메뉴 건너뛰기




Volumn 43, Issue 5, 2011, Pages 255-264

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines

Author keywords

Glycolysis; Lactate de hydrogenase; Monocarboxylate transporters; Warburg effect

Indexed keywords

LACTATE DEHYDROGENASE; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1;

EID: 79955725303     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00177.2010     Document Type: Article
Times cited : (138)

References (59)
  • 2
    • 0015172953 scopus 로고
    • Histochemistry of lactic dehydrogenase in heart and pectoralis muscles of rat
    • Baba N, Sharma HM. Histochemistry of lactic dehydrogenase in heart and pectoralis muscles of rat. J Cell Biol 51: 621-635, 1971.
    • (1971) J Cell Biol , vol.51 , pp. 621-635
    • Baba, N.1    Sharma, H.M.2
  • 3
    • 77953608893 scopus 로고    scopus 로고
    • Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes.Barking up the right tree?
    • Bayley JP, Devilee P. Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree? Curr Opin Genet Dev 20: 324-329, 2010.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 324-329
    • Bayley, J.P.1    Devilee, P.2
  • 6
    • 72649092649 scopus 로고    scopus 로고
    • Glutathione peroxidases in different stages of carcinogenesis
    • Brigelius-Flohe R, Kipp A. Glutathione peroxidases in different stages of carcinogenesis. Biochim Biophys Acta 1790: 1555-1568, 2009.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 1555-1568
    • Brigelius-Flohe, R.1    Kipp, A.2
  • 7
    • 71249103087 scopus 로고    scopus 로고
    • Cell-cell and intracellular lactate shuttles
    • Brooks GA. Cell-cell and intracellular lactate shuttles. J Physiol 587: 5591-5600, 2009.
    • (2009) J Physiol , vol.587 , pp. 5591-5600
    • Brooks, G.A.1
  • 8
    • 0033997483 scopus 로고    scopus 로고
    • Intra- and extra-cellular lactate shuttles
    • Brooks GA. Intra- and extra-cellular lactate shuttles. Med Sci Sports Exerc 32: 790-799, 2000.
    • (2000) Med Sci Sports Exerc , vol.32 , pp. 790-799
    • Brooks, G.A.1
  • 9
    • 0036545332 scopus 로고    scopus 로고
    • Lactate shuttles in nature
    • Brooks GA. Lactate shuttles in nature. Biochem Soc Trans 30: 258-264, 2002.
    • (2002) Biochem Soc Trans , vol.30 , pp. 258-264
    • Brooks, G.A.1
  • 10
    • 0033514475 scopus 로고    scopus 로고
    • Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle
    • Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE. Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc Natl Acad Sci USA 96: 1129-1134, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1129-1134
    • Brooks, G.A.1    Dubouchaud, H.2    Brown, M.3    Sicurello, J.P.4    Butz, C.E.5
  • 11
    • 0021964203 scopus 로고
    • Prooxidant States tumor Promotion
    • Cerutti PA. Prooxidant states and tumor promotion. Science 227: 375-381, 1985.
    • (1985) Science , vol.227 , pp. 375-381
    • Cerutti, P.A.1
  • 13
    • 77952954872 scopus 로고    scopus 로고
    • L-lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative L-lactate oxidase localized in the intermembrane space
    • de Bari L, Valenti D, Atlante A, Passarella S. L-lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative L-lactate oxidase localized in the intermembrane space. FEBS Lett 584: 2285-2290, 2010.
    • (2010) FEBS Lett , vol.584 , pp. 2285-2290
    • de Bari, L.1    Valenti, D.2    Atlante, A.3    Passarella, S.4
  • 14
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104: 19345-19350, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 17
    • 69949124867 scopus 로고    scopus 로고
    • Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
    • Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 92: 329-333, 2009.
    • (2009) Radiother Oncol , vol.92 , pp. 329-333
    • Feron, O.1
  • 18
    • 75749136883 scopus 로고    scopus 로고
    • Signaling functions of reactive oxygen species
    • Forman HJ, Maiorino M, Ursini F. Signaling functions of reactive oxygen species. Biochemistry 49: 835-842, 2010.
    • (2010) Biochemistry , vol.49 , pp. 835-842
    • Forman, H.J.1    Maiorino, M.2    Ursini, F.3
  • 19
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 61: 6020-6024, 2001.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 20
    • 34249293335 scopus 로고    scopus 로고
    • Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231
    • Gallagher SM, Castorino JJ, Wang D, Philp NJ. Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 67: 4182-4189, 2007.
    • (2007) Cancer Res , vol.67 , pp. 4182-4189
    • Gallagher, S.M.1    Castorino, J.J.2    Wang, D.3    Philp, N.J.4
  • 21
    • 70350223685 scopus 로고    scopus 로고
    • Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells
    • Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, Feiler HS, Wyrobek AJ, Stampfer MR. Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res 69: 7557-7568, 2009.
    • (2009) Cancer Res , vol.69 , pp. 7557-7568
