-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
PMID:21376230
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013.
-
(2011)
Cell
, vol.144
, pp. 646-74
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
12444279265
-
On the origin of cancer cells
-
PMID:13298683
-
Warburg O. On the origin of cancer cells. Science 1956; 123:309-14; PMID:13298683; http://dx.doi.org/10.1126/science.123.3191.309.
-
(1956)
Science
, vol.123
, pp. 309-14
-
-
Warburg, O.1
-
3
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
PMID:12209157
-
Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2002; 2:683-93; PMID:12209157; http://dx.doi.org/10. 1038/nrc882.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 683-93
-
-
Gambhir, S.S.1
-
4
-
-
80054046029
-
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
-
PMID:21985671
-
Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011; 27:441-64; PMID:21985671; http://dx.doi.org/10.1146/annurevcellbio-092910-154237.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 441-64
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
5
-
-
0037348402
-
Contributions of cell metabolism and h+ diffusion to the acidic ph of tumors
-
PMID:12659686
-
Schornack PA, Gillies RJ. Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia 2003; 5:135-45; PMID:12659686.
-
(2003)
Neoplasia
, vol.5
, pp. 135-45
-
-
Schornack, P.A.1
Gillies, R.J.2
-
6
-
-
20344404485
-
The role of acidity in solid tumour growth and invasion
-
PMID:15935166
-
Smallbone K, Gavaghan DJ, Gatenby RA, Maini PK. The role of acidity in solid tumour growth and invasion. J Theor Biol 2005; 235:476-84; PMID:15935166; http://dx.doi.org/10.1016/j.jtbi.2005.02.001.
-
(2005)
J Theor Biol
, vol.235
, pp. 476-84
-
-
Smallbone, K.1
Gavaghan, D.J.2
Gatenby, R.A.3
Maini, P.K.4
-
7
-
-
79251517382
-
Regulation of cancer cell metabolism
-
PMID:21258394
-
Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11:85-95; PMID:21258394; http://dx.doi.org/10.1038/nrc2981.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
8
-
-
0030772117
-
Overexpression of glut1 and glut3 in stage i nonsmall cell lung carcinoma is associated with poor survival
-
PMID:9305704
-
Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT. Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 1997; 80:1046-51; PMID:9305704; http://dx.doi.org/10.1002/ (SICI)1097-0142(19970915)80:6;1046::AIDCNCR6; 3.0.CO;2-7.
-
(1997)
Cancer
, vol.80
, pp. 1046-51
-
-
Younes, M.1
Brown, R.W.2
Stephenson, M.3
Gondo, M.4
Cagle, P.T.5
-
9
-
-
0036808431
-
Clinical significance of glucose transporter 1 (glut1) expression in human breast carcinoma
-
PMID:12417042
-
Kang SS, Chun YK, Hur MH, Lee HK, Kim YJ, Hong SR, et al. Clinical significance of glucose transporter 1 (GLUT1) expression in human breast carcinoma. Jpn J Cancer Res 2002; 93:1123-8; PMID:12417042; http://dx.doi.org/ 10.1111/j.1349-7006.2002.tb01214.x.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 1123-8
-
-
Kang, S.S.1
Chun, Y.K.2
Hur, M.H.3
Lee, H.K.4
Kim, Y.J.5
Hong, S.R.6
-
10
-
-
33846270366
-
Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
-
PMID:16906425
-
Cao X, Fang L, Gibbs S, Huang Y, Dai Z, Wen P, et al. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother Pharmacol 2007; 59:495-505; PMID:16906425; http://dx.doi.org/10.1007/s00280-006-0291-9.
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 495-505
-
-
Cao, X.1
Fang, L.2
Gibbs, S.3
Huang, Y.4
Dai, Z.5
Wen, P.6
-
11
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
326;PMID:21242296
-
Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, et al. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 2011; 208:313-26; PMID:21242296; http://dx.doi.org/10.1084/jem.20101470.
