-
1
-
-
79960230433
-
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
-
Martinou J.C., Youle R.J. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell 2011, 21:92-101.
-
(2011)
Dev. Cell
, vol.21
, pp. 92-101
-
-
Martinou, J.C.1
Youle, R.J.2
-
2
-
-
84860389354
-
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
-
Strasser A., et al. Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J. 2011, 30:3667-3683.
-
(2011)
EMBO J.
, vol.30
, pp. 3667-3683
-
-
Strasser, A.1
-
3
-
-
84871235883
-
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
-
Rautureau G.J., et al. The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. Cell Death Dis. 2012, 13:e443.
-
(2012)
Cell Death Dis.
, vol.13
-
-
Rautureau, G.J.1
-
4
-
-
43449132366
-
Multisite phosphorylation regulates Bim stability and apoptotic activity
-
Hübner A., et al. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol. Cell 2008, 30:415-425.
-
(2008)
Mol. Cell
, vol.30
, pp. 415-425
-
-
Hübner, A.1
-
5
-
-
84875736175
-
PUMA and BIM are required for oncogene inactivation-induced apoptosis
-
Bean G.R., et al. PUMA and BIM are required for oncogene inactivation-induced apoptosis. Sci. Signal. 2013, 6:ra20.
-
(2013)
Sci. Signal.
, vol.6
-
-
Bean, G.R.1
-
6
-
-
84882289067
-
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice
-
Parsons M.J., et al. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013, 10.1038/cdd.2013.38.
-
(2013)
Cell Death Differ.
-
-
Parsons, M.J.1
-
7
-
-
0025251664
-
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
-
Strasser A., et al. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990, 348:331-333.
-
(1990)
Nature
, vol.348
, pp. 331-333
-
-
Strasser, A.1
-
8
-
-
75549084068
-
MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts
-
Brunelle J.K., et al. MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts. J. Cell Biol. 2009, 187:429-442.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 429-442
-
-
Brunelle, J.K.1
-
9
-
-
0023786047
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
-
Vaux D.L., et al. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1998, 335:440-442.
-
(1998)
Nature
, vol.335
, pp. 440-442
-
-
Vaux, D.L.1
-
10
-
-
0032211158
-
Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage
-
Zhou P., et al. Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood 1998, 92:3226-3239.
-
(1998)
Blood
, vol.92
, pp. 3226-3239
-
-
Zhou, P.1
-
11
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander-Heiden M.G., et al. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander-Heiden, M.G.1
-
12
-
-
77957122174
-
The engine driving the ship: metabolic steering of cell proliferation and death
-
Buchakjian M.R., Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nat. Rev. Mol. Cell Biol. 2010, 11:715-727.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 715-727
-
-
Buchakjian, M.R.1
Kornbluth, S.2
-
13
-
-
1842813931
-
Transcriptional control of the core cell-death machinery
-
Kumar S., Cakouros D. Transcriptional control of the core cell-death machinery. Trends Biochem. Sci. 2004, 29:193-199.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 193-199
-
-
Kumar, S.1
Cakouros, D.2
-
14
-
-
33645294070
-
Oncomirs - microRNAs with a role in cancer
-
Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
15
-
-
0032006805
-
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse
-
Kaufmann S.H., et al. Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood 1998, 91:991-1000.
-
(1998)
Blood
, vol.91
, pp. 991-1000
-
-
Kaufmann, S.H.1
-
16
-
-
2442663096
-
Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells
-
Taniai M., et al. Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. Cancer Res. 2004, 64:3517-3524.
-
(2004)
Cancer Res.
, vol.64
, pp. 3517-3524
-
-
Taniai, M.1
-
17
-
-
21744457447
-
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival
-
Wuilleme-Toumi S., et al. Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. Leukemia 2005, 19:1248-1252.
-
(2005)
Leukemia
, vol.19
, pp. 1248-1252
-
-
Wuilleme-Toumi, S.1
-
18
-
-
0021934042
-
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18
-
Bakhshi A., et al. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985, 41:899-906.
-
(1985)
Cell
, vol.41
, pp. 899-906
-
-
Bakhshi, A.1
-
19
-
-
0345055662
-
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18
-
Cleary M.L., Sklar J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl. Acad. Sci. U.S.A. 1985, 82:7439-7443.
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 7439-7443
-
-
Cleary, M.L.1
Sklar, J.2
-
20
-
-
0022379447
-
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
-
Tsujimoto Y., et al. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 1985, 229:1390-1393.
-
(1985)
Science
, vol.229
, pp. 1390-1393
-
-
Tsujimoto, Y.1
-
21
-
-
22144433675
-
High-resolution genomic profiles of human lung cancer
-
Tonon G., et al. High-resolution genomic profiles of human lung cancer. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9625-9630.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 9625-9630
-
-
Tonon, G.1
-
22
-
-
33748491903
-
20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome
-
Smith L.T., et al. 20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome. Genes Chromosomes Cancer 2006, 45:957-966.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 957-966
-
-
Smith, L.T.1
-
23
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim R., et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010, 463:899-905.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
-
24
-
-
36749068356
-
Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
-
Kendall J., et al. Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:16663-16668.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 16663-16668
-
-
Kendall, J.1
-
25
-
-
0032772367
-
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
-
Wang J.M., et al. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol. Cell. Biol. 1999, 9:6195-6206.
-
(1999)
Mol. Cell. Biol.
, vol.9
, pp. 6195-6206
-
-
Wang, J.M.1
-
26
-
-
0034284309
-
Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways
-
Huang H.M., et al. Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. Blood 2000, 96:1764-1771.
