-
1
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
10.1016/S0092-8674(04)00045-5
-
Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 16:281-297
-
(2004)
Cell
, vol.16
, pp. 281-297
-
-
Bartel, D.P.1
-
2
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
-
15652477 10.1016/j.cell.2004.12.035 1:CAS:528:DC%2BD2MXot1ChsA%3D%3D
-
Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20
-
(2005)
Cell
, vol.120
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
3
-
-
33645294070
-
Oncomirs - MicroRNAs with a role in cancer
-
16557279 10.1038/nrc1840 1:CAS:528:DC%2BD28XivVyqtrs%3D
-
Esquela-Kerscher A, Slack FJ (2006) Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6:259-269
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
4
-
-
36148958682
-
MicroRNAs in cell proliferation, cell death, and tumorigenesis
-
17393584
-
Hwang HW, Mendell JT (2007) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96(Suppl):R40-R44
-
(2007)
Br J Cancer
, vol.96
, Issue.SUPPL.
-
-
Hwang, H.W.1
Mendell, J.T.2
-
5
-
-
4143142117
-
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
-
15284443 10.1073/pnas.0404432101 1:CAS:528:DC%2BD2cXntVersro%3D
-
Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, Shimizu M, Cimmino A, Zupo S, Dono M, Dell'Aquila ML, Alder H, Rassenti L, Kipps TJ, Bullrich F, Negrini M, Croce CM (2004) MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A 101:11755-11760
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 11755-11760
-
-
Calin, G.A.1
Liu, C.G.2
Sevignani, C.3
Ferracin, M.4
Felli, N.5
Dumitru, C.D.6
Shimizu, M.7
Cimmino, A.8
Zupo, S.9
Dono, M.10
Dell'Aquila, M.L.11
Alder, H.12
Rassenti, L.13
Kipps, T.J.14
Bullrich, F.15
Negrini, M.16
Croce, C.M.17
-
6
-
-
12144290519
-
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
-
14973191 10.1073/pnas.0307323101 1:CAS:528:DC%2BD2cXitlWhtr8%3D
-
Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, Croce CM (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101:2999-3004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 2999-3004
-
-
Calin, G.A.1
Sevignani, C.2
Dumitru, C.D.3
Hyslop, T.4
Noch, E.5
Yendamuri, S.6
Shimizu, M.7
Rattan, S.8
Bullrich, F.9
Negrini, M.10
Croce, C.M.11
-
7
-
-
20444460289
-
MicroRNA expression profiles classify human cancers
-
15944708 10.1038/nature03702 1:CAS:528:DC%2BD2MXkvVGgsLc%3D
-
Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR (2005) MicroRNA expression profiles classify human cancers. Nature 435:834-838
-
(2005)
Nature
, vol.435
, pp. 834-838
-
-
Lu, J.1
Getz, G.2
Miska, E.A.3
Alvarez-Saavedra, E.4
Lamb, J.5
Peck, D.6
Sweet-Cordero, A.7
Ebert, B.L.8
Mak, R.H.9
Ferrando, A.A.10
Downing, J.R.11
Jacks, T.12
Horvitz, H.R.13
Golub, T.R.14
-
8
-
-
0348014686
-
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
-
14633975 10.1101/gad.1156903 1:CAS:528:DC%2BD3sXpvVGiu78%3D
-
Cuconati A, Mukherjee C, Perez D, White E (2003) DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17:2922-2932
-
(2003)
Genes Dev
, vol.17
, pp. 2922-2932
-
-
Cuconati, A.1
