Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy) 2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38 MAPK/p53 signalling axis: Evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

Biochemical Journal

Volumn 437, Issue 3, 2011, Pages 443-453

  Filomeni, Giuseppe ^a   Cardaci, Simone ^a   Da Costa Ferreira, Ana Maria ^b   Rotilio, Giuseppe ^a,c   Ciriolo, Maria Rosa ^a,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

3 Bromopyruvate; AMP activated protein kinase (AMPK); Delocalized lipophilic cation; Neuroblastoma; p38 mitogen activated protein kinase (p38 MAPK); p53

Indexed keywords

BROMOPYRUVIC ACID; COPPER COMPLEX; GLUCOSE; ISATIN DI IMINE COPPER COMPLEX; MITOGEN ACTIVATED PROTEIN KINASE P38; PRASTERONE; PROTEIN P53; PYRUVIC ACID DERIVATIVE; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; GLYCOLYSIS; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; MICE; MOLECULAR STRUCTURE; NEUROBLASTOMA; NEURONS; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRUVATES; SCHIFF BASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79960263592     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110510     Document Type: Article

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