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Volumn 63, Issue 13, 2003, Pages 3755-3763

SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SEMAXANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 0038756364     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (152)

References (30)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., and Jain, R. K. Angiogenesis in cancer and other diseases. Nature (Lond.), 407: 249-257, 2000.
    • (2000) Nature (Lond.) , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 2
    • 0034303726 scopus 로고    scopus 로고
    • Cancer: Looking outside the genome
    • Folkman, J., Hahnfeldt, P., and Hlatky, L. Cancer: looking outside the genome. Nat. Rev., 1: 76-79, 2000.
    • (2000) Nat. Rev. , vol.1 , pp. 76-79
    • Folkman, J.1    Hahnfeldt, P.2    Hlatky, L.3
  • 4
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong, T. A. T., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., Kim, Y. H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, K. P., and McMahon, G. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res., 59: 99-106, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.T.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13
  • 6
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2antibody induces sustained tumor regression without overt toxicity
    • Klement, G., Baruchel, S., Rak, J., Man, S., Clark, K., Hicklin, D. J., Bohlen, P., and Kerbel, R. S. Continuous low-dose therapy with vinblastine and VEGF receptor-2antibody induces sustained tumor regression without overt toxicity. J. Clin. Investig., 105: R15-R24, 2000.
    • (2000) J. Clin. Investig. , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 7
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder, T., Butterfield, C. E., Kraling, B. M., Shi, B., Marshall, B., O'Reilly, M. S., and Folkman, J. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res., 60: 1878-1886, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3    Shi, B.4    Marshall, B.5    O'Reilly, M.S.6    Folkman, J.7
  • 8
    • 0037458325 scopus 로고    scopus 로고
    • Minimizing long-term tumor burden: The logic for metronomic chemotherapeutic dosing and its antiangiogenic basis
    • Hahnfeldt, P., Folkman, J., and Hlatky, L. Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis. J. Theor. Biol., 220: 545-554, 2003.
    • (2003) J. Theor. Biol. , vol.220 , pp. 545-554
    • Hahnfeldt, P.1    Folkman, J.2    Hlatky, L.3
  • 10
    • 0031821938 scopus 로고    scopus 로고
    • In vivo radioprotective effects of angiogenic growth factors on the small bowel of C3H mice
    • Okunieff, P., Mester, M., Wang, J., Maddox, T., Gong, X., Tang, D., Coffee, M., and Ding, I. In vivo radioprotective effects of angiogenic growth factors on the small bowel of C3H mice. Radiat Res., 150: 204-211, 1998.
    • (1998) Radiat Res. , vol.150 , pp. 204-211
    • Okunieff, P.1    Mester, M.2    Wang, J.3    Maddox, T.4    Gong, X.5    Tang, D.6    Coffee, M.7    Ding, I.8
  • 13
    • 0035854505 scopus 로고    scopus 로고
    • Cancer. What does radiotherapy do to endothelial cells?
    • Folkman, J., and Camphausen, K. Cancer. What does radiotherapy do to endothelial cells? Science, 293: 227-228, 2001.
    • (2001) Science , vol.293 , pp. 227-228
    • Folkman, J.1    Camphausen, K.2
  • 14
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J., 13: 9-22, 1999.
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 15
    • 0344578062 scopus 로고    scopus 로고
    • Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis
    • Valter, M., Hugel, A., Huang, S., Cavenee, W., Wiestler, O., Pietsch, T., and Wernert, N. Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. Cancer Res., 59: 5608-5614, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 5608-5614
    • Valter, M.1    Hugel, A.2    Huang, S.3    Cavenee, W.4    Wiestler, O.5    Pietsch, T.6    Wernert, N.7
  • 16
    • 0342545909 scopus 로고    scopus 로고
    • Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency
    • Pena, L. A., Fuks, Z., and Kolesnick, R. N. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res., 60: 321-327, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 321-327
    • Pena, L.A.1    Fuks, Z.2    Kolesnick, R.N.3
  • 19
    • 0035132923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
    • Kozin, S. V., Boucher, Y., Hicklin, D. J., Bohlen, P., Jain, R. K., and Suit, H. D. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res., 61: 39-44. 2001.
    • (2001) Cancer Res. , vol.61 , pp. 39-44
    • Kozin, S.V.1    Boucher, Y.2    Hicklin, D.J.3    Bohlen, P.4    Jain, R.K.5    Suit, H.D.6
  • 20
    • 0035866771 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy
    • Geng, L., Donnelly, E., McMahon, G., Lin, P. C., Sierra-Rivera, E., Oshinka, H., and Hallahan, D. E. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res, 61: 2413-2419, 2001.