Mukherjee, C.2
Perez, D.3
White, E.4
-
9
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
15694340 10.1016/j.molcel.2004.12.030 1:CAS:528:DC%2BD2MXhs1Oit78%3D
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17:393-403
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.10
-
10
-
-
0038046166
-
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
-
12783855 10.1101/gad.1093903 1:CAS:528:DC%2BD3sXkvFSisrY%3D
-
Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Wang X (2003) Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17:1475-1486
-
(2003)
Genes Dev
, vol.17
, pp. 1475-1486
-
-
Nijhawan, D.1
Fang, M.2
Traer, E.3
Zhong, Q.4
Gao, W.5
Du, F.6
Wang, X.7
-
11
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
17097560 10.1016/j.ccr.2006.10.006 1:CAS:528:DC%2BD28Xht1Glu7nJ
-
Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, Deng X, Zhai D, Shi YX, Sneed T, Verhaegen M, Soengas M, Ruvolo VR, McQueen T, Schober WD, Watt JC, Jiffar T, Ling X, Marini FC, Harris D, Dietrich M, Estrov Z, McCubrey J, May WS, Reed JC, Andreeff M (2006) Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10:375-388
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
Deng, X.7
Zhai, D.8
Shi, Y.X.9
Sneed, T.10
Verhaegen, M.11
Soengas, M.12
Ruvolo, V.R.13
McQueen, T.14
Schober, W.D.15
Watt, J.C.16
Jiffar, T.17
Ling, X.18
Marini, F.C.19
Harris, D.20
Dietrich, M.21
Estrov, Z.22
McCubrey, J.23
May, W.S.24
Reed, J.C.25
Andreeff, M.26
more..
-
12
-
-
0032006805
-
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse
-
9446661 1:CAS:528:DyaK1cXovFahuw%3D%3D
-
Kaufmann SH, Karp JE, Svingen PA, Krajewski S, Burke PJ, Gore SD, Reed JC (1998) Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood 91:991-1000
-
(1998)
Blood
, vol.91
, pp. 991-1000
-
-
Kaufmann, S.H.1
Karp, J.E.2
Svingen, P.A.3
Krajewski, S.4
Burke, P.J.5
Gore, S.D.6
Reed, J.C.7
-
13
-
-
21744457447
-
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival
-
15902294 10.1038/sj.leu.2403784 1:CAS:528:DC%2BD2MXmvVOisrk%3D
-
Wuilleme-Toumi S, Robillard N, Gomez P, Moreau P, Le Gouill S, Avet-Loiseau H, Harousseau JL, Amiot M, Bataille R (2005) Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. Leukemia 19:1248-1252
-
(2005)
Leukemia
, vol.19
, pp. 1248-1252
-
-
Wuilleme-Toumi, S.1
Robillard, N.2
Gomez, P.3
Moreau, P.4
Le Gouill, S.5
Avet-Loiseau, H.6
Harousseau, J.L.7
Amiot, M.8
Bataille, R.9
-
14
-
-
22244464818
-
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
-
15901672 10.1101/gad.1304105 1:CAS:528:DC%2BD2MXlt1ymsr4%3D
-
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-1305
-
(2005)
Genes Dev
, vol.19
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.8
-
15
-
-
33845312687
-
MicroRNA responses to cellular stress
-
17108120 10.1158/0008-5472.CAN-06-1894 1:CAS:528:DC%2BD2sXivVyqsbo%3D
-
Marsit CJ, Eddy K, Kelsey KT (2006) MicroRNA responses to cellular stress. Cancer Res 66:10843-10848
-
(2006)
Cancer Res
, vol.66
, pp. 10843-10848
-
-
Marsit, C.J.1
Eddy, K.2
Kelsey, K.T.3
-
16
-
-
68149161140
-