-
(2000)
Blood
, vol.96
, pp. 1764-1771
-
-
Huang, H.M.1
-
27
-
-
0037902100
-
Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival
-
Liu H., et al. Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. Blood 2003, 102:344-352.
-
(2003)
Blood
, vol.102
, pp. 344-352
-
-
Liu, H.1
-
28
-
-
0038046166
-
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
-
Nijhawan D., et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 2003, 17:1475-1486.
-
(2003)
Genes Dev.
, vol.17
, pp. 1475-1486
-
-
Nijhawan, D.1
-
29
-
-
34547949167
-
Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation
-
Fritsch R.M., et al. Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. J. Biol. Chem. 2007, 282:22551-22562.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22551-22562
-
-
Fritsch, R.M.1
-
30
-
-
85047699682
-
Direct repression of the Mcl-1 promoter by E2F1
-
Croxton R., et al. Direct repression of the Mcl-1 promoter by E2F1. Oncogene 2002, 21:1359-1369.
-
(2002)
Oncogene
, vol.21
, pp. 1359-1369
-
-
Croxton, R.1
-
31
-
-
49449108291
-
MTORC1 promotes survival through translational control of Mcl-1
-
Mills J.R., et al. mTORC1 promotes survival through translational control of Mcl-1. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10853-10858.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 10853-10858
-
-
Mills, J.R.1
-
32
-
-
25444520537
-
MiR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino A., et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:13944-13949.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
-
33
-
-
34548687035
-
Mir-29 regulates Mcl-1 protein expression and apoptosis
-
Mott J.L., et al. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007, 26:6133-6140.
-
(2007)
Oncogene
, vol.26
, pp. 6133-6140
-
-
Mott, J.L.1
-
34
-
-
84878685848
-
Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1
-
Kwon J.E., et al. Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1. Apoptosis 2013, 18:896-909.
-
(2013)
Apoptosis
, vol.18
, pp. 896-909
-
-
Kwon, J.E.1
-
35
-
-
59149098054
-
MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
-
Su H., et al. MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res. 2009, 69:1135-1142.
-
(2009)
Cancer Res.
, vol.69
, pp. 1135-1142
-
-
Su, H.1
-
36
-
-
78651511540
-
MiR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis
-
Kole A.J., et al. miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev. 2011, 25:125-130.
-
(2011)
Genes Dev.
, vol.25
, pp. 125-130
-
-
Kole, A.J.1
-
37
-
-
84877617507
-
MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells
-
Xie Y., et al. MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells. Oncogene 2012, 32:2442-2451.
-
(2012)
Oncogene
, vol.32
, pp. 2442-2451
-
-
Xie, Y.1
-
38
-
-
84879690994
-
MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells
-
Liu S., et al. MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells. FEBS Lett. 2013, 587:2247-2253.
-
(2013)
FEBS Lett.
, vol.587
, pp. 2247-2253
-
-
Liu, S.1
-
39
-
-
0025894713
-
P53 mutations in human cancers
-
Hollstein D., et al. p53 mutations in human cancers. Science 1991, 253:49-53.
-
(1991)
Science
, vol.253
, pp. 49-53
-
-
Hollstein, D.1
-
40
-
-
7044224706
-
Mutational spectrum of p53 mutations in primary breast and ovarian tumors
-
Feki I., Irminger-Finger I. Mutational spectrum of p53 mutations in primary breast and ovarian tumors. Crit. Rev. Oncol. Hematol. 2004, 52:103-116.
-
(2004)
Crit. Rev. Oncol. Hematol.
, vol.52
, pp. 103-116
-
-
Feki, I.1
Irminger-Finger, I.2
-
41
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E., et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000, 288:1053-1058.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
-
42
-
-
0035265686
-
PUMA, a novel proapoptotic gene is induced by p53
-
Nakano K., Vousden K.H. PUMA, a novel proapoptotic gene is induced by p53. Mol. Cell 2001, 7:683-694.
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
43
-
-
0035889087
-
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
-
Fortin A., et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J. Cell Biol. 2001, 155:207-216.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 207-216
-
-
Fortin, A.1
-
44
-
-
0034977277
-
Apaf-1 is a transcriptional target for E2F and p53
-
Moroni M.C., et al. Apaf-1 is a transcriptional target for E2F and p53. Nat. Cell Biol. 2001, 3:552-558.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 552-558
-
-
Moroni, M.C.1
-
45
-
-
0031018674
-
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
-
Rampino N., et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997, 275:967-969.
-
(1997)
Science
, vol.275
, pp. 967-969
-
-
Rampino, N.1
-
46
-
-
0037349289
-
P53 has a direct apoptogenic role at the mitochondria
-
Mihara M., et al. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 2003, 11:577-590.
-
(2003)
Mol. Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
-
47
-
-
24644436766
-
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
Chipuk J.E., et al. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 2004, 309:1732-1735.
-
(2004)
Science
, vol.309
, pp. 1732-1735
-
-
Chipuk, J.E.1
-
48
-
-
84877868017
-
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
-
Nieminen A., et al. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:E1839-E1848.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
-
-
Nieminen, A.1
-
49
-
-
0037094096
-
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
-
Stahl M., et al. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J. Immunol. 2002, 168:5024-5031.