    • (2001) Cancer Res , vol.61 , pp. 2413-2419
    • Geng, L.1    Donnelly, E.2    McMahon, G.3    Lin, P.C.4    Sierra-Rivera, E.5    Oshinka, H.6    Hallahan, D.E.7
  • 21
    • 0035555907 scopus 로고    scopus 로고
    • Effect of VEGF receptor inhibitor PTK787/ZK22258 combined with ionizing radiation on endothelial cells and tumour growth
    • Hess, C., Vuong, V., Hegyi, I., Riesterer, O., Wood, J., Fabbro, D., Glanzmann, C., Bodis, S., and Pruschky, M. Effect of VEGF receptor inhibitor PTK787/ZK22258 combined with ionizing radiation on endothelial cells and tumour growth. Br. J. Cancer, 85: 2010-2016, 2001.
    • (2001) Br. J. Cancer , vol.85 , pp. 2010-2016
    • Hess, C.1    Vuong, V.2    Hegyi, I.3    Riesterer, O.4    Wood, J.5    Fabbro, D.6    Glanzmann, C.7    Bodis, S.8    Pruschky, M.9
  • 22
    • 0037516417 scopus 로고    scopus 로고
    • Phase I trial results of recombinant human angiostatin protein (rhA) and external beam radiation therapy (EBRT)
    • Abstract No.
    • Dicker. A. P., Anne, R., Bonanni, R., Sidor, C., Gubish, E., and Curran, W. J., Jr. Phase I trial results of recombinant human angiostatin protein (rhA) and external beam radiation therapy (EBRT). Am. Soc. Clin. Oncol., Abstract No. 23, 2002.
    • (2002) Am. Soc. Clin. Oncol. , pp. 23
    • Dicker, A.P.1    Anne, R.2    Bonanni, R.3    Sidor, C.4    Gubish, E.5    Curran W.J., Jr.6
  • 23
    • 0032953873 scopus 로고    scopus 로고
    • FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury
    • Houchen, C. W., George, R. J., Sturmoski, M. A., and Cohn, S. M. FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury. Am. J. Physiol., 276: G249-G258, 1999.
    • (1999) Am. J. Physiol. , vol.276
    • Houchen, C.W.1    George, R.J.2    Sturmoski, M.A.3    Cohn, S.M.4
  • 24
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidyl-inositol 3-kinase/Akt signal transduction pathway
    • Gerber, H. P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V., and Ferrara, N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidyl-inositol 3-kinase/Akt signal transduction pathway. J. Biol. Chem., 273: 30336-30343, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6    Ferrara, N.7
  • 25
    • 0031596142 scopus 로고    scopus 로고
    • Role of the β3 integrin subunit in human primary melanoma progression. Multifunctional activities associated with avb3 integrin expression
    • Seftor, R. E. B. Role of the β3 integrin subunit in human primary melanoma progression. Multifunctional activities associated with avb3 integrin expression. Am. J. Pathol., 153: 1347-1351, 1998.
    • (1998) Am. J. Pathol. , vol.153 , pp. 1347-1351
    • Seftor, R.E.B.1
  • 26
    • 0030875480 scopus 로고    scopus 로고
    • Apoptosis and mitotic cell death: Their relative contributions to normal tissue and tumour-radiation response
    • Hendry, J. H., and West, C. M. Apoptosis and mitotic cell death: their relative contributions to normal tissue and tumour-radiation response. Int. J. Radiat. Biol., 71: 709-719, 1997.
    • (1997) Int. J. Radiat. Biol. , vol.71 , pp. 709-719
    • Hendry, J.H.1    West, C.M.2
  • 27
    • 0034091587 scopus 로고    scopus 로고
    • Vascular protection: A novel, non-angiogenic cardiovascular role for vascular endothelial growth factor
    • Zachary, I., Mathur, A., Yla-Herttuala, S., and Martin, J. F. Vascular protection: a novel, non-angiogenic cardiovascular role for vascular endothelial growth factor. Arterioscler. Thromb. Vasc. Biol., 20: 1512-1520, 2000.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1512-1520
    • Zachary, I.1    Mathur, A.2    Yla-Herttuala, S.3    Martin, J.F.4
  • 28
    • 0035866813 scopus 로고    scopus 로고
    • Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma
    • Wild-Bode, C., Weller, M., Rimner, A., Dichgans, J., and Wick, W. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res., 61: 2744-2750, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 2744-2750
    • Wild-Bode, C.1    Weller, M.2    Rimner, A.3    Dichgans, J.4    Wick, W.5
  • 29
    • 0022363207 scopus 로고
    • Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves
    • Fertil, B., and Malaise, E. P. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves. Int. J. Radiat. Oncol. Biol. Phys., 11: 1699-1707, 1985.
    • (1985) Int. J. Radiat. Oncol. Biol. Phys. , vol.11 , pp. 1699-1707
    • Fertil, B.1    Malaise, E.P.2
  • 30
    • 0029889701 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Environmental controls and effects in angiogenesis
    • Hlatky, L., Hahnfeldt, P., Tsionou, C., and Coleman, C. N. Vascular endothelial growth factor: environmental controls and effects in angiogenesis. Br. J. Cancer, 74 (Suppl. XXVII): S151-S156, 1996.
    • (1996) Br. J. Cancer , vol.74 , Issue.SUPPL. XXVII
    • Hlatky, L.1    Hahnfeldt, P.2    Tsionou, C.3    Coleman, C.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.