-
1
-
-
33646404606
-
Age and acute myeloid leukemia
-
F.R. Appelbaum, H. Gundacker, D.R. Head, M.L. Slovak, C.L. Willman, J.E. Godwin, J.E. Anderson, and S.H. Petersdorf Age and acute myeloid leukemia Blood 107 2006 3481 3485
-
(2006)
Blood
, vol.107
, pp. 3481-3485
-
-
Appelbaum, F.R.1
Gundacker, H.2
Head, D.R.3
Slovak, M.L.4
Willman, C.L.5
Godwin, J.E.6
Anderson, J.E.7
Petersdorf, S.H.8
-
2
-
-
64849113485
-
Control of mitochondrial apoptosis by the Bcl-2 family
-
J.K. Brunelle, and A. Letai Control of mitochondrial apoptosis by the Bcl-2 family J. Cell Sci. 122 2009 437 441
-
(2009)
J. Cell Sci.
, vol.122
, pp. 437-441
-
-
Brunelle, J.K.1
Letai, A.2
-
3
-
-
75549084068
-
MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts
-
J.K. Brunelle, J. Ryan, D. Yecies, J.T. Opferman, and A. Letai MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts J. Cell Biol. 187 2009 429 442
-
(2009)
J. Cell Biol.
, vol.187
, pp. 429-442
-
-
Brunelle, J.K.1
Ryan, J.2
Yecies, D.3
Opferman, J.T.4
Letai, A.5
-
4
-
-
33646354381
-
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
M. Certo, V. Del Gaizo Moore, M. Nishino, G. Wei, S. Korsmeyer, S.A. Armstrong, and A. Letai Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members Cancer Cell 9 2006 351 365
-
(2006)
Cancer Cell
, vol.9
, pp. 351-365
-
-
Certo, M.1
Del Gaizo Moore, V.2
Nishino, M.3
Wei, G.4
Korsmeyer, S.5
Armstrong, S.A.6
Letai, A.7
-
5
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
L. Chen, S.N. Willis, A. Wei, B.J. Smith, J.I. Fletcher, M.G. Hinds, P.M. Colman, C.L. Day, J.M. Adams, and D.C. Huang Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function Mol. Cell 17 2005 393 403
-
(2005)
Mol. Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.10
-
6
-
-
0034786019
-
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
-
E.H. Cheng, M.C. Wei, S. Weiler, R.A. Flavell, T.W. Mak, T. Lindsten, and S.J. Korsmeyer BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis Mol. Cell 8 2001 705 711
-
(2001)
Mol. Cell
, vol.8
, pp. 705-711
-
-
Cheng, E.H.1
Wei, M.C.2
Weiler, S.3
Flavell, R.A.4
Mak, T.W.5
Lindsten, T.6
Korsmeyer, S.J.7
-
7
-
-
0027374638
-
A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′- tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
-
A. Cossarizza, M. Baccarani-Contri, G. Kalashnikova, and C. Franceschi A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′- tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1) Biochem. Biophys. Res. Commun. 197 1993 40 45
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.197
, pp. 40-45
-
-
Cossarizza, A.1
Baccarani-Contri, M.2
Kalashnikova, G.3
Franceschi, C.4
-
8
-
-
0842281645
-
Cell death: Critical control points
-
N.N. Danial, and S.J. Korsmeyer Cell death: critical control points Cell 116 2004 205 219
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
9
-
-
34547603628
-
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
-
J. Deng, N. Carlson, K. Takeyama, P. Dal Cin, M. Shipp, and A. Letai BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents Cancer Cell 12 2007 171 185
-
(2007)
Cancer Cell
, vol.12
, pp. 171-185
-
-
Deng, J.1
Carlson, N.2
Takeyama, K.3
Dal Cin, P.4
Shipp, M.5
Letai, A.6
-
10
-
-
77449159028
-
Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
-
European LeukemiaNet
-
H. Döhner, E.H. Estey, S. Amadori, F.R. Appelbaum, T. Büchner, A.K. Burnett, H. Dombret, P. Fenaux, D. Grimwade, R.A. Larson European LeukemiaNet Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet Blood 115 2010 453 474
-
(2010)
Blood
, vol.115
, pp. 453-474
-
-
Döhner, H.1
Estey, E.H.2
Amadori, S.3
