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Volumn 12, Issue 1, 2013, Pages 25-36

Nonsense-mediated mRNA decay: From mechanistic insights to impacts on human health

Author keywords

Development; Disease; Gene expression; Growth; Quality control; RNA decay

Indexed keywords

RNA;

EID: 84872795590     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/els051     Document Type: Article
Times cited : (36)

References (112)
  • 1
    • 0018675870 scopus 로고
    • Suppression of the nonsense mutation in homozygous beta 0 thalassaemia
    • Chang JC, Temple GF, Trecartin RF, et al. Suppression of the nonsense mutation in homozygous beta 0 thalassaemia. Nature 1979;281:602-3.
    • (1979) Nature , vol.281 , pp. 602-603
    • Chang, J.C.1    Temple, G.F.2    Trecartin, R.F.3
  • 2
    • 0009461277 scopus 로고
    • Interference of nonsense mutations with eukaryotic messenger RNA stability
    • Losson R, Lacroute F. Interference of nonsense mutations with eukaryotic messenger RNA stability. Proc Natl Acad Sci USA 1979;76:5134-7.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 5134-5137
    • Losson, R.1    Lacroute, F.2
  • 3
    • 77949904260 scopus 로고    scopus 로고
    • Nonsensemediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    • Nicholson P, Yepiskoposyan H, Metze S, et al. Nonsensemediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 2010;67:677-700.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 677-700
    • Nicholson, P.1    Yepiskoposyan, H.2    Metze, S.3
  • 4
    • 0033082394 scopus 로고    scopus 로고
    • RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
    • Culbertson MR. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. Trends Genet 1999;15:74-80.
    • (1999) Trends Genet , vol.15 , pp. 74-80
    • Culbertson, M.R.1
  • 5
    • 79958192752 scopus 로고    scopus 로고
    • Control of human betaglobin mRNA stability and its impact on beta-thalassemia phenotype
    • Peixeiro I, Silva AL, Romao L. Control of human betaglobin mRNA stability and its impact on beta-thalassemia phenotype. Haematologica 2011;96:905-13.
    • (2011) Haematologica , vol.96 , pp. 905-913
    • Peixeiro, I.1    Silva, A.L.2    Romao, L.3
  • 6
    • 77956663450 scopus 로고    scopus 로고
    • NMD: RNA biology meets human genetic medicine
    • Bhuvanagiri M, Schlitter AM, Hentze MW, et al. NMD: RNA biology meets human genetic medicine. Biochem J 2010;430:365-77.
    • (2010) Biochem J , vol.430 , pp. 365-377
    • Bhuvanagiri, M.1    Schlitter, A.M.2    Hentze, M.W.3
  • 7
    • 0037300234 scopus 로고    scopus 로고
    • Screening for PAX6 gene mutations is consistent with haploinsufficiency as the main mechanism leading to various ocular defects
    • Vincent MC, Pujo AL, Olivier D, et al. Screening for PAX6 gene mutations is consistent with haploinsufficiency as the main mechanism leading to various ocular defects. Eur J Hum Genet 2003;11:163-9.
    • (2003) Eur J Hum Genet , vol.11 , pp. 163-169
    • Vincent, M.C.1    Pujo, A.L.2    Olivier, D.3
  • 8
    • 0141702288 scopus 로고    scopus 로고
    • Allelic variation in normal human FBN1 expression in a family with Marfan syndrome: a potential modifier of phenotype?
    • Hutchinson S, Furger A, Halliday D, et al. Allelic variation in normal human FBN1 expression in a family with Marfan syndrome: a potential modifier of phenotype? Hum Mol Genet 2003;12:2269-76.
    • (2003) Hum Mol Genet , vol.12 , pp. 2269-2276
    • Hutchinson, S.1    Furger, A.2    Halliday, D.3
  • 10
    • 13944249950 scopus 로고    scopus 로고
    • A new function for nonsense-mediated mRNA-decay factors
    • Wilkinson MF. A new function for nonsense-mediated mRNA-decay factors. Trends Genet 2005;21:143-8.
    • (2005) Trends Genet , vol.21 , pp. 143-148
    • Wilkinson, M.F.1
  • 11
    • 80052324997 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay and cystic fibrosis
    • Linde L, Kerem B. Nonsense-mediated mRNA decay and cystic fibrosis. Methods Mol Biol 2011;741:137-54.
    • (2011) Methods Mol Biol , vol.741 , pp. 137-154
    • Linde, L.1    Kerem, B.2
  • 12
    • 78649741328 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay and development: shoot the messenger to survive?
    • Vicente-Crespo M, Palacios IM. Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Biochem Soc Trans 2010;38:1500-5.
    • (2010) Biochem Soc Trans , vol.38 , pp. 1500-1505
    • Vicente-Crespo, M.1    Palacios, I.M.2
  • 13
    • 84863218026 scopus 로고    scopus 로고
    • Aberrant growth and lethality of Arabidopsis deficient in nonsensemediated RNA decay factors is caused by autoimmune-like response
    • Riehs-Kearnan N, Gloggnitzer J, Dekrout B, et al. Aberrant growth and lethality of Arabidopsis deficient in nonsensemediated RNA decay factors is caused by autoimmune-like response. Nucleic Acids Res 2012;40:5615-24.
