Scatter factors and invasive growth

Seminars in Cancer Biology

Volumn 11, Issue 2, 2001, Pages 153-165

  Comoglio, Paolo M ^a   Boccaccio, Carla ^a  

^a CANDIOLO CANCER INSTITUTE   (Italy)

Author keywords

HGF; Invasion; Met; Metastasis; Ron; SF

Indexed keywords

SCATTER FACTOR;

CANCER INVASION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; GENETIC ANALYSIS; MORPHOGENESIS; NONHUMAN; ONCOGENE; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EID: 0035010198     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0366     Document Type: Article

References (118)

1. Plasminogen-related growth factor and semaphorin receptors: A gene superfamily controlling invasive growth
2. Signalling by semaphorin receptors: Cell guidance and beyond
3. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors
4. Scatter factor is a fibroblast derived modulator of epithelial cell mobility
5. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor
6. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells
7. The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro
8. Hepatocyte growth factor/scatter factor is an axonal chemoattracrant and a neurotrophic factor for spinal motor neurons
9. Hepatocyte growth factor, a versatile signal for developing neurons
10. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
11. Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors
12. Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro
13. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
14. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures
15. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor
16. Molecular cloning and expression of human hepatocyte growth factor
17. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
18. Structure-function analysis of hepatocyte growth factor: Identification of variants that lack mitogenic activity yet retain high affinity receptor binding
19. Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)
20. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA
21. Proteolytic activation of hepatocyte growth factor in response to tissue injury
22. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
23. Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator
24. Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF
25. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network
26. Hepatocyte growth factor increases urokinase-type plasminogen activator (uPA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells
27. Macrophage stimulating protein: Purification, partial amino acid sequence, and cellular activity
28. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3
29. Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain
30. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP
31. Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade
32. Scatter factor/hepatocyte growth factor is essential for liver development
33. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
34. Essential role for the c-Met receptor in the migration of myogenic precursor cells into the limb bud
35. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
36. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
37. Hepatocyte growth factor is involved in the morphogenesis of tooth germ in murine molars
38. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
39. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland
40. Involvement of hepatocyte growth factor/scatter factor and met receptor signaling in hair follicle morphogenesis and cycling
41. Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice
42. Liver regeneration
43. Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury
44. Hepatocyte growth factor gene therapy of liver cirrhosis in rats
45. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
46. Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes
47. +)
48. The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse
49. Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice
50. The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues
51. Tyrosine kinase receptor indistinguishable from the c-met protein
52. A novel putative receptor protein tyrosine kinase of the met family
53. Chicken macrophage stimulating protein is a ligand of the receptor protein-tyrosine kinase Sea
54. Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum
55. Biosynthesis of the protein encoded by the c-met proto-oncogene
56. A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor
57. Plexin A is a neuronal semaphorin receptor that controls axon guidance
58. Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase
59. Tyrosines 1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)
60. The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation
61. Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET
62. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase
63. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
64. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential
65. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
66. The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase
67. Hepatocyte growth factor/scatter factor stimulates the Rasguanine nucleotide exchanger
68. Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis
69. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
70. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
71. The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
72. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
73. A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor
74. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
75. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development
76. Motogenic and morphogenic activity, of epithelial receptor tyrosine kinases
77. Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth
78. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras
79. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells
80. Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility
81. Activation of both MAP kinase and phosphatidylinositide 3-kinase by ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly
82. Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering
83. Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, or urokinase expression and in vitro invasion
84. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase
85. HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
86. A point mutation in the MET oncogene abrogates metastasis without affecting transformation
87. Concomitant activation of pathways downstream of Grb2 and Pl 3-kinase is required for MET-mediated metastasis
88. The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering
89. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
90. Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation
91. Coupling of gab1 to c-met, grb2, and shp2 mediates biological responses
92. Plexin: A novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions
93. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
94. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ
95. Identification of semaphorin E as a non-MDR drug resistance gene of human cancers
96. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines
97. Molecular cloning of a new transforming gene from a chemically transformed human cell line
98. Mechanism of met oncogene activation
99. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions
100. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas
101. 'Invasive-growth' signaling by the Met/HGF receptor: The hereditary renal carcinoma connection
102. RET mutations in human disease
103. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
104. Activating mutations for the met tyrosine kinase receptor in human cancer
105. Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists
106. The mutationally activated Met receptor mediates motility and metastasis
107. Different point mutations in the met oncogene elicit distinct biological properties
108. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas
109. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas
110. Overexpression of the Met/HGF receptor in ovarian cancer
111. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
112. Expression of Met/hepatocyte growth factor receptor gene and malignant behaviour of musculoskeletal tumors
113. Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas
114. A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation
115. Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat
116. Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity
117. Transcriptional activation of the hepatocyte growth actor receptor (c-met) gene by its ligand (hepatocyte growth factor) is mediated through AP-1
118. Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model