Organizing principles of Mammalian nonsense-mediated mRNA decay

Annual Review of Genetics

Volumn 47, Issue , 2013, Pages 139-165

  Wei Lin Popp, Maximilian ^a,b   Maquat, Lynne E ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Nonsense mediated mRNA decay; Posttranscriptional gene regulation; Posttranslational gene regulation; Premature termination codon; Quality control; Translational repression; Ubiquitin proteasome system

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMLEXANOX; APTAMER; ATALUREN; BORTEZOMIB; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA; GENTAMICIN; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; MESSENGER RNA; PROTEASOME; PROTEIN MDM2; SELENOCYSTEINE; SELENOPROTEIN; SMALL INTERFERING RNA; TRANSFER RNA; UBIQUITIN;

ANEMIA; ASTHMA; BETA THALASSEMIA; COCHLEA INJURY; CODON; CYSTIC FIBROSIS; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE SYSTEM; MAMMAL CELL; MOLECULARLY TARGETED THERAPY; MULTIPLE MYELOMA; NEPHROTOXICITY; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; PHASE 3 CLINICAL TRIAL (TOPIC); POSTTRANSCRIPTIONAL GENE REGULATION; POSTTRANSLATIONAL GENE REGULATION; PREMATURE TERMINATION CODON; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN QUALITY; QUALITY CONTROL; REVIEW; RNA TRANSLATION; TRANSCRIPTION REGULATION; TUMOR CELL; ULCER;

MAMMALIA;

3' UNTRANSLATED REGIONS; ANIMALS; CELL NUCLEUS; CODON, NONSENSE; EXONS; FORECASTING; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, VIRAL; GENETIC DISEASES, INBORN; HUMANS; MAMMALS; MODELS, GENETIC; NONSENSE MEDIATED MRNA DECAY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBONUCLEOPROTEINS; RNA, MESSENGER; UBIQUITINATION; VIRAL PROTEINS;

EID: 84888617099     PISSN: 00664197     EISSN: 15452948     Source Type: Book Series    
DOI: 10.1146/annurev-genet-111212-133424     Document Type: Review

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