Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33436-33446

  Wanka, Christina ^a   Steinbach, Joachim P ^a   Rieger, Johannes ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATOR; CELLULAR REDOX; CORE COMPONENTS; DEFENSE MECHANISM; ECTOPIC EXPRESSIONS; ENERGY YIELDS; GLIOBLASTOMA CELLS; GLIOBLASTOMAS; GLIOMA CELLS; METABOLIC ANALYSIS; MICROENVIRONMENTS; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; STARVATION CONDITIONS; TRANSKETOLASE; TUMOR CELLS; WILD TYPES;

GLUCOSE; METABOLISM; OXYGEN; PATHOLOGY; TUMORS;

CELL DEATH;

GLUCOSE; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; TRANSKETOLASE; TRANSKETOLASE LIKE 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL HYPOXIA; CELL SURVIVAL; CONTROLLED STUDY; ENERGY BALANCE; ENERGY YIELD; GENE; GLIOBLASTOMA; GLIOMA CELL; GLYCOLYSIS; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; P53 GENE; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; REGULATOR GENE; TP53 INDUCED GLYCOLYSIS AND APOPTOSIS REGULATOR GENE;

ANIMALS; ANOXIA; APOPTOSIS; BRAIN NEOPLASMS; CELL DEATH; CELL LINE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; GLYCOLYSIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE PATHWAY; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866910992     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.384578     Document Type: Article

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