-
3
-
-
34547140875
-
The human disease network
-
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL. 2007. The human disease network. Proc. Natl. Acad. Sci. USA 104:8685-90
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 8685-8690
-
-
Goh, K.I.1
Cusick, M.E.2
Valle, D.3
Childs, B.4
Vidal, M.5
Barabasi, A.L.6
-
4
-
-
41649119247
-
Protein networks in disease
-
Ideker T, Sharan R. 2008. Protein networks in disease. Genome Res. 18:644-52
-
(2008)
Genome Res
, vol.18
, pp. 644-652
-
-
Ideker, T.1
Sharan, R.2
-
5
-
-
0015859467
-
Principles that govern the folding of protein chains
-
Anfinsen CB. 1973. Principles that govern the folding of protein chains. Science 181:223-30
-
(1973)
Science
, vol.181
, pp. 223-230
-
-
Anfinsen, C.B.1
-
6
-
-
33747592347
-
The experimental survey of protein-folding energy landscapes
-
Oliveberg M,Wolynes PG. 2005. The experimental survey of protein-folding energy landscapes. Q. Rev. Biophys. 38:245-88
-
(2005)
Q. Rev. Biophys
, vol.38
, pp. 245-288
-
-
Oliveberg, M.1
Wolynes, P.G.2
-
7
-
-
48249140760
-
Multiple routes and structural heterogeneity in protein folding
-
Udgaonkar JB. 2008. Multiple routes and structural heterogeneity in protein folding. Annu. Rev. Biophys. 37:489-510
-
(2008)
Annu. Rev. Biophys
, vol.37
, pp. 489-510
-
-
Udgaonkar, J.B.1
-
9
-
-
35648949836
-
Importance of metastable states in the free energy landscapes of polypeptide chains
-
Auer S, Miller MA, Krivov SV, Dobson CM, Karplus M,Vendruscolo M. 2007. Importance of metastable states in the free energy landscapes of polypeptide chains. Phys. Rev. Lett. 99:178104
-
(2007)
Phys. Rev. Lett
, vol.99
, pp. 178104
-
-
Auer, S.1
Miller, M.A.2
Krivov, S.V.3
Dobson, C.M.4
Karplus, M.5
Vendruscolo, M.6
-
11
-
-
48249097986
-
Intrinsically disordered proteins in human diseases: Introducing the D2 concept
-
Uversky VN, Oldfield CJ, Dunker AK. 2008. Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu. Rev. Biophys. 37:215-46
-
(2008)
Annu. Rev. Biophys
, vol.37
, pp. 215-246
-
-
Uversky, V.N.1
Oldfield, C.J.2
Dunker, A.K.3
-
12
-
-
50649095790
-
Macromolecular modeling with rosetta
-
Das R, Baker D. 2008. Macromolecular modeling with rosetta. Annu. Rev. Biochem. 77:363-82
-
(2008)
Annu. Rev. Biochem
, vol.77
, pp. 363-382
-
-
Das, R.1
Baker, D.2
-
13
-
-
47549108636
-
Costly mistakes: Translational infidelity and protein homeostasis
-
Powers ET, Balch WE. 2008. Costly mistakes: translational infidelity and protein homeostasis. Cell 134:204-6
-
(2008)
Cell
, vol.134
, pp. 204-206
-
-
Powers, E.T.1
Balch, W.E.2
-
14
-
-
47549097539
-
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
-
Drummond DA,Wilke CO. 2008. Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell 134:341-52
-
(2008)
Cell
, vol.134
, pp. 341-352
-
-
Drummond, D.A.1
Wilke, C.O.2
-
15
-
-
41049090929
-
Macromolecular crowding and confinement: Biochemical, biophysical, and potential physiological consequences
-
Zhou HX, Rivas G, Minton AP. 2008. Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences. Annu. Rev. Biophys. 37:375-97
-
(2008)
Annu. Rev. Biophys
, vol.37
, pp. 375-397
-
-
Zhou, H.X.1
Rivas, G.2
Minton, A.P.3
-
16
-
-
33646447690
-
The integration of cell and chemical biology in protein folding
-
Kelly JW, Balch WE. 2006. The integration of cell and chemical biology in protein folding. Nat. Chem. Biol. 2:224-27
-
(2006)
Nat. Chem. Biol
, vol.2
, pp. 224-227
-
-
Kelly, J.W.1
Balch, W.E.2
-
17
-
-
44849094781
-
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
-
Morimoto RI. 2008. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev. 22:1427-38
-
(2008)
Genes Dev
, vol.22
, pp. 1427-1438
-
-
Morimoto, R.I.1
-
19
-
-
39149143645
-
Chaperone machines in action
-
Saibil HR. 2008. Chaperone machines in action. Curr. Opin. Struct. Biol. 18:35-42
-
(2008)
Curr. Opin. Struct. Biol
, vol.18
, pp. 35-42
-
-
Saibil, H.R.1
-
20
-
-
33646127577
-
Molecular chaperones and protein quality control
-
Bukau B,Weissman J, Horwich A. 2006. Molecular chaperones and protein quality control. Cell 125:443-51
-
(2006)
Cell
, vol.125
, pp. 443-451
-
-
Bukau, B.1
Weissman, J.2
Horwich, A.3
-
21
-
-
33746330168
-
Hsp70 molecular chaperones: Emerging roles in human disease and identification of small molecule modulators
-
Brodsky JL, Chiosis G. 2006. Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Curr. Top. Med. Chem. 6:1215-25
-
(2006)
Curr. Top. Med. Chem
, vol.6
, pp. 1215-1225
-
-
Brodsky, J.L.1
Chiosis, G.2
-
22
-
-
34447558236
-
ER chaperones in mammalian development and human diseases
-
Ni M, Lee AS. 2007. ER chaperones in mammalian development and human diseases. FEBS Lett. 581:3641-51
-
(2007)
FEBS Lett
, vol.581
, pp. 3641-3651
-
-
Ni, M.1
Lee, A.S.2
-
23
-
-
84934442760
-
Organization of the functions and components of the endoplasmic reticulum
-
Shimizu Y, Hendershot LM. 2007. Organization of the functions and components of the endoplasmic reticulum. Adv. Exp. Med. Biol. 594:37-46
-
(2007)
Adv. Exp. Med. Biol
, vol.594
, pp. 37-46
-
-
Shimizu, Y.1
Hendershot, L.M.2
-
24
-
-
41549159471
-
The human PDI family: Versatility packed into a single fold
-
Appenzeller-Herzog C, Ellgaard L. 2008. The human PDI family: versatility packed into a single fold. Biochim. Biophys. Acta 1783:535-48
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 535-548
-
-
Appenzeller-Herzog, C.1
Ellgaard, L.2
-
25
-
-
0742304951
-
HSP47 as a collagen-specific molecular chaperone: Function and expression in normal mouse development
-
Nagata K. 2003. HSP47 as a collagen-specific molecular chaperone: function and expression in normal mouse development. Semin. Cell Dev. Biol. 14:275-82
-
(2003)
Semin. Cell Dev. Biol
, vol.14
, pp. 275-282
-
-
Nagata, K.1
-
26
-
-
43249096797
-
Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism
-
Hussain MM, Rava P, Pan X, Dai K, Dougan SK, et al. 2008. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr. Opin. Lipidol. 19:277-84
