Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis

Clinical Cancer Research

Volumn 6, Issue 6, 2000, Pages 2166-2174

  Huang, Shyh Min ^a   Harari, Paul M ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; CETUXIMAB; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; PROTEIN KINASE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL CYCLE; CONTROLLED STUDY; DNA REPAIR; FEMALE; FLOW CYTOMETRY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; TUMOR REGRESSION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL NUCLEUS; CYTOSOL; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENDOTHELIAL GROWTH FACTORS; FACTOR VIII; FEMALE; FLOW CYTOMETRY; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KINETICS; LYMPHOKINES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS; TIME FACTORS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034084314     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Ang, K. K., Thames, H. D., and Peters, L. J. Altered fractionation schedules. In: C. A. Perez and L. W. Brady (eds.), Principles and Practice of Radiation Oncology, pp. 119-142. Philadelphia: Lippincott-Raven, 1997.
2. Harari, P. M., and Kinsella, T. J. Advances in radiation therapy for head and neck cancer. Curr. Opin. Oncol., 7: 248-254, 1995.
3. Adelstein, D. J. Recent randomized trials of chemoradiation in the management of locally advanced head and neck cancer. Curr. Opin. Oncol., 10: 213-218, 1998.
4. Fan, Z., and Mendelsohn, J. Therapeutic application of anti-growth factor receptor antibodies. Curr. Opin. Oncol., 10: 67-73, 1998.
5. Huang, S. M., and Harari, P. M. Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results. Invest. New Drugs., 17: 259-269, 1999.
6. Huang, S. M., Bock, J. M., and Harari, P. M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res., 59: 1935-1940, 1999.
7. Baselga, J., Norton, L., Masui, H., Pandiella, A., Coplan, K., Miller, W., Jr., and Mendelsohn, J. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J. Natl. Cancer Inst., 85: 1327-1333, 1993.
8. Fan, Z., Baselga, J., Masui, H., and Mendelsohn, J. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res., 53: 4637-4642, 1993.
9. Ciardiello, F., R., B., Damiano, V., De Lorenzo, S., Pepe, S., de Placido, S., Fan, Z., Mendelsohn, J., Bianco, A. R., and Tortora, G. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin. Cancer Res., 5: 909-916, 1999.
10. KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res., 56; 3666-3669, 1996.
11. Bandyopadhyay, D., Mandal, M., Adam, L., Mendelsohn, J., and Kumar, R. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J. Biol. Chem., 273: 1568-1573, 1998.
12. Perrotte, P., Matsumoto, T., Inoue, K., Kuniyasu, H., Eve, B. Y., Hicklin, D. J., Radinsky, R., and Dinney, C. P. N. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin. Cancer Res., 5: 257-264, 1999.
13. Jackson, S. P., and Jeggo, P. A. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem. Sci., 20: 412-415, 1995.
14. Finnie, N. J., Gottlieb, T. M., Blunt, T., Jeggo, P. A., and Jackson, S. P. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA., 92: 320-324, 1995.
15. Akimoto, T., Hunter, N. R., Buchmiller, L., Mason, K., Ang, K. K., and Milas, L. Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clin. Cancer Res., 5; 2884-2890, 1999.
16. Hall, E. J., Marchese, M., Hei, T. K., and Zaider, M. Radiation response characteristics of human cells in vitro. Radiat. Res., 114: 415-424, 1988.
17. Haimovitz-Friedman, A., Vlodavsky, I., Chaudhuri, A., Witte, L., and Fuks. Z. Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells. Cancer Res., 51: 2552-2558, 1991.
18. Jayanth, V. R., Belfi, C. A., Swick, A. R., and Varnes, M. E. Insulin and insulin-like growth factor-1 (IGF-1) inhibit repair of potentially lethal radiation damage and chromosome aberrations and alter DNA repair kinetics in plateau-phase A549 cells. Radiat. Res., 143: 165-174, 1995.
19. Pietras, R. J., Poen, J. C., Gallardo, D., Wongvipat, P. N., Lee, H. J., and Slamon, D. J. Monoclonal antibody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res., 59: 1347-1355, 1999.
20. Frankenberg-Schwager, M., Jha, B., Bar, K., and Frankenberg, D. Molecular mechanism of potentially lethal damage repair. J. Enhanced fidelity of DNA double-strand break rejoining under conditions allowing potentially lethal damage repair. Int. J. Radiat. Biol., 67: 277-285, 1995.
21. Li, L. Y., Nakajima, H., and Nomura, T. Dose rate effectiveness and potentially lethal damage repair in normal and double-strand break repair deficient murine cells by γ-rays and 5-fluorouracil. Cancer Lett., 123: 227-232, 1998.
22. Allalunis-Turner, M. J., Zia, P. K., Barron, G. M., Mirzayans, R., and Day, R. S. Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line. Radiat. Res., 144: 288-293, 1995.
23. Lichter, A. S., and Lawrence, T. S. Recent advances in radiation oncology. N. Eng. J. Med., 332: 371-379, 1995.
24. Coleman, C. N., and Stevenson, M. A. Biologic basis for radiation oncology. Oncology, 10: 399-411, 1996.
25. Jung, M., and Dritschilo, A. Signal transduction and cellular responses to ionizing radiation. Semin. Radiat. Oncol., 6: 268-272, 1996.
26. Iliakis, G. Cell cycle regulation in irradiated and nonirradiated cells. Semin. Oncol., 24: 602-615, 1997.
27. 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene, 12: 1397-1403, 1996.
28. Mauceri, H. J., Hanna, N. N., Beckett, M. A., Gorski, D. H., Staba, M. J., Stellato, K. A., Bigelow, K., Heimann, R., Gately, S., Dhanabal, M., Soff, G. A., Sukhatme, V. P., Kufe, D. W., and Weichselbaum, R. R. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature (Lond.), 394: 287-291, 1998.
29. Petit, A. M., Rak, J., Hung, M. C., Rockwell, P., Goldstein, N., Fendly, B., and Kerbel, R. S. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am. J. Pathol., 151: 1523-1530, 1997.
30. Radinsky, R., Risin, S., Fan, D., Dong, Z., Bielenberg, D., Bucana, C. D., and Fidler, I. J. Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clin. Cancer Res., 1: 19-31, 1995.