Modeling general proteostasis: Proteome balance in health and disease

Current Opinion in Cell Biology

Volumn 23, Issue 2, 2011, Pages 126-134

  Roth, Daniela M ^a   Balch, William E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOME;

GENETIC CONSERVATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMALS; HOMEOSTASIS; HUMANS; MODELS, BIOLOGICAL; PROTEIN FOLDING; PROTEOME;

EID: 79954414554     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2010.11.001     Document Type: Review

References (55)

1. Balch W.E., Morimoto R.I., Dillin A., Kelly J.W. Adapting proteostasis for disease intervention. Science 2008, 319:916-919.
2. Powers E.T., Morimoto R.I., Dillin A., Kelly J.W., Balch W.E. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 2009, 78:959-991.
3. Douglas P.M., Dillin A. Protein homeostasis and aging in neurodegeneration. J Cell Biol 2010, 190:719-729.
4. Hutt D., Balch W.E. Cell Biology. The proteome in balance. Science 2010, 329:766-767.
5. Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 2008, 22:1427-1438.
6. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
7. Prahlad V., Morimoto R.I. Integrating the stress response: lessons for neurodegenerative diseases from C. elegans. Trends Cell Biol 2009, 19:52-61.
8. Prahlad V., Cornelius T., Morimoto R.I. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 2008, 320:811-814.
9. Lindquist S. Protein folding sculpting evolutionary change. Cold Spring Harb Symp Quant Biol 2009, 74:103-108.
10. Oliveberg M., Wolynes P.G. The experimental survey of protein-folding energy landscapes. Q Rev Biophys 2005, 38:245-288.
11. Anfinsen C.B. Principles that govern the folding of protein chains. Science 1973, 181:223-230.
12. Broadley S.A., Hartl F.U. The role of molecular chaperones in human misfolding diseases. FEBS Lett 2009, 583:2647-2653.
13. Vos M.J., Hageman J., Carra S., Kampinga H.H. Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families. Biochemistry 2008, 47:7001-7011.
14. Hartl F.U., Hayer-Hartl M. Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol 2009, 16:574-581.
15. Shamovsky I., Nudler E. New insights into the mechanism of heat shock response activation. Cell Mol Life Sci 2008, 65:855-861.
16. Konstantinova I.M., Tsimokha A.S., Mittenberg A.G. Role of proteasomes in cellular regulation. Int Rev Cell Mol Biol 2008, 267:59-124.
17. Scheuner D., Kaufman R.J. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 2008, 29:317-333.
18. Westerheide S.D., Anckar J., Stevens S.M., Sistonen L., Morimoto R.I. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009, 323:1063-1066.
19. Zeng L., Chen R., Liang F., Tsuchiya H., Murai H., Nakahashi T., Iwai K., Takahashi T., Kanda T., Morimoto S. Silent information regulator, Sirtuin 1, and age-related diseases. Geriatr Gerontol Int 2009, 9:7-15.
20. Boutten A., Goven D., Boczkowski J., Bonay M. Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway. Expert Opin Ther Targets 2010, 14:329-346.
21. Hutt D.M., Powers E.T., Balch W.E. The proteostasis boundary in misfolding diseases of membrane traffic. FEBS Lett 2009, 583:2639-2646.
22. Zhang J., Baker M.L., Schroder G.F., Douglas N.R., Reissmann S., Jakana J., Dougherty M., Fu C.J., Levitt M., Ludtke S.J., et al. Mechanism of folding chamber closure in a group II chaperonin. Nature 2010, 463:379-383.
23. Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem 2009, 78:477-513.
24. Kampinga H.H., Craig E.A. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol 2010, 11:579-592.
25. Gamerdinger M., Hajieva P., Kaya A.M., Wolfrum U., Hartl F.U., Behl C. Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J 2009, 28:889-901.
26. Wang A.M., Morishima Y., Clapp K.M., Peng H.M., Pratt W.B., Gestwicki J.E., Osawa Y., Lieberman A.P. Inhibition of Hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem 2010, 285:15714-15723.
27. Taipale M., Jarosz D.F., Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010, 11:515-528.
28. Wandinger S.K., Richter K., Buchner J. The Hsp90 chaperone machinery. J Biol Chem 2008, 283:18473-18477.
29. He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009, 43:67-93.