-
(2002)
J. Immunol.
, vol.168
, pp. 5024-5031
-
-
Stahl, M.1
-
50
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers P.F., et al. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 2000, 10:1201-1204.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
-
51
-
-
10744230034
-
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines
-
Sunters A., et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J. Biol. Chem. 2003, 278:49795-49805.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49795-49805
-
-
Sunters, A.1
-
52
-
-
33745018595
-
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis
-
Yano T., et al. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol. Cell. Biol. 2006, 26:4474-4488.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4474-4488
-
-
Yano, T.1
-
53
-
-
30344450087
-
Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells
-
Jin H.O., et al. Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells. J. Cell. Physiol. 2006, 206:477-486.
-
(2006)
J. Cell. Physiol.
, vol.206
, pp. 477-486
-
-
Jin, H.O.1
-
54
-
-
84872093149
-
Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer
-
Gogada R., et al. Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. J. Biol. Chem. 2013, 288:368-381.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 368-381
-
-
Gogada, R.1
-
55
-
-
0042477712
-
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
-
Gilley J., et al. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 2003, 162:613-622.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 613-622
-
-
Gilley, J.1
-
56
-
-
35648949422
-
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
-
Costa D.B., et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med. 2007, 4:1669-1679.
-
(2007)
PLoS Med.
, vol.4
, pp. 1669-1679
-
-
Costa, D.B.1
-
57
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
Cragg M.S., et al. Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med. 2007, 4:1681-1689.
-
(2007)
PLoS Med.
, vol.4
, pp. 1681-1689
-
-
Cragg, M.S.1
-
58
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
Gong Y., et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 2007, 4:e294.
-
(2007)
PLoS Med.
, vol.4
-
-
Gong, Y.1
-
59
-
-
84857002194
-
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors
-
Faber A.C., et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 2011, 1:352-365.
-
(2011)
Cancer Discov.
, vol.1
, pp. 352-365
-
-
Faber, A.C.1
-
60
-
-
84862777672
-
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
-
Ng K.P., et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat. Med. 2012, 18:521-528.
-
(2012)
Nat. Med.
, vol.18
, pp. 521-528
-
-
Ng, K.P.1
-
61
-
-
1542379662
-
P73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
-
Melino G., et al. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem. 2004, 279:8076-8083.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 8076-8083
-
-
Melino, G.1
-
62
-
-
33745841375
-
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
-
You H., et al. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J. Exp. Med. 2006, 203:1657-1663.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1657-1663
-
-
You, H.1
-
63
-
-
0042346302
-
The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism
-
Liedtke C., et al. The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism. J. Biol. Chem. 2003, 278:27593-27604.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27593-27604
-
-
Liedtke, C.1
-
64
-
-
85006277004
-
Direct coupling of the cell cycle and cell death machinery by E2F
-
Nahle Z., et al. Direct coupling of the cell cycle and cell death machinery by E2F. Nat. Cell Biol. 2003, 4:859-864.
-
(2003)
Nat. Cell Biol.
, vol.4
, pp. 859-864
-
-
Nahle, Z.1
-
65
-
-
44149110803
-
Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner
-
Baptiste-Okoh N., et al. Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle 2008, 7:1133-1138.
-
(2008)
Cell Cycle
, vol.7
, pp. 1133-1138
-
-
Baptiste-Okoh, N.1
-
66
-
-
18644381327
-
Apaf-1 is a mediator of E2F-1-induced apoptosis
-
Furukawa Y., et al. Apaf-1 is a mediator of E2F-1-induced apoptosis. J. Biol. Chem. 2002, 277:39760-39768.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39760-39768
-
-
Furukawa, Y.1
-
67
-
-
0034677589
-
Initiation of Apaf-1 translation by internal ribosome entry
-
Coldwell M.J., et al. Initiation of Apaf-1 translation by internal ribosome entry. Oncogene 2000, 19:899-905.
-
(2000)
Oncogene
, vol.19
, pp. 899-905
-
-
Coldwell, M.J.1
-
68
-
-
0035843169
-
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
-
Soengas M.S., et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001, 409:207-211.
-
(2001)
Nature
, vol.409
, pp. 207-211
-
-
Soengas, M.S.1
-
69
-
-
5044237664
-
Reduced Apaf-1 expression in human cutaneous melanomas
-
Dai D.L., et al. Reduced Apaf-1 expression in human cutaneous melanomas. Br. J. Cancer 2004, 91:1089-1095.
-
(2004)
Br. J. Cancer
, vol.91
, pp. 1089-1095
-
-
Dai, D.L.1
-
70
-
-
1542510618
-
Allelic imbalance of 12q22-23 associated with APAF-1 locus correlates with poor disease outcome in cutaneous melanoma
-
Fujimoto A., et al. Allelic imbalance of 12q22-23 associated with APAF-1 locus correlates with poor disease outcome in cutaneous melanoma. Cancer Res. 2004, 64:2245-2250.
-
(2004)
Cancer Res.
, vol.64
, pp. 2245-2250
-
-
Fujimoto, A.1
-
71
-
-
8844281553
-
Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma
-
Umetani N., et al. Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma. Oncogene 2004, 23:8292-8300.
-
(2004)
Oncogene
, vol.23
, pp. 8292-8300
-
-
Umetani, N.1
-
72
-
-
33947693893
-
Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer
-
Zlobec I., et al. Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer. Eur. J. Cancer 2007, 43:1101-1107.
-
(2007)
Eur. J. Cancer
, vol.43
, pp. 1101-1107
-
-
Zlobec, I.1
-
73
-
-
34948824005
-
Rationales for expression and altered expression of apoptotic protease activating factor-1 gene in gastric cancer
-
Wang H.L., et al. Rationales for expression and altered expression of apoptotic protease activating factor-1 gene in gastric cancer. World J. Gastroenterol. 2007, 13:5060-5064.
-
(2007)
World J. Gastroenterol.
