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Volumn 10, Issue 8, 1999, Pages 2493-2506

Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

EID: 0032815618     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.8.2493     Document Type: Article
Times cited : (313)

References (59)
  • 1
    • 0033613944 scopus 로고    scopus 로고
    • 2/M checkpoint arrest in cells exposed to ionizing radiation
    • 2/M checkpoint arrest in cells exposed to ionizing radiation. J. Biol. Chem. 274, 2732-2742.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2732-2742
    • Abbott, D.W.1    Holt, J.2
  • 2
    • 0030989155 scopus 로고    scopus 로고
    • Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
    • Aktas, H., Cai, H., and Cooper, G.M. (1997). Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol. Cell. Biol. 17, 3850-3857.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3850-3857
    • Aktas, H.1    Cai, H.2    Cooper, G.M.3
  • 3
    • 0031916439 scopus 로고    scopus 로고
    • Stimulation of DNA synthesis in primary cultures of rat hepatocytes via a Ras/Rac1/Cdc42/SEK/JNK/c-Jun dependent mechanism
    • Auer, K., et al. (1998a). Stimulation of DNA synthesis in primary cultures of rat hepatocytes via a Ras/Rac1/Cdc42/SEK/JNK/c-Jun dependent mechanism. Mol. Biol. Cell 9, 561-573.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 561-573
    • Auer, K.1
  • 5
    • 0000091450 scopus 로고    scopus 로고
    • The effect of ionizing radiation on signal transduction: Antibodies to EGF receptor sensitize A431 cells to radiation
    • Balaban, N., Moni, J., Shannon, M., Dang, L., Murphy, E., and Goldkorn, T. (1996). The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. Biochim. Biophys. Acta 1314, 147-156.
    • (1996) Biochim. Biophys. Acta , vol.1314 , pp. 147-156
    • Balaban, N.1    Moni, J.2    Shannon, M.3    Dang, L.4    Murphy, E.5    Goldkorn, T.6
  • 6
    • 0030038201 scopus 로고    scopus 로고
    • Autocrine regulation of membrane transforming growth factor-α cleavage
    • Baselga, J., Mendelson, J., Kim, Y.-M., and Pandiella, A. (1996). Autocrine regulation of membrane transforming growth factor-α cleavage. J. Biol. Chem. 271, 3279-3284.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3279-3284
    • Baselga, J.1    Mendelson, J.2    Kim, Y.-M.3    Pandiella, A.4
  • 7
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized antiHER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • Baselga, J., Norton, L., Albanell, J., Kim, Y.M., and Mendelsohn, J. (1998). Recombinant humanized antiHER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res. 58, 2825-2831.
    • (1998) Cancer Res. , vol.58 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.M.4    Mendelsohn, J.5
  • 9
    • 0023158779 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colon-metric assay: Assessment of radiosensitivity
    • Carmichael, J., DeGraff, W.G., Gazdar, A.F., Minna, J.D., and Mitchell, J.B. (1987). Evaluation of a tetrazolium-based semiautomated colon-metric assay: assessment of radiosensitivity. Cancer Res. 47, 943-946.
    • (1987) Cancer Res. , vol.47 , pp. 943-946
    • Carmichael, J.1    DeGraff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5
  • 10
    • 0032575135 scopus 로고    scopus 로고
    • Potentiation of ionizing radiation induced cell killing by inhibition of the mitogen activated protein (MAP) kinase cascade in A431 human squamous carcinoma cells
    • Carter, S., Auer, K.L., Birrer, M., Fisher, P.B., Scmidtt-Ullrich, R., Valerie, K., Mikkelsen, R., and Dent, P. (1998). Potentiation of ionizing radiation induced cell killing by inhibition of the mitogen activated protein (MAP) kinase cascade in A431 human squamous carcinoma cells. Oncogene 16, 2787-2796.