Ionizing radiation-induced oxidative stress alters miRNA expression
-
19633716 10.1371/journal.pone.0006377
-
Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB (2009) Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS ONE 4:e6377
-
(2009)
PLoS ONE
, vol.4
, pp. 6377
-
-
Simone, N.L.1
Soule, B.P.2
Ly, D.3
Saleh, A.D.4
Savage, J.E.5
Degraff, W.6
Cook, J.7
Harris, C.C.8
Gius, D.9
Mitchell, J.B.10
-
17
-
-
77952270043
-
MicroRNA expression after ionizing radiation in human endothelial cells
-
20346162 10.1186/1748-717X-5-25
-
Wagner-Ecker M, Schwager C, Wirkner U, Abdollahi A, Huber PE (2010) MicroRNA expression after ionizing radiation in human endothelial cells. Radiat Oncol 5:25
-
(2010)
Radiat Oncol
, vol.5
, pp. 25
-
-
Wagner-Ecker, M.1
Schwager, C.2
Wirkner, U.3
Abdollahi, A.4
Huber, P.E.5
-
18
-
-
79953224859
-
MicroRNA expression profiles in human cancer cells after ionizing radiation
-
21453501 10.1186/1748-717X-6-29 1:CAS:528:DC%2BC3MXltVWlurg%3D
-
Niemoeller OM, Niyazi M, Corradini S, Zehentmayr F, Li M, Lauber K, Belka C (2011) MicroRNA expression profiles in human cancer cells after ionizing radiation. Radiat Oncol 6:29
-
(2011)
Radiat Oncol
, vol.6
, pp. 29
-
-
Niemoeller, O.M.1
Niyazi, M.2
Corradini, S.3
Zehentmayr, F.4
Li, M.5
Lauber, K.6
Belka, C.7
-
19
-
-
84860836067
-
Contribution of microRNAs to radio- and chemoresistance of brain tumors and their therapeutic potential
-
22484336 10.1016/j.ejphar.2012.03.031 1:CAS:528:DC%2BC38XlsFGgtrw%3D
-
Chistiakov DA, Chekhonin VP (2012) Contribution of microRNAs to radio- and chemoresistance of brain tumors and their therapeutic potential. Eur J Pharmacol 684:8-18
-
(2012)
Eur J Pharmacol
, vol.684
, pp. 8-18
-
-
Chistiakov, D.A.1
Chekhonin, V.P.2
-
20
-
-
58149215802
-
MiR-29 miRNAs activate p53 by targeting p85 alpha and CDC42
-
19079265 10.1038/nsmb.1533 1:CAS:528:DC%2BD1cXhsV2hsrvF
-
Park SY, Lee JH, Ha M, Nam JW, Kim VN (2009) miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 16:23-29
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 23-29
-
-
Park, S.Y.1
Lee, J.H.2
Ha, M.3
Nam, J.W.4
Kim, V.N.5
-
21
-
-
34548687035
-
Mir-29 regulates Mcl-1 protein expression and apoptosis
-
17404574 10.1038/sj.onc.1210436 1:CAS:528:DC%2BD2sXhtVeisLvJ
-
Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007) mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26:6133-6140
-
(2007)
Oncogene
, vol.26
, pp. 6133-6140
-
-
Mott, J.L.1
Kobayashi, S.2
Bronk, S.F.3
Gores, G.J.4
-
22
-
-
0032793203
-
Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system
-
10.1038/sj.cdd.4400544
-
Zhaohui P, David WV (1999) Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system. Cell Death Differ 6:683-688
-
(1999)
Cell Death Differ
, vol.6
, pp. 683-688
-
-
Zhaohui, P.1
David, W.V.2
-
23
-
-
84855685435
-
Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage
-
22185779 10.4161/cc.11.1.18408 1:CAS:528:DC%2BC38XitVKlsro%3D
-
Mills JR, Malina A, Pelletier J (2012) Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage. Cell Cycle 11:88-98