, vol.13
, pp. 5060-5064
-
-
Wang, H.L.1
-
74
-
-
34248199269
-
A gene expression profile of tumor suppressor genes commonly methylated in bladder cancer
-
Christoph F., et al. A gene expression profile of tumor suppressor genes commonly methylated in bladder cancer. J. Cancer Res. Clin. Oncol. 2007, 133:343-349.
-
(2007)
J. Cancer Res. Clin. Oncol.
, vol.133
, pp. 343-349
-
-
Christoph, F.1
-
75
-
-
34250793839
-
EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder
-
Hinz S., et al. EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder. Tumour Biol. 2007, 28:151-157.
-
(2007)
Tumour Biol.
, vol.28
, pp. 151-157
-
-
Hinz, S.1
-
76
-
-
79959539790
-
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
-
Vucic D., et al. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat. Rev. Mol. Cell Biol. 2011, 12:439-452.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 439-452
-
-
Vucic, D.1
-
77
-
-
78049302116
-
P53 post-translational modification: deregulated in tumorigenesis
-
Dai C., Gu W. p53 post-translational modification: deregulated in tumorigenesis. Trends Mol. Med. 2010, 16:528-536.
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 528-536
-
-
Dai, C.1
Gu, W.2
-
78
-
-
69449095860
-
Caspases and kinases in a death grip
-
Kurokawa M., Kornbluth S. Caspases and kinases in a death grip. Cell 2009, 138:838-854.
-
(2009)
Cell
, vol.138
, pp. 838-854
-
-
Kurokawa, M.1
Kornbluth, S.2
-
79
-
-
80051978811
-
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation
-
Weissman A.M., et al. The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat. Rev. Mol. Cell Biol. 2011, 12:605-620.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 605-620
-
-
Weissman, A.M.1
-
80
-
-
84877601864
-
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53
-
Kurokawa M., et al. A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Sci. Signal. 2013, 6:ra32.
-
(2013)
Sci. Signal.
, vol.6
-
-
Kurokawa, M.1
-
81
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
Maurer U., et al. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 2005, 21:749-760.
-
(2005)
Mol. Cell
, vol.21
, pp. 749-760
-
-
Maurer, U.1
-
82
-
-
84872288551
-
Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
-
Magiera M.M., et al. Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons. Cell Death Differ. 2013, 20:281-292.
-
(2013)
Cell Death Differ.
, vol.20
, pp. 281-292
-
-
Magiera, M.M.1
-
83
-
-
77953378973
-
Ubiquitin-independent degradation of antiapoptotic MCL-1
-
Stewart D.P., et al. Ubiquitin-independent degradation of antiapoptotic MCL-1. Mol. Cell. Biol. 2010, 30:3099-3110.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3099-3110
-
-
Stewart, D.P.1
-
84
-
-
34347350211
-
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
Ding Q., et al. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol. Cell. Biol. 2007, 27:4006-4017.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
-
85
-
-
67650076845
-
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis
-
Morel C., et al. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol. Cell. Biol. 2009, 29:3845-3852.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3845-3852
-
-
Morel, C.1
-
86
-
-
79954620635
-
Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
-
Liao M., et al. Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells. Mol. Cancer 2011, 10:44.
-
(2011)
Mol. Cancer
, vol.10
, pp. 44
-
-
Liao, M.1
-
87
-
-
84867289719
-
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer
-
Nifoussi S.K., et al. Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer. PLoS ONE 2012, 7:e47060.
-
(2012)
PLoS ONE
, vol.7
-
-
Nifoussi, S.K.1
-
88
-
-
34250327394
-
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer
-
Ding Q., et al. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Res. 2007, 67:4564-4571.
-
(2007)
Cancer Res.
, vol.67
, pp. 4564-4571
-
-
Ding, Q.1
-
89
-
-
77954884045
-
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
-
Harley M.E., et al. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J. 2010, 29:2407-2420.
-
(2010)
EMBO J.
, vol.29
, pp. 2407-2420
-
-
Harley, M.E.1
-
90
-
-
79952261405
-
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
Inuzuka H., et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011, 471:104-109.
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
-
91
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz I.E., et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 2011, 471:110-114.
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
-
92
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
Akhoondi S., et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res. 2007, 67:9006-9012.
-
(2007)
Cancer Res.
, vol.67
, pp. 9006-9012
-
-
Akhoondi, S.1
-
93
-
-
34250863886
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
-
Maser R.S., et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 2007, 47:966-971.
-
(2007)
Nature
, vol.47
, pp. 966-971
-
-
Maser, R.S.1
-
94
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood L.D., et al. The genomic landscapes of human breast and colorectal cancers. Science 2007, 318:1108-1113.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
-
95
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
-
Zhong Q., et al. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 2005, 121:1085-1095.
-
(2005)
Cell
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
-
96
-
-
79960839567
-
Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells
-
Pervin S., et al. Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells. Br. J. Cancer 2011, 105:428-437.
-
(2011)
Br. J. Cancer
, vol.105
, pp. 428-437
-
-
Pervin, S.1
-
97
-
-
73849083434
-
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
-
Schwickart M., et al. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010, 463:103-107.
-
(2010)
Nature
, vol.463
, pp. 103-107
-
-
Schwickart, M.1
-
98
-
-
0038482050
-
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
-
Ley R., et al. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 2003, 278:18811-18816.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18811-18816
-
-
Ley, R.1
-
99
-
-
0242521470
-
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
-
Luciano F., et al. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 2003, 22:6785-6793.
