, D.M.; Kollar, A.; Beer, K.T.; Laissue, J.; Greiner, R.H.; Djonov, V. Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation. Int. J. Cancer 2001, 96, 41-54.
    • (2001) Int. J. Cancer , vol.96 , pp. 41-54
    • Aebersold, D.M.1    Kollar, A.2    Beer, K.T.3    Laissue, J.4    Greiner, R.H.5    Djonov, V.6
  • 113
    • 80052999263 scopus 로고    scopus 로고
    • Immunohistochemical study identifying prognostic biomolecular markers in nasopharyngeal carcinoma treated by radiotherapy
    • Kim, Y.J.; Go, H.; Wu, H.G.; Jeon, Y.K.; Park, S.W.; Lee, S.H. Immunohistochemical study identifying prognostic biomolecular markers in nasopharyngeal carcinoma treated by radiotherapy. Head Neck 2011, 33, 1458-1466.
    • (2011) Head Neck , vol.33 , pp. 1458-1466
    • Kim, Y.J.1    Go, H.2    Wu, H.G.3    Jeon, Y.K.4    Park, S.W.5    Lee, S.H.6
  • 114
    • 84856020870 scopus 로고    scopus 로고
    • Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma
    • Gao, J.; Inagaki, Y.; Song, P.; Qu, X.; Kokudo, N.; Tang, W. Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma. Pharmacol. Res. 2012, 65, 23-30.
    • (2012) Pharmacol. Res. , vol.65 , pp. 23-30
    • Gao, J.1    Inagaki, Y.2    Song, P.3    Qu, X.4    Kokudo, N.5    Tang, W.6
  • 116
    • 78649672549 scopus 로고    scopus 로고
    • c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma
    • Kim, C.H.; Koh, Y.W.; Han, J.H.; Kim, J.W.; Lee, J.S.; Baek, S.J.; Hwang, H.S.; Choi, E.C. c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Head Neck 2010, 32, 1655-1664.
    • (2010) Head Neck , vol.32 , pp. 1655-1664
    • Kim, C.H.1    Koh, Y.W.2    Han, J.H.3    Kim, J.W.4    Lee, J.S.5    Baek, S.J.6    Hwang, H.S.7    Choi, E.C.8
  • 118
    • 0346753584 scopus 로고    scopus 로고
    • Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx
    • Aebersold, D.M.; Landt, O.; Berthou, S.; Gruber, G.; Beer, K.T.; Greiner, R.H.; Zimmer, Y. Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx. Oncogene 2003, 22, 8519-8523.
    • (2003) Oncogene , vol.22 , pp. 8519-8523
    • Aebersold, D.M.1    Landt, O.2    Berthou, S.3    Gruber, G.4    Beer, K.T.5    Greiner, R.H.6    Zimmer, Y.7
  • 119
    • 79960088597 scopus 로고    scopus 로고
    • The role of the c-Met pathway in lung cancer and the potential for targeted therapy
    • Sattler, M.; Reddy, M.M.; Hasina, R.; Gangadhar, T.; Salgia, R. The role of the c-Met pathway in lung cancer and the potential for targeted therapy. Ther. Adv. Med. Oncol. 2011, 3, 171-184.
    • (2011) Ther. Adv. Med. Oncol. , vol.3 , pp. 171-184
    • Sattler, M.1    Reddy, M.M.2    Hasina, R.3    Gangadhar, T.4    Salgia, R.5
  • 120
    • 65249122512 scopus 로고    scopus 로고
    • Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
    • Eder, J.P.; vande Woude, G.F.; Boerner, S.A.; LoRusso, P.M. Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin. Cancer Res. 2009, 15, 2207-2214.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2207-2214
    • Eder, J.P.1    vande Woude, G.F.2    Boerner, S.A.3    LoRusso, P.M.4
  • 121
    • 20444467263 scopus 로고    scopus 로고
    • Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation
    • Lal, B.; Xia, S.; Abounader, R.; Laterra, J. Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation. Clin. Cancer Res. 2005, 11, 4479-4486.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4479-4486
    • Lal, B.1    Xia, S.2    Abounader, R.3    Laterra, J.4
  • 122
    • 33750352906 scopus 로고    scopus 로고
    • In vitro and in vivo potentiating the cytotoxic effect of radiation on human U251 gliomas by the c-Met antisense oligodeoxynucleotides
    • Chu, S.H.; Zhu, Z.A.; Yuan, X.H.; Li, Z.Q.; Jiang, P.C. In vitro and in vivo potentiating the cytotoxic effect of radiation on human U251 gliomas by the c-Met antisense oligodeoxynucleotides. J. Neurooncol. 2006, 80, 143-149.