-
(2011)
J Exp Med
, vol.208
, pp. 313-208
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
Cairns, R.6
-
12
-
-
52449089360
-
Voltage dependent anion channels (vdacs): A brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "warburg effect" in cancer
-
PMID:18780167
-
Pedersen PL. Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer. J Bioenerg Biomembr 2008; 40:123-6; PMID:18780167; http://dx.doi.org/10.1007/ s10863-008-9165-7.
-
(2008)
J Bioenerg Biomembr
, vol.40
, pp. 123-6
-
-
Pedersen, P.L.1
-
13
-
-
0035829074
-
Glucose catabolism in the rabbit vx2 tumor model for liver cancer: Characterization and targeting hexokinase
-
PMID:11578813
-
Ko YH, Pedersen PL, Geschwind JF. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett 2001; 173:83-91; PMID:11578813; http://dx.doi.org/10.1016/S0304-3835(01) 00667-X.
-
(2001)
Cancer Lett
, vol.173
, pp. 83-91
-
-
Ko, Y.H.1
Pedersen, P.L.2
Geschwind, J.F.3
-
14
-
-
80052731244
-
No evidence for a shift in pyruvate kinase pkm1 to pkm2 expression during tumorigenesis
-
PMID:21789790
-
Bluemlein K, Grüning NM, Feichtinger RG, Lehrach H, Kofler B, Ralser M. No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis. Oncotarget 2011; 2:393-400; PMID:21789790.
-
(2011)
Oncotarget
, vol.2
, pp. 393-400
-
-
Bluemlein, K.1
Grüning, N.M.2
Feichtinger, R.G.3
Lehrach, H.4
Kofler, B.5
Ralser, M.6
-
15
-
-
82755166890
-
Inhibition of pyruvate kinase m2 by reactive oxygen species contributes to cellular antioxidant responses
-
PMID:22052977
-
Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011; 334:1278-83; PMID:22052977; http://dx.doi.org/10.1126/science. 1211485.
-
(2011)
Science
, vol.334
, pp. 1278-83
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
-
16
-
-
84856913587
-
Pyruvate kinase m2-specific sirna induces apoptosis and tumor regression
-
PMID:22271574
-
Goldberg MS, Sharp PA. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med 2012; 209:217-24; PMID:22271574; http://dx.doi.org/10.1084/jem.20111487.
-
(2012)
J Exp Med
, vol.209
, pp. 217-24
-
-
Goldberg, M.S.1
Sharp, P.A.2
-
17
-
-
0034652620
-
High lactate levels predict likelihood of metastases, tumor recurrence and restricted patient survival in human cervical cancers
-
PMID:10706105
-
Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, et al. High lactate levels predict likelihood of metastases, tumor recurrence and restricted patient survival in human cervical cancers. Cancer Res 2000; 60:916-21; PMID:10706105.
-
(2000)
Cancer Res
, vol.60
, pp. 916-21
-
-
Walenta, S.1
Wetterling, M.2
Lehrke, M.3
Schwickert, G.4
Sundfør, K.5
Rofstad, E.K.6
-
18
-
-
76649126249
-
Inhibition of lactate dehydrogenase a induces oxidative stress and inhibits tumor progression
-
2042; PMID:20133848
-
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 2010; 107:2037-42; PMID:20133848; http://dx.doi.org/10.1073/pnas.0914433107.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 2037-107
-
-
Le A Cooper, C.R.1
Gouw, A.M.2
Dinavahi, R.3
Maitra, A.4
Deck, L.M.5
-
19
-
-
80052886169
-
Efficient elimination of cancer cells by deoxyglucose-abt-263/737 combination therapy
-
PMID:21949692
-
Yamaguchi R, Janssen E, Perkins G, Ellisman M, Kitada S, Reed JC. Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS One 2011; 6:e24102; PMID:21949692; http://dx.doi.org/10.1371/ journal.pone.0024102.