-
(2003)
Oncogene
, vol.22
, pp. 6785-6793
-
-
Luciano, F.1
-
100
-
-
10744232926
-
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
-
Akiyama T., et al. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J. 2003, 22:6653-6664.
-
(2003)
EMBO J.
, vol.22
, pp. 6653-6664
-
-
Akiyama, T.1
-
101
-
-
58149312710
-
BetaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
-
Dehan E., et al. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol. Cell 2009, 33:109-116.
-
(2009)
Mol. Cell
, vol.33
, pp. 109-116
-
-
Dehan, E.1
-
102
-
-
79957598477
-
Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection
-
Thompson S., et al. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J. Biol. Chem. 2011, 286:19331-19339.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 19331-19339
-
-
Thompson, S.1
-
103
-
-
47749086687
-
RACK1 and CIS mediate the degradation of BimEL in cancer cells
-
Zhang W., et al. RACK1 and CIS mediate the degradation of BimEL in cancer cells. J. Biol. Chem. 2008, 283:16416-16426.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16416-16426
-
-
Zhang, W.1
-
104
-
-
0030780106
-
Movement of Bax from the cytosol to mitochondria during apoptosis
-
Walter K.G., et al. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 1998, 139:1281-1292.
-
(1998)
J. Cell Biol.
, vol.139
, pp. 1281-1292
-
-
Walter, K.G.1
-
105
-
-
84876852297
-
Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming
-
Schellenberg B., et al. Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming. Mol. Cell 2013, 49:959-971.
-
(2013)
Mol. Cell
, vol.49
, pp. 959-971
-
-
Schellenberg, B.1
-
106
-
-
79953276389
-
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
-
Edlich F., et al. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 2011, 145:104-116.
-
(2011)
Cell
, vol.145
, pp. 104-116
-
-
Edlich, F.1
-
107
-
-
41949136647
-
Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL
-
Liu F.T., et al. Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL. Blood 2008, 111:2797-2805.
-
(2008)
Blood
, vol.111
, pp. 2797-2805
-
-
Liu, F.T.1
-
108
-
-
77951464624
-
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
-
Benard G., et al. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J. 2010, 29:1458-1471.
-
(2010)
EMBO J.
, vol.29
, pp. 1458-1471
-
-
Benard, G.1
-
109
-
-
41949096727
-
Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia
-
Agrawal S.G., et al. Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia. Blood 2008, 111:2790-2796.
-
(2008)
Blood
, vol.111
, pp. 2790-2796
-
-
Agrawal, S.G.1
-
110
-
-
58149299435
-
Baxβ: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism
-
Fu N.Y., et al. Baxβ: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism. Mol. Cell 2009, 33:15-29.
-
(2009)
Mol. Cell
, vol.33
, pp. 15-29
-
-
Fu, N.Y.1
-
111
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
Zha J., et al. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996, 87:619-628.
-
(1996)
Cell
, vol.87
, pp. 619-628
-
-
Zha, J.1
-
112
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta S.R., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
-
113
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso L., et al. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278:687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
del Peso, L.1
-
114
-
-
0037860975
-
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis
-
Putcha G.V., et al. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 2003, 38:899-914.
-
(2003)
Neuron
, vol.38
, pp. 899-914
-
-
Putcha, G.V.1
-
115
-
-
5444234359
-
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis
-
Becker E.B., et al. Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J. Neurosci. 2004, 24:8762-8770.
-
(2004)
J. Neurosci.
, vol.24
, pp. 8762-8770
-
-
Becker, E.B.1
-
116
-
-
7444243152
-
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
-
Harada H., et al. Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15313-15317.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 15313-15317
-
-
Harada, H.1
-
117
-
-
33748747786
-
P38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65
-
Cai B., et al. p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J. Biol. Chem. 2006, 281:25215-25222.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25215-25222
-
-
Cai, B.1
-
118
-
-
84862777482
-
Rsk-mediated phosphorylation and 14-3-3e{open} binding of Apaf-1 suppresses cytochrome c-induced apoptosis
-
Kim J., et al. Rsk-mediated phosphorylation and 14-3-3e{open} binding of Apaf-1 suppresses cytochrome c-induced apoptosis. EMBO J. 2012, 31:1279-1292.
-
(2012)
EMBO J.
, vol.31
, pp. 1279-1292
-
-
Kim, J.1
-
119
-
-
17144376084
-
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation
-
Clark D.E., et al. The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation. Cancer Res. 2005, 65:3108-3116.
-
(2005)
Cancer Res.
, vol.65
, pp. 3108-3116
-
-
Clark, D.E.1
-
120
-
-
50249168335
-
Inhibition of apoptosome formation by suppression of Hsp90β phosphorylation in tyrosine kinase-induced leukemias
-
Kurokawa M., et al. Inhibition of apoptosome formation by suppression of Hsp90β phosphorylation in tyrosine kinase-induced leukemias. Mol. Cell. Biol. 2007, 28:5494-5506.
-
(2007)
Mol. Cell. Biol.
, vol.28
, pp. 5494-5506
-
-
Kurokawa, M.1
-
121
-
-
0034799401
-
Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8
-
Desagher S., et al. Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol. Cell 2001, 8:601-611.
-
(2001)
Mol. Cell
, vol.8
, pp. 601-611
-
-
Desagher, S.1
-
122
-
-
27144512715
-
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
-
Shin S., et al. Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J. 2005, 24:3532-3542.
-
(2005)
EMBO J.
, vol.24
, pp. 3532-3542
-
-
Shin, S.1
-
123
-
-
26244453715
-
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2
-
Nutt K.L., et al. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 2005, 123:89-103.
