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Volumn 18, Issue 7, 2013, Pages 896-909

Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1

Author keywords

Apoptosis; Mcl 1; microRNA; miR 193a 3p; ROS

Indexed keywords

CYTOCHROME C; DNA; GAMMA HISTONE H2AX; HISTONE H2AX; LUCIFERASE; MICRORNA; MICRORNA 193A 3P; PROTEIN BCL 2; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84878685848     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0841-7     Document Type: Article
Times cited : (93)

References (51)
  • 1
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • 10.1016/S0092-8674(04)00045-5
    • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 16:281-297
    • (2004) Cell , vol.16 , pp. 281-297
    • Bartel, D.P.1
  • 2
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • 15652477 10.1016/j.cell.2004.12.035 1:CAS:528:DC%2BD2MXot1ChsA%3D%3D
    • Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 3
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • 16557279 10.1038/nrc1840 1:CAS:528:DC%2BD28XivVyqtrs%3D
    • Esquela-Kerscher A, Slack FJ (2006) Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6:259-269
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 4
    • 36148958682 scopus 로고    scopus 로고
    • MicroRNAs in cell proliferation, cell death, and tumorigenesis
    • 17393584
    • Hwang HW, Mendell JT (2007) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96(Suppl):R40-R44
    • (2007) Br J Cancer , vol.96 , Issue.SUPPL.
    • Hwang, H.W.1    Mendell, J.T.2
  • 8
    • 0348014686 scopus 로고    scopus 로고
    • DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
    • 14633975 10.1101/gad.1156903 1:CAS:528:DC%2BD3sXpvVGiu78%3D
    • Cuconati A, Mukherjee C, Perez D, White E (2003) DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17:2922-2932
    • (2003) Genes Dev , vol.17 , pp. 2922-2932
    • Cuconati, A.1    Mukherjee, C.2    Perez, D.3    White, E.4
  • 9
    • 19944432123 scopus 로고    scopus 로고
    • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    • 15694340 10.1016/j.molcel.2004.12.030 1:CAS:528:DC%2BD2MXhs1Oit78%3D
    • Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17:393-403
    • (2005) Mol Cell , vol.17 , pp. 393-403
    • Chen, L.1    Willis, S.N.2    Wei, A.3    Smith, B.J.4    Fletcher, J.I.5    Hinds, M.G.6    Colman, P.M.7    Day, C.L.8    Adams, J.M.9    Huang, D.C.10
  • 10
    • 0038046166 scopus 로고    scopus 로고
    • Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    • 12783855 10.1101/gad.1093903 1:CAS:528:DC%2BD3sXkvFSisrY%3D
    • Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Wang X (2003) Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17:1475-1486
    • (2003) Genes Dev , vol.17 , pp. 1475-1486
    • Nijhawan, D.1    Fang, M.2    Traer, E.3    Zhong, Q.4    Gao, W.5    Du, F.6    Wang, X.7
  • 12
    • 0032006805 scopus 로고    scopus 로고
    • Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse
    • 9446661 1:CAS:528:DyaK1cXovFahuw%3D%3D
    • Kaufmann SH, Karp JE, Svingen PA, Krajewski S, Burke PJ, Gore SD, Reed JC (1998) Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood 91:991-1000
    • (1998) Blood , vol.91 , pp. 991-1000
    • Kaufmann, S.H.1    Karp, J.E.2    Svingen, P.A.3    Krajewski, S.4    Burke, P.J.5    Gore, S.D.6    Reed, J.C.7
  • 14
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • 15901672 10.1101/gad.1304105 1:CAS:528:DC%2BD2MXlt1ymsr4%3D
    • Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-1305
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5    Fletcher, J.I.6    Adams, J.M.7    Huang, D.C.8
  • 15
    • 33845312687 scopus 로고    scopus 로고
    • MicroRNA responses to cellular stress
    • 17108120 10.1158/0008-5472.CAN-06-1894 1:CAS:528:DC%2BD2sXivVyqsbo%3D
    • Marsit CJ, Eddy K, Kelsey KT (2006) MicroRNA responses to cellular stress. Cancer Res 66:10843-10848
    • (2006) Cancer Res , vol.66 , pp. 10843-10848
    • Marsit, C.J.1    Eddy, K.2    Kelsey, K.T.3
  • 17
    • 77952270043 scopus 로고    scopus 로고
    • MicroRNA expression after ionizing radiation in human endothelial cells
    • 20346162 10.1186/1748-717X-5-25
    • Wagner-Ecker M, Schwager C, Wirkner U, Abdollahi A, Huber PE (2010) MicroRNA expression after ionizing radiation in human endothelial cells. Radiat Oncol 5:25
    • (2010) Radiat Oncol , vol.5 , pp. 25
    • Wagner-Ecker, M.1    Schwager, C.2    Wirkner, U.3    Abdollahi, A.4    Huber, P.E.5
  • 18
    • 79953224859 scopus 로고    scopus 로고
    • MicroRNA expression profiles in human cancer cells after ionizing radiation
    • 21453501 10.1186/1748-717X-6-29 1:CAS:528:DC%2BC3MXltVWlurg%3D
    • Niemoeller OM, Niyazi M, Corradini S, Zehentmayr F, Li M, Lauber K, Belka C (2011) MicroRNA expression profiles in human cancer cells after ionizing radiation. Radiat Oncol 6:29
    • (2011) Radiat Oncol , vol.6 , pp. 29
    • Niemoeller, O.M.1    Niyazi, M.2    Corradini, S.3    Zehentmayr, F.4    Li, M.5    Lauber, K.6    Belka, C.7
  • 19
    • 84860836067 scopus 로고    scopus 로고
    • Contribution of microRNAs to radio- and chemoresistance of brain tumors and their therapeutic potential
    • 22484336 10.1016/j.ejphar.2012.03.031 1:CAS:528:DC%2BC38XlsFGgtrw%3D
    • Chistiakov DA, Chekhonin VP (2012) Contribution of microRNAs to radio- and chemoresistance of brain tumors and their therapeutic potential. Eur J Pharmacol 684:8-18
    • (2012) Eur J Pharmacol , vol.684 , pp. 8-18
    • Chistiakov, D.A.1    Chekhonin, V.P.2
  • 20
    • 58149215802 scopus 로고    scopus 로고
    • MiR-29 miRNAs activate p53 by targeting p85 alpha and CDC42
    • 19079265 10.1038/nsmb.1533 1:CAS:528:DC%2BD1cXhsV2hsrvF
    • Park SY, Lee JH, Ha M, Nam JW, Kim VN (2009) miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 16:23-29
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 23-29
    • Park, S.Y.1    Lee, J.H.2    Ha, M.3    Nam, J.W.4    Kim, V.N.5
  • 21
    • 34548687035 scopus 로고    scopus 로고
    • Mir-29 regulates Mcl-1 protein expression and apoptosis
    • 17404574 10.1038/sj.onc.1210436 1:CAS:528:DC%2BD2sXhtVeisLvJ
    • Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007) mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26:6133-6140
    • (2007) Oncogene , vol.26 , pp. 6133-6140
    • Mott, J.L.1    Kobayashi, S.2    Bronk, S.F.3    Gores, G.J.4
  • 22
    • 0032793203 scopus 로고    scopus 로고
    • Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system
    • 10.1038/sj.cdd.4400544
    • Zhaohui P, David WV (1999) Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system. Cell Death Differ 6:683-688
    • (1999) Cell Death Differ , vol.6 , pp. 683-688
    • Zhaohui, P.1    David, W.V.2
  • 23
    • 84855685435 scopus 로고    scopus 로고
    • Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage
    • 22185779 10.4161/cc.11.1.18408 1:CAS:528:DC%2BC38XitVKlsro%3D
    • Mills JR, Malina A, Pelletier J (2012) Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage. Cell Cycle 11:88-98
    • (2012) Cell Cycle , vol.11 , pp. 88-98
    • Mills, J.R.1    Malina, A.2    Pelletier, J.3
  • 24
    • 80051546884 scopus 로고    scopus 로고
    • Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1
    • 21516346 10.1007/s10495-011-0599-8 1:CAS:528:DC%2BC3MXmtl2htrs%3D
    • Wensveen FM, Alves NL, Derks IA, Reedquist KA, Eldering E (2011) Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. Apoptosis 16:708-721
    • (2011) Apoptosis , vol.16 , pp. 708-721
    • Wensveen, F.M.1    Alves, N.L.2    Derks, I.A.3    Reedquist, K.A.4    Eldering, E.5
  • 25
    • 84863142634 scopus 로고    scopus 로고
    • DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression
    • 22117060 10.1074/jbc.M111.291229 1:CAS:528:DC%2BC38XisVyltLY%3D
    • Ma K, He Y, Zhang H, Fei Q, Niu D, Wang D, Ding X, Xu H, Chen X, Zhu J (2012) DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression. J Biol Chem 287:5639-5649
    • (2012) J Biol Chem , vol.287 , pp. 5639-5649
    • Ma, K.1    He, Y.2    Zhang, H.3    Fei, Q.4    Niu, D.5    Wang, D.6    Ding, X.7    Xu, H.8    Chen, X.9    Zhu, J.10
  • 26
    • 25844497007 scopus 로고    scopus 로고
    • The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals
    • 16027162 10.1074/jbc.M503210200 1:CAS:528:DC%2BD2MXhtVensb%2FI
    • Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH (2005) The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J Biol Chem 280:33637-33644
    • (2005) J Biol Chem , vol.280 , pp. 33637-33644
    • Minagawa, N.1    Kruglov, E.A.2    Dranoff, J.A.3    Robert, M.E.4    Gores, G.J.5    Nathanson, M.H.6
  • 29
    • 78651303018 scopus 로고    scopus 로고
    • Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis
    • 20798690 10.1038/cdd.2010.105 1:CAS:528:DC%2BC3MXjs1Cmsg%3D%3D
    • Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK (2011) Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis. Cell Death Differ 18:328-337
    • (2011) Cell Death Differ , vol.18 , pp. 328-337
    • Allagnat, F.1    Cunha, D.2    Moore, F.3    Vanderwinden, J.M.4    Eizirik, D.L.5    Cardozo, A.K.6
  • 30
    • 40749122965 scopus 로고    scopus 로고
    • Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis
    • 18234961 10.1158/1541-7786.MCR-07-0080 1:CAS:528:DC%2BD1cXhtFyisbc%3D
    • Chetoui N, Sylla K, Gagnon-Houde JV, Alcaide-Loridan C, Charron D, Al-Daccak R, Aoudjit F (2008) Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis. Mol Cancer Res 6:42-52
    • (2008) Mol Cancer Res , vol.6 , pp. 42-52
    • Chetoui, N.1    Sylla, K.2    Gagnon-Houde, J.V.3    Alcaide-Loridan, C.4    Charron, D.5    Al-Daccak, R.6    Aoudjit, F.7
  • 31
    • 77951911859 scopus 로고    scopus 로고
    • PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes
    • 20173022 10.4049/jimmunol.0903025 1:CAS:528:DC%2BC3cXis1yit7g%3D
    • Chan G, Nogalski MT, Bentz GL, Smith MS, Parmater A, Yurochko AD (2010) PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J Immunol 184:3213-3222
    • (2010) J Immunol , vol.184 , pp. 3213-3222
    • Chan, G.1    Nogalski, M.T.2    Bentz, G.L.3    Smith, M.S.4    Parmater, A.5    Yurochko, A.D.6
  • 32
    • 67650076845 scopus 로고    scopus 로고
    • Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis
    • 19433446 10.1128/MCB.00279-09 1:CAS:528:DC%2BD1MXos1Gns78%3D
    • Morel C, Carlson SM, White FM, Davis RJ (2009) Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol 29:3845-3852
    • (2009) Mol Cell Biol , vol.29 , pp. 3845-3852
    • Morel, C.1    Carlson, S.M.2    White, F.M.3    Davis, R.J.4
  • 33
    • 77954659814 scopus 로고    scopus 로고
    • TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1
    • 20168333 10.1038/cdd.2010.9 1:CAS:528:DC%2BC3cXos1Kjsrg%3D
    • Son JK, Varadarajan S, Bratton SB (2010) TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ 17:1288-1301
    • (2010) Cell Death Differ , vol.17 , pp. 1288-1301
    • Son, J.K.1    Varadarajan, S.2    Bratton, S.B.3
  • 34
    • 33646846666 scopus 로고    scopus 로고
    • Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
    • 16380381 10.1074/jbc.M505688200 1:CAS:528:DC%2BD28XhvVejtLY%3D
    • Clohessy JG, Zhuang J, de Boer J, Gil-Gomez G, Brady HJ (2006) Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J Biol Chem 281:5750-5759
    • (2006) J Biol Chem , vol.281 , pp. 5750-5759
    • Clohessy, J.G.1    Zhuang, J.2    De Boer, J.3    Gil-Gomez, G.4    Brady, H.J.5
  • 35
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • 17322918 10.1038/sj.onc.1210220 1:CAS:528:DC%2BD2sXitVKhsL8%3D
    • Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26:1324-1337
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 36
    • 77954175674 scopus 로고    scopus 로고
    • Mcl-1; The molecular regulation of protein function
    • 20540941 10.1016/j.febslet.2010.05.061 1:CAS:528:DC%2BC3cXosVyhu7s%3D
    • Thomas LW, Lam C, Edwards SW (2010) Mcl-1; the molecular regulation of protein function. FEBS Lett 584:2981-2989
    • (2010) FEBS Lett , vol.584 , pp. 2981-2989
    • Thomas, L.W.1    Lam, C.2    Edwards, S.W.3
  • 37
    • 34548036251 scopus 로고    scopus 로고
    • Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells
    • 17510660 10.1038/sj.cdd.4402165 1:CAS:528:DC%2BD2sXptFymtb0%3D
    • Chen ZX, Pervaiz S (2007) Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Differ 14:1617-1627
    • (2007) Cell Death Differ , vol.14 , pp. 1617-1627
    • Chen, Z.X.1    Pervaiz, S.2
  • 38
    • 7444223594 scopus 로고    scopus 로고
    • Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells
    • 15520193 10.1158/0008-5472.CAN-04-0648 1:CAS:528:DC%2BD2cXptFelsrw%3D
    • Ahmad KA, Iskandar KB, Hirpara JL, Clement MV, Pervaiz S (2004) Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res 64:7867-7878
    • (2004) Cancer Res , vol.64 , pp. 7867-7878
    • Ahmad, K.A.1    Iskandar, K.B.2    Hirpara, J.L.3    Clement, M.V.4    Pervaiz, S.5
  • 39
    • 77954922243 scopus 로고    scopus 로고
    • Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells
    • 20367277 10.1089/ars.2009.3050 1:CAS:528:DC%2BC3cXptVeis7Y%3D
    • Low IC, Chen ZX, Pervaiz S (2010) Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells. Antioxid Redox Signal 13:807-819
    • (2010) Antioxid Redox Signal , vol.13 , pp. 807-819
    • Low, I.C.1    Chen, Z.X.2    Pervaiz, S.3
  • 40
    • 70349617479 scopus 로고    scopus 로고
    • ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress
    • 19404643 10.1007/s00280-009-1001-1 1:CAS:528:DC%2BD1MXhtFegurbL
    • Howard AN, Bridges KA, Meyn RE, Chandra J (2009) ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Cancer Chemother Pharmacol 65:41-54