-
(2011)
PLoS One
, vol.6
-
-
Yamaguchi, R.1
Janssen, E.2
Perkins, G.3
Ellisman, M.4
Kitada, S.5
Reed, J.C.6
-
20
-
-
77951075491
-
Glycolytic enzyme inhibitors affect pancreatic cancer survival by modulating its signaling and energetics
-
PMID:20392992
-
Bhardwaj V, Rizvi N, Lai MB, Lai JC, Bhushan A. Glycolytic enzyme inhibitors affect pancreatic cancer survival by modulating its signaling and energetics. Anticancer Res 2010; 30:743-9; PMID:20392992.
-
(2010)
Anticancer Res
, vol.30
, pp. 743-9
-
-
Bhardwaj, V.1
Rizvi, N.2
Lai, M.B.3
Lai, J.C.4
Bhushan, A.5
-
21
-
-
84858749705
-
3-Bromopyruvate Antagonizes Effects Of Lactate And Pyruvate Synergizes With Citrate And Exerts Novel Anti-glioma Effects
-
PMID:22318356
-
El Sayed SM, El-Magd RM, Shishido Y, Chung SP, Diem TH, Sakai T, et al. 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects. J Bioenerg Biomembr 2012; 44:61-79; PMID:22318356; http://dx.doi.org/10.1007/s10863-012-9409-4.
-
(2012)
J Bioenerg Biomembr
, vol.44
, pp. 61-79
-
-
El Sayed, S.M.1
El-Magd, R.M.2
Shishido, Y.3
Chung, S.P.4
Diem, T.H.5
Sakai, T.6
-
22
-
-
53049103850
-
Dichloroacetate (dca) as a potential metabolic-targeting therapy for cancer
-
PMID:18766181
-
Michelakis ED, Webster L, Mackey Jr. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 2008; 99:989-94; PMID:18766181; http://dx.doi.org/10.1038/sj.bjc.6604554.
-
(2008)
Br J Cancer
, vol.99
, pp. 989-94
-
-
Michelakis, E.D.1
Webster, L.2
Mackey, J.R.3
-
23
-
-
0034107704
-
Human glucose-6-phosphate dehydrogenase (g6pd) gene transforms nih 3t3 cells and induces tumors in nude mice
-
PMID:10709108
-
Kuo W, Lin J, Tang TK. Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer 2000; 85:857-64; PMID:10709108; http://dx.doi.org/10.1002/(SICI)1097- 0215(20000315856857AID-IJC2030CO2-U
-
(2000)
Int J Cancer
, vol.85
, pp. 857-64
-
-
Kuo, W.1
Lin, J.2
Tang, T.K.3
-
24
-
-
23644437291
-
Radiosensitization by 6-aminonicotinamide and 2-deoxy-d-glucose in human cancer cells
-
PMID:16076755
-
Varshney R, Dwarakanath B, Jain V. Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells. Int J Radiat Biol 2005; 81:397-408; PMID:16076755; http://dx.doi.org/10.1080/ 09553000500148590.
-
(2005)
Int J Radiat Biol
, vol.81
, pp. 397-408
-
-
Varshney, R.1
Dwarakanath, B.2
Jain, V.3
-
25
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
PMID:16971499
-
Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 2007; 292:C125-36; PMID:16971499; http://dx.doi.org/10.1152/ajpcell.00247.2006.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
Moran, R.4
Tamagnine, J.5
Parslow, D.6
-
26
-
-
34447547148
-
Regulation of tumor ph and the role of carbonic anhydrase 9
-
PMID:17415526
-
Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev 2007; 26:299-310; PMID:17415526; http://dx.doi.org/10.1007/s10555-007-9064-0.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 299-310
-
-
Swietach, P.1
Vaughan-Jones, R.D.2
Harris, A.L.3
-
27
-
-
0034698178
-
Deregulation of glucose transporter 1 and glycolytic gene expression by c-myc
-
PMID:10823814
-
Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 2000; 275:21797-800; PMID:10823814; http://dx.doi.org/10.1074/jbc.C000023200.
