K-ras G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

Cell Research

Volumn 22, Issue 2, 2012, Pages 399-412

  Hu, Yumin ^a,b   Lu, Weiqin ^b   Chen, Gang ^b   Wang, Peng ^a   Chen, Zhao ^b   Zhou, Yan ^b   Ogasawara, Marcia ^b   Trachootham, Dunyaporn ^b,c   Feng, Li ^b   Pelicano, Helene ^b   Chiao, Paul J ^b   Keating, Michael J ^b   Garcia Manero, Guillermo ^b   Huang, Peng ^a,b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c THAMMASAT UNIVERSITY   (Thailand)

Author keywords

Glycolysis; K ras; Mitochondrial dysfunction

Indexed keywords

CYCLOSPORIN DERIVATIVE; DOXYCYCLINE; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL; ARTICLE; CELL LINE; CELL STRAIN HEK293; DRUG ANTAGONISM; GENETICS; GLYCOLYSIS; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NUDE MOUSE; OXIDATIVE PHOSPHORYLATION; PATHOLOGY;

ANIMALS; CELL LINE; CYCLOSPORINS; DOXYCYCLINE; ELECTRON TRANSPORT COMPLEX I; GLYCOLYSIS; HEK293 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; RAS PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84856595714     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.145     Document Type: Article

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