-
(2008)
Curr. Opin. Lipidol
, vol.19
, pp. 277-284
-
-
Hussain, M.M.1
Rava, P.2
Pan, X.3
Dai, K.4
Dougan, S.K.5
-
28
-
-
44349090822
-
Essential role of the chaperonin folding compartment in vivo
-
Tang YC, Chang HC, Chakraborty K, Hartl FU, Hayer-Hartl M. 2008. Essential role of the chaperonin folding compartment in vivo. EMBO J. 27:1458-68
-
(2008)
EMBO J
, vol.27
, pp. 1458-1468
-
-
Tang, Y.C.1
Chang, H.C.2
Chakraborty, K.3
Hartl, F.U.4
Hayer-Hartl, M.5
-
29
-
-
41149089882
-
Monitoring protein conformation along the pathway of chaperonin-assisted folding
-
Sharma S, Chakraborty K, Muller BK, Astola N, Tang YC, et al. 2008. Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell 133:142-53
-
(2008)
Cell
, vol.133
, pp. 142-153
-
-
Sharma, S.1
Chakraborty, K.2
Muller, B.K.3
Astola, N.4
Tang, Y.C.5
-
31
-
-
35548974677
-
The mammalian N-end rule pathway: New insights into its components and physiological roles
-
Tasaki T, Kwon YT. 2007. The mammalian N-end rule pathway: new insights into its components and physiological roles. Trends Biochem. Sci. 32:520-28
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 520-528
-
-
Tasaki, T.1
Kwon, Y.T.2
-
32
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. 2008. Autophagy in the pathogenesis of disease. Cell 132:27-42
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
33
-
-
41749114288
-
Autophagy: Basic principles and relevance to disease
-
Kundu M, Thompson CB. 2008. Autophagy: basic principles and relevance to disease. Annu. Rev. Pathol. 3:427-55
-
(2008)
Annu. Rev. Pathol
, vol.3
, pp. 427-455
-
-
Kundu, M.1
Thompson, C.B.2
-
34
-
-
36248949141
-
The endoplasmic reticulum and the unfolded protein response
-
Malhotra JD, Kaufman RJ. 2007. The endoplasmic reticulum and the unfolded protein response. Semin. Cell Dev. Biol. 18:716-31
-
(2007)
Semin. Cell Dev. Biol
, vol.18
, pp. 716-731
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
35
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8:519-29
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
36
-
-
41749108854
-
Endoplasmic reticulum stress in disease pathogenesis
-
Lin JH,Walter P, Yen TS. 2008. Endoplasmic reticulum stress in disease pathogenesis. Annu. Rev. Pathol. 3:399-425
-
(2008)
Annu. Rev. Pathol
, vol.3
, pp. 399-425
-
-
Lin, J.H.1
Walter, P.2
Yen, T.S.3
-
37
-
-
43249125196
-
New insights into the mechanism of heat shock response activation
-
Shamovsky I, Nudler E. 2008. New insights into the mechanism of heat shock response activation. Cell Mol. Life Sci. 65:855-61
-
(2008)
Cell Mol. Life Sci
, vol.65
, pp. 855-861
-
-
Shamovsky, I.1
Nudler, E.2
-
39
-
-
24644438715
-
Intraluminal calcium as a primary regulator of endoplasmic reticulum function
-
Burdakov D, Petersen OH, Verkhratsky A. 2005. Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium 38:303-10
-
(2005)
Cell Calcium
, vol.38
, pp. 303-310
-
-
Burdakov, D.1
Petersen, O.H.2
Verkhratsky, A.3
-
40
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov R. 2008. Origin and physiological roles of inflammation. Nature 454:428-35
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
41
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang K, Kaufman RJ. 2008. From endoplasmic-reticulum stress to the inflammatory response. Nature 454:455-62
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
42
-
-
44049095652
-
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
-
Prahlad V, Cornelius T, Morimoto RI. 2008. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 320:811-14
-
(2008)
Science
, vol.320
, pp. 811-814
-
-
Prahlad, V.1
Cornelius, T.2
Morimoto, R.I.3
-
43
-
-
33845875966
-
Gut hormones and the regulation of energy homeostasis
-
Murphy KG, Bloom SR. 2006. Gut hormones and the regulation of energy homeostasis. Nature 444:854-59
-
(2006)
Nature
, vol.444
, pp. 854-859
-
-
Murphy, K.G.1
Bloom, S.R.2
-
44
-
-
11144358198
-
A gene atlas of the mouse and human protein-encoding transcriptomes
-
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, et al. 2004. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 101:6062-67
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6062-6067
-
-
Su, A.I.1
Wiltshire, T.2
Batalov, S.3
Lapp, H.4
Ching, K.A.5
-
45
-
-
17044402604
-
The biological and chemical basis for tissue-selective amyloid disease
-
Sekijima Y, Wiseman RL, Matteson J, Hammarstrom P, Miller SR, et al. 2005. The biological and chemical basis for tissue-selective amyloid disease. Cell 121:73-85
-
(2005)
Cell
, vol.121
, pp. 73-85
-
-
Sekijima, Y.1
Wiseman, R.L.2
Matteson, J.3
Hammarstrom, P.4
Miller, S.R.5
-
46
-
-
36049032748
-
An adaptable standard for protein export from the endoplasmic reticulum
-
Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. 2007. An adaptable standard for protein export from the endoplasmic reticulum. Cell 131:809-21
-
(2007)
Cell
, vol.131
, pp. 809-821
-
-
Wiseman, R.L.1
Powers, E.T.2
Buxbaum, J.N.3
Kelly, J.W.4
Balch, W.E.5
-
47
-
-
33748074139
-
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes
-
Haynes C, Oldfield CJ, Ji F, Klitgord N, Cusick ME, et al. 2006. Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput. Biol. 2:e100
-
(2006)
PLoS Comput. Biol
, vol.2
-
-
Haynes, C.1
Oldfield, C.J.2
Ji, F.3
Klitgord, N.4
Cusick, M.E.5
-
48
-
-
42349100173
-
The chemical genomic portrait of yeast: Uncovering a phenotype for all genes
-
Hillenmeyer ME, Fung E,Wildenhain J, Pierce SE, Hoon S, et al. 2008. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science 320:362-65
-
(2008)
Science
, vol.320
, pp. 362-365
-
-
Hillenmeyer, M.E.1
Fung, E.2
Wildenhain, J.3
Pierce, S.E.4
Hoon, S.5
-
49
-
-
84934437633
-
The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging
-
Brignull HR, Morley JF, Morimoto RI. 2007. The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. Adv. Exp. Med. Biol. 594:167-89
-
(2007)
Adv. Exp. Med. Biol
, vol.594
, pp. 167-189
-
-