    • (2006) J. Neurooncol. , vol.80 , pp. 143-149
    • Chu, S.H.1    Zhu, Z.A.2    Yuan, X.H.3    Li, Z.Q.4    Jiang, P.C.5
  • 123
    • 84867885479 scopus 로고    scopus 로고
    • c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation
    • Yu, H.; Li, X.; Sun, S.; Gao, X.; Zhou, D. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Biochem. Biophys. Res. Commun. 2012, 427, 659-665.
    • (2012) Biochem. Biophys. Res. Commun. , vol.427 , pp. 659-665
    • Yu, H.1    Li, X.2    Sun, S.3    Gao, X.4    Zhou, D.5
  • 125
    • 77957130831 scopus 로고    scopus 로고
    • Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer
    • Lin, C.I.; Whang, E.E.; Donner, D.B.; Du, J.; Lorch, J.; He, F.; Jiang, X.; Price, B.D.; Moore, F.D., Jr.; Ruan, D.T. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol. Cancer Res. 2010, 8, 1217-1226.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 1217-1226
    • Lin, C.I.1    Whang, E.E.2    Donner, D.B.3    Du, J.4    Lorch, J.5    He, F.6    Jiang, X.7    Price, B.D.8    Moore Jr., F.D.9    Ruan, D.T.10
  • 126
    • 77958603109 scopus 로고    scopus 로고
    • Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
    • Buchanan, I.M.; Scott, T.; Tandle, A.T.; Burgan, W.E.; Burgess, T.L.; Tofilon, P.J.; Camphausen, K. Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102. J. Cell. Mol. Med. 2011, 15, 1999-2006.
    • (2011) J. Cell. Mol. Med. , vol.15 , pp. 1999-2006
    • Buchanan, I.M.1    Scott, T.2    Tandle, A.T.3    Burgan, W.E.4    Burgess, T.L.5    Tofilon, P.J.6    Camphausen, K.7
  • 127
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna, K.K.; Jackson, S.P. DNA double-strand breaks: Signaling, repair and the cancer connection. Nat. Genet. 2001, 27, 247-254.
    • (2001) Nat. Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 129
    • 4444225676 scopus 로고    scopus 로고
    • Mutational analyses of the human Rad51-Tyr315 residue, a site for phosphorylation in leukaemia cells
    • Takizawa, Y.; Kinebuchi, T.; Kagawa, W.; Yokoyama, S.; Shibata, T.; Kurumizaka, H. Mutational analyses of the human Rad51-Tyr315 residue, a site for phosphorylation in leukaemia cells. Genes Cells 2004, 9, 781-790.
    • (2004) Genes Cells , vol.9 , pp. 781-790
    • Takizawa, Y.1    Kinebuchi, T.2    Kagawa, W.3    Yokoyama, S.4    Shibata, T.5    Kurumizaka, H.6
  • 130
    • 63849187827 scopus 로고    scopus 로고
    • Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
    • Cook, P.J.; Ju, B.G.; Telese, F.; Wang, X.; Glass, C.K.; Rosenfeld, M.G. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 2009, 458, 591-596.
    • (2009) Nature , vol.458 , pp. 591-596
    • Cook, P.J.1    Ju, B.G.2    Telese, F.3    Wang, X.4    Glass, C.K.5    Rosenfeld, M.G.6
  • 134
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R.K. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005, 307, 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 135
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-A key regulatory factor in tumour growth
    • Harris, A.L. Hypoxia-A key regulatory factor in tumour growth. Nat. Rev. Cancer 2002, 2, 38-47.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 137
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel, M.; Schlenger, K.; Aral, B.; Mitze, M.; Schaffer, U.; Vaupel, P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996, 56, 4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 139
    • 26444466467 scopus 로고    scopus 로고
    • Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    • Nordsmark, M.; Bentzen, S.M.; Rudat, V.; Brizel, D.; Lartigau, E.; Stadler, P.; Becker, A.; Adam, M.; Molls, M.; Dunst, J.; et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother. Oncol. 2005, 77, 18-24.
    • (2005) Radiother. Oncol. , vol.77 , pp. 18-24
    • Nordsmark, M.1    Bentzen, S.M.2    Rudat, V.3    Brizel, D.4    Lartigau, E.5    Stadler, P.6    Becker, A.7    Adam, M.8    Molls, M.9    Dunst, J.10
  • 140
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel, P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin. Radiat. Oncol. 2004, 14, 198-206.