-
(2000)
J Biol Chem
, vol.275
, pp. 21797-800
-
-
Osthus, R.C.1
Shim, H.2
Kim, S.3
Li, Q.4
Reddy, R.5
Mukherjee, M.6
-
28
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
PMID:15172999
-
Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, et al. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 2004; 64:3892-9; PMID:15172999; http://dx.doi.org/10.1158/0008-5472.CAN-03-2904.
-
(2004)
Cancer Res
, vol.64
, pp. 3892-9
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
-
29
-
-
33747487110
-
Ras transformation requires metabolic control by 6-phosphofructo-2-kinase
-
PMID:16715124
-
Telang S, Yalcin A, Clem AL, Bucala R, Lane AN, Eaton JW, et al. Ras transformation requires metabolic control by 6-phosphofructo-2-kinase. Oncogene 2006; 25:7225-34; PMID:16715124; http://dx.doi.org/10.1038/sj.onc.1209709.
-
(2006)
Oncogene
, vol.25
, pp. 7225-34
-
-
Telang, S.1
Yalcin, A.2
Clem, A.L.3
Bucala, R.4
Lane, A.N.5
Eaton, J.W.6
-
30
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
PMID:18772396
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321:1807-12; PMID:18772396; http://dx.doi.org/10.1126/science.1164382.
-
(2008)
Science
, vol.321
, pp. 1807-12
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
31
-
-
58349111311
-
Idh1 mutations at residue p.r132 (idh1(r132)) occur frequently in highgrade gliomas but not in other solid tumors
-
PMID:19117336
-
Bleeker FE, Lamba S, Leenstra S, Troost D, Hulsebos T, Vandertop WP, et al. IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in highgrade gliomas but not in other solid tumors. Hum Mutat 2009; 30:7-11; PMID:19117336; http://dx.doi.org/10.1002/humu.20937.
-
(2009)
Hum Mutat
, vol.30
, pp. 7-11
-
-
Bleeker, F.E.1
Lamba, S.2
Leenstra, S.3
Troost, D.4
Hulsebos, T.5
Vandertop, W.P.6
-
32
-
-
64849098267
-
Glioma-derived mutations in idh1 dominantly inhibit idh1 catalytic activity and induce hif-1alpha
-
PMID:19359588
-
Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009; 324:261-5; PMID:19359588; http://dx.doi.org/10.1126/ science.1170944.
-
(2009)
Science
, vol.324
, pp. 261-5
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
Jiang, W.4
Zha, Z.5
Wang, P.6
-
33
-
-
72049125350
-
Cancer-associated idh1 mutations produce 2-hydroxyglutarate
-
PMID:19935646
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009; 462:739-44; PMID:19935646; http://dx.doi.org/10.1038/nature08617.
-
(2009)
Nature
, vol.462
, pp. 739-44
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
35
-
-
33845718704
-
Mitochondrial respiration defects in cancer cells cause activation of akt survival pathway through a redox-mediated mechanism
-
PMID:17158952
-
Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, et al. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol 2006; 175:913-23; PMID:17158952; http://dx.doi.org/10.1083/jcb.200512100.
-
(2006)
J Cell Biol
, vol.175
, pp. 913-923
-
-
Pelicano, H.1
Xu, R.H.2
Du, M.3
Feng, L.4
Sasaki, R.5
Carew, J.S.6
-
36
-
-
77749334738
-
Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
-
PMID:20100866
-
Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol 2010; 30:1303-18; PMID:20100866; http://dx.doi.org/10.1128/MCB.01101-09.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 1303-18
-
-
Fogal, V.1
Richardson, A.D.2
Karmali, P.P.3
Scheffler, I.E.4
Smith, J.W.5
Ruoslahti, E.6
-
37
-
-
79952228407
-
Activated ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
PMID:21317241
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25:460-70; PMID:21317241; http://dx.doi.org/10. 1101/gad.2016311.