    • Garbe, J.C.1    Bhattacharya, S.2    Merchant, B.3    Bassett, E.4    Swisshelm, K.5    Feiler, H.S.6    Wyrobek, A.J.7    Stampfer, M.R.8
  • 22
    • 0028294023 scopus 로고
    • Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle
    • Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 76: 865-873, 1994.
    • (1994) Cell , vol.76 , pp. 865-873
    • Garcia, C.K.1    Goldstein, J.L.2    Pathak, R.K.3    Anderson, R.G.4    Brown, M.S.5
  • 23
    • 0000831018 scopus 로고
    • L-(+)-lactate determination with lactate dehydrogenase and NAD
    • Edited by Bergmeyer HU. New York: Academic
    • Gutmann I, Wahlefeld A. L-(+)-lactate determination with lactate dehydrogenase and NAD. In: Methods of Enzymatic Analysis. Edited by Bergmeyer HU. New York: Academic, 1974.
    • (1974) Methods of Enzymatic Analysis
    • Gutmann, I.1    Wahlefeld, A.2
  • 24
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family-from monocarboxy-late transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxy-late transporters (MCTs) to aromatic amino acid transporters and beyond. Pflügers Arch 447: 619-628, 2004.
    • (2004) Pflügers Arch , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 25
    • 33744931101 scopus 로고    scopus 로고
    • Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: Evidence of a mitochondrial lactate oxidation complex
    • Hashimoto T, Hussien R, Brooks GA. Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. Am J Physiol Endocrinol Metab 290: E1237-E1244, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Hashimoto, T.1    Hussien, R.2    Brooks, G.A.3
  • 26
    • 51449120723 scopus 로고    scopus 로고
    • Evidence for the mitochondrial lactate oxidation complex in rat neurons: Demonstration of an essential component of brain lactate shuttles
    • Hashimoto T, Hussien R, Cho HS, Kaufer D, Brooks GA. Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles. PLoS One 3: e2915, 2008.
    • (2008) PLoS One , vol.3
    • Hashimoto, T.1    Hussien, R.2    Cho, H.S.3    Kaufer, D.4    Brooks, G.A.5
  • 27
    • 34547790342 scopus 로고    scopus 로고
    • Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis
    • Hashimoto T, Hussien R, Oommen S, Gohil K, Brooks GA. Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis. FASEB J 21: 2602-2612, 2007.
    • (2007) FASEB J , vol.21 , pp. 2602-2612
    • Hashimoto, T.1    Hussien, R.2    Oommen, S.3    Gohil, K.4    Brooks, G.A.5
  • 28
    • 23844526132 scopus 로고    scopus 로고
    • Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle
    • Hashimoto T, Masuda S, Taguchi S, Brooks GA. Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle. J Physiol 567: 121-129, 2005.
    • (2005) J Physiol , vol.567 , pp. 121-129
    • Hashimoto, T.1    Masuda, S.2    Taguchi, S.3    Brooks, G.A.4
  • 29
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell Metabolism:Warburg and beyond
    • Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 134: 703-707, 2008.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 30
    • 21644466088 scopus 로고    scopus 로고
    • Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability
    • Jungmann RA, Kiryukhina O. Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability. J Biol Chem 280: 25170-25177, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 25170-25177
    • Jungmann, R.A.1    Kiryukhina, O.2
  • 31
    • 77955926498 scopus 로고    scopus 로고
    • Glutamine as indispensable nutrient in oncology: Experimental and clinical evidence
    • Kuhn KS, Muscaritoli M, Wischmeyer P, Stehle P. Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. Eur J Nutr 49: 197-210, 2010.
    • (2010) Eur J Nutr , vol.49 , pp. 197-210
    • Kuhn, K.S.1    Muscaritoli, M.2    Wischmeyer, P.3    Stehle, P.4
  • 32
    • 1342326910 scopus 로고    scopus 로고
    • Relevance of breast cancer cell lines as models for breast tumours: An update
    • Lacroix M, Leclercq G. Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 83: 249-289, 2004.
    • (2004) Breast Cancer Res Treat , vol.83 , pp. 249-289
    • Lacroix, M.1    Leclercq, G.2
  • 34
    • 45249095191 scopus 로고    scopus 로고
    • Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1)
    • Lemire J, Mailloux RJ, Appanna VD. Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1). PLoS One 3: e1550, 2008.
    • (2008) PLoS One , vol.3
    • Lemire, J.1    Mailloux, R.J.2    Appanna, V.D.3
  • 35
    • 34247383169 scopus 로고    scopus 로고
    • Why do tumors metastasize?
    • Lopez-Lazaro M. Why do tumors metastasize? Cancer Biol Ther 6: 141-144, 2007.
    • (2007) Cancer Biol Ther , vol.6 , pp. 141-144
    • Lopez-Lazaro, M.1
  • 36
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277: 23111-23115, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 38
    • 76049105429 scopus 로고    scopus 로고
    • Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives
    • Menendez JA. Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives. Biochim Biophys Acta 1801: 381-391, 2010.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 381-391