-
(2012)
Cell Cycle
, vol.11
, pp. 88-98
-
-
Mills, J.R.1
Malina, A.2
Pelletier, J.3
-
24
-
-
80051546884
-
Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1
-
21516346 10.1007/s10495-011-0599-8 1:CAS:528:DC%2BC3MXmtl2htrs%3D
-
Wensveen FM, Alves NL, Derks IA, Reedquist KA, Eldering E (2011) Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. Apoptosis 16:708-721
-
(2011)
Apoptosis
, vol.16
, pp. 708-721
-
-
Wensveen, F.M.1
Alves, N.L.2
Derks, I.A.3
Reedquist, K.A.4
Eldering, E.5
-
25
-
-
84863142634
-
DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression
-
22117060 10.1074/jbc.M111.291229 1:CAS:528:DC%2BC38XisVyltLY%3D
-
Ma K, He Y, Zhang H, Fei Q, Niu D, Wang D, Ding X, Xu H, Chen X, Zhu J (2012) DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression. J Biol Chem 287:5639-5649
-
(2012)
J Biol Chem
, vol.287
, pp. 5639-5649
-
-
Ma, K.1
He, Y.2
Zhang, H.3
Fei, Q.4
Niu, D.5
Wang, D.6
Ding, X.7
Xu, H.8
Chen, X.9
Zhu, J.10
-
26
-
-
25844497007
-
The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals
-
16027162 10.1074/jbc.M503210200 1:CAS:528:DC%2BD2MXhtVensb%2FI
-
Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH (2005) The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J Biol Chem 280:33637-33644
-
(2005)
J Biol Chem
, vol.280
, pp. 33637-33644
-
-
Minagawa, N.1
Kruglov, E.A.2
Dranoff, J.A.3
Robert, M.E.4
Gores, G.J.5
Nathanson, M.H.6
-
27
-
-
79960148142
-
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site
-
21613222 10.1074/jbc.M111.218321 1:CAS:528:DC%2BC3MXosFGmt7o%3D
-
Warr MR, Mills JR, Nguyen M, Lemaire-Ewing S, Baardsnes J, Sun KL, Malina A, Young JC, Jeyaraju DV, O'Connor-McCourt M, Pellegrini L, Pelletier J, Shore GC (2011) Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. J Biol Chem 286:25098-25107
-
(2011)
J Biol Chem
, vol.286
, pp. 25098-25107
-
-
Warr, M.R.1
Mills, J.R.2
Nguyen, M.3
Lemaire-Ewing, S.4
Baardsnes, J.5
Sun, K.L.6
Malina, A.7
Young, J.C.8
Jeyaraju, D.V.9
O'Connor-Mccourt, M.10
Pellegrini, L.11
Pelletier, J.12
Shore, G.C.13
-
28
-
-
34250877841
-
A mammalian microRNA expression atlas based on small RNA library sequencing
-
17604727 10.1016/j.cell.2007.04.040 1:CAS:528:DC%2BD2sXotV2hsLk%3D
-
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129:1401-1414
-
(2007)
Cell
, vol.129
, pp. 1401-1414
-
-
Landgraf, P.1
Rusu, M.2
Sheridan, R.3
Sewer, A.4
Iovino, N.5
Aravin, A.6
Pfeffer, S.7
Rice, A.8
Kamphorst, A.O.9
Landthaler, M.10
Lin, C.11
Socci, N.D.12
Hermida, L.13
Fulci, V.14
Chiaretti, S.15
Foa, R.16
Schliwka, J.17
Fuchs, U.18
Novosel, A.19
Muller, R.U.20
Schermer, B.21
Bissels, U.22
Inman, J.23
Phan, Q.24
Chien, M.25
Weir, D.B.26
Choksi, R.27
De Vita, G.28
Frezzetti, D.29
Trompeter, H.I.30
Hornung, V.31
Teng, G.32
Hartmann, G.33
Palkovits, M.34
Di Lauro, R.35
Wernet, P.36
Macino, G.37
Rogler, C.E.38
Nagle, J.W.39
Ju, J.40
Papavasiliou, F.N.41
Benzing, T.42
Lichter, P.43
Tam, W.44
Brownstein, M.J.45
Bosio, A.46
Borkhardt, A.47
Russo, J.J.48
Sander, C.49
Zavolan, M.50
Tuschl, T.51
more..