    • (2012) Nucleic Acids Res , vol.40 , pp. 5615-5624
    • Riehs-Kearnan, N.1    Gloggnitzer, J.2    Dekrout, B.3
  • 14
    • 18744393105 scopus 로고    scopus 로고
    • Nonsense-mediated RNA decay: a molecular system micromanaging individual gene activities and suppressing genomic noise
    • Alonso CR. Nonsense-mediated RNA decay: a molecular system micromanaging individual gene activities and suppressing genomic noise. Bioessays 2005;27:463-6.
    • (2005) Bioessays , vol.27 , pp. 463-466
    • Alonso, C.R.1
  • 15
    • 0037080771 scopus 로고    scopus 로고
    • T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts
    • Gudikote JP, Wilkinson MF. T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J 2002;21:125-34.
    • (2002) EMBO J , vol.21 , pp. 125-134
    • Gudikote, J.P.1    Wilkinson, M.F.2
  • 16
    • 0033856880 scopus 로고    scopus 로고
    • Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans
    • Mitrovich QM, Anderson P. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Genes Dev 2000;14:2173-84.
    • (2000) Genes Dev , vol.14 , pp. 2173-2184
    • Mitrovich, Q.M.1    Anderson, P.2
  • 17
    • 0027242173 scopus 로고
    • Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1-mutant
    • He F, Peltz SW, Donahue JL, et al. Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1-mutant. Proc Natl Acad Sci USA 1993;90:7034-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7034-7038
    • He, F.1    Peltz, S.W.2    Donahue, J.L.3
  • 18
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, et al. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008;40:1413-5.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3
  • 19
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang ET, Sandberg R, Luo S, et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008;456:470-6.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3
  • 20
    • 0037422575 scopus 로고    scopus 로고
    • Evidence for the widespread coupling of alternative splicing and nonsensemediated mRNA decay in humans
    • Lewis BP, Green RE, Brenner SE. Evidence for the widespread coupling of alternative splicing and nonsensemediated mRNA decay in humans. Proc Natl Acad Sci USA 2003;100:189-92.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 189-192
    • Lewis, B.P.1    Green, R.E.2    Brenner, S.E.3
  • 21
    • 4944223388 scopus 로고    scopus 로고
    • Widespread predicted nonsense-mediated mRNA decay of alternativelyspliced transcripts of human normal and disease genes
    • Green RE, Lewis BP, Hillman RT, et al. Widespread predicted nonsense-mediated mRNA decay of alternativelyspliced transcripts of human normal and disease genes. Bioinformatics 2003;19(Suppl 1):I118-21.
    • (2003) Bioinformatics , vol.19 , Issue.SUPPL. 1
    • Green, R.E.1    Lewis, B.P.2    Hillman, R.T.3
  • 22
    • 33744994837 scopus 로고    scopus 로고
    • EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length
    • Buhler M, Steiner S, Mohn F, et al. EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 30 UTR length. Nat Struct Mol Biol 2006;13:462-4.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 462-464
    • Buhler, M.1    Steiner, S.2    Mohn, F.3
  • 23
    • 0036205348 scopus 로고    scopus 로고
    • Boundaryindependent polar nonsense-mediated decay
    • Wang J, Gudikote JP, Olivas OR, et al. Boundaryindependent polar nonsense-mediated decay. EMBO Rep 2002;3:274-9.
    • (2002) EMBO Rep , vol.3 , pp. 274-279
    • Wang, J.1    Gudikote, J.P.2    Olivas, O.R.3
  • 24
    • 8544253956 scopus 로고    scopus 로고
    • A faux 3'-UTR promotes aberrant termination and triggers nonsensemediated mRNA decay
    • Amrani N, Ganesan R, Kervestin S, et al. A faux 30-UTR promotes aberrant termination and triggers nonsensemediated mRNA decay. Nature 2004;432:112-8.
    • (2004) Nature , vol.432 , pp. 112-118
    • Amrani, N.1    Ganesan, R.2    Kervestin, S.3
  • 25
    • 34247556560 scopus 로고    scopus 로고
    • Mechanistic insights and identification of two novel factors in the C. elegans, NMD pathway
    • Longman D, Plasterk RH, Johnstone IL, et al. Mechanistic insights and identification of two novel factors in the C. elegans. NMD pathway. Genes Dev 2007;21:1075-1085.
    • (2007) Genes Dev , vol.21 , pp. 1075-1085
    • Longman, D.1    Plasterk, R.H.2    Johnstone, I.L.3
  • 26
    • 43249093760 scopus 로고    scopus 로고
    • Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region
    • Eberle AB, Stalder L, Mathys H, et al. Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. PLoS Biol 2008;6:e92.
