Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

Radiotherapy and Oncology

Volumn 92, Issue 3, 2009, Pages 329-333

  Feron, Olivier ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Lactate; Metabolism; Warburg

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID; MITOCHONDRIAL DNA; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PYRUVATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

BIOMASS; BIOSYNTHESIS; CELL HYPOXIA; CELL METABOLISM; CITRIC ACID CYCLE; GLYCOLYSIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIZATION; REVIEW; TUMOR CELL;

CELL DEATH; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; ENERGY METABOLISM; GLYCOLYSIS; HUMANS; LACTIC ACID; NAD; NADP; NEOPLASMS; OXIDATION-REDUCTION; PYRUVIC ACID; RADIATION TOLERANCE; SENSITIVITY AND SPECIFICITY;

EID: 69949124867     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2009.06.025     Document Type: Review

References (37)

1. Warburg O. On respiratory impairment in cancer cells. Science 124 (1956) 269-270
2. Warburg O. On the origin of cancer cells. Science 123 (1956) 309-314
3. Cuezva J.M., Krajewska M., de Heredia M.L., et al. The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res 62 (2002) 6674-6681
4. Lopez-Rios F., Sanchez-Arago M., Garcia-Garcia E., et al. Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas. Cancer Res 67 (2007) 9013-9017
5. Brandon M., Baldi P., and Wallace D.C. Mitochondrial mutations in cancer. Oncogene 25 (2006) 4647-4662
6. Baysal B.E., Ferrell R.E., Willett-Brozick J.E., et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287 (2000) 848-851
7. Tomlinson I.P., Alam N.A., Rowan A.J., et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30 (2002) 406-410
8. Moreno-Sanchez R., Rodriguez-Enriquez S., Marin-Hernandez A., and Saavedra E. Energy metabolism in tumor cells. FEBS J 274 (2007) 1393-1418
9. Guppy M., Greiner E., and Brand K. The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes. Eur J Biochem 212 (1993) 95-99
10. Pfeiffer T., Schuster S., and Bonhoeffer S. Cooperation and competition in the evolution of ATP-producing pathways. Science 292 (2001) 504-507
11. Mazurek S., Boschek C.B., Hugo F., and Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15 (2005) 300-308
12. Christofk H.R., Vander Heiden M.G., Harris M.H., et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452 (2008) 230-233
13. Kim J.W., Tchernyshyov I., Semenza G.L., and Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3 (2006) 177-185
14. Papandreou I., Cairns R.A., Fontana L., Lim A.L., and Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3 (2006) 187-197
15. Shim H., Dolde C., Lewis B.C., et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci USA 94 (1997) 6658-6663
16. Fantin V.R., St-Pierre J., and Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9 (2006) 425-434
17. Christofk H.R., Vander Heiden M.G., Wu N., Asara J.M., and Cantley L.C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452 (2008) 181-186
18. Kovacevic Z., and McGivan J.D. Mitochondrial metabolism of glutamine and glutamate and its physiological significance. Physiol Rev 63 (1983) 547-605
19. DeBerardinis R.J., Mancuso A., Daikhin E., et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104 (2007) 19345-19350
20. Shaw R.J., and Cantley L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441 (2006) 424-430
21. Sansal I., and Sellers W.R. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 22 (2004) 2954-2963
22. Fingar D.C., and Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23 (2004) 3151-3171
23. Jiang B.H., Jiang G., Zheng J.Z., et al. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 12 (2001) 363-369
24. Martinive P., Defresne F., Quaghebeur E., et al. Impact of cyclic hypoxia on HIF-1alpha regulation in endothelial cells - new insights for anti-tumor treatments. FEBS J 276 (2009) 509-518
25. Gillies R.J., Robey I., and Gatenby R.A. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 49 (2008) 24S-42S
26. Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 4 (2004) 891-899
27. Crabtree H.G. The carbohydrate metabolism of certain pathological overgrowths. Biochem J 22 (1928) 1289-1298
28. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3 (2003) 721-732
29. Fukuda R., Zhang H., Kim J.W., et al. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129 (2007) 111-122
30. Li F., Wang Y., Zeller K.I., et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 25 (2005) 6225-6234
31. O'Connell B.C., Cheung A.F., Simkevich C.P., et al. A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem 278 (2003) 12563-12573
32. Yuneva M., Zamboni N., Oefner P., Sachidanandam R., and Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 178 (2007) 93-105
33. Wise D.R., DeBerardinis R.J., Mancuso A., et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 105 (2008) 18782-18787
34. Gao P., Tchernyshyov I., Chang T.C., et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458 (2009) 762-765
35. Guppy M., Leedman P., Zu X., and Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J 364 (2002) 309-315
36. Sonveaux P., Vegran F., Schroeder T., et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118 (2008) 3930-3942
37. Bonen A. The expression of lactate transporters (MCT1 and MCT4) in heart and muscle. Eur J Appl Physiol 86 (2001) 6-11