-
(2011)
Genes Dev
, vol.25
, pp. 460-70
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
-
38
-
-
79954504372
-
Stromalepithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment
-
PMID:21300172
-
Martinez-Outschoorn UE, Pavlides S, Howell A, Pestell RG, Tanowitz HB, Sotgia F, et al. Stromalepithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment. Int J Biochem Cell Biol 2011; 43:1045-51; PMID:21300172; http://dx.doi.org/10.1016/j.biocel. 2011.01.023.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 1045-51
-
-
Martinez-Outschoorn, U.E.1
Pavlides, S.2
Howell, A.3
Pestell, R.G.4
Tanowitz, H.B.5
Sotgia, F.6
-
39
-
-
77954154374
-
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling
-
PMID:20562527
-
Migneco G, Whitaker-Menezes D, Chiavarina B, Castello-Cros R, Pavlides S, Pestell RG, et al. Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. Cell Cycle 2010; 9:2412-22; PMID:20562527; http://dx.doi.org/10.4161/cc.9.12.11989.
-
(2010)
Cell Cycle
, vol.9
, pp. 2412-22
-
-
Migneco, G.1
Whitaker-Menezes, D.2
Chiavarina, B.3
Castello-Cros, R.4
Pavlides, S.5
Pestell, R.G.6
-
40
-
-
77956419439
-
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
-
PMID:20818174
-
Bonuccelli G, Tsirigos A, Whitaker-Menezes D, Pavlides S, Pestell RG, Chiavarina B, et al. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010; 9:3506-14; PMID:20818174; http://dx.doi.org/10. 4161/cc.9.17.12731.
-
(2010)
Cell Cycle
, vol.9
, pp. 3506-14
-
-
Bonuccelli, G.1
Tsirigos, A.2
Whitaker-Menezes, D.3
Pavlides, S.4
Pestell, R.G.5
Chiavarina, B.6
-
41
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
PMID:19033663
-
Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008; 118:3930-42; PMID:19033663.
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-42
-
-
Sonveaux, P.1
Végran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
-
42
-
-
79954537559
-
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics
-
PMID:21512313
-
Martinez-Outschoorn UE, Prisco M, Ertel A, Tsirigos A, Lin Z, Pavlides S, et al. Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle 2011; 10:1271-86; PMID:21512313; http://dx.doi.org/10.4161/cc.10.8.15330.
-
(2011)
Cell Cycle
, vol.10
, pp. 1271-86
-
-
Martinez-Outschoorn, U.E.1
Prisco, M.2
Ertel, A.3
Tsirigos, A.4
Lin, Z.5
Pavlides, S.6
-
43
-
-
81255157465
-
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
-
1498-17:1503; PMID:22037646
-
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med 2011; 17:1498-503; PMID:22037646; http://dx.doi.org/10.1038/nm.2492.
-
(2011)
Nat Med
, vol.17
-
-
Nieman, K.M.1
Kenny, H.A.2
Penicka, C.V.3
Ladanyi, A.4
Buell-Gutbrod, R.5
Zillhardt, M.R.6
-
44
-
-
78349266054
-
The autophagic tumor stroma model of cancer or "battery-operated tumor growth: A simple solution to the autophagy paradox
-
PMID:21051947
-
Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, Chiavarina B, Bonuccelli G, Casey T, et al. The autophagic tumor stroma model of cancer or "battery-operated tumor growth: A simple solution to the autophagy paradox. Cell Cycle 2010; 9:4297-306; PMID:21051947; http://dx.doi.org/10.4161/cc.9.21. 13817.
-
(2010)
Cell Cycle
, vol.9
, pp. 4297-94306
-
-
Martinez-Outschoorn, U.E.1
Whitaker-Menezes, D.2
Pavlides, S.3
Chiavarina, B.4
Bonuccelli, G.5
Casey, T.6
-
46
-
-
75849160168
-
Rotenone induces apoptosis in mcf-7 human breast cancer cell-mediated ros through jnk and p38 signaling
-
PMID:19777565
-
Deng YT, Huang HC, Lin JK. Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. Mol Carcinog 2010; 49:141-51; PMID:19777565.