    • (2008) PLoS Biol , vol.6
    • Eberle, A.B.1    Stalder, L.2    Mathys, H.3
  • 27
    • 77957771429 scopus 로고    scopus 로고
    • The exon junction complex differentially marks spliced junctions
    • Sauliere J, Haque N, Harms S, et al. The exon junction complex differentially marks spliced junctions. Nat Struct Mol Biol 2010;17:1269-71.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1269-1271
    • Sauliere, J.1    Haque, N.2    Harms, S.3
  • 28
    • 33947609704 scopus 로고    scopus 로고
    • A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay
    • Behm-Ansmant I, Gatfield D, Rehwinkel J, et al. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J 2007;26:1591-601.
    • (2007) EMBO J , vol.26 , pp. 1591-1601
    • Behm-Ansmant, I.1    Gatfield, D.2    Rehwinkel, J.3
  • 29
    • 77951976646 scopus 로고    scopus 로고
    • Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe
    • Wen J, Brogna S. Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe. EMBO J 2010; 29:1537-51.
    • (2010) EMBO J , vol.29 , pp. 1537-1551
    • Wen, J.1    Brogna, S.2
  • 30
    • 0035005985 scopus 로고    scopus 로고
    • A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition
    • Noensie EN, Dietz HC. A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nat Biotechnol 2001;19:434-9.
    • (2001) Nat Biotechnol , vol.19 , pp. 434-439
    • Noensie, E.N.1    Dietz, H.C.2
  • 31
    • 34247854948 scopus 로고    scopus 로고
    • Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells
    • Ivanov I, Lo KC, Hawthorn L, et al. Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells. Oncogene 2007;26:2873-84.
    • (2007) Oncogene , vol.26 , pp. 2873-2884
    • Ivanov, I.1    Lo, K.C.2    Hawthorn, L.3
  • 32
    • 77949811343 scopus 로고    scopus 로고
    • Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis
    • Gardner LB. Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis. Mol Cancer Res 2010;8:295-308.
    • (2010) Mol Cancer Res , vol.8 , pp. 295-308
    • Gardner, L.B.1
  • 33
    • 77949904260 scopus 로고    scopus 로고
    • Nonsensemediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    • Nicholson P, Yepiskoposyan H, Metze S, et al. Nonsensemediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 2010;67:677-700.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 677-700
    • Nicholson, P.1    Yepiskoposyan, H.2    Metze, S.3
  • 34
    • 44149104364 scopus 로고    scopus 로고
    • NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements
    • Weischenfeldt J, Damgaard I, Bryder D, et al. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev 2008;22:1381-96.
    • (2008) Genes Dev , vol.22 , pp. 1381-1396
    • Weischenfeldt, J.1    Damgaard, I.2    Bryder, D.3
  • 35
    • 33947305594 scopus 로고    scopus 로고
    • Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
    • Ni JZ, Grate L, Donohue JP, et al. Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes Dev 2007;21:708-18.
    • (2007) Genes Dev , vol.21 , pp. 708-718
    • Ni, J.Z.1    Grate, L.2    Donohue, J.P.3
  • 36
    • 67651233776 scopus 로고    scopus 로고
    • Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila
    • Hansen KD, Lareau LF, Blanchette M, et al. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet 2009;5:e1000525.
    • (2009) PLoS Genet , vol.5
    • Hansen, K.D.1    Lareau, L.F.2    Blanchette, M.3
  • 37
    • 6944256813 scopus 로고    scopus 로고
    • Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
    • Mendell JT, Sharifi NA, Meyers JL, et al. Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet 2004;36: 1073-8.
    • (2004) Nat Genet , vol.36 , pp. 1073-1078
    • Mendell, J.T.1    Sharifi, N.A.2    Meyers, J.L.3
  • 38
    • 49949105213 scopus 로고    scopus 로고
    • The multiple lives of NMD factors: balancing roles in gene and genome regulation
    • Isken O, Maquat LE. The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet 2008;9:699-712.
    • (2008) Nat Rev Genet , vol.9 , pp. 699-712
    • Isken, O.1    Maquat, L.E.2
  • 39
    • 76349096255 scopus 로고    scopus 로고
    • High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans
    • Ramani AK, Nelson AC, Kapranov P, et al. High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans. Genome Biol 2009;10: R101.
    • (2009) Genome Biol , vol.10
    • Ramani, A.K.1    Nelson, A.C.2    Kapranov, P.3
  • 40
    • 79952651144 scopus 로고    scopus 로고
    • Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner
    • Avery P, Vicente-Crespo M, Francis D, et al. Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. RNA 2011;17:624-38.
    • (2011) RNA , vol.17 , pp. 624-638
    • Avery, P.1    Vicente-Crespo, M.2    Francis, D.3
  • 41
    • 84868260851 scopus 로고    scopus 로고
    • Analysis of nonsense-mediated mRNA decay in Mammalian cells
    • Chapter 27 Unit27.4
    • Nicholson P, Joncourt R, Muhlemann O. Analysis of nonsense-mediated mRNA decay in Mammalian cells. Curr Protoc Cell Biol 2012; Chapter 27:Unit27.4.
