메뉴 건너뛰기




Volumn 45, Issue 10, 2013, Pages

Cancer cell metabolism: Implications for therapeutic targets

Author keywords

aerobic glycolysis; cancer; metabolism; Warburg effect

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 6 PHOSPHOFRUCTOKINASE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BROMOPYRUVIC ACID; C 75; DEOXYGLUCOSE; DICHLOROACETIC ACID; ENDOPEPTIDASE LA; FX 11; GLUCOSE; GLUTAMINASE; GLUTAMINE; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR; LACTATE DEHYDROGENASE; LONIDAMINE; MAMMALIAN TARGET OF RAPAMYCIN; OXAMIC ACID; PACLITAXEL; PHLORETIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE KINASE; UNCLASSIFIED DRUG; WZB 117;

EID: 84890159876     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.85     Document Type: Review
Times cited : (315)

References (96)
  • 1
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 2
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 3
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 4
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011; 11: 325-337.
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 5
    • 0036262039 scopus 로고    scopus 로고
    • Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma
    • Simonnet H, Alazard N, Pfeiffer K, Gallou C, Beroud C, Demont J et al. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 2002; 23: 759-768.
    • (2002) Carcinogenesis , vol.23 , pp. 759-768
    • Simonnet, H.1    Alazard, N.2    Pfeiffer, K.3    Gallou, C.4    Beroud, C.5    Demont, J.6
  • 8
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 2013; 4: e532.
    • (2013) Cell Death Dis , vol.4
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 9
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of ATP-producing pathways
    • Pfeiffer T, Schuster S, Bonhoeffer S. Cooperation and competition in the evolution of ATP-producing pathways. Science 2001; 292: 504-507.
    • (2001) Science , vol.292 , pp. 504-507
    • Pfeiffer, T.1    Schuster, S.2    Bonhoeffer, S.3
  • 11
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 2010; 330: 1340-1344.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 14
    • 60549111398 scopus 로고    scopus 로고
    • Is akt the Warburg kinase-Akt-energy metabolism interactions and oncogenesis
    • Robey RB, Hay N. Is Akt the Warburg kinase-Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol 2009; 19: 25-31.
    • (2009) Semin Cancer Biol , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 15
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia HIF1 and glucose metabolism in the solid tumour
    • Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008; 8: 705-713.
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 16
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 2010; 40: 294-309.
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 17
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 2010; 39: 171-183.
    • (2010) Mol Cell , vol.39 , pp. 171-183
    • Duvel, K.1    Yecies, J.L.2    Menon, S.3    Raman, P.4    Lipovsky, A.I.5    Souza, A.L.6
  • 19
    • 79955779584 scopus 로고    scopus 로고
    • MTOR links oncogenic signaling to tumor cell metabolism
    • Yecies JL, Manning BD. mTOR links oncogenic signaling to tumor cell metabolism. J Mol Med (Berl) 2011; 89: 221-228.
    • (2011) J Mol Med (Berl) , vol.89 , pp. 221-228
    • Yecies, J.L.1    Manning, B.D.2
  • 20
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: Upstream and downstream of cancer metabolism
    • Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 2010; 20: 51-56.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 21
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 22
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3: 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 23
    • 57649130593 scopus 로고    scopus 로고
    • Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
    • Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem 2008; 283: 28106-28114.
    • (2008) J Biol Chem , vol.283 , pp. 28106-28114
    • Lu, C.W.1    Lin, S.C.2    Chen, K.F.3    Lai, Y.Y.4    Tsai, S.J.5
  • 25
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    • Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007; 27: 7381-7393.
    • (2007) Mol Cell Biol , vol.27 , pp. 7381-7393
    • Kim, J.W.1    Gao, P.2    Liu, Y.C.3    Semenza, G.L.4    Dang, C.V.5
  • 27
    • 64749116346 scopus 로고    scopus 로고
    • C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009; 458: 762-765.
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6
  • 28
    • 21744442902 scopus 로고    scopus 로고
    • Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
    • Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 2005; 25: 6225-6234.