-
(2005)
Cell
, vol.123
, pp. 89-103
-
-
Nutt, K.L.1
-
124
-
-
70350347735
-
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
-
Andersen J.L., et al. Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J. 2009, 28:3216-3227.
-
(2009)
EMBO J.
, vol.28
, pp. 3216-3227
-
-
Andersen, J.L.1
-
125
-
-
20444440707
-
Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3
-
Voss O.H., et al. Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3. J. Biol. Chem. 2005, 280:17371-17379.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17371-17379
-
-
Voss, O.H.1
-
126
-
-
1242276248
-
P38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils
-
Alvarado-Kristensson M., et al. p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J. Exp. Med. 2004, 199:449-458.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 449-458
-
-
Alvarado-Kristensson, M.1
-
127
-
-
79959367758
-
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines
-
Li X., et al. Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. J. Biol. Chem. 2011, 286:22291-22299.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22291-22299
-
-
Li, X.1
-
128
-
-
41949117115
-
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
-
Jia S.H., et al. Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8. J. Biol. Chem. 2008, 283:5402-5413.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 5402-5413
-
-
Jia, S.H.1
-
129
-
-
33646542701
-
Src kinase phosphorylates caspase-8 on Tyr380: a novel mechanism of apoptosis suppression
-
Cursi S., et al. Src kinase phosphorylates caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J. 2006, 25:1895-1905.
-
(2006)
EMBO J.
, vol.25
, pp. 1895-1905
-
-
Cursi, S.1
-
130
-
-
17644387220
-
Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c
-
Martin M.C., et al. Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c. J. Biol. Chem. 2005, 280:15449-15455.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15449-15455
-
-
Martin, M.C.1
-
131
-
-
0038726089
-
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
-
Allan L.A., et al. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat. Cell Biol. 2003, 5:647-654.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 647-654
-
-
Allan, L.A.1
-
132
-
-
33746892660
-
Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis
-
Dessauge F., et al. Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis. J. Immunol. 2006, 177:2441-2451.
-
(2006)
J. Immunol.
, vol.177
, pp. 2441-2451
-
-
Dessauge, F.1
-
133
-
-
34247232176
-
Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis
-
Allan A.L., Clarke P.R. Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Mol. Cell 2007, 26:301-310.
-
(2007)
Mol. Cell
, vol.26
, pp. 301-310
-
-
Allan, A.L.1
Clarke, P.R.2
-
134
-
-
57049159874
-
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development
-
Laguna A., et al. The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev. Cell 2008, 15:841-853.
-
(2008)
Dev. Cell
, vol.15
, pp. 841-853
-
-
Laguna, A.1
-
135
-
-
56849127175
-
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
-
Seifert A., et al. DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. FEBS J. 2008, 275:6268-6280.
-
(2008)
FEBS J.
, vol.275
, pp. 6268-6280
-
-
Seifert, A.1
-
136
-
-
69249222504
-
P38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress
-
Seifert A., Clarke P.R. p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress. Cell. Signal. 2009, 21:1626-1633.
-
(2009)
Cell. Signal.
, vol.21
, pp. 1626-1633
-
-
Seifert, A.1
Clarke, P.R.2
-
137
-
-
27944469109
-
Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress
-
Brady S.C., et al. Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress. Mol. Cell. Biol. 2005, 25:10543-10555.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10543-10555
-
-
Brady, S.C.1
-
138
-
-
15744398903
-
C-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage
-
Raina D., et al. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J. Biol. Chem. 2005, 280:11147-11151.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11147-11151
-
-
Raina, D.1
-
139
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone M.H., et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282:1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
-
140
-
-
23944445368
-
A role for proapoptotic BID in the DNA-damage response
-
Zinkel S.S., et al. A role for proapoptotic BID in the DNA-damage response. Cell 2005, 122:579-591.
-
(2005)
Cell
, vol.122
, pp. 579-591
-
-
Zinkel, S.S.1
-
141
-
-
84881001025
-
MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor
-
Chakraborty A.R., et al. MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor. Blood 2013, 121:4115-4125.
-
(2013)
Blood
, vol.121
, pp. 4115-4125
-
-
Chakraborty, A.R.1
-
142
-
-
40949152993
-
Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia
-
Leung K.T., et al. Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis 2008, 29:544-551.
-
(2008)
Carcinogenesis
, vol.29
, pp. 544-551
-
-
Leung, K.T.1
-
143
-
-
78650886200
-
Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim
-
Moujalled D., et al. Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim. EMBO Rep. 2011, 12:77-83.
-
(2011)
EMBO Rep.
, vol.12
, pp. 77-83
-
-
Moujalled, D.1
-
144
-
-
79958753992
-
Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
-
Fricker M., et al. Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis. 2010, 1:e59.
-
(2010)
Cell Death Dis.
, vol.1
-
-
Fricker, M.1
-
145
-
-
84858156535
-
Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death
-
Sandow J.J., et al. Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death Differ. 2012, 19:633-641.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 633-641
-
-
Sandow, J.J.1
-
146
-
-
84872587266
-
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation
-
Yan J., et al. Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell 2013, 152:304-315.
-
(2013)
Cell
, vol.152
, pp. 304-315
-
-
Yan, J.1
-
147
-
-
80855156758
-
P21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112
-
Ye D.Z., et al. p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS ONE 2011, 6:e27637.
-
(2011)
PLoS ONE
, vol.6
-
-
Ye, D.Z.1
-
148
-
-
0033120591
-
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
-
Harada H., et al. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell 1999, 3:413-422.