    • (2012) Curr Protoc Cell Biol
    • Nicholson, P.1    Joncourt, R.2    Muhlemann, O.3
  • 42
    • 3542995089 scopus 로고    scopus 로고
    • Nonsense-mediated decay approaches the clinic
    • Holbrook JA, Neu-Yilik G, Hentze MW, et al. Nonsense-mediated decay approaches the clinic. Nat Genet 2004;36:801-808.
    • (2004) Nat Genet , vol.36 , pp. 801-808
    • Holbrook, J.A.1    Neu-Yilik, G.2    Hentze, M.W.3
  • 43
    • 34249870085 scopus 로고    scopus 로고
    • mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons
    • Behm-Ansmant I, Kashima I, Rehwinkel J, et al. mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett 2007; 581:2845-53.
    • (2007) FEBS Lett , vol.581 , pp. 2845-2853
    • Behm-Ansmant, I.1    Kashima, I.2    Rehwinkel, J.3
  • 44
    • 34247197937 scopus 로고    scopus 로고
    • The nonsensemediated decay RNA surveillance pathway
    • Chang YF, Imam JS, Wilkinson MF. The nonsensemediated decay RNA surveillance pathway. Annu Rev Biochem 2007;76:51-74.
    • (2007) Annu Rev Biochem , vol.76 , pp. 51-74
    • Chang, Y.F.1    Imam, J.S.2    Wilkinson, M.F.3
  • 45
    • 66049162655 scopus 로고    scopus 로고
    • Execution of nonsense-mediated mRNA decay: what defines a substrate?
    • Rebbapragada I, Lykke-Andersen J. Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol 2009;21:394-402.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 394-402
    • Rebbapragada, I.1    Lykke-Andersen, J.2
  • 46
    • 32044435368 scopus 로고    scopus 로고
    • Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
    • Kashima I, Yamashita A, Izumi N, et al. Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev 2006;20: 355-67.
    • (2006) Genes Dev , vol.20 , pp. 355-367
    • Kashima, I.1    Yamashita, A.2    Izumi, N.3
  • 47
    • 84856875524 scopus 로고    scopus 로고
    • Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations
    • Peixeiro I, Inacio A, Barbosa C, et al. Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations. Nucleic Acids Res 2012;40:1160-73.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1160-1173
    • Peixeiro, I.1    Inacio, A.2    Barbosa, C.3
  • 48
    • 40449131535 scopus 로고    scopus 로고
    • Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay
    • Silva AL, Ribeiro P, Inacio A, et al. Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. RNA 2008;14:563-76.
    • (2008) RNA , vol.14 , pp. 563-576
    • Silva, A.L.1    Ribeiro, P.2    Inacio, A.3
  • 49
    • 40949148553 scopus 로고    scopus 로고
    • Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
    • Ivanov PV, Gehring NH, Kunz JB, et al. Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J 2008;27:736-47.
    • (2008) EMBO J , vol.27 , pp. 736-747
    • Ivanov, P.V.1    Gehring, N.H.2    Kunz, J.B.3
  • 50
    • 43249084802 scopus 로고    scopus 로고
    • A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
    • Singh G, Rebbapragada I, Lykke-Andersen J. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol 2008;6:e111.
    • (2008) PLoS Biol , vol.6
    • Singh, G.1    Rebbapragada, I.2    Lykke-Andersen, J.3
  • 51
    • 0035823036 scopus 로고    scopus 로고
    • Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsensemediated decay in mammalian cells are bound by CBP80 and CBP20
    • Ishigaki Y, Li X, Serin G, et al. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsensemediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 2001;106:607-17.
    • (2001) Cell , vol.106 , pp. 607-617
    • Ishigaki, Y.1    Li, X.2    Serin, G.3
  • 52
    • 77958459763 scopus 로고    scopus 로고
    • Upf1 senses 3'UTR length to potentiate mRNA decay
    • Hogg JR, Goff SP. Upf1 senses 30UTR length to potentiate mRNA decay. Cell 2010;143:379-89.
    • (2010) Cell , vol.143 , pp. 379-389
    • Hogg, J.R.1    Goff, S.P.2
  • 53
    • 38149035044 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail
    • Meaux S, van Hoof A, Baker KE. Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail. Mol Cell 2008;29:134-40.
    • (2008) Mol Cell , vol.29 , pp. 134-140
    • Meaux, S.1    van Hoof, A.2    Baker, K.E.3
  • 54
    • 84860751669 scopus 로고    scopus 로고
    • The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end
    • S491-2
    • Melero R, Buchwald G, Castano R, et al. The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 30 end. Nat Struct Mol Biol 2012;19:498-505, S491-2.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 498-505
    • Melero, R.1    Buchwald, G.2    Castano, R.3
  • 55
    • 37849005006 scopus 로고    scopus 로고
    • NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
    • Chamieh H, Ballut L, Bonneau F, et al. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat Struct Mol Biol 2008; 15:85-93.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 85-93
    • Chamieh, H.1    Ballut, L.2    Bonneau, F.3
  • 56
    • 79952686670 scopus 로고    scopus 로고
    • Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2
    • Chakrabarti S, Jayachandran U, Bonneau F, et al. Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol Cell 2011;41:693-703.