    • (2004) Semin. Radiat. Oncol. , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 141
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J.W.; Tchernyshyov, I.; Semenza, G.L.; Dang, C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3, 177-185.
    • (2006) Cell Metab. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 143
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang, N.; Wang, L.; Esko, J.; Giordano, F.J.; Huang, Y.; Gerber, H.P.; Ferrara, N.; Johnson, R.S. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004, 6, 485-495.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6    Ferrara, N.7    Johnson, R.S.8
  • 146
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • Hockel, M.; Vaupel, P. Biological consequences of tumor hypoxia. Semin. Oncol. 2001, 28, 36-41.
    • (2001) Semin. Oncol. , vol.28 , pp. 36-41
    • Hockel, M.1    Vaupel, P.2
  • 147
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel, M.; Vaupel, P. Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 2001, 93, 266-276.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 148
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark, M.; Overgaard, M.; Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 1996, 41, 31-39.
    • (1996) Radiother. Oncol. , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 150
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • Brizel, D.M.; Dodge, R.K.; Clough, R.W.; Dewhirst, M.W. Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome. Radiother. Oncol. 1999, 53, 113-117.
    • (1999) Radiother. Oncol. , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 151
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold, D.M.; Burri, P.; Beer, K.T.; Laissue, J.; Djonov, V.; Greiner, R.H.; Semenza, G.L. Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 2001, 61, 2911-2916.
    • (2001) Cancer Res. , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3    Laissue, J.4    Djonov, V.5    Greiner, R.H.6    Semenza, G.L.7
  • 152
    • 0037500967 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
    • Bachtiary, B.; Schindl, M.; Potter, R.; Dreier, B.; Knocke, T.H.; Hainfellner, J.A.; Horvat, R.; Birner, P. Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin. Cancer Res. 2003, 9, 2234-2240.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2234-2240
    • Bachtiary, B.1    Schindl, M.2    Potter, R.3    Dreier, B.4    Knocke, T.H.5    Hainfellner, J.A.6    Horvat, R.7    Birner, P.8
  • 153
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino, L.; Bertotti, A.; Comoglio, P.M. MET signalling: Principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2010, 11, 834-848.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 154
    • 33745354482 scopus 로고    scopus 로고
    • Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells
    • Hara, S.; Nakashiro, K.; Klosek, S.K.; Ishikawa, T.; Shintani, S.; Hamakawa, H. Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. Oral Oncol. 2006, 42, 593-598.
    • (2006) Oral Oncol. , vol.42 , pp. 593-598
    • Hara, S.1    Nakashiro, K.2    Klosek, S.K.3    Ishikawa, T.4    Shintani, S.5    Hamakawa, H.6
  • 155
    • 34249006269 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha correlates with MET and metastasis in node-negative breast cancer
    • Chen, H.H.; Su, W.C.; Lin, P.W.; Guo, H.R.; Lee, W.Y. Hypoxia-inducible factor-1alpha correlates with MET and metastasis in node-negative breast cancer. Breast Cancer Res. Treat. 2007, 103, 167-175.
    • (2007) Breast Cancer Res. Treat. , vol.103 , pp. 167-175
    • Chen, H.H.1    Su, W.C.2    Lin, P.W.3    Guo, H.R.4    Lee, W.Y.5
  • 156
    • 1542345403 scopus 로고    scopus 로고
    • Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid
    • Scarpino, S.; Cancellario d'Alena, F.; Di Napoli, A.; Pasquini, A.; Marzullo, A.; Ruco, L.P. Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid. J. Pathol. 2004, 202, 352-358.
    • (2004) J. Pathol. , vol.202 , pp. 352-358
    • Scarpino, S.1    Cancellario d'Alena, F.2    Di Napoli, A.3    Pasquini, A.4    Marzullo, A.5    Ruco, L.P.6
  • 157
    • 33751569391 scopus 로고    scopus 로고
    • Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    • Ide, T.; Kitajima, Y.; Miyoshi, A.; Ohtsuka, T.; Mitsuno, M.; Ohtaka, K.; Koga, Y.; Miyazaki, K. Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int. J. Cancer 2006, 119, 2750-2759.
    • (2006) Int. J. Cancer , vol.119 , pp. 2750-2759
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6    Koga, Y.7    Miyazaki, K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.