-
(1999)
Mol. Cell
, vol.3
, pp. 413-422
-
-
Harada, H.1
-
149
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni A., et al. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999, 286:1358-1362.
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
-
150
-
-
0033581927
-
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
-
Fang X., et al. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene 1999, 18:6635-6640.
-
(1999)
Oncogene
, vol.18
, pp. 6635-6640
-
-
Fang, X.1
-
151
-
-
0033520937
-
P90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway
-
Tan Y., et al. p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway. J. Biol. Chem. 1999, 274:34859-34867.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34859-34867
-
-
Tan, Y.1
-
152
-
-
0040056864
-
P21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
-
Schürmann A., et al. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol. Cell. Biol. 2000, 20:453-461.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 453-461
-
-
Schürmann, A.1
-
153
-
-
0035957986
-
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis
-
Gnesutta N., et al. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J. Biol. Chem. 2001, 276:14414-14419.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14414-14419
-
-
Gnesutta, N.1
-
154
-
-
0041631073
-
P21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
-
Cotteret S., et al. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol. Cell. Biol. 2003, 23:5526-5539.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5526-5539
-
-
Cotteret, S.1
-
155
-
-
18144429360
-
Survival function of protein kinase Cι as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
-
Jin Z., et al. Survival function of protein kinase Cι as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. J. Biol. Chem. 2005, 280:16045-16052.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16045-16052
-
-
Jin, Z.1
-
156
-
-
0035859956
-
P70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
-
Harada H., et al. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:9666-9670.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 9666-9670
-
-
Harada, H.1
-
157
-
-
0034682812
-
BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival
-
Tan Y., et al. BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J. Biol. Chem. 2000, 275:25865-25869.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25865-25869
-
-
Tan, Y.1
-
158
-
-
0034661857
-
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155
-
Lizcano J.M., et al. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem. J. 2000, 349:547-557.
-
(2000)
Biochem. J.
, vol.349
, pp. 547-557
-
-
Lizcano, J.M.1
-
159
-
-
78649973189
-
The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose
-
Lowman X.H., et al. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol. Cell 2010, 40:823-833.
-
(2010)
Mol. Cell
, vol.40
, pp. 823-833
-
-
Lowman, X.H.1
-
160
-
-
0037418238
-
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
-
Lei K., Davis R.J. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:2432-2437.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 2432-2437
-
-
Lei, K.1
Davis, R.J.2
-
161
-
-
84856926348
-
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity
-
Shao Y., Aplin A.E. ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. Cell Death Dis. 2012, 3:e253.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Shao, Y.1
Aplin, A.E.2
-
162
-
-
84865200796
-
Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik
-
Lopez J., et al. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell Death Dis. 2012, 19:1459-1469.
-
(2012)
Cell Death Dis.
, vol.19
, pp. 1459-1469
-
-
Lopez, J.1
-
163
-
-
36849095428
-
Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria
-
Arokium H., et al. Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria. J. Biol. Chem. 2007, 282:35104-35112.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35104-35112
-
-
Arokium, H.1
-
164
-
-
7744227096
-
Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
-
Linseman D.A., et al. Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J. Neurosci. 2004, 24:9993-10002.
-
(2004)
J. Neurosci.
, vol.24
, pp. 9993-10002
-
-
Linseman, D.A.1
-
165
-
-
60749100315
-
The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
-
Shen Z.J., et al. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat. Immunol. 2009, 10:257-265.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 257-265
-
-
Shen, Z.J.1
-
166
-
-
2442681877
-
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
-
Gardai S.J., et al. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J. Biol. Chem. 2004, 279:21085-21095.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 21085-21095
-
-
Gardai, S.J.1
-
167
-
-
33745812349
-
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation
-
Xin M., Deng X. Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. J. Biol. Chem. 2006, 281:18859-18867.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 18859-18867
-
-
Xin, M.1
Deng, X.2
-
168
-
-
34547101741
-
Protein kinase Cζ abrogates the proapoptotic function of Bax through phosphorylation
-
Xin M., et al. Protein kinase Cζ abrogates the proapoptotic function of Bax through phosphorylation. J. Biol. Chem. 2007, 282:21268-21277.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 21268-21277
-
-
Xin, M.1
-
169
-
-
33746379603
-
JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
-
Kim B.J., et al. JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J. Biol. Chem. 2006, 281:21256-21265.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 21256-21265
-
-
Kim, B.J.1
-
170
-
-
70350028199
-
Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK
-
Owens T.W., et al. Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK. Cell Death Differ. 2009, 16:1551-1562.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1551-1562
-
-
Owens, T.W.1
-
171
-
-
78449278358
-
Tyrosine dephosphorylation is required for Bak activation in apoptosis
-
Fox J.L., et al. Tyrosine dephosphorylation is required for Bak activation in apoptosis. EMBO J. 2010, 29:3852-3868.
-
(2010)
EMBO J.
, vol.29
, pp. 3852-3868
-
-
Fox, J.L.1
-
172
-
-
84870003427
-
Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis
-
Azad A., et al. Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. PLoS ONE 2012, 7:e49601.
-
(2012)
PLoS ONE
, vol.7
-
-
Azad, A.1
-
173
-
-
80053270735
-
Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints
-
Wang J., et al. Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. Cell. Signal. 2011, 23:2030-2038.
-
(2011)
Cell. Signal.
, vol.23
, pp. 2030-2038
-
-
Wang, J.1
-
174
-
-
75149132946
-
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis
-
Terrano D., et al. Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Mol. Cell. Biol. 2010, 30:640-656.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 640-656
-
-
Terrano, D.1
-
175
-
-
84861843880
-
Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint
-
Wang J., et al. Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint. Cell Cycle 2012, 11:2159-2169.