    • (2011) Mol Cell , vol.41 , pp. 693-703
    • Chakrabarti, S.1    Jayachandran, U.2    Bonneau, F.3
  • 57
    • 1842473091 scopus 로고    scopus 로고
    • The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3
    • Kadlec J, Izaurralde E, Cusack S. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol 2004;11: 330-7.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 330-337
    • Kadlec, J.1    Izaurralde, E.2    Cusack, S.3
  • 58
    • 67650096774 scopus 로고    scopus 로고
    • Nonsensemediated mRNA decay effectors are essential for zebrafish embryonic development and survival
    • Wittkopp N, Huntzinger E, Weiler C, et al. Nonsensemediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol 2009;29: 3517-28.
    • (2009) Mol Cell Biol , vol.29 , pp. 3517-3528
    • Wittkopp, N.1    Huntzinger, E.2    Weiler, C.3
  • 59
    • 65449178454 scopus 로고    scopus 로고
    • SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
    • Yamashita A, Izumi N, Kashima I, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev 2009;23: 1091-105.
    • (2009) Genes Dev , vol.23 , pp. 1091-1105
    • Yamashita, A.1    Izumi, N.2    Kashima, I.3
  • 60
    • 78651337717 scopus 로고    scopus 로고
    • Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex
    • Fernandez IS, Yamashita A, Arias-Palomo E, et al. Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res 2011;39:347-58.
    • (2011) Nucleic Acids Res , vol.39 , pp. 347-358
    • Fernandez, I.S.1    Yamashita, A.2    Arias-Palomo, E.3
  • 61
    • 78651507958 scopus 로고    scopus 로고
    • The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8
    • Arias-Palomo E, Yamashita A, Fernandez IS, et al. The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev 2011;25:153-64.
    • (2011) Genes Dev , vol.25 , pp. 153-164
    • Arias-Palomo, E.1    Yamashita, A.2    Fernandez, I.S.3
  • 62
    • 13944259434 scopus 로고    scopus 로고
    • SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
    • Fukuhara N, Ebert J, Unterholzner L, et al. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell 2005;17:537-47.
    • (2005) Mol Cell , vol.17 , pp. 537-547
    • Fukuhara, N.1    Ebert, J.2    Unterholzner, L.3
  • 63
    • 84856858152 scopus 로고    scopus 로고
    • Nand C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5: SMG-7 during NMD
    • Okada-Katsuhata Y, Yamashita A, Kutsuzawa K, et al. Nand C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res 2012;40:1251-66.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1251-1266
    • Okada-Katsuhata, Y.1    Yamashita, A.2    Kutsuzawa, K.3
  • 64
    • 85011942476 scopus 로고    scopus 로고
    • Assembly, disassembly and recycling: the dynamics of exon junction complexes
    • Bono F, Gehring NH. Assembly, disassembly and recycling: the dynamics of exon junction complexes. RNA Biol 2011; 8:24-9.
    • (2011) RNA Biol , vol.8 , pp. 24-29
    • Bono, F.1    Gehring, N.H.2
  • 65
    • 1442354190 scopus 로고    scopus 로고
    • An eIF4AIIIcontaining complex required for mRNA localization and nonsense-mediated mRNA decay
    • Palacios IM, Gatfield D, St Johnston D, et al. An eIF4AIIIcontaining complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 2004;427:753-7.
    • (2004) Nature , vol.427 , pp. 753-757
    • Palacios, I.M.1    Gatfield, D.2    St Johnston, D.3
  • 66
    • 84864052299 scopus 로고    scopus 로고
    • Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6
    • Frizzell KA, Rynearson SG, Metzstein MM. Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA 2012;18:1475-86.
    • (2012) RNA , vol.18 , pp. 1475-1486
    • Frizzell, K.A.1    Rynearson, S.G.2    Metzstein, M.M.3
  • 67
    • 0032771414 scopus 로고    scopus 로고
    • SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
    • Page MF, Carr B, Anders KR, et al. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol 1999;19: 5943-51.
    • (1999) Mol Cell Biol , vol.19 , pp. 5943-5951
    • Page, M.F.1    Carr, B.2    Anders, K.R.3
  • 68
    • 78649720695 scopus 로고    scopus 로고
    • Cutting the nonsense: the degradation of PTC-containing mRNAs
    • Nicholson P, Muhlemann O. Cutting the nonsense: the degradation of PTC-containing mRNAs. Biochem Soc Trans 2010;38:1615-20.
    • (2010) Biochem Soc Trans , vol.38 , pp. 1615-1620
    • Nicholson, P.1    Muhlemann, O.2
  • 69
    • 0027932513 scopus 로고
    • Premature translational termination triggers mRNA decapping
    • Muhlrad D, Parker R. Premature translational termination triggers mRNA decapping. Nature 1994;370:578-81.