Brignull, H.R.1
Morley, J.F.2
Morimoto, R.I.3
-
50
-
-
33644850056
-
Progressive disruption of cellular protein folding in models of polyglutamine diseases
-
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI. 2006. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311:1471-74
-
(2006)
Science
, vol.311
, pp. 1471-1474
-
-
Gidalevitz, T.1
Ben-Zvi, A.2
Ho, K.H.3
Brignull, H.R.4
Morimoto, R.I.5
-
51
-
-
42949165604
-
Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
-
Palotai R, Szalay MS, Csermely P. 2008. Chaperones as integrators of cellular networks: changes of cellular integrity in stress and diseases. IUBMB Life 60:10-18
-
(2008)
IUBMB Life
, vol.60
, pp. 10-18
-
-
Palotai, R.1
Szalay, M.S.2
Csermely, P.3
-
52
-
-
34748871331
-
G protein-coupled receptor trafficking in health and disease: Lessons learned to prepare for therapeutic mutant rescue in vivo
-
Conn PM, Ulloa-Aguirre A, Ito J, Janovick JA. 2007. G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacol. Rev. 59:225-50
-
(2007)
Pharmacol. Rev
, vol.59
, pp. 225-250
-
-
Conn, P.M.1
Ulloa-Aguirre, A.2
Ito, J.3
Janovick, J.A.4
-
53
-
-
42949114337
-
Assembly and trafficking of nicotinic acetylcholine receptors (Review)
-
Millar NS, Harkness PC. 2008. Assembly and trafficking of nicotinic acetylcholine receptors (Review). Mol. Membr. Biol. 25:279-92
-
(2008)
Mol. Membr. Biol
, vol.25
, pp. 279-292
-
-
Millar, N.S.1
Harkness, P.C.2
-
54
-
-
41349085850
-
Treatment perspectives for the lysosomal storage diseases
-
Grabowski GA. 2008. Treatment perspectives for the lysosomal storage diseases. Expert Opin. Emerg. Drugs 13:197-211
-
(2008)
Expert Opin. Emerg. Drugs
, vol.13
, pp. 197-211
-
-
Grabowski, G.A.1
-
55
-
-
0037180511
-
Chemical chaperones increase the cellular activity of N370S beta-glucosidase: A therapeutic strategy for Gaucher disease
-
Sawkar AR, Cheng W-C, Beutler E, Wong C-H, Balch WE, Kelly JW. 2002. Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease. Proc. Natl. Acad. Sci. USA 99:15428-33
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 15428-15433
-
-
Sawkar, A.R.1
Cheng, W.-C.2
Beutler, E.3
Wong, C.-H.4
Balch, W.E.5
Kelly, J.W.6
-
56
-
-
0033018496
-
Accelerated transport and maturation of lysosomal alphagalactosidase A in Fabry lymphoblasts by an enzyme inhibitor
-
Fan J-Q, Ishii S, Asano N, Suzuki Y. 1999. Accelerated transport and maturation of lysosomal alphagalactosidase A in Fabry lymphoblasts by an enzyme inhibitor. Nat. Med. 5:112-15
-
(1999)
Nat. Med
, vol.5
, pp. 112-115
-
-
Fan, J.-Q.1
Ishii, S.2
Asano, N.3
Suzuki, Y.4
-
57
-
-
41849133213
-
4′-Methyl-4,5′-bithiazole-based correctors of defective △F508-CFTR cellular processing
-
Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. 2008. 4′-Methyl-4,5′-bithiazole-based correctors of defective △F508-CFTR cellular processing. Bioorg. Med. Chem. Lett. 18:2610-14
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 2610-2614
-
-
Yoo, C.L.1
Yu, G.J.2
Yang, B.3
Robins, L.I.4
Verkman, A.S.5
Kurth, M.J.6
-
58
-
-
34347333381
-
Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis
-
Amaral MD, Kunzelmann K. 2007. Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis. Trends Pharmacol. Sci. 28:334-41
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 334-341
-
-
Amaral, M.D.1
Kunzelmann, K.2
-
59
-
-
24644464284
-
Small-molecule correctors of defective △F508-CFTR cellular processing identified by high-throughput screening
-
Pedemonte N, Lukacs GL, Du K, Caci E, Zegarra-Moran O, et al. 2005. Small-molecule correctors of defective △F508-CFTR cellular processing identified by high-throughput screening. J. Clin. Investig. 115:2564-71
-
(2005)
J. Clin. Investig
, vol.115
, pp. 2564-2571
-
-
Pedemonte, N.1
Lukacs2
GL, D.K.3
Caci, E.4
Zegarra-Moran, O.5
-
60
-
-
46249118125
-
Correctors promote folding of the CFTR in the endoplasmic reticulum
-
Loo TW, Bartlett MC, Clarke DM. 2008. Correctors promote folding of the CFTR in the endoplasmic reticulum. Biochem. J. 413:29-36
-
(2008)
Biochem. J
, vol.413
, pp. 29-36
-
-
Loo, T.W.1
Bartlett, M.C.2
Clarke, D.M.3
-
61
-
-
40649128574
-
Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr-/- mice
-
Noel S, Strale PO, Dannhoffer L,Wilke M, DeJonge H, et al. 2008. Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr-/- mice. J. Cyst. Fibros. 7:128-33
-
(2008)
J. Cyst. Fibros
, vol.7
, pp. 128-133
-
-
Noel, S.1
Strale, P.O.2
Dannhoffer, L.3
Wilke, M.4
DeJonge, H.5
-
62
-
-
33745282127
-
Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones
-
Wang Y, Bartlett MC, Loo TW, Clarke DM. 2006. Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones. Mol. Pharmacol. 70:297-302
-
(2006)
Mol. Pharmacol
, vol.70
, pp. 297-302
-
-
Wang, Y.1
Bartlett, M.C.2
Loo, T.W.3
Clarke, D.M.4
-
63
-
-
34548154971
-
Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants
-
Wang Y, Loo TW, Bartlett MC, Clarke DM. 2007. Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants. Biochem. J. 406:257-63
-
(2007)
Biochem. J
, vol.406
, pp. 257-263
-
-
Wang, Y.1
Loo, T.W.2
Bartlett, M.C.3
Clarke, D.M.4
-
64
-
-
34748914170
-
Pharmacologic chaperoning as a strategy to treat Gaucher disease
-
Yu Z, Sawkar AR, Kelly JW. 2007. Pharmacologic chaperoning as a strategy to treat Gaucher disease. FEBS J. 274:4944-50
-
(2007)
FEBS J
, vol.274
, pp. 4944-4950
-
-
Yu, Z.1
Sawkar, A.R.2
Kelly, J.W.3
-
65
-
-
33846265304
-
Isofagomine- and 2,5-anhydro-2,5-iminod-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention
-
Yu Z, Sawkar AR, Whalen LJ, Wong CH, Kelly JW. 2007. Isofagomine- and 2,5-anhydro-2,5-iminod-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. J. Med. Chem. 50:94-100
-
(2007)
J. Med. Chem
, vol.50
, pp. 94-100
-
-
Yu, Z.1
Sawkar, A.R.2
Whalen, L.J.3
Wong, C.H.4
Kelly, J.W.5
-
66
-
-
0037473750
-
Prevention of transthyretin amyloid disease by changing protein misfolding energetics
-