    • (1998) Oncogene , vol.16 , pp. 2787-2796
    • Carter, S.1    Auer, K.L.2    Birrer, M.3    Fisher, P.B.4    Scmidtt-Ullrich, R.5    Valerie, K.6    Mikkelsen, R.7    Dent, P.8
  • 11
    • 0030815108 scopus 로고    scopus 로고
    • Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor cell killing by ionizing radiation
    • Chmura, S.J., Mauceri, H.J., Advani, S., Heimann, R., Nodzenski, E., Quintans, J., Kufe, D.W., and Weichselbaum, R.R. (1997). Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor cell killing by ionizing radiation. Cancer Res. 57, 4340-4347.
    • (1997) Cancer Res. , vol.57 , pp. 4340-4347
    • Chmura, S.J.1    Mauceri, H.J.2    Advani, S.3    Heimann, R.4    Nodzenski, E.5    Quintans, J.6    Kufe, D.W.7    Weichselbaum, R.R.8
  • 13
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P. (1995). Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 14
    • 0032479289 scopus 로고    scopus 로고
    • Involvement of Ras in Bruton's tyrosine kinase-mediated JNK activation
    • Deng, J., Kawakami, Y., Hartman, S.E., Satoh, T., and Kawakami, T. (1998). Involvement of Ras in Bruton's tyrosine kinase-mediated JNK activation. J. Biol. Chem. 273, 16787-16791.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16787-16791
    • Deng, J.1    Kawakami, Y.2    Hartman, S.E.3    Satoh, T.4    Kawakami, T.5
  • 15
    • 0031759748 scopus 로고    scopus 로고
    • The roles of signaling by the p42/44 mitogen-activated protein (MAP) kinase pathway: A potential route to radio- and chemosensitization of tumor cells
    • Dent, P., Jarvis, W.D., Birrer, M.J., Fisher, P.B., Schmidt-Ullrich, R.K., and Grant, S. (1998). The roles of signaling by the p42/44 mitogen-activated protein (MAP) kinase pathway: a potential route to radio- and chemosensitization of tumor cells. Leukemia 12, 1843-1850.
    • (1998) Leukemia , vol.12 , pp. 1843-1850
    • Dent, P.1    Jarvis, W.D.2    Birrer, M.J.3    Fisher, P.B.4    Schmidt-Ullrich, R.K.5    Grant, S.6
  • 16
    • 14444279192 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of mitogen-activated protein kinase kinase
    • Favata, M.F., et al. (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273, 18623-18632.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18623-18632
    • Favata, M.F.1
  • 17
    • 0024796870 scopus 로고
    • Modulation of transforming growth factor α-dependent expression of epidermal growth factor receptor gene by transforming growth factor β, triiodothyronine, and retinoic acid
    • Fernandez-Pol, J.A., Klos, D.J., and Hamilton, P.D. (1989). Modulation of transforming growth factor α-dependent expression of epidermal growth factor receptor gene by transforming growth factor β, triiodothyronine, and retinoic acid. J. Cell. Biochem. 41, 159-170.
    • (1989) J. Cell. Biochem. , vol.41 , pp. 159-170
    • Fernandez-Pol, J.A.1    Klos, D.J.2    Hamilton, P.D.3
  • 18
    • 0032575091 scopus 로고    scopus 로고
    • Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells
    • Fiddes, R.J., Janes, P.W., Sivertsen, S.P., Sutherland, R.L., Musgrove, E.A., and Daly, R.J. (1998). Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells. Oncogene 16, 2803-2813.
    • (1998) Oncogene , vol.16 , pp. 2803-2813
    • Fiddes, R.J.1    Janes, P.W.2    Sivertsen, S.P.3    Sutherland, R.L.4    Musgrove, E.A.5    Daly, R.J.6
  • 19
    • 0029892754 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase
    • Gardner, A.M., and Johnson, G.L. (1996). Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. J. Biol. Chem. 271, 14560-14566.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14560-14566
    • Gardner, A.M.1    Johnson, G.L.2
  • 20
    • 0032581532 scopus 로고    scopus 로고
    • Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation
    • Giani, C., Casalini, P., Pupa, S.M., De Vecchi, R., Ardini, E., Colnaghi, M.I., Giordano, A., and Menard, S. (1998). Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation. Oncogene 30, 425-432.