    • (2005) Mol Cell Biol , vol.25 , pp. 6225-6234
    • Li, F.1    Wang, Y.2    Zeller, K.I.3    Potter, J.J.4    Wonsey, D.R.5    O'Donnell, K.A.6
  • 29
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 2008; 105: 18782-18787.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18782-18787
    • Wise, D.R.1    Deberardinis, R.J.2    Mancuso, A.3    Sayed, N.4    Zhang, X.Y.5    Pfeiffer, H.K.6
  • 30
    • 79960006190 scopus 로고    scopus 로고
    • 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    • Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ et al. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab 2011; 14: 131-142.
    • (2011) Cell Metab , vol.14 , pp. 131-142
    • Hu, S.1    Balakrishnan, A.2    Bok, R.A.3    Anderton, B.4    Larson, P.E.5    Nelson, S.J.6
  • 35
    • 0033767445 scopus 로고    scopus 로고
    • Mutations in SDHC cause autosomal dominant paraganglioma, type 3
    • Niemann S, Muller U. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet 2000; 26: 268-270.
    • (2000) Nat Genet , vol.26 , pp. 268-270
    • Niemann, S.1    Muller, U.2
  • 36
    • 0034964421 scopus 로고    scopus 로고
    • Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
    • Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 2001; 69: 49-54.
    • (2001) Am J Hum Genet , vol.69 , pp. 49-54
    • Astuti, D.1    Latif, F.2    Dallol, A.3    Dahia, P.L.4    Douglas, F.5    George, E.6
  • 37
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 2002; 30: 406-410.
    • (2002) Nat Genet , vol.30 , pp. 406-410
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3    Barclay, E.4    Jaeger, E.E.5    Kelsell, D.6
  • 40
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009; 324: 261-265.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5    Wang, P.6
  • 41
    • 77149134353 scopus 로고    scopus 로고
    • Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
    • Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med 2010; 207: 339-344.
    • (2010) J Exp Med , vol.207 , pp. 339-344
    • Gross, S.1    Cairns, R.A.2    Minden, M.D.3    Driggers, E.M.4    Bittinger, M.A.5    Jang, H.G.6
  • 42
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010; 17: 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 44
    • 77953608893 scopus 로고    scopus 로고
    • Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
    • Bayley JP, Devilee P. Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree? Curr Opin Genet Dev 2010; 20: 324-329.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 324-329
    • Bayley, J.P.1    Devilee, P.2
  • 46
    • 80051923932 scopus 로고    scopus 로고
    • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    • Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011; 476: 346-350.
    • (2011) Nature , vol.476 , pp. 346-350
    • Possemato, R.1    Marks, K.M.2    Shaul, Y.D.3    Pacold, M.E.4    Kim, D.5    Birsoy, K.6
  • 47
    • 84856087055 scopus 로고    scopus 로고
    • Glycine decarboxylase activity drives non-small cell lung cancer tumorinitiating cells and tumorigenesis
    • Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S et al. Glycine decarboxylase activity drives non-small cell lung cancer tumorinitiating cells and tumorigenesis. Cell 2012; 148: 259-272.
    • (2012) Cell , vol.148 , pp. 259-272
    • Zhang, W.C.1    Shyh-Chang, N.2    Yang, H.3    Rai, A.4    Umashankar, S.5    Ma, S.6
  • 48
    • 33845609726 scopus 로고    scopus 로고
    • Does hypoxia really control tumor growth?
    • Lopez-Lazaro M. Does hypoxia really control tumor growth? Cell Oncol 2006; 28: 327-329.
    • (2006) Cell Oncol , vol.28 , pp. 327-329
    • Lopez-Lazaro, M.1
  • 50
    • 34247383169 scopus 로고    scopus 로고
    • Why do tumors metastasize?
    • Lopez-Lazaro M. Why do tumors metastasize? Cancer Biol Ther 2007; 6: 141-144.
    • (2007) Cancer Biol Ther , vol.6 , pp. 141-144
    • Lopez-Lazaro, M.1
  • 51
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25: 4633-4646.
    • (2006) Oncogene , vol.25 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 52
    • 1642494855 scopus 로고    scopus 로고
    • 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
    • Maschek G, Savaraj N, Priebe W, Braunschweiger P, Hamilton K, Tidmarsh GF et al. 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res 2004; 64: 31-34.
    • (2004) Cancer Res , vol.64 , pp. 31-34
    • Maschek, G.1    Savaraj, N.2    Priebe, W.3    Braunschweiger, P.4    Hamilton, K.5    Tidmarsh, G.F.6
  • 53
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN et al. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 2005; 65: 613-621.