Appelbaum, F.R.4
Büchner, T.5
Burnett, A.K.6
Dombret, H.7
Fenaux, P.8
Grimwade, D.9
Larson, R.A.10
-
11
-
-
70349467775
-
Anthracycline dose intensification in acute myeloid leukemia
-
H.F. Fernandez, Z. Sun, X. Yao, M.R. Litzow, S.M. Luger, E.M. Paietta, J. Racevskis, G.W. Dewald, R.P. Ketterling, and J.M. Bennett Anthracycline dose intensification in acute myeloid leukemia N. Engl. J. Med. 361 2009 1249 1259
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1249-1259
-
-
Fernandez, H.F.1
Sun, Z.2
Yao, X.3
Litzow, M.R.4
Luger, S.M.5
Paietta, E.M.6
Racevskis, J.7
Dewald, G.W.8
Ketterling, R.P.9
Bennett, J.M.10
-
12
-
-
54549114986
-
BAX activation is initiated at a novel interaction site
-
E. Gavathiotis, M. Suzuki, M.L. Davis, K. Pitter, G.H. Bird, S.G. Katz, H.C. Tu, H. Kim, E.H. Cheng, N. Tjandra, and L.D. Walensky BAX activation is initiated at a novel interaction site Nature 455 2008 1076 1081
-
(2008)
Nature
, vol.455
, pp. 1076-1081
-
-
Gavathiotis, E.1
Suzuki, M.2
Davis, M.L.3
Pitter, K.4
Bird, G.H.5
Katz, S.G.6
Tu, H.C.7
Kim, H.8
Cheng, E.H.9
Tjandra, N.10
Walensky, L.D.11
-
13
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
R.M. Kluck, E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science 275 1997 1132 1136
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
14
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
M. Konopleva, R. Contractor, T. Tsao, I. Samudio, P.P. Ruvolo, S. Kitada, X. Deng, D. Zhai, Y.X. Shi, and T. Sneed Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia Cancer Cell 10 2006 375 388
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
Deng, X.7
Zhai, D.8
Shi, Y.X.9
Sneed, T.10
-
15
-
-
13944277343
-
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
-
T. Kuwana, L. Bouchier-Hayes, J.E. Chipuk, C. Bonzon, B.A. Sullivan, D.R. Green, and D.D. Newmeyer BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly Mol. Cell 17 2005 525 535
-
(2005)
Mol. Cell
, vol.17
, pp. 525-535
-
-
Kuwana, T.1
Bouchier-Hayes, L.2
Chipuk, J.E.3
Bonzon, C.4
Sullivan, B.A.5
Green, D.R.6
Newmeyer, D.D.7
-
16
-
-
0030715023
-
Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia
-
F. Lacombe, F. Durrieu, A. Briais, P. Dumain, F. Belloc, E. Bascans, J. Reiffers, M.R. Boisseau, and P. Bernard Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia Leukemia 11 1997 1878 1886
-
(1997)
Leukemia
, vol.11
, pp. 1878-1886
-
-
Lacombe, F.1
Durrieu, F.2
Briais, A.3
Dumain, P.4
Belloc, F.5
Bascans, E.6
Reiffers, J.7
Boisseau, M.R.8
Bernard, P.9
-
17
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
T. Lapidot, C. Sirard, J. Vormoor, B. Murdoch, T. Hoang, J. Caceres-Cortes, M. Minden, B. Paterson, M.A. Caligiuri, and J.E. Dick A cell initiating human acute myeloid leukaemia after transplantation into SCID mice Nature 367 1994 645 648
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
Minden, M.7
Paterson, B.8
Caligiuri, M.A.9
Dick, J.E.10
-
18
-
-
38549145044
-
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
-
A.G. Letai Diagnosing and exploiting cancer's addiction to blocks in apoptosis Nat. Rev. Cancer 8 2008 121 132
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 121-132
-
-
Letai, A.G.1
-
19
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
A. Letai, M.C. Bassik, L.D. Walensky, M.D. Sorcinelli, S. Weiler, and S.J. Korsmeyer Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics Cancer Cell 2 2002 183 192
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
20
-
-
36749098400
-
Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
-
