Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-I (HIF-I) in tumour cells in papillary carcinoma of the thyroid

Journal of Pathology

Volumn 202, Issue 3, 2004, Pages 352-358

  Scarpino, Stefania ^a   d'Alena, Francesca Cancellario ^a   Di Napoli, Arianna ^a   Pasquini, Anna ^a   Marzullo, Antonella ^a   Ruco, Luigi P ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Hypoxia inducible factor; Met protein; Papillary carcinoma; Thyroid

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; RNA; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CANCER INVASION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; HYPOXEMIA; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSAMMOMA BODY; RNA TRANSCRIPTION; THYROID PAPILLARY CARCINOMA; TISSUE NECROSIS; TRANSCRIPTION INITIATION; TUMOR BLEEDING; TUMOR CELL; TUMOR DIFFERENTIATION; UPREGULATION;

CARCINOMA, PAPILLARY; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MICRODISSECTION; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; RECEPTORS, GROWTH FACTOR; RNA, MESSENGER; THYROID NEOPLASMS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 1542345403     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1522     Document Type: Article

References (30)

1. Giordano S, Ponzetto C, Di Renzo MF, Cooper CS, Comoglio PM. Tyrosine kinase receptor indistinguishable from the c-met protein. Nature 1989; 339: 155-156.
2. Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991; 251: 802-804.
3. Naldini L, Vigna E, Narsimhan RP, et al. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-Met. Oncogene 1991; 6: 501-504.
4. Prat M, Narsimhan R, Crepaldi T, Nicotra MR, Natali PG, Comoglio PM. The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int J Cancer 1991; 49: 323-328.
5. Di Renzo MF, Olivero M, Ferro S, et al. Overexpression of the c-met/hgf receptor gene in human thyroid carcinomas. Oncogene 1992; 7: 2549-2553.
6. Ruco LP, Ranalli T, Marzullo A, et al. Expression of Met protein in thyroid tumours. J Pathol 1996; 180: 266-270.
7. Belfiore A, Gangemi P, Costantino A, et al. Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases. J Clin Endocrinol Metab 1997; 82: 2322-2328.
8. Zanetti A, Stoppacciaro A, Marzullo A, et al. Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid. J Pathol 1998; 186: 287-291.
9. Oyama T, Ichimura E, Sano T, Kashiwabara K, Fukuda T, Nakajima T. c-Met expression of thyroid tissue with special reference to papillary carcinoma. Pathol Int 1998; 48: 763-768.
10. Trovato M, Villari D, Bartolone L, et al. Expression of the hepatocyte growth factor and c-met in normal thyroid, non-neoplastic, and neoplastic nodules. Thyroid 1998; 8: 125-131.
11. Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signalling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994; 77: 261-271.
12. Nusrat A, Parkos CA, Bacarra AE, et al. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and non-transformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J Clin Invest 1994; 93: 2056-2065.
13. Rosen EM, Nigam SK, Goldberg I. Scatter factor and c-Met receptor: a paradigm for mesenchymal/epithelial interaction. J Cell Biol 1994; 127: 1783-1787.
14. Tamagnone L, Comoglio PM. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. Cytokine Growth Factor Rev 1997; 8: 129-142.
15. Scarpino S, Stoppacciaro A, Colarossi C, et al. Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid. J Pathol 1999; 189: 570-575.
16. Scarpino S, Stoppacciaro A, Ballarini F, et al. Papillary carcinoma of the thyroid: hepatocyte growth factor (HGF) stimulates tumor cells to release chemokines active in recruiting dendritic cells. Am J Pathol 2000; 156: 831-837.
17. Scarpino S, Cancellario d'Alena F, Di Napoli A, Ballarini F, Prat M, Ruco LP. Papillary carcinoma of the thyroid: evidence for a role of hepatocyte growth factor (HGF) in promoting tumour angiogenesis. J Pathol 2003; 199: 243-250.
18. Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003; 3: 347-361.
19. Rosai J, Carcangiu ML, De Lellis LA. Atlas of Tumor Pathology. Tumors of the Thyroid Gland. Armed Forces Institute of Pathology: Washington, DC, 1992.
20. Prat M, Crepaldi T, Gandino L, Giordano S, Longati P, Comoglio PM. C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol Cell Biol 1991; 11: 5954-5962.
21. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Med 2003; 9: 677-684.
22. Ivan M, Bond JA, Prat M, Comoglio PM, Wynford-Thomas D. Activated ras and ret oncogenes induce overexpression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene 1997; 14: 2417-2423.
23. Akslen LA, LiVolsi VA. Increased angiogenesis in papillary carcinoma but lack of prognostic importance. Hum Pathol 2000; 31: 439-442.
24. Katoh R, Hemmi A, Komiyama A, Kawaoi A. Confocal laser scanning microscopic observation of angioarchitectures in human thyroid neoplasm. Hum Pathol 1999; 30: 1226-1231.
25. Scarpino S, Stoppacciaro A, Pellegrini C, et al. Expression of EDA/EDB isoforms of fibronectin in papillary carcinoma of the thyroid. J Pathol 1999; 188: 163-167.
26. Johannessen JV, Sobrinho-Simoes M. The origin and significance of thyroid psammoma bodies. Lab Invest 1980; 43: 287-296.
27. Viglietto G, Maglione D, Rambaldi M, et al. Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PIGF) associated with malignancy in human thyroid tumors and cell lines. Oncogene 1995; 11: 1569-1579.
28. Katoh R, Miyagi E, Kawaoi A, et al. Expression of vascular endothelial growth factor (VEGF) in human thyroid neoplasms. Hum Pathol 1999; 30: 891-897.
29. Bunone G, Vigneri P, Mariani L, et al. Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am J Pathol 1999; 155: 1967-1976.
30. Brabletz T, Jung A, Reu S, et al. Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. PNAS 2001; 98: 10 356-10 361.