Hammarstrom P,Wiseman RL, Powers ET, Kelly JW. 2003. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science 299:713-16
-
(2003)
Science
, vol.299
, pp. 713-716
-
-
Hammarstrom, P.1
Wiseman, R.L.2
Powers, E.T.3
Kelly, J.W.4
-
67
-
-
28244502156
-
Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amyloidoses
-
Johnson SM,Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. 2005. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Acc. Chem. Res. 38:911-21
-
(2005)
Acc. Chem. Res
, vol.38
, pp. 911-921
-
-
Johnson, S.M.1
Wiseman, R.L.2
Sekijima, Y.3
Green, N.S.4
Adamski-Werner, S.L.5
Kelly, J.W.6
-
68
-
-
40149095757
-
Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis
-
Mu T-W, Fowler DM, Kelly JW. 2008. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol. 6:e26
-
(2008)
PLoS Biol
, vol.6
-
-
Mu, T.-W.1
Fowler, D.M.2
Kelly, J.W.3
-
69
-
-
38349124184
-
Molecular physiology of preconditioning-induced brain tolerance to ischemia
-
Obrenovitch TP. 2008. Molecular physiology of preconditioning-induced brain tolerance to ischemia. Physiol. Rev. 88:211-47
-
(2008)
Physiol. Rev
, vol.88
, pp. 211-247
-
-
Obrenovitch, T.P.1
-
70
-
-
13644256191
-
A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress
-
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, et al. 2005. A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307:935-39
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
-
71
-
-
39449091637
-
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death
-
Boyce M, Py BF, Ryazanov AG, Minden JS, Long K, et al. 2008. A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. Cell Death Differ. 15:589-99
-
(2008)
Cell Death Differ
, vol.15
, pp. 589-599
-
-
Boyce, M.1
Py, B.F.2
Ryazanov, A.G.3
Minden, J.S.4
Long, K.5
-
72
-
-
41649104650
-
Activation of heat shock and antioxidant responses by the natural product celastrol: Transcriptional signatures of a thiol-targeted molecule
-
Trott A, West JD, Klaic L, Westerheide SD, Silverman RB, et al. 2008. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol. Biol. Cell 19:1104-12
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 1104-1112
-
-
Trott, A.1
West, J.D.2
Klaic, L.3
Westerheide, S.D.4
Silverman, R.B.5
-
73
-
-
34548279788
-
Molecular understanding and modern application of traditional medicines: Triumphs and trials
-
Corson TW, Crews CM. 2007. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130:769-74
-
(2007)
Cell
, vol.130
, pp. 769-774
-
-
Corson, T.W.1
Crews, C.M.2
-
74
-
-
25844466597
-
Heat shock response modulators as therapeutic tools for diseases of protein conformation
-
Westerheide SD, Morimoto RI. 2005. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J. Biol. Chem. 280:33097-100
-
(2005)
J. Biol. Chem
, vol.280
, pp. 33097-33100
-
-
Westerheide, S.D.1
Morimoto, R.I.2
-
75
-
-
12944335007
-
Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
-
Wang J, Gines S, MacDonald ME, Gusella JF. 2005. Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. BMC Neurosci. 6:1
-
(2005)
BMC Neurosci
, vol.6
, pp. 1
-
-
Wang, J.1
Gines, S.2
MacDonald, M.E.3
Gusella, J.F.4
-
76
-
-
38349153572
-
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
-
Zhang T, Hamza A, Cao X,Wang B, Yu S, et al. 2008. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther. 7:162-70
-
(2008)
Mol. Cancer Ther
, vol.7
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
Wang, B.4
Yu, S.5
-
77
-
-
38049121045
-
Celastrol inhibits production of nitric oxide and proin-flammatory cytokines throughMAPKsignal transduction and NF-κB in LPS-stimulatedBV-2 microglial cells
-
Jung HW, Chung YS, Kim YS, Park YK. 2007. Celastrol inhibits production of nitric oxide and proin-flammatory cytokines throughMAPKsignal transduction and NF-κB in LPS-stimulatedBV-2 microglial cells. Exp. Mol. Med. 39:715-21
-
(2007)
Exp. Mol. Med
, vol.39
, pp. 715-721
-
-
Jung, H.W.1
Chung, Y.S.2
Kim, Y.S.3
Park, Y.K.4
-
78
-
-
33846454701
-
The tumor proteasome is a primary target for the natural anticancer compoundWithaferin A isolated from "Indian winter cherry
-
Yang H, Shi G, Dou QP. 2007. The tumor proteasome is a primary target for the natural anticancer compoundWithaferin A isolated from "Indian winter cherry". Mol. Pharmacol. 71:426-37
-
(2007)
Mol. Pharmacol
, vol.71
, pp. 426-437
-
-
Yang, H.1
Shi, G.2
Dou, Q.P.3
-
79
-
-
47749130766
-
Therapeutic effect of tripterine on adjuvant arthritis in rats
-
Li H, Zhang YY, Tan HW, Jia YF, Li D. 2008. Therapeutic effect of tripterine on adjuvant arthritis in rats. J. Ethnopharmacol. 118:479-84
-
(2008)
J. Ethnopharmacol
, vol.118
, pp. 479-484
-
-
Li, H.1
Zhang, Y.Y.2
Tan, H.W.3
Jia, Y.F.4
Li, D.5
-
80
-
-
0035682911
-
Antioxidant properties of acetaminophen and cardioprotection
-
Merrill GF, Goldberg E. 2001. Antioxidant properties of acetaminophen and cardioprotection. Basic Res. Cardiol. 96:423-30
-
(2001)
Basic Res. Cardiol
, vol.96
, pp. 423-430
-
-
Merrill, G.F.1
Goldberg, E.2
-
81
-
-
39749199371
-
Acetaminophen normalizes glucose homeostasis in mouse models for diabetes
-
Shertzer HG, Schneider SN, Kendig EL, Clegg DJ, D'Alessio DA, Genter MB. 2008. Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. Biochem. Pharmacol. 75:1402-10
-
(2008)
Biochem. Pharmacol
, vol.75
, pp. 1402-1410
-
-
Shertzer, H.G.1
Schneider, S.N.2
Kendig, E.L.3
Clegg, D.J.4
D'Alessio, D.A.5
Genter, M.B.6
-
82
-
-
33750902737
-
The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control
-
Gorlach A, Klappa P, Kietzmann T. 2006. The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid. Redox Signal. 8:1391-418
-
(2006)
Antioxid. Redox Signal
, vol.8
, pp. 1391-1418
-
-
Gorlach, A.1
Klappa, P.2
Kietzmann, T.3
-
83
-
-
50249175120
-
Chemical and biological approaches synergize to ameliorate protein-folding diseases
-
Mu T-W, Ong DST, Wang Y-J, Balch WE, Yates JR, et al. 2008. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 134:769-81
-
(2008)
Cell
, vol.134
, pp. 769-781
-
-
Mu, T.-W.1
Ong, D.S.T.2