R. Majeti, C.Y. Park, and I.L. Weissman Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood Cell Stem Cell 1 2007 635 645
-
(2007)
Cell Stem Cell
, vol.1
, pp. 635-645
-
-
Majeti, R.1
Park, C.Y.2
Weissman, I.L.3
-
22
-
-
82255192310
-
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
-
T. Ni Chonghaile, K.A. Sarosiek, T.T. Vo, J.A. Ryan, A. Tammareddi, Vdel.G. Moore, J. Deng, K.C. Anderson, P. Richardson, and Y.T. Tai Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy Science 334 2011 1129 1133
-
(2011)
Science
, vol.334
, pp. 1129-1133
-
-
Ni Chonghaile, T.1
Sarosiek, K.A.2
Vo, T.T.3
Ryan, J.A.4
Tammareddi, A.5
Moore, Vdel.G.6
Deng, J.7
Anderson, K.C.8
Richardson, P.9
Tai, Y.T.10
-
23
-
-
64649090292
-
Targeting DNA topoisomerase II in cancer chemotherapy
-
J.L. Nitiss Targeting DNA topoisomerase II in cancer chemotherapy Nat. Rev. Cancer 9 2009 338 350
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 338-350
-
-
Nitiss, J.L.1
-
24
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
T. Oltersdorf, S.W. Elmore, A.R. Shoemaker, R.C. Armstrong, D.J. Augeri, B.A. Belli, M. Bruncko, T.L. Deckwerth, J. Dinges, and P.J. Hajduk An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 2005 677 681
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
-
25
-
-
0348148880
-
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
-
J.T. Opferman, A. Letai, C. Beard, M.D. Sorcinelli, C.C. Ong, and S.J. Korsmeyer Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 Nature 426 2003 671 676
-
(2003)
Nature
, vol.426
, pp. 671-676
-
-
Opferman, J.T.1
Letai, A.2
Beard, C.3
Sorcinelli, M.D.4
Ong, C.C.5
Korsmeyer, S.J.6
-
26
-
-
13844319184
-
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells
-
J.T. Opferman, H. Iwasaki, C.C. Ong, H. Suh, S. Mizuno, K. Akashi, and S.J. Korsmeyer Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells Science 307 2005 1101 1104
-
(2005)
Science
, vol.307
, pp. 1101-1104
-
-
Opferman, J.T.1
Iwasaki, H.2
Ong, C.C.3
Suh, H.4
Mizuno, S.5
Akashi, K.6
Korsmeyer, S.J.7
-
27
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase i study of navitoclax in patients with relapsed or refractory disease
-
A.W. Roberts, J.F. Seymour, J.R. Brown, W.G. Wierda, T.J. Kipps, S.L. Khaw, D.A. Carney, S.Z. He, D.C. Huang, and H. Xiong Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease J. Clin. Oncol. 30 2012 488 496
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
Wierda, W.G.4
Kipps, T.J.5
Khaw, S.L.6
Carney, D.A.7
He, S.Z.8
Huang, D.C.9
Xiong, H.10
-
28
-
-
77955616572
-
Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes
-
J.A. Ryan, J.K. Brunelle, and A. Letai Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes Proc. Natl. Acad. Sci. USA 107 2010 12895 12900
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 12895-12900
-
-
Ryan, J.A.1
Brunelle, J.K.2
Letai, A.3
-
29
-
-
42949142189
-
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
-
German-Austrian Acute Myeloid Leukemia Study Group
-
R.F. Schlenk, K. Döhner, J. Krauter, S. Fröhling, A. Corbacioglu, L. Bullinger, M. Habdank, D. Späth, M. Morgan, A. Benner German-Austrian Acute Myeloid Leukemia Study Group Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia N. Engl. J. Med. 358 2008 1909 1918
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 1909-1918
-
-
Schlenk, R.F.1
Döhner, K.2
Krauter, J.3
Fröhling, S.4
Corbacioglu, A.5
Bullinger, L.6
Habdank, M.7
Späth, D.8
Morgan, M.9
Benner, A.10
-
30
-
-
0036716004
-
Older adults with acute myeloid leukemia
-
M.A. Sekeres, and R. Stone Older adults with acute myeloid leukemia Curr. Oncol. Rep. 4 2002 403 409
-
(2002)
Curr. Oncol. Rep.