-
(2012)
Cell Cycle
, vol.11
, pp. 2159-2169
-
-
Wang, J.1
-
176
-
-
0030959304
-
Bcl-2 phosphorylation required for anti-apoptosis function
-
Ito T., et al. Bcl-2 phosphorylation required for anti-apoptosis function. J. Biol. Chem. 1997, 272:11671-11673.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11671-11673
-
-
Ito, T.1
-
177
-
-
0034652115
-
Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases
-
Deng X., et al. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:1578-1583.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 1578-1583
-
-
Deng, X.1
-
178
-
-
0033499801
-
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
-
Yamamoto K., et al. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol. Cell. Biol. 1999, 19:8469-8478.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 8469-8478
-
-
Yamamoto, K.1
-
179
-
-
0033532543
-
Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway
-
Dimmeler S., et al. Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway. J. Exp. Med. 1999, 189:1815-1822.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1815-1822
-
-
Dimmeler, S.1
-
180
-
-
0033974063
-
Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway
-
Breitschopf K., et al. Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol. Cell. Biol. 2000, 20:1886-1896.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1886-1896
-
-
Breitschopf, K.1
-
181
-
-
34547092443
-
Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1
-
Kobayashi S., et al. Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1. J. Biol. Chem. 2007, 282:18407-18417.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 18407-18417
-
-
Kobayashi, S.1
-
182
-
-
38049136542
-
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues
-
Johnson C.E., et al. Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:20820-20825.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 20820-20825
-
-
Johnson, C.E.1
-
183
-
-
19944419093
-
XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis
-
Tamm I., et al. XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis. Hematol. J. 2004, 5:489-495.
-
(2004)
Hematol. J.
, vol.5
, pp. 489-495
-
-
Tamm, I.1
-
184
-
-
39749166979
-
Immunohistochemical detection of the X-linked inhibitor of apoptosis protein (XIAP) in cervical squamous intraepithelial neoplasia and squamous carcinoma
-
Burstein D.E., et al. Immunohistochemical detection of the X-linked inhibitor of apoptosis protein (XIAP) in cervical squamous intraepithelial neoplasia and squamous carcinoma. Ann. Diagn. Pathol. 2008, 12:85-89.
-
(2008)
Ann. Diagn. Pathol.
, vol.12
, pp. 85-89
-
-
Burstein, D.E.1
-
185
-
-
84866517256
-
XIAP as a radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinoma
-
Moussata D., et al. XIAP as a radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinoma. Am. J. Pathol. 2012, 181:1271-1278.
-
(2012)
Am. J. Pathol.
, vol.181
, pp. 1271-1278
-
-
Moussata, D.1
-
186
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan H.C., et al. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J. Biol. Chem. 2004, 279:5405-5412.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
-
187
-
-
84856812315
-
IκB kinase e{open}-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis
-
Nakhaei P., et al. IκB kinase e{open}-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis. J. Virol. 2012, 86:726-737.
-
(2012)
J. Virol.
, vol.86
, pp. 726-737
-
-
Nakhaei, P.1
-
188
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T., et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2012, 435:677-681.
-
(2012)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
-
189
-
-
44849112219
-
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C., et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008, 68:3421-3428.
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
-
190
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
Souers A.J., et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 2013, 19:202-208.
-
(2013)
Nat. Med.
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
-
191
-
-
77951442337
-
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
-
Yecies D., et al. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 2010, 115:3304-3313.
-
(2010)
Blood
, vol.115
, pp. 3304-3313
-
-
Yecies, D.1
-
192
-
-
84859825629
-
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
-
Wei G., et al. Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. Cancer Cell 2012, 21:547-562.
-
(2012)
Cancer Cell
, vol.21
, pp. 547-562
-
-
Wei, G.1
-
193
-
-
84866654914
-
A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival
-
Cohen N.A., et al. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem. Biol. 2012, 19:1175-1186.
-
(2012)
Chem. Biol.
, vol.19
, pp. 1175-1186
-
-
Cohen, N.A.1
-
194
-
-
84867490138
-
Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML
-
Vo T.T., et al. Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML. Cell 2012, 151:344-355.
-
(2012)
Cell
, vol.151
, pp. 344-355
-
-
Vo, T.T.1
-
195
-
-
84877102240
-
Cellular mechanisms controlling caspase activation and function
-
Parrish A.B., et al. Cellular mechanisms controlling caspase activation and function. Cold Spring Harb. Perspect. Biol. 2013, 5:a008672.
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
-
-
Parrish, A.B.1
-
196
-
-
77952909686
-
Resistance to caspase-independent cell death requires persistence of intact mitochondria
-
Tait S.W., et al. Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev. Cell 2010, 18:802-813.
-
(2010)
Dev. Cell
, vol.18
, pp. 802-813
-
-
Tait, S.W.1
-
197
-
-
4844222278
-
Regulation of caspase-6 and FLIP by the AMPK family member ARK5
-
Suzuki A., et al. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. Oncogene 2004, 23:7067-7075.
-
(2004)
Oncogene
, vol.23
, pp. 7067-7075
-
-
Suzuki, A.1
-
198
-
-
79953214075
-
Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability
-
Peng C., et al. Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability. J. Biol. Chem. 2011, 286:6946-6954.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6946-6954
-
-
Peng, C.1
-
199
-
-
79960297569
-
Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity
-
Matthess Y., et al. Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity. Mol. Cell. Biol. 2010, 30:5726-5740.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 5726-5740
-
-
Matthess, Y.1
|