Wang, Y.-J.3
Balch, W.E.4
Yates, J.R.5
-
84
-
-
33947532026
-
Histone acetyltransferase complexes: One size doesn't fit all
-
Lee KK,Workman JL. 2007. Histone acetyltransferase complexes: One size doesn't fit all. Nat. Rev.Mol. Cell Biol. 8:284-95
-
(2007)
Nat. Rev.Mol. Cell Biol
, vol.8
, pp. 284-295
-
-
Lee, K.K.1
Workman, J.L.2
-
85
-
-
38649092744
-
Regulation of protein turnover by acetyltransferases and deacetylases
-
Sadoul K, Boyault C, Pabion M, Khochbin S. 2008. Regulation of protein turnover by acetyltransferases and deacetylases. Biochimie 90:306-12
-
(2008)
Biochimie
, vol.90
, pp. 306-312
-
-
Sadoul, K.1
Boyault, C.2
Pabion, M.3
Khochbin, S.4
-
86
-
-
47249095889
-
Histone deacetylase inhibitors: Therapeutic agents and research tools for deciphering motor neuron diseases
-
Echaniz-Laguna A, Bousiges O, Loeffler JP, Boutillier AL. 2008. Histone deacetylase inhibitors: therapeutic agents and research tools for deciphering motor neuron diseases. Curr. Med. Chem. 15:1263-73
-
(2008)
Curr. Med. Chem
, vol.15
, pp. 1263-1273
-
-
Echaniz-Laguna, A.1
Bousiges, O.2
Loeffler, J.P.3
Boutillier, A.L.4
-
87
-
-
34547864236
-
Histone deacetylase inhibitors: Molecular mechanisms of action
-
Xu WS, Parmigiani RB, Marks PA. 2007. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26:5541-52
-
(2007)
Oncogene
, vol.26
, pp. 5541-5552
-
-
Xu, W.S.1
Parmigiani, R.B.2
Marks, P.A.3
-
88
-
-
34547919621
-
Class IIa histone deacetylases: Regulating the regulators
-
Martin M, Kettmann R, Dequiedt F. 2007. Class IIa histone deacetylases: regulating the regulators. Oncogene 26:5450-67
-
(2007)
Oncogene
, vol.26
, pp. 5450-5467
-
-
Martin, M.1
Kettmann, R.2
Dequiedt, F.3
-
90
-
-
44649119816
-
Transcriptional targets of sirtuins in the coordination of mammalian physiology
-
Feige JN, Johan A. 2008.Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr. Opin. Cell Biol. 20:303-9
-
(2008)
Curr. Opin. Cell Biol
, vol.20
, pp. 303-309
-
-
Feige, J.N.1
Johan, A.2
-
91
-
-
33846583673
-
SIR2: A potential target for calorie restriction mimetics
-
Chen D, Guarente L. 2007. SIR2: a potential target for calorie restriction mimetics. Trends Mol. Med. 13:64-71
-
(2007)
Trends Mol. Med
, vol.13
, pp. 64-71
-
-
Chen, D.1
Guarente, L.2
-
92
-
-
34447625911
-
Epigenetics and aging: The targets and the marks
-
Fraga MF, Esteller M. 2007. Epigenetics and aging: the targets and the marks. Trends Genet. 23:413-18
-
(2007)
Trends Genet
, vol.23
, pp. 413-418
-
-
Fraga, M.F.1
Esteller, M.2
-
94
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, et al. 2007. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-16
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
-
95
-
-
40849135481
-
The Sirtuin family: Therapeutic targets to treat diseases of aging
-
Milne JC, Denu JM. 2008. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 12:11-17
-
(2008)
Curr. Opin. Chem. Biol
, vol.12
, pp. 11-17
-
-
Milne, J.C.1
Denu, J.M.2
-
96
-
-
44649158252
-
HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions
-
Valenzuela-Fernandez A, Cabrero JR, Serrador JM, Sanchez-Madrid F. 2008. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol. 18:291-97
-
(2008)
Trends Cell Biol
, vol.18
, pp. 291-297
-
-
Valenzuela-Fernandez, A.1
Cabrero, J.R.2
Serrador, J.M.3
Sanchez-Madrid, F.4
-
97
-
-
38349195601
-
HDAC6 a new cellular stress surveillance factor
-
Matthias P, Yoshida M, Khochbin S. 2008. HDAC6 a new cellular stress surveillance factor. Cell Cycle 7:7-10
-
(2008)
Cell Cycle
, vol.7
, pp. 7-10
-
-
Matthias, P.1
Yoshida, M.2
Khochbin, S.3
-
98
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide SD, Anckar J, Stevens SM, Sistonen L, Morimoto RI. 2009. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323:1063-66
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens, S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
99
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, et al. 2006. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-40
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
-
100
-
-
46749108883
-
Chemical rescue of △F508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells
-
Singh OV, Pollard HB, Zeitlin PL. 2008. Chemical rescue of △F508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells. Mol. Cell Proteomics 7:1099-110
-
(2008)
Mol. Cell Proteomics
, vol.7
, pp. 1099-1110
-
-
Singh, O.V.1
Pollard, H.B.2
Zeitlin, P.L.3
-
101
-
-
36348931759
-
Modulation of epithelial sodium channel trafficking and function by sodium 4-phenylbutyrate in human nasal epithelial cells
-
Pruliere-Escabasse V, Planes C, Escudier E, Fanen P, Coste A, Clerici C. 2007. Modulation of epithelial sodium channel trafficking and function by sodium 4-phenylbutyrate in human nasal epithelial cells. J. Biol. Chem. 282:34048-57
-
(2007)
J. Biol. Chem
, vol.282
, pp. 34048-34057
-
-
Pruliere-Escabasse, V.1
Planes, C.2
Escudier, E.3
Fanen, P.4
Coste, A.5
Clerici, C.6
-
102
-
-
33748419472
-
The role of autophagy in α-1-antitrypsin deficiency: A specific cellular response in genetic diseases associated with aggregation-prone proteins
-
Perlmutter DH. 2006. The role of autophagy in α-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins. Autophagy 2:258-63
-
(2006)
Autophagy
, vol.2
, pp. 258-263
-
-
Perlmutter, D.H.1
-
103
-
-
38949096081
-
Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
-
Ding WX, Yin XM. 2008. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 4:141-50
-
(2008)
Autophagy
, vol.4
, pp. 141-150
-
-
Ding, W.X.1
Yin, X.M.2
-
104
-
-
34250822281
-
Chaperone-mediated autophagy
-
Dice JF. 2007. Chaperone-mediated autophagy. Autophagy 3:295-99
-
(2007)
Autophagy
, vol.3
, pp. 295-299
-
-
Dice, J.F.1
-
106
-
-
57649227693
-
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine- expanded huntingtin and related proteinopathies
-
Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. 2009. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine- expanded huntingtin and related proteinopathies. Cell Death Differ. 16:46-56
-
(2009)
Cell Death Differ
, vol.16
, pp. 46-56
-
-
Sarkar, S.1
Ravikumar, B.2
Floto, R.A.3
Rubinsztein, D.C.4
-
107
-
-
38749092258
-
The mTOR pathway as a potential target for the development of therapies against neurological disease
-
Zemke D, Azhar S, Majid A. 2007. The mTOR pathway as a potential target for the development of therapies against neurological disease. Drug News Perspect. 20:495-99
-
(2007)
Drug News Perspect
, vol.20
, pp. 495-499
-
-
Zemke, D.1
Azhar, S.2
Majid, A.3
-
108
-
-
40649120732
-
Increased mTORC1 signaling UPRegulates stress
-
Reiling JH, Sabatini DM. 2008. Increased mTORC1 signaling UPRegulates stress. Mol. Cell 29:533-35
-
(2008)
Mol. Cell
, vol.29
, pp. 533-535
-
-
Reiling, J.H.1
Sabatini, D.M.2
-
109
-
-
40649104735
-
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
-
Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, et al. 2008. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 29:541-51
-
(2008)
Mol. Cell
, vol.29
, pp. 541-551
-
-
Ozcan, U.1
Ozcan, L.2
Yilmaz, E.3
Duvel, K.4
Sahin, M.5
-
110
-
-
57649181445
-
Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in α-1-antitrypsin deficiency
-
Perlmutter DH. 2009. Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in α-1-antitrypsin deficiency. Cell Death Differ. 16:39-45
-
(2009)
Cell Death Differ
, vol.16
, pp. 39-45
-
-
Perlmutter, D.H.1
-
111
-
-
41449086243
-
Inclusion bodies and autophagosomes: Are ER-derived protective organelles different than classical autophagosomes?
-
Granell S, Baldini G. 2008. Inclusion bodies and autophagosomes: Are ER-derived protective organelles different than classical autophagosomes? Autophagy 4:375-77
-
(2008)
Autophagy
, vol.4
, pp. 375-377
-
-
Granell, S.1
Baldini, G.2
-
112
-
-
37849026130
-
The daily job of night killers: Alternative roles of the BCL-2 family in organelle physiology
-
Hetz C, Glimcher L. 2008. The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology. Trends Cell Biol. 18:38-44
-
(2008)
Trends Cell Biol
, vol.18
, pp. 38-44
-
-
Hetz, C.1
Glimcher, L.2
-
113
-
-
36248980418
-
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans postsynaptic muscle cells
-
Garcia SM, Casanueva MO, Silva MC, Amaral MD,Morimoto RI. 2007. Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans postsynaptic muscle cells. Genes Dev. 21:3006-16
-
(2007)
Genes Dev
, vol.21
, pp. 3006-3016
-
-
Garcia, S.M.1
Casanueva, M.O.2
Silva, M.C.3
Amaral, M.D.4
Morimoto, R.I.5
-
114
-
-
34247140294
-
Role of insulin-like signalling in Drosophila lifespan
-
Giannakou ME, Partridge L. 2007. Role of insulin-like signalling in Drosophila lifespan. Trends Biochem. Sci. 32:180-88
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 180-188
-
-
Giannakou, M.E.1
Partridge, L.2
-
115
-
-
50649099122
-
Aging and survival: The genetics of life span extension by dietary restriction
-
Mair W, Dillin A. 2008. Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77:727-54
-
(2008)
Annu. Rev. Biochem
, vol.77
, pp. 727-754
-
-
Mair, W.1
Dillin, A.2
-
116
-
-
33645472504
-
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
-
Hansen M, Hsu AL, Dillin A, Kenyon C. 2005. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1:119-28
-
(2005)
PLoS Genet
, vol.1
, pp. 119-128
-
-
Hansen, M.1
Hsu, A.L.2
Dillin, A.3
Kenyon, C.4
-
117
-
-
40849118472
-
Direct inhibition of the longevitypromoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, et al. 2008. Direct inhibition of the longevitypromoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132:1025-38
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
-
118
-
-
47549100826
-
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
-
Budovskaya YV, Wu K, Southworth LK, Jiang M, Tedesco P, et al. 2008. An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134:291-303
-
(2008)
Cell
, vol.134
, pp. 291-303
-
-
Budovskaya, Y.V.1
Wu, K.2
Southworth, L.K.3
Jiang, M.4
Tedesco, P.5
-
119
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, Utzschneider KM. 2006. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-46
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
120
-
-
34548419344
-
Adipocyte stress: The endoplasmic reticulum and metabolic disease
-
Gregor MG, Hotamisligil GS. 2007. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48:1905-14
-
(2007)
J. Lipid Res
, vol.48
, pp. 1905-1914
-
-
Gregor, M.G.1
Hotamisligil, G.S.2
-
121
-
-
43549105167
-
The unfolded protein response: A pathway that links insulin demand with β-cell failure and diabetes
-
Scheuner D, Kaufman RJ. 2008. The unfolded protein response: a pathway that links insulin demand with β-cell failure and diabetes. Endocr. Rev. 29:317-33
-
(2008)
Endocr. Rev
, vol.29
, pp. 317-333
-
-
Scheuner, D.1
Kaufman, R.J.2
-
122
-
-
34548419344
-
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
-
Gregor MF, Hotamisligil GS. 2007. Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48:1905-14
-
(2007)
J. Lipid Res
, vol.48
, pp. 1905-1914
-
-
Gregor, M.F.1
Hotamisligil, G.S.2
-
123
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK, Cnop M. 2008. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 29:42-61
-
(2008)
Endocr. Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
124
-
-
43549100675
-
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
-
Haataja L, Gurlo T, Huang CJ, Butler PC. 2008. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr. Rev. 29:303-16
-
(2008)
Endocr. Rev
, vol.29
, pp. 303-316
-
-
Haataja, L.1
Gurlo, T.2
Huang, C.J.3
Butler, P.C.4
-
126
-
-
55849096988
-
CHOP deletion reduces oxidative stress, improves β-cell function, and promotes cell survival in multiple mouse models of diabetes
-
Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. 2008. CHOP deletion reduces oxidative stress, improves β-cell function, and promotes cell survival in multiple mouse models of diabetes. J. Clin. Investig. 118:3378-89