    • (2005) Cancer Res , vol.65 , pp. 613-621
    • Xu, R.H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6
  • 54
    • 0037099685 scopus 로고    scopus 로고
    • Novel therapy for liver cancer: Direct intraarterial injection of a potent inhibitor of ATP production
    • Geschwind JF, Ko YH, Torbenson MS, Magee C, Pedersen PL. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res 2002; 62: 3909-3913.
    • (2002) Cancer Res , vol.62 , pp. 3909-3913
    • Geschwind, J.F.1    Ko, Y.H.2    Torbenson, M.S.3    Magee, C.4    Pedersen, P.L.5
  • 55
    • 61849134364 scopus 로고    scopus 로고
    • Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells
    • Hulleman E, Kazemier KM, Holleman A, VanderWeele DJ, Rudin CM, Broekhuis MJ et al. Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood 2009; 113: 2014-2021.
    • (2009) Blood , vol.113 , pp. 2014-2021
    • Hulleman, E.1    Kazemier, K.M.2    Holleman, A.3    Vanderweele, D.J.4    Rudin, C.M.5    Broekhuis, M.J.6
  • 56
  • 57
    • 0037174915 scopus 로고    scopus 로고
    • Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells
    • Li YC, Fung KP, Kwok TT, Lee CY, Suen YK, Kong SK. Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells. Life Sci 2002; 71: 2729-2740.
    • (2002) Life Sci , vol.71 , pp. 2729-2740
    • Li, Y.C.1    Fung, K.P.2    Kwok, T.T.3    Lee, C.Y.4    Suen, Y.K.5    Kong, S.K.6
  • 58
    • 0033594404 scopus 로고    scopus 로고
    • Lonidamine triggers apoptosis via a direct. Bcl-2-inhibited effect on the mitochondrial permeability transition pore
    • Ravagnan L, Marzo I, Costantini P, Susin SA, Zamzami N, Petit PX et al. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene 1999; 18: 2537-2546.
    • (1999) Oncogene , vol.18 , pp. 2537-2546
    • Ravagnan, L.1    Marzo, I.2    Costantini, P.3    Susin, S.A.4    Zamzami, N.5    Petit, P.X.6
  • 59
    • 33645124651 scopus 로고    scopus 로고
    • Lonidamine: Basic science and rationale for treatment of prostatic proliferative disorders
    • Brawer MK. Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Rev Urol 2005; 7 (Suppl 7), S21-S26.
    • (2005) Rev Urol , vol.7 , Issue.SUPPL. 7
    • Brawer, M.K.1
  • 61
    • 34447094919 scopus 로고    scopus 로고
    • Glycolysis in cancer: A potential target for therapy
    • Gatenby RA, Gillies RJ. Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol 2007; 39: 1358-1366.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1358-1366
    • Gatenby, R.A.1    Gillies, R.J.2
  • 62
    • 33744457297 scopus 로고    scopus 로고
    • HIF-1: Hypoxia-inducible factor or dysoxia-inducible factor?
    • Lopez-Lazaro M. HIF-1: hypoxia-inducible factor or dysoxia-inducible factor? FASEB J 2006; 20: 828-832.
    • (2006) FASEB J , vol.20 , pp. 828-832
    • Lopez-Lazaro, M.1
  • 63
    • 0028818539 scopus 로고
    • The effect of pH on glycolysis and phosphofructokinase activity in cultured cells and synaptosomes
    • Erecinska M, Deas J, Silver IA. The effect of pH on glycolysis and phosphofructokinase activity in cultured cells and synaptosomes. J Neurochem 1995; 65: 2765-2772.
    • (1995) J Neurochem , vol.65 , pp. 2765-2772
    • Erecinska, M.1    Deas, J.2    Silver, I.A.3
  • 64
    • 0014011016 scopus 로고
    • Effect of pH on the kinetics of frog muscle phosphofructokinase
    • Trivedi B, Danforth WH. Effect of pH on the kinetics of frog muscle phosphofructokinase. J Biol Chem 1966; 241: 4110-4112.
    • (1966) J Biol Chem , vol.241 , pp. 4110-4112
    • Trivedi, B.1    Danforth, W.H.2
  • 65
    • 0033746761 scopus 로고    scopus 로고
    • Na\+/H\+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
    • Reshkin SJ, Bellizzi A, Caldeira S, Albarani V, Malanchi I, Poignee M et al. Na\+/H\+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB J 2000; 14: 2185-2197.