    • (1998) Oncogene , vol.30 , pp. 425-432
    • Giani, C.1    Casalini, P.2    Pupa, S.M.3    De Vecchi, R.4    Ardini, E.5    Colnaghi, M.I.6    Giordano, A.M.S.7
  • 21
    • 0031450606 scopus 로고    scopus 로고
    • Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: Implication for gene therapy of radioresistant cancer
    • Gokhale, P.C., Soldatenkov, V., Wang, F.H., Rahman, A., Dritschilo, A., and Kasid, U. (1997). Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: implication for gene therapy of radioresistant cancer. Gene Ther. 12, 1289-1299.
    • (1997) Gene Ther. , vol.12 , pp. 1289-1299
    • Gokhale, P.C.1    Soldatenkov, V.2    Wang, F.H.3    Rahman, A.4    Dritschilo, A.5    Kasid, U.6
  • 22
  • 23
    • 0031742150 scopus 로고    scopus 로고
    • Radiation-induced signal transduction and stress response
    • Haimovitz-Friedman, A. (1998). Radiation-induced signal transduction and stress response. Radiat. Res. 150, S102-S108.
    • (1998) Radiat. Res. , vol.150
    • Haimovitz-Friedman, A.1
  • 24
    • 0029993503 scopus 로고    scopus 로고
    • UV activates growth factor receptors via reactive oxygen intermediates
    • Huang, R.P., Wu, J.X., Fan, Y., and Adamson, E.D. (1996). UV activates growth factor receptors via reactive oxygen intermediates. J. Cell Biol. 133, 211-220.
    • (1996) J. Cell Biol. , vol.133 , pp. 211-220
    • Huang, R.P.1    Wu, J.X.2    Fan, Y.3    Adamson, E.D.4
  • 25
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous carcinomas of the head and neck
    • Huang, S.M., Bock, J.M., and Harari, P.M. (1999). Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous carcinomas of the head and neck. Cancer Res. 59, 1935-1940.
    • (1999) Cancer Res. , vol.59 , pp. 1935-1940
    • Huang, S.M.1    Bock, J.M.2    Harari, P.M.3
  • 26
    • 0030013561 scopus 로고    scopus 로고
    • Growth inhibitory concentrations of EGF induce p21 (WAF1/Cip1) and alter cell cycle control in squamous carcinoma cells
    • Jakus, J., and Yeudall, W.A. Growth inhibitory concentrations of EGF induce p21 (WAF1/Cip1) and alter cell cycle control in squamous carcinoma cells. Oncogene 12, 2369-2376.
    • Oncogene , vol.12 , pp. 2369-2376
    • Jakus, J.1    Yeudall, W.A.2
  • 27
    • 85031514302 scopus 로고    scopus 로고
    • Membrane recruitment followed by tyrosine phosphorylation and activation of Raf-1 kinase marks the ionizing radiation-responsive signaling pathway
    • Kasid, U., Suy, S., Dent, P., Whiteside, T., and Sturgill, T.W. (1996). Membrane recruitment followed by tyrosine phosphorylation and activation of Raf-1 kinase marks the ionizing radiation-responsive signaling pathway. Nature 382, 316-318.
    • (1996) Nature , vol.382 , pp. 316-318
    • Kasid, U.1    Suy, S.2    Dent, P.3    Whiteside, T.4    Sturgill, T.W.5
  • 28
    • 0031806483 scopus 로고    scopus 로고
    • Ca 2+-dependent stimulation of mitogen activated protein kinase activity in A431 cells by low dose ionizing radiation
    • Kavanagh, B.D., Dent, P., Schmidt-Ullrich, R.K., Chen, P., and Mikkelsen, R.B. (1998). Ca 2+-dependent stimulation of mitogen activated protein kinase activity in A431 cells by low dose ionizing radiation. Radiat. Res. 149, 579-587.