-
(2010)
Mol Carcinog
, vol.49
, pp. 141-51
-
-
Deng, Y.T.1
Huang, H.C.2
Lin, J.K.3
-
47
-
-
0028267301
-
Mitochondrial respiratory chain inhibitors induce apoptosis
-
PMID:8313978
-
Wolvetang EJ, Johnson KL, Krauer K, Ralph SJ, Linnane AW. Mitochondrial respiratory chain inhibitors induce apoptosis. FEBS Lett 1994; 339:40-4; PMID:8313978; http://dx.doi.org/10.1016/0014-5793(94)80380-3.
-
(1994)
FEBS Lett
, vol.339
, pp. 40-4
-
-
Wolvetang, E.J.1
Johnson, K.L.2
Krauer, K.3
Ralph, S.J.4
Linnane, A.W.5
-
48
-
-
47549092354
-
Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex ii
-
PMID:18372923
-
Dong LF, Low P, Dyason JC, Wang XF, Prochazka L, Witting PK, et al. Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene 2008; 27:4324-35; PMID:18372923; http://dx.doi.org/10.1038/onc.2008.69.
-
(2008)
Oncogene
, vol.27
, pp. 4324-35
-
-
Dong, L.F.1
Low, P.2
Dyason, J.C.3
Wang, X.F.4
Prochazka, L.5
Witting, P.K.6
-
49
-
-
57649174596
-
Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells
-
28330151 63 PMID:18768478
-
Xiao D, Powolny AA, Singh SV. Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. J Biol Chem 2008; 283:30151-63; PMID:18768478; http://dx.doi.org/10.1074/jbc. M802529200.
-
(2008)
J Biol Chem
-
-
Xiao, D.1
Powolny, A.A.2
Singh, S.V.3
-
50
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
PMID:16732220
-
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5:493-506; PMID:16732220; http://dx.doi.org/10.1038/nrd2060.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
51
-
-
0001572284
-
Nutrition needs of mammalian cells in tissue culture
-
PMID:13255879
-
Eagle H. Nutrition needs of mammalian cells in tissue culture. Science 1955; 122:501-14; PMID:13255879; http://dx.doi.org/10.1126/science.122.3168.501.
-
(1955)
Science
, vol.122
, pp. 501-14
-
-
Eagle, H.1
-
52
-
-
0015288919
-
The role of glutamine in the oxidative metabolism of malignant cells
-
PMID:4400467
-
Kovacevic Z, Morris HP. The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res 1972; 32:326-33; PMID:4400467.
-
(1972)
Cancer Res
, vol.32
, pp. 326-33
-
-
Kovacevic, Z.1
Morris, H.P.2
-
53
-
-
84855453655
-
Glucose-independent glutamine metabolism via tca cycling for proliferation and survival in b cells
-
PMID:22225880
-
Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012; 15:110-21; PMID:22225880; http://dx.doi.org/10.1016/j.cmet.2011.12.009.
-
(2012)
Cell Metab
, vol.15
, pp. 110-21
-
-
Le A Lane, A.N.1
Hamaker, M.2
Bose, S.3
Gouw, A.4
Barbi, J.5
-
54
-
-
77955281020
-
Glutamine addiction: A new therapeutic target in cancer
-
PMID:20570523
-
Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci 2010; 35:427-33; PMID:20570523; http://dx.doi.org/10. 1016/j.tibs.2010.05.003.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 427-33
-
-
Wise, D.R.1
Thompson, C.B.2
-
55
-
-
26644441651
-
Atp citrate lyase inhibition can suppress tumor cell growth
-
PMID:16226706
-
Hatzivassiliou G, Zhao F, Bauer DE, Andreadis C, Shaw AN, Dhanak D, et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005; 8:311-21; PMID:16226706; http://dx.doi.org/10.1016/j.ccr.2005.09.008.