30. Brodsky J.L., Wojcikiewicz R.J. Substrate-specific mediators of ER associated degradation (ERAD). Curr Opin Cell Biol 2009, 21:516-521.
31. Nakatsukasa K., Brodsky J.L. The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum. Traffic 2008, 9:861-870.
32. Okiyoneda T., Barriere H., Bagdany M., Rabeh W.M., Du K., Hohfeld J., Young J.C., Lukacs G.L. Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science 2010, 329:805-810.
33. Cuervo A.M. Chaperone-mediated autophagy: selectivity pays off. Trends Endocrinol Metab 2010, 21:142-150.
34. Wiseman R.L., Powers E.T., Buxbaum J.N., Kelly J.W., Balch W.E. An adaptable standard for protein export from the endoplasmic reticulum. Cell 2007, 131:809-821.
35. Morimoto R.I., Cuervo A.M. Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci 2009, 64:167-170.
36. Ben-Zvi A., Miller E.A., Morimoto R.I. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 2009, 106:14914-14919.
37. Yamanaka T., Miyazaki H., Oyama F., Kurosawa M., Washizu C., Doi H., Nukina N. Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor. EMBO J 2008, 27:827-839.
38. Cohen E., Paulsson J.F., Blinder P., Burstyn-Cohen T., Du D., Estepa G., Adame A., Pham H.M., Holzenberger M., Kelly J.W., et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 2009, 139:1157-1169.
39. Carra S., Seguin S.J., Landry J. HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. Autophagy 2008, 4:237-239.
40. Wang X., Venable J., LaPointe P., Hutt D.M., Koulov A.V., Coppinger J., Gurkan C., Kellner W., Matteson J., Plutner H., et al. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell 2006, 127:803-815.
41. Grove D.E., Rosser M.F., Ren H.Y., Naren A.P., Cyr D.M. Mechanisms for rescue of correctable folding defects in CFTR{Delta}F508. Mol Biol Cell 2009.
42. Wu Y., Cao Z., Klein W.L., Luo Y. Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers. Neurobiol Aging 2010, 31:1055-1058.
43. Rambold A.S., Miesbauer M., Rapaport D., Bartke T., Baier M., Winklhofer K.F., Tatzelt J. Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell 2006, 17:3356-3368.
44. Tetzlaff J.E., Putcha P., Outeiro T.F., Ivanov A., Berezovska O., Hyman B.T., McLean P.J. CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem 2008, 283:17962-17968.
45. Kumar P., Ambasta R.K., Veereshwarayya V., Rosen K.M., Kosik K.S., Band H., Mestril R., Patterson C., Querfurth H.W. CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Hum Mol Genet 2007, 16:848-864.
46. Sroka K., Voigt A., Deeg S., Reed J.C., Schulz J.B., Bahr M., Kermer P. BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution. J Neurochem 2009, 111:801-807.
47. Kirstein-Miles J., Morimoto R.I. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Dev Dyn 2010, 239:1529-1538.
48. Conn P.J., Christopoulos A., Lindsley C.W. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat Rev Drug Discov 2009, 8:41-54.
49. Mu T.W., Ong D.S.T., Segatori L., Wang Y.J., Balch W.E., Yates J.R., Kelly J.W. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 2008, 134:769-781.
50. Chauhan D., Hideshima T., Anderson K.C. Targeting proteasomes as therapy in multiple myeloma. Adv Exp Med Biol 2008, 615:251-260.
51. Connelly S., Choi S., Johnson S.M., Kelly J.W., Wilson I.A. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Curr Opin Struct Biol 2010, 20:54-62.
52. Hutt D.M., Herman D., Rodrigues A.P., Noel S., Pilewski J.M., Matteson J., Hoch B., Kellner W., Kelly J.W., Schmidt A., et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol 2010, 6:25-33.
53. Rai M., Soragni E., Jenssen K., Burnett R., Herman D., Coppola G., Geschwind D.H., Gottesfeld J.M., Pandolfo M. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 2008, 3:e1958.
54. Thomas E.A., Coppola G., Desplats P.A., Tang B., Soragni E., Burnett R., Gao F., Fitzgerald K.M., Borok J.F., Herman D., et al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci USA 2008, 105:15564-15569.
55. Wisen S., Bertelsen E.B., Thompson A.D., Patury S., Ung P., Chang L., Evans C.G., Walter G.M., Wipf P., Carlson H.A., Brodsky J.L., Zuiderweg E.R., Gestwicki J.E. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. ACS Chem Biol 2010, 5:611-622.