    • (1998) Radiat. Res. , vol.149 , pp. 579-587
    • Kavanagh, B.D.1    Dent, P.2    Schmidt-Ullrich, R.K.3    Chen, P.4    Mikkelsen, R.B.5
  • 29
    • 0031779534 scopus 로고    scopus 로고
    • The estrogen-like effect of 4-hydroxytamoxifen on induction of transfroming growth factor α mRNA in MDA-MB-231 breast cancer cells stably expressing the estrogen receptor"
    • Levenson, A.S., Tonetti, D.A., and Jordan, V.C. (1998). The estrogen-like effect of 4-hydroxytamoxifen on induction of transfroming growth factor α mRNA in MDA-MB-231 breast cancer cells stably expressing the estrogen receptor" Br. J. Cancer 77, 1812-1819.
    • (1998) Br. J. Cancer , vol.77 , pp. 1812-1819
    • Levenson, A.S.1    Tonetti, D.A.2    Jordan, V.C.3
  • 31
    • 0031054990 scopus 로고    scopus 로고
    • Epidermal growth factor receptor family and chemosensitization
    • Mendelson, J., and Fan, Z. (1997). Epidermal growth factor receptor family and chemosensitization. J. Natl. Cancer Inst. 89, 341-343.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 341-343
    • Mendelson, J.1    Fan, Z.2
  • 33
    • 0031746850 scopus 로고    scopus 로고
    • Correlation of epidermal growth factor receptor and radiosensitivity in human maxillary carcinoma cell lines
    • Miyaguchi, M., Takeuchi, T., Morimoto, K., and Kubo, T. (1998). Correlation of epidermal growth factor receptor and radiosensitivity in human maxillary carcinoma cell lines. Acta Otolaryngol. 118, 428-431.
    • (1998) Acta Otolaryngol. , vol.118 , pp. 428-431
    • Miyaguchi, M.1    Takeuchi, T.2    Morimoto, K.3    Kubo, T.4
  • 34
    • 0030298455 scopus 로고    scopus 로고
    • Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumor cells
    • Nutt, J.E., and Lunec, J. (1996). Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumor cells. Eur. J. Cancer 32, 2127-2135.
    • (1996) Eur. J. Cancer , vol.32 , pp. 2127-2135
    • Nutt, J.E.1    Lunec, J.2
  • 35
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized antip185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram, M.D., et al. (1998). Phase II study of receptor-enhanced chemosensitivity using recombinant humanized antip185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J. Clin. Oncol. 16, 2659-2671.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2659-2671
    • Pegram, M.D.1
  • 36
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by rumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid rumors
    • Petit, A.M., Rak, J., Hung, M.C., Rockwell, P., Goldstein, N., Fendly, B., and Kerbel, R.S. (1997). Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by rumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid rumors. Am. J. Pathol. 151, 1523-1530.
    • (1997) Am. J. Pathol. , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3    Rockwell, P.4    Goldstein, N.5    Fendly, B.6    Kerbel, R.S.7
  • 37
    • 0031035485 scopus 로고    scopus 로고
    • UVC activation of the HeLa cell membrane "TGF α-ase," a metalloenzyme
    • Piva, T.J., Krause, D.R., and Ellem, K.O. (1997). UVC activation of the HeLa cell membrane "TGF α-ase," a metalloenzyme. J. Cell. Biochem. 64, 353-368.
    • (1997) J. Cell. Biochem. , vol.64 , pp. 353-368
    • Piva, T.J.1    Krause, D.R.2    Ellem, K.O.3
  • 38
    • 0033584391 scopus 로고    scopus 로고
    • Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells
    • in press
    • Reardon, D.B., Contessa, J.N., Mikkelsen, R.B., Valerie, K., Amir, C., Dent, P., and Schmidt-Ullrich, R.K. (1999). Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. Oncogene (in press).
    • (1999) Oncogene
    • Reardon, D.B.1    Contessa, J.N.2    Mikkelsen, R.B.3    Valerie, K.4    Amir, C.5    Dent, P.6    Schmidt-Ullrich, R.K.7
  • 39
    • 0032506781 scopus 로고    scopus 로고
    • Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation
    • Reed, M.F., Liu, V.F., Ladha, M.H., Ando, K., Griffin, J.D., Weaver, D.T., and Ewen, M.E. (1998). Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation. Oncogene 17, 2961-2971.