    • (1994) Nature , vol.370 , pp. 578-581
    • Muhlrad, D.1    Parker, R.2
  • 70
    • 0347416978 scopus 로고    scopus 로고
    • Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast
    • He F, Li X, Spatrick P, et al. Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 50 to 30 mRNA decay pathways in yeast. Mol Cell 2003;12:1439-52.
    • (2003) Mol Cell , vol.12 , pp. 1439-1452
    • He, F.1    Li, X.2    Spatrick, P.3
  • 71
    • 80055122225 scopus 로고    scopus 로고
    • Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae
    • Swisher KD, Parker R. Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae. PLoS One 2011;6:e26547.
    • (2011) PLoS One , vol.6
    • Swisher, K.D.1    Parker, R.2
  • 72
    • 33750490399 scopus 로고    scopus 로고
    • Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
    • Glavan F, Behm-Ansmant I, Izaurralde E, et al. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J 2006;25: 5117-25.
    • (2006) EMBO J , vol.25 , pp. 5117-5125
    • Glavan, F.1    Behm-Ansmant, I.2    Izaurralde, E.3
  • 73
    • 58149265041 scopus 로고    scopus 로고
    • SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells
    • Eberle AB, Lykke-Andersen S, Muhlemann O, et al. SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol 2009;16:49-55.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 49-55
    • Eberle, A.B.1    Lykke-Andersen, S.2    Muhlemann, O.3
  • 74
    • 57049126216 scopus 로고    scopus 로고
    • SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
    • Huntzinger E, Kashima I, Fauser M, et al. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 2008;14:2609-17.
    • (2008) RNA , vol.14 , pp. 2609-2617
    • Huntzinger, E.1    Kashima, I.2    Fauser, M.3
  • 75
    • 0042025014 scopus 로고    scopus 로고
    • Nonsensemediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways
    • Gatfield D, Unterholzner L, Ciccarelli FD, et al. Nonsensemediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J 2003;22: 3960-70.
    • (2003) EMBO J , vol.22 , pp. 3960-3970
    • Gatfield, D.1    Unterholzner, L.2    Ciccarelli, F.D.3
  • 76
    • 78049447110 scopus 로고    scopus 로고
    • SMG6 interacts with the exon junction complex via two conserved EJCbinding motifs (EBMs) required for nonsense-mediated mRNA decay
    • Kashima I, Jonas S, Jayachandran U, et al. SMG6 interacts with the exon junction complex via two conserved EJCbinding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev 2010;24:2440-50.
    • (2010) Genes Dev , vol.24 , pp. 2440-2450
    • Kashima, I.1    Jonas, S.2    Jayachandran, U.3
  • 77
    • 25844435702 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets
    • Rehwinkel J, Letunic I, Raes J, et al. Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA 2005;11:1530-44.
    • (2005) RNA , vol.11 , pp. 1530-1544
    • Rehwinkel, J.1    Letunic, I.2    Raes, J.3
  • 78
    • 33846015866 scopus 로고    scopus 로고
    • Functions of the nonsense-mediated mRNA decay pathway in Drosophila development
    • Metzstein MM, Krasnow MA. Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. PLoS Genet 2006;2:e180.
    • (2006) PLoS Genet , vol.2
    • Metzstein, M.M.1    Krasnow, M.A.2
  • 79
    • 0035862813 scopus 로고    scopus 로고
    • Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability
    • Medghalchi SM, Frischmeyer PA, Mendell JT, et al. Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability. Hum Mol Genet 2001;10:99-105.
    • (2001) Hum Mol Genet , vol.10 , pp. 99-105
    • Medghalchi, S.M.1    Frischmeyer, P.A.2    Mendell, J.T.3
  • 80
    • 77955448359 scopus 로고    scopus 로고
    • Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay
    • McIlwain DR, Pan Q, Reilly PT, et al. Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proc Natl Acad Sci USA 2010;107:12186-91.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12186-12191
    • McIlwain, D.R.1    Pan, Q.2    Reilly, P.T.3
  • 81
    • 32944458421 scopus 로고    scopus 로고
    • The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
    • Azzalin CM, Lingner J. The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr Biol 2006;16:433-9.
    • (2006) Curr Biol , vol.16 , pp. 433-439
    • Azzalin, C.M.1    Lingner, J.2
  • 82
    • 84864391764 scopus 로고    scopus 로고
    • UPF1 involvement in nuclear functions
    • Varsally W, Brogna S. UPF1 involvement in nuclear functions. Biochem Soc Trans 2012;40:778-83.
    • (2012) Biochem Soc Trans , vol.40 , pp. 778-783
    • Varsally, W.1    Brogna, S.2
  • 83
    • 49149098054 scopus 로고    scopus 로고
    • A meta-analysis of nonsense mutations causing human genetic disease
    • Mort M, Ivanov D, Cooper DN, et al. A meta-analysis of nonsense mutations causing human genetic disease. Hum Mutat 2008;29:1037-47.