, vol.4
, pp. 403-409
-
-
Sekeres, M.A.1
Stone, R.2
-
31
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
C. Tse, A.R. Shoemaker, J. Adickes, M.G. Anderson, J. Chen, S. Jin, E.F. Johnson, K.C. Marsh, M.J. Mitten, and P. Nimmer ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor Cancer Res. 68 2008 3421 3428
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
Johnson, E.F.7
Marsh, K.C.8
Mitten, M.J.9
Nimmer, P.10
-
32
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
M.F. van Delft, A.H. Wei, K.D. Mason, C.J. Vandenberg, L. Chen, P.E. Czabotar, S.N. Willis, C.L. Scott, C.L. Day, and S. Cory The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized Cancer Cell 10 2006 389 399
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
Van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
Chen, L.5
Czabotar, P.E.6
Willis, S.N.7
Scott, C.L.8
Day, C.L.9
Cory, S.10
-
33
-
-
0034663829
-
TBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
-
M.C. Wei, T. Lindsten, V.K. Mootha, S. Weiler, A. Gross, M. Ashiya, C.B. Thompson, and S.J. Korsmeyer tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c Genes Dev. 14 2000 2060 2071
-
(2000)
Genes Dev.
, vol.14
, pp. 2060-2071
-
-
Wei, M.C.1
Lindsten, T.2
Mootha, V.K.3
Weiler, S.4
Gross, A.5
Ashiya, M.6
Thompson, C.B.7
Korsmeyer, S.J.8
-
34
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
M.C. Wei, W.X. Zong, E.H. Cheng, T. Lindsten, V. Panoutsakopoulou, A.J. Ross, K.A. Roth, G.R. MacGregor, C.B. Thompson, and S.J. Korsmeyer Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death Science 292 2001 727 730
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
MacGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
35
-
-
22244464818
-
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
-
S.N. Willis, L. Chen, G. Dewson, A. Wei, E. Naik, J.I. Fletcher, J.M. Adams, and D.C. Huang Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins Genes Dev. 19 2005 1294 1305
-
(2005)
Genes Dev.
, vol.19
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.8
-
36
-
-
78649630259
-
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
-
W.H. Wilson, O.A. O'Connor, M.S. Czuczman, A.S. LaCasce, J.F. Gerecitano, J.P. Leonard, A. Tulpule, K. Dunleavy, H. Xiong, and Y.L. Chiu Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity Lancet Oncol. 11 2010 1149 1159
-
(2010)
Lancet Oncol.
, vol.11
, pp. 1149-1159
-
-
Wilson, W.H.1
O'Connor, O.A.2
Czuczman, M.S.3
Lacasce, A.S.4
Gerecitano, J.F.5
Leonard, J.P.6
Tulpule, A.7
Dunleavy, K.8
Xiong, H.9
Chiu, Y.L.10
-
37
-
-
0033596980
-
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
H. Zou, Y. Li, X. Liu, and X. Wang An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 J. Biol. Chem. 274 1999 11549 11556
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
|