-
(2008)
J. Clin. Investig
, vol.118
, pp. 3378-3389
-
-
Song, B.1
Scheuner, D.2
Ron, D.3
Pennathur, S.4
Kaufman, R.J.5
-
127
-
-
34548456881
-
Dietary histone deacetylase inhibitors: From cells to mice to man
-
Dashwood RH, Ho E. 2007. Dietary histone deacetylase inhibitors: from cells to mice to man. Semin. Cancer Biol. 17:363-69
-
(2007)
Semin. Cancer Biol
, vol.17
, pp. 363-369
-
-
Dashwood, R.H.1
Ho, E.2
-
128
-
-
48349112953
-
The role of sirtuin proteins in obesity
-
Metoyer CF, Pruitt K. 2008. The role of sirtuin proteins in obesity. Pathophysiology 15:103-8
-
(2008)
Pathophysiology
, vol.15
, pp. 103-108
-
-
Metoyer, C.F.1
Pruitt, K.2
-
130
-
-
35148850628
-
Sirtuins and β-cell function
-
Bordone L, Guarente L. 2007. Sirtuins and β-cell function. Diabetes Obes. Metab. 9(Suppl. 2):23-27
-
(2007)
Diabetes Obes. Metab
, vol.9
, Issue.SUPPL. 2
, pp. 23-27
-
-
Bordone, L.1
Guarente, L.2
-
131
-
-
43549114067
-
Targeting β-cell mass in type 2 diabetes: Promise and limitations of new drugs based on incretins
-
Salehi M, Aulinger BA, D'Alessio DA. 2008. Targeting β-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins. Endocr. Rev. 29:367-79
-
(2008)
Endocr. Rev
, vol.29
, pp. 367-379
-
-
Salehi, M.1
Aulinger, B.A.2
D'Alessio, D.A.3
-
132
-
-
47149099786
-
DPP-4 inhibitors and GLP-1 analogues: For whom? Which place for incretins in the management of type 2 diabetic patients?
-
Halimi S. 2008. DPP-4 inhibitors and GLP-1 analogues: for whom? Which place for incretins in the management of type 2 diabetic patients? Diabetes Metab. 34(Suppl. 2):S91-95
-
(2008)
Diabetes Metab
, vol.34
, Issue.SUPPL. 2
-
-
Halimi, S.1
-
133
-
-
56749171368
-
Regulation of pancreatic β-cell mass by neuronal signals from the liver
-
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, et al. 2008. Regulation of pancreatic β-cell mass by neuronal signals from the liver. Science 322:1250-54
-
(2008)
Science
, vol.322
, pp. 1250-1254
-
-
Imai, J.1
Katagiri, H.2
Yamada, T.3
Ishigaki, Y.4
Suzuki, T.5
-
134
-
-
34248187981
-
Heat shock protein 90: The cancer chaperone
-
Neckers L. 2007. Heat shock protein 90: the cancer chaperone. J. Biosci. 32:517-30
-
(2007)
J. Biosci
, vol.32
, pp. 517-530
-
-
Neckers, L.1
-
136
-
-
41149111451
-
The Hsp90 molecular chaperone: An open and shut case for treatment
-
Pearl LH, Prodromou C, Workman P. 2008. The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem. J. 410:439-53
-
(2008)
Biochem. J
, vol.410
, pp. 439-453
-
-
Pearl, L.H.1
Prodromou, C.2
Workman, P.3
-
137
-
-
33746365169
-
Discovery and development of purine-scaffold Hsp90 inhibitors
-
Chiosis G. 2006. Discovery and development of purine-scaffold Hsp90 inhibitors. Curr. Top. Med. Chem. 6:1183-91
-
(2006)
Curr. Top. Med. Chem
, vol.6
, pp. 1183-1191
-
-
Chiosis, G.1
-
138
-
-
37649024109
-
Development and application of Hsp90 inhibitors
-
Solit DB, Chiosis G. 2008. Development and application of Hsp90 inhibitors. Drug Discov. Today 13:38-43
-
(2008)
Drug Discov. Today
, vol.13
, pp. 38-43
-
-
Solit, D.B.1
Chiosis, G.2
-
139
-
-
51449093764
-
Targeting Hsp90: Small-molecule inhibitors and their clinical development
-
Taldone T, Gozman A, Maharaj R, Chiosis G. 2008. Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr. Opin. Pharmacol. 8:370-74
-
(2008)
Curr. Opin. Pharmacol
, vol.8
, pp. 370-374
-
-
Taldone, T.1
Gozman, A.2
Maharaj, R.3
Chiosis, G.4
-
140
-
-
34447507818
-
Inhibitors of the heat shock response: Biology and pharmacology
-
Powers MV,Workman P. 2007. Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett. 581:3758-69
-
(2007)
FEBS Lett
, vol.581
, pp. 3758-3769
-
-
Powers, M.V.1
Workman, P.2
-
141
-
-
42449161986
-
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
-
Wang L, Zhou GB, Liu P, Song JH, Liang Y, et al. 2008. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 105:4826-31
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 4826-4831
-
-
Wang, L.1
Zhou, G.B.2
Liu, P.3
Song, J.H.4
Liang, Y.5
-
143
-
-
36148975760
-
Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases
-
Nakamura T, Lipton SA. 2008. Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxid. Redox Signal. 10:87-101
-
(2008)
Antioxid. Redox Signal
, vol.10
, pp. 87-101
-
-
Nakamura, T.1
Lipton, S.A.2
-
144
-
-
47349100951
-
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment
-
Yang H, Landis-Piwowar KR, Chen D, Milacic V, Dou QP. 2008. Natural compounds with proteasome inhibitory activity for cancer prevention and treatment. Curr. Protein Pept. Sci. 9:227-39
-
(2008)
Curr. Protein Pept. Sci
, vol.9
, pp. 227-239
-
-
Yang, H.1
Landis-Piwowar, K.R.2
Chen, D.3
Milacic, V.4
Dou, Q.P.5
-
145
-
-
33847366186
-
Restoration of wild-type p53 function in human cancer: Relevance for tumor therapy
-
Bossi G, Sacchi A. 2007. Restoration of wild-type p53 function in human cancer: relevance for tumor therapy. Head Neck 29:272-84
-
(2007)
Head Neck
, vol.29
, pp. 272-284
-
-
Bossi, G.1
Sacchi, A.2
-
148
-
-
33748792821
-
Opposing activities protect against age-onset proteotoxicity
-
Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. 2006. Opposing activities protect against age-onset proteotoxicity. Science 313:1604-10
-
(2006)
Science
, vol.313
, pp. 1604-1610
-
-
Cohen, E.1
Bieschke, J.2
Perciavalle, R.M.3
Kelly, J.W.4
Dillin, A.5
-
149
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
Haass C, Selkoe DJ. 2007. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. Nat. Rev. Mol. Cell Biol. 8:101-12
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
150
-
-
50649116818
-
Misfolded proteins partition between two distinct quality control compartments
-
Kaganovich D, Kopito R, Frydman J. 2008. Misfolded proteins partition between two distinct quality control compartments. Nature 454:1088-95
-
(2008)
Nature
, vol.454
, pp. 1088-1095
-
-
Kaganovich, D.1
Kopito, R.2
Frydman, J.3
-
151