    • (1998) Oncogene , vol.17 , pp. 2961-2971
    • Reed, M.F.1    Liu, V.F.2    Ladha, M.H.3    Ando, K.4    Griffin, J.D.5    Weaver, D.T.6    Ewen, M.E.7
  • 40
    • 0029860936 scopus 로고    scopus 로고
    • UV light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
    • Rosette, C., and Karin, M. (1996). UV light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194-1197.
    • (1996) Science , vol.274 , pp. 1194-1197
    • Rosette, C.1    Karin, M.2
  • 43
    • 0026529225 scopus 로고
    • Expression of oestrogen receptor and transforming growth factor-α in MCF-7 cells after exposure to fractionated irradiation
    • Schmidt-Ullrich, R.K., Valerie, K., Chan, W., Wazer, D.E., and Lin, P.S. (1992). Expression of oestrogen receptor and transforming growth factor-α in MCF-7 cells after exposure to fractionated irradiation. Int. J. Radiat. Biol. 61, 405-415.
    • (1992) Int. J. Radiat. Biol. , vol.61 , pp. 405-415
    • Schmidt-Ullrich, R.K.1    Valerie, K.2    Chan, W.3    Wazer, D.E.4    Lin, P.S.5
  • 44
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
    • Sewing, A., Wiseman, B., Lloyd, A.C., and Land, H. (1997). High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol. Cell. Biol. 17, 5588-5597.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 45
    • 0032548030 scopus 로고    scopus 로고
    • Uv-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1
    • Sheikh, M.S., Antimore, M.J., Huang, Y., and Fornace, A. (1998). UV-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1 Oncogene 17, 2555-2563.
    • (1998) Oncogene , vol.17 , pp. 2555-2563
    • Sheikh, M.S.1    Antimore, M.J.2    Huang, Y.3    Fornace, A.4
  • 46
    • 0031788046 scopus 로고    scopus 로고
    • Differential dose-dependent effects of epidermal growth factor on gene expression in A431 cells: Evidence for a signal transduction pathway that can bypass Raf-1 activation
    • Silvy, M., Martin, P.M., Chajry, N., and Berthois, Y. (1998). Differential dose-dependent effects of epidermal growth factor on gene expression in A431 cells: evidence for a signal transduction pathway that can bypass Raf-1 activation. Endocrinology 139, 2382-2391.
    • (1998) Endocrinology , vol.139 , pp. 2382-2391
    • Silvy, M.1    Martin, P.M.2    Chajry, N.3    Berthois, Y.4
  • 47
    • 0030849058 scopus 로고    scopus 로고
    • Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells
    • Suy, S., Anderson, W.B., Dent, P., Chang, E., and Kasid, U. (1997). Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells. Oncogene 15, 53-61.
    • (1997) Oncogene , vol.15 , pp. 53-61
    • Suy, S.1    Anderson, W.B.2    Dent, P.3    Chang, E.4    Kasid, U.5
  • 48
    • 0032521642 scopus 로고    scopus 로고
    • The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
    • Tombes, R., Auer, K.L., Brenz-Verca, S., Marshall, C.J., McMahon, M., Mikkelsen, R.S., Valerie, K., Wymann, M.P., and Dent, P. (1998). The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem. J. 330, 1451-1460.
    • (1998) Biochem. J. , vol.330 , pp. 1451-1460
    • Tombes, R.1    Auer, K.L.2    Brenz-Verca, S.3    Marshall, C.J.4    McMahon, M.5    Mikkelsen, R.S.6    Valerie, K.7    Wymann, M.P.8    Dent, P.9
  • 49
    • 0032544570 scopus 로고    scopus 로고
    • Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced p21 (WAF1/Cip1) expression and growth inhibition of A431 cells
    • Toyoda, M., Gotoh, N., Handa, H., and Shibuya, M. (1998). Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced p21 (WAF1/Cip1) expression and growth inhibition of A431 cells. Biochem. Biophys. Res. Commun. 250, 430-435.