    • (2009) Cancer Chemother Pharmacol , vol.65 , pp. 41-54
    • Howard, A.N.1    Bridges, K.A.2    Meyn, R.E.3    Chandra, J.4
  • 41
    • 12344252927 scopus 로고    scopus 로고
    • The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism
    • 15634644 1:CAS:528:DC%2BD2MXmtV2k
    • Pei XY, Dai Y, Grant S (2004) The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. Mol Cancer Ther 3:1513-1524
    • (2004) Mol Cancer Ther , vol.3 , pp. 1513-1524
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 43
    • 32944479992 scopus 로고    scopus 로고
    • Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
    • 16317687 10.1002/hep.20966 1:CAS:528:DC%2BD2MXhtlGns7rJ
    • Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, Gores GJ (2005) Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 42:1329-1338
    • (2005) Hepatology , vol.42 , pp. 1329-1338
    • Isomoto, H.1    Kobayashi, S.2    Werneburg, N.W.3    Bronk, S.F.4    Guicciardi, M.E.5    Frank, D.A.6    Gores, G.J.7
  • 44
    • 0034525417 scopus 로고    scopus 로고
    • Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: Interleukin-6, interferon-alpha and insulin-like growth factor 1
    • 11175262 10.1038/sj.cdd.4400758 1:CAS:528:DC%2BD3MXmsFOnuw%3D%3D
    • Jourdan M, De Vos J, Mechti N, Klein B (2000) Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1. Cell Death Differ 7:1244-1252
    • (2000) Cell Death Differ , vol.7 , pp. 1244-1252
    • Jourdan, M.1    De Vos, J.2    Mechti, N.3    Klein, B.4
  • 45
    • 0037370472 scopus 로고    scopus 로고
    • Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway
    • 12612065 10.1128/MCB.23.6.1896-1909.2003 1:CAS:528:DC%2BD3sXhvF2isL4%3D
    • Wang JM, Lai MZ, Yang-Yen HF (2003) Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway. Mol Cell Biol 23:1896-1909
    • (2003) Mol Cell Biol , vol.23 , pp. 1896-1909
    • Wang, J.M.1    Lai, M.Z.2    Yang-Yen, H.F.3
  • 46
    • 21244472965 scopus 로고    scopus 로고
    • Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
    • 15989957 10.1016/j.cell.2005.06.009 1:CAS:528:DC%2BD2MXmtF2ntrw%3D
    • Zhong Q, Gao W, Du F, Wang X (2005) Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121:1085-1095
    • (2005) Cell , vol.121 , pp. 1085-1095
    • Zhong, Q.1    Gao, W.2    Du, F.3    Wang, X.4
  • 47
    • 34347350211 scopus 로고    scopus 로고
    • Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
    • 17387146 10.1128/MCB.00620-06 1:CAS:528:DC%2BD2sXlvVGksLg%3D
    • Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC (2007) Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol 27:4006-4017
    • (2007) Mol Cell Biol , vol.27 , pp. 4006-4017
    • Ding, Q.1    He, X.2    Hsu, J.M.3    Xia, W.4    Chen, C.T.5    Li, L.Y.6    Lee, D.F.7    Liu, J.C.8    Zhong, Q.9    Wang, X.10    Hung, M.C.11
  • 50
    • 59149098054 scopus 로고    scopus 로고
    • MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
    • 19155302 10.1158/0008-5472.CAN-08-2886 1:CAS:528:DC%2BD1MXhtFOluro%3D
    • Su H, Yang JR, Xu T, Huang J, Xu L, Yuan Y, Zhuang SM (2009) MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 69:1135-1142
    • (2009) Cancer Res , vol.69 , pp. 1135-1142
    • Su, H.1    Yang, J.R.2    Xu, T.3    Huang, J.4    Xu, L.5    Yuan, Y.6    Zhuang, S.M.7


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