-
29
-
-
78651303018
-
Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis
-
20798690 10.1038/cdd.2010.105 1:CAS:528:DC%2BC3MXjs1Cmsg%3D%3D
-
Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK (2011) Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis. Cell Death Differ 18:328-337
-
(2011)
Cell Death Differ
, vol.18
, pp. 328-337
-
-
Allagnat, F.1
Cunha, D.2
Moore, F.3
Vanderwinden, J.M.4
Eizirik, D.L.5
Cardozo, A.K.6
-
30
-
-
40749122965
-
Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis
-
18234961 10.1158/1541-7786.MCR-07-0080 1:CAS:528:DC%2BD1cXhtFyisbc%3D
-
Chetoui N, Sylla K, Gagnon-Houde JV, Alcaide-Loridan C, Charron D, Al-Daccak R, Aoudjit F (2008) Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis. Mol Cancer Res 6:42-52
-
(2008)
Mol Cancer Res
, vol.6
, pp. 42-52
-
-
Chetoui, N.1
Sylla, K.2
Gagnon-Houde, J.V.3
Alcaide-Loridan, C.4
Charron, D.5
Al-Daccak, R.6
Aoudjit, F.7
-
31
-
-
77951911859
-
PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes
-
20173022 10.4049/jimmunol.0903025 1:CAS:528:DC%2BC3cXis1yit7g%3D
-
Chan G, Nogalski MT, Bentz GL, Smith MS, Parmater A, Yurochko AD (2010) PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J Immunol 184:3213-3222
-
(2010)
J Immunol
, vol.184
, pp. 3213-3222
-
-
Chan, G.1
Nogalski, M.T.2
Bentz, G.L.3
Smith, M.S.4
Parmater, A.5
Yurochko, A.D.6
-
32
-
-
67650076845
-
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis
-
19433446 10.1128/MCB.00279-09 1:CAS:528:DC%2BD1MXos1Gns78%3D
-
Morel C, Carlson SM, White FM, Davis RJ (2009) Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol 29:3845-3852
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3845-3852
-
-
Morel, C.1
Carlson, S.M.2
White, F.M.3
Davis, R.J.4
-
33
-
-
77954659814
-
TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1
-
20168333 10.1038/cdd.2010.9 1:CAS:528:DC%2BC3cXos1Kjsrg%3D
-
Son JK, Varadarajan S, Bratton SB (2010) TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ 17:1288-1301
-
(2010)
Cell Death Differ
, vol.17
, pp. 1288-1301
-
-
Son, J.K.1
Varadarajan, S.2
Bratton, S.B.3
-
34
-
-
33646846666
-
Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
-
16380381 10.1074/jbc.M505688200 1:CAS:528:DC%2BD28XhvVejtLY%3D
-
Clohessy JG, Zhuang J, de Boer J, Gil-Gomez G, Brady HJ (2006) Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J Biol Chem 281:5750-5759
-
(2006)
J Biol Chem
, vol.281
, pp. 5750-5759
-
-
Clohessy, J.G.1
Zhuang, J.2
De Boer, J.3
Gil-Gomez, G.4
Brady, H.J.5
-
35
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
17322918 10.1038/sj.onc.1210220 1:CAS:528:DC%2BD2sXitVKhsL8%3D
-
Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26:1324-1337
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
36
-
-
77954175674
-
Mcl-1; The molecular regulation of protein function
-
20540941 10.1016/j.febslet.2010.05.061 1:CAS:528:DC%2BC3cXosVyhu7s%3D
-
Thomas LW, Lam C, Edwards SW (2010) Mcl-1; the molecular regulation of protein function. FEBS Lett 584:2981-2989
-
(2010)
FEBS Lett
, vol.584
, pp. 2981-2989
-
-
Thomas, L.W.1
Lam, C.2
Edwards, S.W.3
-
37
-
-
34548036251
-
Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells
-
17510660 10.1038/sj.cdd.4402165 1:CAS:528:DC%2BD2sXptFymtb0%3D
-
Chen ZX, Pervaiz S (2007) Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Differ 14:1617-1627