    • (1998) Biochem. Biophys. Res. Commun. , vol.250 , pp. 430-435
    • Toyoda, M.1    Gotoh, N.2    Handa, H.3    Shibuya, M.4
  • 51
    • 0028870645 scopus 로고
    • Host-cell reactivation of reporter genes introduced into cells by adenovirus as a convenient way to measure cellular DNA repair
    • Valerie, K., and Singhal, A. (1995). Host-cell reactivation of reporter genes introduced into cells by adenovirus as a convenient way to measure cellular DNA repair. Mutat. Res. 336, 91-100.
    • (1995) Mutat. Res. , vol.336 , pp. 91-100
    • Valerie, K.1    Singhal, A.2
  • 52
    • 0028148409 scopus 로고
    • Evidence for a growth effect of epidermal growth factor on MDA-MB-231 breast cancer cells
    • Veber, N., Prevost, G., Planchon, P., and Starzec, A. (1994). Evidence for a growth effect of epidermal growth factor on MDA-MB-231 breast cancer cells. Eur. J. Cancer 30, 1352-1359.
    • (1994) Eur. J. Cancer , vol.30 , pp. 1352-1359
    • Veber, N.1    Prevost, G.2    Planchon, P.3    Starzec, A.4
  • 53
    • 0032780627 scopus 로고    scopus 로고
    • Inhibition of the MAPK pathway abrogates Bcl-2-mediated leukemic cell survival after exposure of HL60 cells to low dose ionizing radiation
    • Vrana, J., Grant, S., and Dent, P. (1999). Inhibition of the MAPK pathway abrogates Bcl-2-mediated leukemic cell survival after exposure of HL60 cells to low dose ionizing radiation. Radiat. Res. 151, 559-569.
    • (1999) Radiat. Res. , vol.151 , pp. 559-569
    • Vrana, J.1    Grant, S.2    Dent, P.3
  • 54
    • 0031474756 scopus 로고    scopus 로고
    • Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
    • Wang, Y.A., Elson, A., and Leder, P. (1997). Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. USA 94, 14590-14595.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14590-14595
    • Wang, Y.A.1    Elson, A.2    Leder, P.3
  • 55
    • 0029661835 scopus 로고    scopus 로고
    • Exit from G2 phase after 2 Gy gamma irradiation is faster in radiosensitive human cells with high expression of the RAF1 proto-oncogene
    • Warenius, H.M., Jones, M.D., and Thompson, C.C. (1996). Exit from G2 phase after 2 Gy gamma irradiation is faster in radiosensitive human cells with high expression of the RAF1 proto-oncogene. Radiat. Res. 146, 485-493.
    • (1996) Radiat. Res. , vol.146 , pp. 485-493
    • Warenius, H.M.1    Jones, M.D.2    Thompson, C.C.3
  • 56
    • 0030883584 scopus 로고    scopus 로고
    • Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase
    • Weber, J.D., Raben, D.M., Phillips, P.J., and Baldassare, J.J. (1997). Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem. J. 326, 61-68.
    • (1997) Biochem. J. , vol.326 , pp. 61-68
    • Weber, J.D.1    Raben, D.M.2    Phillips, P.J.3    Baldassare, J.J.4
  • 57
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
    • Woods, D., Parry, D., Cherwinski, H., Bosch, E., Lees, E., and McMahon, M. (1997). Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell. Biol. 17, 5598-5611.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 58
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J., and Greenberg, M.E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 59
    • 0031806910 scopus 로고    scopus 로고
    • Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/-mice
    • Xu, Y., Yang, E.M., Brugarolas, J., Jacks, T., and Baltimore, D. (1998). Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/-mice. Mol. Cell. Biol. 18, 4385-4390.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4385-4390
    • Xu, Y.1    Yang, E.M.2    Brugarolas, J.3    Jacks, T.4    Baltimore, D.5


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