    • Menendez, J.A.1
  • 39
    • 59149090614 scopus 로고    scopus 로고
    • Monocarboxylate transporters: Past, present, future
    • Merezhinskaya N, Fishbein WN. Monocarboxylate transporters: past, present, future. Histol Histopathol 24: 243-264, 2009.
    • (2009) Histol Histopathol , vol.24 , pp. 243-264
    • Merezhinskaya, N.1    Fishbein, W.N.2
  • 41
    • 53749107434 scopus 로고    scopus 로고
    • Overview of the proton-coupled MCT (SLC16A) family of transporters: Characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid
    • Morris ME, Felmlee MA. Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J 10: 311-321, 2008.
    • (2008) AAPS J , vol.10 , pp. 311-321
    • Morris, M.E.1    Felmlee, M.A.2
  • 42
    • 33646843717 scopus 로고    scopus 로고
    • Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes
    • Nishikawa M, Hashida M. Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes. Expert Opin Drug Deliv 3: 355-369, 2006.
    • (2006) Expert Opin Drug Deliv , vol.3 , pp. 355-369
    • Nishikawa, M.1    Hashida, M.2
  • 43
    • 67449158992 scopus 로고    scopus 로고
    • Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization
    • Novak P, Jensen TJ, Garbe JC, Stampfer MR, Futscher BW. Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res 69: 5251-5258, 2009.
    • (2009) Cancer Res , vol.69 , pp. 5251-5258
    • Novak, P.1    Jensen, T.J.2    Garbe, J.C.3    Stampfer, M.R.4    Futscher, B.W.5
  • 44
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast.1889
    • Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 8: 98-101, 1989.
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 47
    • 15044362438 scopus 로고    scopus 로고
    • Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
    • Rhee SG, Kang SW, Jeong W, Chang TS, Yang KS, Woo HA. Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr Opin Cell Biol 17: 183-189, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 183-189
    • Rhee, S.G.1    Kang, S.W.2    Jeong, W.3    Chang, T.S.4    Yang, K.S.5    Woo, H.A.6
  • 48
    • 33746228395 scopus 로고    scopus 로고
    • Oxidative metabolism in cancer growth
    • Ristow M. Oxidative metabolism in cancer growth. Curr Opin Clin Nutr Metab Care 9: 339-345, 2006.
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , pp. 339-345
    • Ristow, M.1
  • 49
    • 0025286025 scopus 로고
    • Lactate and pyruvate transport is dominated by a pH gradient-sensitive carrier in rat skeletal muscle sarcolemmal vesicles
    • Roth DA, Brooks GA. Lactate and pyruvate transport is dominated by a pH gradient-sensitive carrier in rat skeletal muscle sarcolemmal vesicles. Arch Biochem Biophys 279: 386-394, 1990.
    • (1990) Arch Biochem Biophys , vol.279 , pp. 386-394
    • Roth, D.A.1    Brooks, G.A.2
  • 50
    • 0025362226 scopus 로고
    • Lactate transport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesicles
    • Roth DA, Brooks GA. Lactate transport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesicles. Arch Biochem Biophys 279: 377-385, 1990.
    • (1990) Arch Biochem Biophys , vol.279 , pp. 377-385
    • Roth, D.A.1    Brooks, G.A.2
  • 52
    • 0034725054 scopus 로고    scopus 로고
    • Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway
    • Short S, Tian D, Short ML, Jungmann RA. Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway. J Biol Chem 275: 12963-12969, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 12963-12969
    • Short, S.1    Tian, D.2    Short, M.L.3    Jungmann, R.A.4
  • 54
    • 33646698671 scopus 로고    scopus 로고
    • Hydrogen peroxide: A signaling messenger
    • Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 8: 243-270, 2006.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 243-270
    • Stone, J.R.1    Yang, S.2
  • 55
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281: 9030-9037, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 56
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60: 916-921, 2000.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 57
    • 30644467361 scopus 로고    scopus 로고
    • Donut-like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: A novel structure-function module of the adult calyx of Held
    • Wimmer VC, Horstmann H, Groh A, Kuner T. Donut-like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: a novel structure-function module of the adult calyx of Held. J Neurosci 26: 109-116, 2006.
    • (2006) J Neurosci , vol.26 , pp. 109-116
    • Wimmer, V.C.1    Horstmann, H.2    Groh, A.3    Kuner, T.4
  • 59
    • 13844296556 scopus 로고    scopus 로고
    • Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression
    • Yan L, Zucker S, Toole BP. Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost 93: 199-204, 2005.
    • (2005) Thromb Haemost , vol.93 , pp. 199-204
    • Yan, L.1    Zucker, S.2    Toole, B.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.