    • (2008) Hum Mutat , vol.29 , pp. 1037-1047
    • Mort, M.1    Ivanov, D.2    Cooper, D.N.3
  • 84
    • 77952380547 scopus 로고    scopus 로고
    • Induction of tumour immunity by targeted inhibition of nonsensemediated mRNA decay
    • Pastor F, Kolonias D, Giangrande PH, et al. Induction of tumour immunity by targeted inhibition of nonsensemediated mRNA decay. Nature 2010;465:227-30.
    • (2010) Nature , vol.465 , pp. 227-230
    • Pastor, F.1    Kolonias, D.2    Giangrande, P.H.3
  • 85
    • 38149054906 scopus 로고    scopus 로고
    • Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?
    • Anczukow O, Ware MD, Buisson M, et al. Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? Hum. Mutat 2008;29:65-73.
    • (2008) Hum Mutat , vol.29 , pp. 65-73
    • Anczukow, O.1    Ware, M.D.2    Buisson, M.3
  • 86
    • 84861434815 scopus 로고    scopus 로고
    • RNA surveillance is required for endoplasmic reticulum homeostasis
    • Sakaki K, Yoshina S, Shen X, et al. RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci USA 2012;109:8079-84.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8079-8084
    • Sakaki, K.1    Yoshina, S.2    Shen, X.3
  • 87
    • 79960902609 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question
    • Hwang J, Maquat LE. Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev 2011;21:422-30.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 422-430
    • Hwang, J.1    Maquat, L.E.2
  • 88
    • 0028948708 scopus 로고
    • Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen
    • He F, Jacobson A. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 1995;9:437-54.
    • (1995) Genes Dev , vol.9 , pp. 437-454
    • He, F.1    Jacobson, A.2
  • 89
    • 0025786141 scopus 로고
    • The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
    • Leeds P, Peltz SW, Jacobson A, et al. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev 1991;5:2303-14.
    • (1991) Genes Dev , vol.5 , pp. 2303-2314
    • Leeds, P.1    Peltz, S.W.2    Jacobson, A.3
  • 90
    • 0028934876 scopus 로고
    • Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon
    • Cui Y, Hagan KW, Zhang S, et al. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev 1995;9:423-36.
    • (1995) Genes Dev , vol.9 , pp. 423-436
    • Cui, Y.1    Hagan, K.W.2    Zhang, S.3
  • 91
    • 0028862895 scopus 로고
    • Identification of an additional gene required for eukaryotic nonsense mRNA turnover
    • Lee BS, Culbertson MR. Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Proc Natl Acad Sci USA 1995;92:10354-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10354-10358
    • Lee, B.S.1    Culbertson, M.R.2
  • 92
    • 0034460323 scopus 로고    scopus 로고
    • Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes
    • Mendell JT, Medghalchi SM, Lake RG, et al. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mol Cell Biol 2000;20:8944-57.
    • (2000) Mol Cell Biol , vol.20 , pp. 8944-8957
    • Mendell, J.T.1    Medghalchi, S.M.2    Lake, R.G.3
  • 93
    • 0024444026 scopus 로고
    • A new kind of informational suppression in the nematode Caenorhabditis elegans
    • Hodgkin J, Papp A, Pulak R, et al. A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics 1989;123:301-13.
    • (1989) Genetics , vol.123 , pp. 301-313
    • Hodgkin, J.1    Papp, A.2    Pulak, R.3
  • 94
    • 25844454826 scopus 로고    scopus 로고
    • Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster
    • Chen Z, Smith KR, Batterham P, et al. Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Genetics 2005;171:403-6.
    • (2005) Genetics , vol.171 , pp. 403-406
    • Chen, Z.1    Smith, K.R.2    Batterham, P.3
  • 95
    • 79955954056 scopus 로고    scopus 로고
    • Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish
    • Anastasaki C, Longman D, Capper A, et al. Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res 2011;39:3686-94.
    • (2011) Nucleic Acids Res , vol.39 , pp. 3686-3694
    • Anastasaki, C.1    Longman, D.2    Capper, A.3
  • 96
    • 77955368630 scopus 로고    scopus 로고
    • UPF2 is a critical regulator of liver development, function and regeneration
    • Thoren LA, Norgaard GA, Weischenfeldt J, et al. UPF2 is a critical regulator of liver development, function and regeneration. PLoS One 2010;5:e11650.
    • (2010) PLoS One , vol.5
    • Thoren, L.A.1    Norgaard, G.A.2    Weischenfeldt, J.3
  • 97
    • 84856785689 scopus 로고    scopus 로고
    • A conserved microRNA/NMD regulatory circuit controls gene expression
    • Karam R, Wilkinson M. A conserved microRNA/NMD regulatory circuit controls gene expression. RNA Biol 2012; 9:22-6.
    • (2012) RNA Biol , vol.9 , pp. 22-26
    • Karam, R.1    Wilkinson, M.2
  • 98
    • 79955964537 scopus 로고    scopus 로고
    • Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay
    • Bruno IG, Karam R, Huang L, et al. Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell 2011;42:500-10.