-
(2005)
Cancer Cell
, vol.8
, pp. 311-21
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
Andreadis, C.4
Shaw, A.N.5
Dhanak, D.6
-
56
-
-
57349175482
-
Fatty acid synthase inhibition with orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
-
1232557 65 PMID:18770866
-
Carvalho MA, Zecchin KG, Seguin F, Bastos DC, Agostini M, Rangel AL, et al. Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer 2008; 123:2557-65; PMID:18770866; http://dx.doi.org/10.1002/ijc.23835.
-
(2008)
Int J Cancer
-
-
Carvalho, M.A.1
Zecchin, K.G.2
Seguin, F.3
Bastos, D.C.4
Agostini, M.5
Rangel, A.L.6
-
57
-
-
37249017959
-
Selective inhibition of fatty acid synthase for lung cancer treatment
-
PMID:18056164
-
Orita H, Coulter J, Lemmon C, Tully E, Vadlamudi A, Medghalchi SM, et al. Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res 2007; 13:7139-45; PMID:18056164.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7139-45
-
-
Orita, H.1
Coulter, J.2
Lemmon, C.3
Tully, E.4
Vadlamudi, A.5
Medghalchi, S.M.6
-
58
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
PMID:18032601
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 2007; 104:19345-50; PMID:18032601; http://dx.doi.org/ 10.1073/pnas.0709747104.
-
(2007)
Proc Natl Acad Sci U S A
, vol.1041
, pp. 9345-9350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
-
59
-
-
34347402459
-
Deficiency in glutamine but not glucose induces myc-dependent apoptosis in human cells
-
PMID:17606868
-
Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 2007; 178:93-105; PMID:17606868; http://dx.doi.org/10.1083/jcb. 200703099.
-
(2007)
J Cell Biol
, vol.178
, pp. 93-105
-
-
Yuneva, M.1
Zamboni, N.2
Oefner, P.3
Sachidanandam, R.4
Lazebnik, Y.5
-
60
-
-
77958478353
-
Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells
-
3921-9:3932; PMID:20935507
-
Meng M, Chen S, Lao T, Liang D, Sang N. Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells. Cell Cycle 2010; 9:3921-32; PMID:20935507; http://dx.doi.org/10.4161/cc.9.19.13139.
-
(2010)
Cell Cycle
, vol.9
-
-
Meng, M.1
Chen, S.2
Lao, T.3
Liang, D.4
Sang, N.5
-
61
-
-
61849162778
-
Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts
-
PMID:19262748
-
Gaglio D, Soldati C, Vanoni M, Alberghina L, Chiaradonna F. Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts. PLoS One 2009; 4:e4715; PMID:19262748; http://dx.doi.org/10.1371/journal. pone.0004715.
-
(2009)
PLoS One
, vol.4
-
-
Gaglio, D.1
Soldati, C.2
Vanoni, M.3
Alberghina, L.4
Chiaradonna, F.5
-
62
-
-
0019293446
-
Phase ii study of l-asparaginase in the treatment of pancreatic carcinoma
-
PMID:7471124
-
Lessner HE, Valenstein S, Kaplan R, DeSimone P, Yunis A. Phase II study of L-asparaginase in the treatment of pancreatic carcinoma. Cancer Treat Rep 1980; 64:1359-61; PMID:7471124.
-
(1980)
Cancer Treat Rep
, vol.64
, pp. 1359-61
-
-
Lessner, H.E.1
Valenstein, S.2
Kaplan, R.3
DeSimone, P.4
Yunis, A.5
-
63
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
PMID:17638885
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67:6745-52; PMID:17638885; http://dx.doi.org/10.1158/0008-5472.CAN-06-4447.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-52
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
DeBerardinis, R.J.5
Zhao, F.6
-
64
-
-
59049087460
-
Bidirectional transport of amino acids regulates mtor and autophagy
-
PMID:19203585
-
Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009; 136:521-34; PMID:19203585; http://dx.doi.org/10.1016/j.cell.2008.11.044.