    • (2000) FASEB J , vol.14 , pp. 2185-2197
    • Reshkin, S.J.1    Bellizzi, A.2    Caldeira, S.3    Albarani, V.4    Malanchi, I.5    Poignee, M.6
  • 66
    • 24944481656 scopus 로고    scopus 로고
    • The role of pH dynamics and the Na\+/H\+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin-one single nature
    • Harguindey S, Orive G, Luis Pedraz J, Paradiso A, Reshkin SJ. The role of pH dynamics and the Na\+/H\+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin-one single nature. Biochim Biophys Acta 2005; 1756: 1-24.
    • (2005) Biochim Biophys Acta , vol.1756 , pp. 1-24
    • Harguindey, S.1    Orive, G.2    Luis Pedraz, J.3    Paradiso, A.4    Reshkin, S.J.5
  • 67
    • 25844528025 scopus 로고    scopus 로고
    • The role of disturbed pH dynamics and the Na\+/H\+ exchanger in metastasis
    • Cardone RA, Casavola V, Reshkin SJ. The role of disturbed pH dynamics and the Na\+/H\+ exchanger in metastasis. Nat Rev Cancer 2005; 5: 786-795.
    • (2005) Nat Rev Cancer , vol.5 , pp. 786-795
    • Cardone, R.A.1    Casavola, V.2    Reshkin, S.J.3
  • 68
    • 0031802807 scopus 로고    scopus 로고
    • Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride
    • Evans DM, Sloan-Stakleff K, Arvan M, Guyton DP. Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride. Clin Exp Metastasis 1998; 16: 353-357.
    • (1998) Clin Exp Metastasis , vol.16 , pp. 353-357
    • Evans, D.M.1    Sloan-Stakleff, K.2    Arvan, M.3    Guyton, D.P.4
  • 69
    • 0020661015 scopus 로고
    • Effects of amiloride on tumor growth and intracellular element content of tumor cells in vivo
    • Sparks RL, Pool TB, Smith NK, Cameron IL. Effects of amiloride on tumor growth and intracellular element content of tumor cells in vivo. Cancer Res 1983; 43: 73-77.
    • (1983) Cancer Res , vol.43 , pp. 73-77
    • Sparks, R.L.1    Pool, T.B.2    Smith, N.K.3    Cameron, I.L.4
  • 70
    • 33744969828 scopus 로고    scopus 로고
    • Energy deregulation: Licensing tumors to grow
    • Garber K. Energy deregulation: licensing tumors to grow. Science 2006; 312: 1158-1159.
    • (2006) Science , vol.312 , pp. 1158-1159
    • Garber, K.1
  • 73
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452: 230-233.
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander, H.M.G.2    Harris, M.H.3    Ramanathan, A.4    Gerszten, R.E.5    Wei, R.6
  • 74
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • Mazurek S, Boschek CB, Hugo F, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 2005; 15: 300-308.
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 75
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 76
    • 78650885452 scopus 로고    scopus 로고
    • The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway
    • Fang M, Shen Z, Huang S, Zhao L, Chen S, Mak TW et al. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 2010; 143: 711-724.
    • (2010) Cell , vol.143 , pp. 711-724
    • Fang, M.1    Shen, Z.2    Huang, S.3    Zhao, L.4    Chen, S.5    Mak, T.W.6
  • 77
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 1991; 266: 4706-4712.
    • (1991) J Biol Chem , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 81
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006; 9: 425-434.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 82
    • 33744826296 scopus 로고    scopus 로고
    • Cancer's sweet tooth
    • Bui T, Thompson CB. Cancer's sweet tooth. Cancer Cell 2006; 9: 419-420.
    • (2006) Cancer Cell , vol.9 , pp. 419-420
    • Bui, T.1    Thompson, C.B.2
  • 83
    • 14444286004 scopus 로고    scopus 로고
    • Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum
    • Deck LM, Royer RE, Chamblee BB, Hernandez VM, Malone RR, Torres JE et al. Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum. J Med Chem 1998; 41: 3879-3887.
