Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

Journal of Biological Chemistry

Volumn 283, Issue 42, 2008, Pages 28106-28114

  Lu, Chun Wun ^a   Lin, Shih Chieh ^a   Chen, Ko Fan ^a   Lai, Yen Yu ^a   Tsai, Shaw Jenq ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RESISTANCE; BIOCHEMISTRY; ENZYMES; LACTIC ACID; NUCLEIC ACIDS; ORGANIC ACIDS; PATHOLOGY; RNA;

CANCER CELLS; CANCER PROGRESSIONS; CANCER THERAPIES; CELL SURVIVALS; CELLULAR METABOLISMS; CHROMATIN IMMUNOPRECIPITATION ASSAYS; DRUG RESISTANCES; FORCED EXPRESSIONS; GENE ACTIVITIES; MITOCHONDRIAL RESPIRATIONS; PROMOTER ACTIVITIES; PYRUVATE DEHYDROGENASE KINASES; RNA KNOCKDOWNS; TRANSCRIPTIONAL LEVELS;

PHYSIOLOGY;

HYPOXIA INDUCIBLE FACTOR 1; PHOSPHATASE; PYRUVATE DEHYDROGENASE KINASE 3; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL CULTURE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; DRUG RESISTANCE; ENZYME INDUCTION; GENE ACTIVITY; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLIC ACTIVATION; METABOLIC SWITCH; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION;

CELL DIFFERENTIATION; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; DRUG RESISTANCE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING;

EID: 57649130593     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803508200     Document Type: Article

References (36)

1. Warburg, O., Wind, F., and Neglers, E. (1930) The Metabolism of Tumors Constable and Co., London, pp. 254-270
2. Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., and Semenza, G. L. (1998) Genes Dev. 12, 149-162
3. Seagroves, T. N., Ryan, H. E., Lu, H., Wouters, B. G., Knapp, M., Thibault, P., Laderoute, K., and Johnson, R. S. (2001) Mol. Cell. Biol. 21, 3436-3444
4. Greijer, A. E., van der Groep, P., Kemming, D., Shvarts, A., Semenza, G. L., Meijer, G. A., van de Wiel, M. A., Belien, J. A., van Diest, P. J., and van der Wall, E. (2005) J. Pathol. 206, 291-304
5. Patel, M. S., and Korotchkina, L. G. (2001) Exp. Mol. Med. 33, 191-197
6. Roche, T. E., and Hiromasa, Y. (2007) Cell Mol. Life Sci. 64, 830-849
7. Bowker-Kinley, M. M., Davis, W. I., Wu, P., Harris, R. A., and Popov, K. M. (1998) Biochem. J. 329, 191-196
8. Gudi, R., Bowker-Kinley, M. M., Kedishvili, N. Y., Zhao, Y., and Popov, K. M. (1995) J. Biol. Chem. 270, 28989-28994
9. Kim, J. W., Tchernyshyov, I., Semenza, G. L., and Dang, C. V. (2006) Cell Metab. 3, 177-185
10. Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., and Denko, N. C. (2006) Cell Metab. 3, 187-197
11. Wu, P., Blair, P. V., Sato, J., Jaskiewicz, J., Popov, K. M., and Harris, R. A. (2000) Arch. Biochem. Biophys. 381, 1-7
12. Holness, M. J., Kraus, A., Harris, R. A., and Sugden, M. C. (2000) Diabetes 49, 775-781
13. Wu, P., Inskeep, K., Bowker-Kinley, M. M., Popov, K. M., and Harris, R. A. (1999) Diabetes 48, 1593-1599
14. Tuganova, A., Boulatnikov, I., and Popov, K. M. (2002) Biochem. J. 366, 129-136
15. Baker, J. C., Yan, X., Peng, T., Kasten, S., and Roche, T. E. (2000) J. Biol. Chem. 275, 15773-15781
16. Brown, J. M., and Giaccia, A. J. (1998) Cancer Res. 58, 1408-1416
17. Ke, Q., and Costa, M. (2006) Mol. Pharmacol. 70, 1469-1480
18. Semenza, G. (2002) Biochem. Pharmacol. 64, 993-998
19. Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., and Fujii-Kuriyama, Y. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4273-4278
20. Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., and McKnight, S. L. (1998) Genes Dev. 12, 3320-3324
21. Tian, H., McKnight, S. L., and Russell, D. W. (1997) Genes Dev. 11, 72-82
22. Rosenberger, C., Mandriota, S., Jurgensen, J. S., Wiesener, M. S., Horstrup, J. H., Frei, U., Ratcliffe, P. J., Maxwell, P. H., Bachmann, S., and Eckardt, K. U. (2002) J. Am. Soc. Nephrol. 13, 1721-1732
23. Wiesener, M. S., Jurgensen, J. S., Rosenberger, C., Scholze, C. K., Horstrup, J. H., Warnecke, C., Mandriota, S., Bechmann, I., Frei, U. A., Pugh, C. W., Ratcliffe, P. J., Bachmann, S., Maxwell, P. H., and Eckardt, K. U. (2003) FASEB J. 17, 271-273
24. Holmquist-Mengelbier, L., Fredlund, E., Lofstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, A., Gradin, K., Poellinger, L., and Pahlman, S. (2006) Cancer Cell 10, 413-423
25. Haase, V. H. (2006) Am. J. Physiol. 291, F271-F281
26. Tsai, S. J., Wu, M. H., Chen, H. M., Chuang, P. C., and Wing, L. Y. (2002) Endocrinology 143, 2715-2721
27. Tsai, S. J., Wu, M. H., Lin, C. C., Sun, H. S., and Chen, H. M. (2001) J. Clin. Endocrinol. Metab. 86, 5765-5773
28. Chuang, P. C., Sun, H. S., Chen, T. M., and Tsai, S. J. (2006) Mol. Cell. Biol. 26, 8281-8292
29. Sun, H. S., Hsiao, K. Y., Hsu, C. C., Wu, M. H., and Tsai, S. J. (2003) Endocrinology 144, 3934-3942
30. Chen, K. F., Lai, Y. Y., Sun, H. S., and Tsai, S. J. (2005) Nucleic Acids Res. 33, 5190-5198
31. Wu, M. H., Chen, K. F., Lin, S. C., Lgu, C. W., and Tsai, S. J. (2007) Am. J. Pathol. 170, 590-598
32. Bridge, A. J., Pebernard, S., Ducraux, A., Nicoulaz, A. L., and Iggo, R. (2003) Nature Genet. 34, 263-264
33. Fantin, V. R., St-Pierre, J., and Leder, P. (2006) Cancer Cell 9, 425-434
34. Bonnet, S., Archer, S. L., Allalunis-Turner, J., Haromy, A., Beaulieu, C., Thompson, R., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S., Harry, G., Hashimoto, K., Porter, C. J., Andrade, M. A., Thebaud, B., and Michelakis, E. D. (2007) Cancer Cell 11, 37-51
35. Zhong, H., De Marzo, A. M., Laughner, E., Lim, M., Hilton, D. A., Zagzag, D., Buechler, P., Isaacs, W. B., Semenza, G. L., and Simons, J. W. (1999) Cancer Res. 59, 5830-5835
36. Pelicano, H., Xu, R. H., Du, M., Feng, L., Sasaki, R., Carew, J. S., Hu, Y., Ramdas, L., Hu, L., Keating, M. J., Zhang, W., Plunkett, W., and Huang, P. (2006) J. Cell Biol. 175, 913-923