-
(2007)
Cell Death Differ
, vol.14
, pp. 1617-1627
-
-
Chen, Z.X.1
Pervaiz, S.2
-
38
-
-
7444223594
-
Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells
-
15520193 10.1158/0008-5472.CAN-04-0648 1:CAS:528:DC%2BD2cXptFelsrw%3D
-
Ahmad KA, Iskandar KB, Hirpara JL, Clement MV, Pervaiz S (2004) Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res 64:7867-7878
-
(2004)
Cancer Res
, vol.64
, pp. 7867-7878
-
-
Ahmad, K.A.1
Iskandar, K.B.2
Hirpara, J.L.3
Clement, M.V.4
Pervaiz, S.5
-
39
-
-
77954922243
-
Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells
-
20367277 10.1089/ars.2009.3050 1:CAS:528:DC%2BC3cXptVeis7Y%3D
-
Low IC, Chen ZX, Pervaiz S (2010) Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells. Antioxid Redox Signal 13:807-819
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 807-819
-
-
Low, I.C.1
Chen, Z.X.2
Pervaiz, S.3
-
40
-
-
70349617479
-
ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress
-
19404643 10.1007/s00280-009-1001-1 1:CAS:528:DC%2BD1MXhtFegurbL
-
Howard AN, Bridges KA, Meyn RE, Chandra J (2009) ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Cancer Chemother Pharmacol 65:41-54
-
(2009)
Cancer Chemother Pharmacol
, vol.65
, pp. 41-54
-
-
Howard, A.N.1
Bridges, K.A.2
Meyn, R.E.3
Chandra, J.4
-
41
-
-
12344252927
-
The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism
-
15634644 1:CAS:528:DC%2BD2MXmtV2k
-
Pei XY, Dai Y, Grant S (2004) The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. Mol Cancer Ther 3:1513-1524
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1513-1524
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
42
-
-
33845797913
-
A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species
-
17145881 10.1158/0008-5472.CAN-06-1748 1:CAS:528:DC%2BD28Xht1KnsLzE
-
Verhaegen M, Bauer JA, Martin de la Vega C, Wang G, Wolter KG, Brenner JC, Nikolovska-Coleska Z, Bengtson A, Nair R, Elder JT, Van Brocklin M, Carey TE, Bradford CR, Wang S, Soengas MS (2006) A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res 66:11348-11359
-
(2006)
Cancer Res
, vol.66
, pp. 11348-11359
-
-
Verhaegen, M.1
Bauer, J.A.2
Martin De La Vega, C.3
Wang, G.4
Wolter, K.G.5
Brenner, J.C.6
Nikolovska-Coleska, Z.7
Bengtson, A.8
Nair, R.9
Elder, J.T.10
Van Brocklin, M.11
Carey, T.E.12
Bradford, C.R.13
Wang, S.14
Soengas, M.S.15
-
43
-
-
32944479992
-
Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
-
16317687 10.1002/hep.20966 1:CAS:528:DC%2BD2MXhtlGns7rJ
-
Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, Gores GJ (2005) Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 42:1329-1338
-
(2005)
Hepatology
, vol.42
, pp. 1329-1338
-
-
Isomoto, H.1
Kobayashi, S.2
Werneburg, N.W.3
Bronk, S.F.4
Guicciardi, M.E.5
Frank, D.A.6
Gores, G.J.7
-
44
-
-
0034525417
-
Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: Interleukin-6, interferon-alpha and insulin-like growth factor 1
-
11175262 10.1038/sj.cdd.4400758 1:CAS:528:DC%2BD3MXmsFOnuw%3D%3D
-
Jourdan M, De Vos J, Mechti N, Klein B (2000) Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1. Cell Death Differ 7:1244-1252
-
(2000)
Cell Death Differ
, vol.7
, pp. 1244-1252
-
-
Jourdan, M.1
De Vos, J.2
Mechti, N.3
Klein, B.4
-
45
-
-
0037370472
-
Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway
-
12612065 10.1128/MCB.23.6.1896-1909.2003 1:CAS:528:DC%2BD3sXhvF2isL4%3D
-
Wang JM, Lai MZ, Yang-Yen HF (2003) Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway. Mol Cell Biol 23:1896-1909
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1896-1909
-
-
Wang, J.M.1
Lai, M.Z.2
Yang-Yen, H.F.3
-
46
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
-
15989957 10.1016/j.cell.2005.06.009 1:CAS:528:DC%2BD2MXmtF2ntrw%3D
-
Zhong Q, Gao W, Du F, Wang X (2005) Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121:1085-1095
-
(2005)
Cell
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
Gao, W.2
Du, F.3
Wang, X.4
-
47
-
-
34347350211
-
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
17387146 10.1128/MCB.00620-06 1:CAS:528:DC%2BD2sXlvVGksLg%3D
-
Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC (2007) Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol 27:4006-4017
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
He, X.2
Hsu, J.M.3
Xia, W.4
Chen, C.T.5
Li, L.Y.6
Lee, D.F.7
Liu, J.C.8
Zhong, Q.9
Wang, X.10
Hung, M.C.11
-
48
-
-
79952261405
-
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
21368833 10.1038/nature09732 1:CAS:528:DC%2BC3MXis1Crt78%3D
-
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W (2011) SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471:104-109
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
Shaik, S.2
Onoyama, I.3
Gao, D.4
Tseng, A.5
Maser, R.S.6
Zhai, B.7
Wan, L.8
Gutierrez, A.9
Lau, A.W.10
Xiao, Y.11
Christie, A.L.12
Aster, J.13
Settleman, J.14
Gygi, S.P.15
Kung, A.L.16
Look, T.17
Nakayama, K.I.18
Depinho, R.A.19
Wei, W.20
more..
-
49
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
21368834 10.1038/nature09779 1:CAS:528:DC%2BC3MXis1Cku7g%3D
-
Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM (2011) Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471:110-114
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
Kusam, S.2
Lam, C.3
Okamoto, T.4
Sandoval, W.5
Anderson, D.J.6
Helgason, E.7
Ernst, J.A.8
Eby, M.9
Liu, J.10
Belmont, L.D.11
Kaminker, J.S.12
O'Rourke, K.M.13
Pujara, K.14
Kohli, P.B.15
Johnson, A.R.16
Chiu, M.L.17
Lill, J.R.18
Jackson, P.K.19
Fairbrother, W.J.20
Seshagiri, S.21
Ludlam, M.J.22
Leong, K.G.23
Dueber, E.C.24
Maecker, H.25
Huang, D.C.26
Dixit, V.M.27
more..
-
50
-
-
59149098054
-
MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
-
19155302 10.1158/0008-5472.CAN-08-2886 1:CAS:528:DC%2BD1MXhtFOluro%3D
-
Su H, Yang JR, Xu T, Huang J, Xu L, Yuan Y, Zhuang SM (2009) MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 69:1135-1142
-
(2009)
Cancer Res
, vol.69
, pp. 1135-1142
-
-
Su, H.1
Yang, J.R.2
Xu, T.3
Huang, J.4
Xu, L.5
Yuan, Y.6
Zhuang, S.M.7
-
51
-
-
84859811931
-
Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer
-
22333974 10.1038/msb.2011.100
-
Uhlmann S, Mannsperger H, Zhang JD, Horvat EA, Schmidt C, Kublbeck M, Henjes F, Ward A, Tschulena U, Zweig K, Korf U, Wiemann S, Sahin O (2012) Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol 8:570
-
(2012)
Mol Syst Biol
, vol.8
, pp. 570
-
-
Uhlmann, S.1
Mannsperger, H.2
Zhang, J.D.3
Horvat, E.A.4
Schmidt, C.5
Kublbeck, M.6
Henjes, F.7
Ward, A.8
Tschulena, U.9
Zweig, K.10
Korf, U.11
Wiemann, S.12
Sahin, O.13
|