-
(2009)
Cell
, vol.136
, pp. 521-34
-
-
Nicklin, P.1
Bergman, P.2
Zhang, B.3
Triantafellow, E.4
Wang, H.5
Nyfeler, B.6
-
65
-
-
64749116346
-
C-myc suppression of mir-23ab enhances mitochondrial glutaminase expression and glutamine metabolism
-
PMID:19219026
-
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009; 458:762-5; PMID:19219026; http://dx.doi.org/10.1038/nature07823.
-
(2009)
Nature
, vol.458
, pp. 762-5
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
-
66
-
-
77956497712
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
PMID:20832749
-
Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010; 18:207-19; PMID:20832749; http://dx.doi.org/10.1016/j.ccr. 2010.08.009.
-
(2010)
Cancer Cell
, vol.18
, pp. 207-19
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
Ramachandran, S.4
Gao, P.5
Dinavahi, R.6
-
67
-
-
0021248051
-
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial nad(p)+-dependent malic enzyme
-
PMID:6144677
-
Moreadith RW, Lehninger AL. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J Biol Chem 1984; 259:6215-21; PMID:6144677.
-
(1984)
J Biol Chem
, vol.259
, pp. 6215-21
-
-
Moreadith, R.W.1
Lehninger, A.L.2
-
68
-
-
59449083179
-
Targeting aspartate aminotransferase in breast cancer
-
PMID:18922152
-
Thornburg JM, Nelson KK, Clem BF, Lane AN, Arumugam S, Simmons A, et al. Targeting aspartate aminotransferase in breast cancer. Breast Cancer Res 2008; 10:R84; PMID:18922152; http://dx.doi.org/10.1186/bcr2154.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Thornburg, J.M.1
Nelson, K.K.2
Clem, B.F.3
Lane, A.N.4
Arumugam, S.5
Simmons, A.6
-
69
-
-
83755168277
-
Pet imaging of glutaminolysis in tumors by 18f-(2s,4r)4-fluoroglutamine
-
PMID:22095958
-
Lieberman BP, Ploessl K, Wang L, Qu W, Zha Z, Wise DR, et al. PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine. J Nucl Med 2011; 52:1947-55; PMID:22095958; http://dx.doi.org/10.2967/jnumed.111.093815.
-
(2011)
J Nucl Med
, vol.52
, Issue.55
-
-
Lieberman, B.P.1
Ploessl, K.2
Wang, L.3
Qu, W.4
Zha, Z.5
Wise, D.R.6
-
70
-
-
70349331678
-
Glucose deprivation contributes to the development of kras pathway mutations in tumor cells
-
PMID:19661383
-
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009; 325:1555-9; PMID:19661383; http://dx.doi.org/10. 1126/science.1174229.
-
(2009)
Science
, vol.325
, pp. 1555-9
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
-
71
-
-
84856521923
-
Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and oxphos
-
PMID:22319564
-
Chen V, Staub RE, Fong S, Tagliaferri M, Cohen I, Shtivelman E. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. PLoS One 2012; 7:e30300; PMID:22319564; http://dx.doi.org/10.1371/ journal.pone.0030300.
-
(2012)
PLoS One
, vol.7
-
-
Chen, V.1
Staub, R.E.2
Fong, S.3
Tagliaferri, M.4
Cohen, I.5
Shtivelman, E.6
-
72
-
-
83355163333
-
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models
-
PMID:21992792
-
Cheong JH, Park ES, Liang J, Dennison JB, Tsavachidou D, Nguyen-Charles C, et al. Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models. Mol Cancer Ther 2011; 10:2350-62; PMID:21992792; http://dx.doi.org/10.1158/1535- 7163.MCT-11-0497.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2350-62
-
-
Cheong, J.H.1
Park, E.S.2
Liang, J.3
Dennison, J.B.4
Tsavachidou, D.5
Nguyen-Charles, C.6
|