-
-
33751237087
-
Stress, aging, and neurodegenerative disease
-
Morimoto RI. 2006. Stress, aging, and neurodegenerative disease. N. Engl. J. Med. 355:2254-55
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 2254-2255
-
-
Morimoto, R.I.1
-
152
-
-
33747053662
-
Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model
-
Brignull HR, Moore FE, Tang SJ, Morimoto RI. 2006. Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. J. Neurosci. 26:7597-606
-
(2006)
J. Neurosci
, vol.26
, pp. 7597-7606
-
-
Brignull, H.R.1
Moore, F.E.2
Tang, S.J.3
Morimoto, R.I.4
-
153
-
-
37849030901
-
-
Shao J, Diamond MI. 2007. Polyglutamine diseases: emerging concepts in pathogenesis and therapy. Hum. Mol. Genet. 16(Spec. 2):R115-23
-
Shao J, Diamond MI. 2007. Polyglutamine diseases: emerging concepts in pathogenesis and therapy. Hum. Mol. Genet. 16(Spec. 2):R115-23
-
-
-
-
154
-
-
44449168261
-
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
-
Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, et al. 2008. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc. Natl. Acad. Sci. USA 105:7159-64
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7159-7164
-
-
Wang, H.1
Duennwald, M.L.2
Roberts, B.E.3
Rozeboom, L.M.4
Zhang, Y.L.5
-
155
-
-
44449144587
-
Phenolsulfonphthalein, but not phenolphthalein, inhibits amyloid fibril formation: Implications for the modulation of amyloid self-assembly
-
Levy M, Porat Y, Bacharach E, Shalev DE, Gazit E. 2008. Phenolsulfonphthalein, but not phenolphthalein, inhibits amyloid fibril formation: implications for the modulation of amyloid self-assembly. Biochemistry 47:5896-904
-
(2008)
Biochemistry
, vol.47
, pp. 5896-5904
-
-
Levy, M.1
Porat, Y.2
Bacharach, E.3
Shalev, D.E.4
Gazit, E.5
-
156
-
-
34547779036
-
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease
-
Gan L. 2007. Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease. Drug News Perspect. 20:233-39
-
(2007)
Drug News Perspect
, vol.20
, pp. 233-239
-
-
Gan, L.1
-
157
-
-
39649101710
-
Developing preventive therapies for chronic diseases: Lessons learned from Alzheimer's disease
-
Selkoe DJ. 2007. Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease. Nutr. Rev. 65:S239-43
-
(2007)
Nutr. Rev
, vol.65
-
-
Selkoe, D.J.1
-
158
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, et al. 2007. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447:859-63
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
-
160
-
-
55749103407
-
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
-
Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, et al. 2008. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc. Natl. Acad. Sci. USA 105:15564-69
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15564-15569
-
-
Thomas, E.A.1
Coppola, G.2
Desplats, P.A.3
Tang, B.4
Soragni, E.5
-
161
-
-
37349129281
-
The parkin protein as a therapeutic target in Parkinson's disease
-
Winklhofer KF. 2007. The parkin protein as a therapeutic target in Parkinson's disease. Expert Opin. Ther. Targets 11:1543-52
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1543-1552
-
-
Winklhofer, K.F.1
-
162
-
-
38449084443
-
Role of the ubiquitin proteasome system in Parkinson's disease
-
Lim KL, Tan JM. 2007. Role of the ubiquitin proteasome system in Parkinson's disease. BMC Biochem. 8(Suppl. 1):S13
-
(2007)
BMC Biochem
, vol.8
, Issue.SUPPL. 1
-
-
Lim, K.L.1
Tan, J.M.2
-
163
-
-
37849043062
-
Genetics of familial amyotrophic lateral sclerosis
-
Valdmanis PN, Rouleau GA. 2008. Genetics of familial amyotrophic lateral sclerosis. Neurology 70:144-52
-
(2008)
Neurology
, vol.70
, pp. 144-152
-
-
Valdmanis, P.N.1
Rouleau, G.A.2
-
164
-
-
34547640096
-
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
-
Gruzman A,Wood WL, Alpert E, Prasad MD,Miller RG, et al. 2007. Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 104:12524-29
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12524-12529
-
-
Gruzman, A.1
Wood, W.L.2
Alpert, E.3
Prasad, M.D.4
Miller, R.G.5
-
165
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, et al. 2008. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci. 11:251-53
-
(2008)
Nat. Neurosci
, vol.11
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
Fujimori-Tonou, N.4
Yamashita, H.5
-
167
-
-
40849150376
-
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits
-
SangsterTA, Salathia N, Undurraga S, Milo R, Schellenberg K, et al. 2008. HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc. Natl. Acad. Sci. USA 105:2963-68
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 2963-2968
-
-
Sangster, T.A.1
Salathia, N.2
Undurraga, S.3
Milo, R.4
Schellenberg, K.5
-
168
-
-
35148876623
-
The Hsp90 capacitor, developmental remodeling, and evolution: The robustness of gene networks and the curious evolvability of metamorphosis
-
Rutherford S, Hirate Y, Swalla BJ. 2007. The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis. Crit. Rev. Biochem. Mol. Biol. 42:355-72
-
(2007)
Crit. Rev. Biochem. Mol. Biol
, vol.42
, pp. 355-372
-
-
Rutherford, S.1
Hirate, Y.2
Swalla, B.J.3
-
169
-
-
25844530060
-
Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi
-
Cowen LE, Lindquist S. 2005. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309:2185-89
-
(2005)
Science
, vol.309
, pp. 2185-2189
-
-
Cowen, L.E.1
Lindquist, S.2
-
170
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins AL. 2008. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4:682-90
-
(2008)
Nat. Chem. Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
171
-
-
23044472125
-
Large-scale profiling of Rab GTPase trafficking networks: The membrane
-
Gurkan C, Lapp H, Alory C, Su AI, Hogenesch JB, Balch WE. 2005. Large-scale profiling of Rab GTPase trafficking networks: the membrane. Mol. Biol. Cell 16:3847-64
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 3847-3864
-
-
Gurkan, C.1
Lapp, H.2
Alory, C.3
Su, A.I.4
Hogenesch, J.B.5
Balch, W.E.6
|