    • (1998) J Med Chem , vol.41 , pp. 3879-3887
    • Deck, L.M.1    Royer, R.E.2    Chamblee, B.B.3    Hernandez, V.M.4    Malone, R.R.5    Torres, J.E.6
  • 84
    • 77649094375 scopus 로고    scopus 로고
    • Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes taxolresistant cancer cells to taxol
    • Zhou M, Zhao Y, Ding Y, Liu H, Liu Z, Fodstad O et al. Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxolresistant cancer cells to taxol. Mol Cancer 2010; 9: 33.
    • (2010) Mol Cancer , vol.9 , pp. 33
    • Zhou, M.1    Zhao, Y.2    Ding, Y.3    Liu, H.4    Liu, Z.5    Fodstad, O.6
  • 86
    • 51249087081 scopus 로고    scopus 로고
    • Role of dichloroacetate in the treatment of genetic mitochondrial diseases
    • Stacpoole PW, Kurtz TL, Han Z, Langaee T. Role of dichloroacetate in the treatment of genetic mitochondrial diseases. Adv Drug Deliv Rev 2008; 60: 1478-1487.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1478-1487
    • Stacpoole, P.W.1    Kurtz, T.L.2    Han, Z.3    Langaee, T.4
  • 87
    • 26944452745 scopus 로고    scopus 로고
    • Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines
    • Griguer CE, Oliva CR, Gillespie GY. Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. J Neurooncol 2005; 74: 123-133.
    • (2005) J Neurooncol , vol.74 , pp. 123-133
    • Griguer, C.E.1    Oliva, C.R.2    Gillespie, G.Y.3
  • 88
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394: 485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3    Fukumura, D.4    Brusselmans, K.5    Dewerchin, M.6
  • 89
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008; 8: 967-975.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 90
    • 78149361025 scopus 로고    scopus 로고
    • Metabolic flexibility and cell hierarchy in metastatic cancer
    • Berridge MV, Herst PM, Tan AS. Metabolic flexibility and cell hierarchy in metastatic cancer. Mitochondrion 2010; 10: 584-588.
    • (2010) Mitochondrion , vol.10 , pp. 584-588
    • Berridge, M.V.1    Herst, P.M.2    Tan, A.S.3
  • 91
    • 58149157900 scopus 로고    scopus 로고
    • The genomic analysis of lactic acidosis and acidosis response in human cancers
    • Chen JL, Lucas JE, Schroeder T, Mori S, Wu J, Nevins J et al. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 2008; 4: e1000293.
    • (2008) PLoS Genet , vol.4
    • Chen, J.L.1    Lucas, J.E.2    Schroeder, T.3    Mori, S.4    Wu, J.5    Nevins, J.6
  • 92
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: Causes and consequences
    • Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 2010; 1805: 105-117.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 93
    • 63449097322 scopus 로고    scopus 로고
    • In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter
    • Wu CH, Ho YS, Tsai CY, Wang YJ, Tseng H, Wei PL et al. In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter. Int J Cancer 2009; 124: 2210-2219.
    • (2009) Int J Cancer , vol.124 , pp. 2210-2219
    • Wu, C.H.1    Ho, Y.S.2    Tsai, C.Y.3    Wang, Y.J.4    Tseng, H.5    Wei, P.L.6
  • 94
    • 84864875404 scopus 로고    scopus 로고
    • A smallmolecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo
    • Liu Y, Cao Y, Zhang W, Bergmeier S, Qian Y, Akbar H et al. A smallmolecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 2012; 11: 1672-1682.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1672-1682
    • Liu, Y.1    Cao, Y.2    Zhang, W.3    Bergmeier, S.4    Qian, Y.5    Akbar, H.6
  • 95
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 2010; 107: 2037-2042.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2037-2042
    • Le Cooper, A.C.R.1    Gouw, A.M.2    Dinavahi, R.3    Maitra, A.4    Deck, L.M.5
  • 96
    • 35848962736 scopus 로고    scopus 로고
    • Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin) by transcriptionally inhibiting 'HER2 superexpression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells
    • Vazquez-Martin A, Colomer R, Brunet J, Menendez JA. Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin) by transcriptionally inhibiting 'HER2 superexpression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells. Int J Oncol 2007; 31: 769-776.
    • (2007) Int J Oncol , vol.31 , pp. 769-776
    • Vazquez-Martin, A.1    Colomer, R.2    Brunet, J.3    Menendez, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.