    • (2011) Mol Cell , vol.42 , pp. 500-510
    • Bruno, I.G.1    Karam, R.2    Huang, L.3
  • 99
    • 34347384211 scopus 로고    scopus 로고
    • A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
    • Boutz PL, Stoilov P, Li Q, et al. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev 2007;21:1636-52.
    • (2007) Genes Dev , vol.21 , pp. 1636-1652
    • Boutz, P.L.1    Stoilov, P.2    Li, Q.3
  • 100
    • 77956897649 scopus 로고    scopus 로고
    • The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy
    • Long AA, Mahapatra CT, Woodruff EA, 3rd, et al. The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. J Cell Sci 2010;123:3303-15.
    • (2010) J Cell Sci , vol.123 , pp. 3303-3315
    • Long, A.A.1    Mahapatra, C.T.2    Woodruff III, E.A.3
  • 101
    • 34548353924 scopus 로고    scopus 로고
    • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation
    • Tarpey PS, Raymond FL, Nguyen LS, et al. Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. Nat Genet 2007;39:1127-33.
    • (2007) Nat Genet , vol.39 , pp. 1127-1133
    • Tarpey, P.S.1    Raymond, F.L.2    Nguyen, L.S.3
  • 102
    • 84867895950 scopus 로고    scopus 로고
    • Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability
    • Nguyen LS, Jolly L, Shoubridge C, et al. Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Mol Psychiatry 2011;17:1103-15.
    • (2011) Mol Psychiatry , vol.17 , pp. 1103-1115
    • Nguyen, L.S.1    Jolly, L.2    Shoubridge, C.3
  • 103
    • 54849413018 scopus 로고    scopus 로고
    • Introducing sense into nonsense in treatments of human genetic diseases
    • Linde L, Kerem B. Introducing sense into nonsense in treatments of human genetic diseases. Trends Genet 2008; 24:552-63.
    • (2008) Trends Genet , vol.24 , pp. 552-563
    • Linde, L.1    Kerem, B.2
  • 104
    • 80055011827 scopus 로고    scopus 로고
    • The structure and function of the Rous sarcoma virus RNA stability element
    • Withers JB, Beemon KL. The structure and function of the Rous sarcoma virus RNA stability element. J Cell Biochem 2011;112:3085-92.
    • (2011) J Cell Biochem , vol.112 , pp. 3085-3092
    • Withers, J.B.1    Beemon, K.L.2
  • 105
    • 84861333042 scopus 로고    scopus 로고
    • Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns
    • Weischenfeldt J, Waage J, Tian G, et al. Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome Biol 2012;13:R35.
    • (2012) Genome Biol , vol.13
    • Weischenfeldt, J.1    Waage, J.2    Tian, G.3
  • 106
    • 0030931561 scopus 로고    scopus 로고
    • smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans
    • Morrison M, Harris KS, Roth MB. smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. Proc Natl Acad Sci USA 1997;94: 9782-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9782-9785
    • Morrison, M.1    Harris, K.S.2    Roth, M.B.3
  • 107
    • 19344366251 scopus 로고    scopus 로고
    • Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells
    • Lejeune F, Maquat LE. Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol 2005;17:309-15.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 309-315
    • Lejeune, F.1    Maquat, L.E.2
  • 108
    • 84864063925 scopus 로고    scopus 로고
    • Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae
    • Sayani S, Chanfreau GF. Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae. RNA 2012;18:1563-72.
    • (2012) RNA , vol.18 , pp. 1563-1572
    • Sayani, S.1    Chanfreau, G.F.2
  • 109
    • 81755172088 scopus 로고    scopus 로고
    • Autoregulation of the nonsense-mediated mRNA decay pathway in human cells
    • Yepiskoposyan H, Aeschimann F, Nilsson D, et al. Autoregulation of the nonsense-mediated mRNA decay pathway in human cells. RNA 2011;17:2108-18.
    • (2011) RNA , vol.17 , pp. 2108-2118
    • Yepiskoposyan, H.1    Aeschimann, F.2    Nilsson, D.3
  • 110
    • 80052979901 scopus 로고    scopus 로고
    • RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD
    • Huang L, Lou CH, Chan W, et al. RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell 2011;43:950-61.
    • (2011) Mol Cell , vol.43 , pp. 950-961
    • Huang, L.1    Lou, C.H.2    Chan, W.3
  • 111
    • 34247205419 scopus 로고    scopus 로고
    • An alternative branch of the nonsense-mediated decay pathway
    • Chan WK, Huang L, Gudikote JP, et al. An alternative branch of the nonsense-mediated decay pathway. EMBO J 2007;26:1820-30.
    • (2007) EMBO J , vol.26 , pp. 1820-1830
    • Chan, W.K.1    Huang, L.2    Gudikote, J.P.3
  • 112
    • 44349167189 scopus 로고    scopus 로고
    • Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response
    • Gardner LB. Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response. Mol Cell Biol 2008;28:3729-41.
    • (2008) Mol Cell Biol , vol.28 , pp. 3729-3741
    • Gardner, L.B.1


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