Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

Cell Death and Differentiation

Volumn 19, Issue 4, 2012, Pages 633-641

  Sandow, J J ^a,b,c,d,e   Jabbour, A M ^c,d,e   Condina, M R ^b   Daunt, C P ^c,d   Stomski, F C ^a   Green, B D ^c,d,e   Riffkin, C D ^c,d   Hoffmann, P ^b   Guthridge, M A ^a   Silke, J ^d,e,f   Lopez, A F ^a,b   Ekert, P G ^c,d,e  

^a Division of Human Immunology   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f LA TROBE UNIVERSITY   (Australia)

Author keywords

degradation; IKK; interleukin 3; phosphorylation; post translational; PUMA

Indexed keywords

CYTOKINE RECEPTOR; I KAPPA B; I KAPPA B KINASE; INTERLEUKIN 3; PROTEASOME; PROTEIN BCL 2; PUMA PROTEIN; SERINE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL MATURATION; CELL SURVIVAL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL DEATH; CELL LINE; HEMATOPOIETIC STEM CELLS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-3; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; RECEPTORS, INTERLEUKIN-3; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84858156535     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.131     Document Type: Article

References (31)

1. Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-1936. (Pubitemid 36254551)
2. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ et al. p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003; 302: 1036-1038. (Pubitemid 37386194)
3. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J et al. Puma is an essential mediator of p53-dependent and-independent apoptotic pathways. Cancer Cell 2003; 4: 321-328. (Pubitemid 37329796)
4. Ekoff M, Kaufmann T, Engstrom M, Motoyama N, Villunger A, Jonsson JI et al. The BH3-only protein puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood 2007; 110: 3209-3217. (Pubitemid 350106313)
5. Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. Glucose metabolism attenuates p53 and puma-dependent cell death upon growth factor deprivation. J Biol Chem 2008; 283: 36344-36353.
6. Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK et al. Puma and to a lesser extent noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ 2009; 16: 684-696.
7. Davidsson J, Lilljebjorn H, Andersson A, Veerla S, Heldrup J, Behrendtz M et al. The DNAmethylome of pediatric acute lymphoblastic leukemia. HumMol Genet 2009; 18: 4054-4065.
8. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005; 17: 393-403. (Pubitemid 40193310)
9. Gallenne T, Gautier F, Oliver L, Hervouet E, Noel B, Hickman JA et al. Bax activation by the BH3-only protein puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol 2009; 185: 279-290.
10. Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci USA 2008; 105: 20327-20332.
11. Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood 2006; 108: 1461-1468. (Pubitemid 44316109)
12. Fricker M, O'Prey J, Tolkovsky AM, Ryan KM. Phosphorylation of puma modulates its apoptotic function by regulating protein stability. Cell Death Dis 2010; 1: e59.
13. Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA et al. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ 2009; 16: 555-563.
14. Waelchli R, Bollbuck B, Bruns C, Buhl T, Eder J, Feifel R et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett 2006; 16: 108-112. (Pubitemid 41625653)
15. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998; 93: 385-395. (Pubitemid 28232083)
16. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7: 683-694. (Pubitemid 32706359)
17. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7: 673-682. (Pubitemid 32706358)
18. Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS et al. Myeloid progenitor cells lacking p53 exhibit delayed upregulation of puma and prolonged survival after cytokine deprivation. Blood 2010; 115: 344-352.
19. You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M et al. FOXO3adependent regulation of puma in response to cytokine/growth factor withdrawal. J Exp Med 2006; 203: 1657-1663. (Pubitemid 44036270)
20. Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005; 123: 641-653. (Pubitemid 41613746)
21. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci USA 2001; 98: 11318-11323. (Pubitemid 32928726)
22. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278: 687-689. (Pubitemid 27464966)
23. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996; 87: 619-628. (Pubitemid 26386936)
24. Tan Y, Demeter MR, Ruan H, Comb MJ. BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J Biol Chem 2000; 275: 25865-25869.
25. Hubner A, Barrett T, Flavell RA, Davis RJ. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell 2008; 30: 415-425. (Pubitemid 351672377)
26. Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007; 8: 49-62. (Pubitemid 46012014)
27. Ebner K, Bandion A, Binder BR, de Martin R, Schmid JA. GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta. Blood 2003; 102: 192-199. (Pubitemid 36759654)
28. Perugini M, Brown AL, Salerno DG, Booker GW, Stojkoski C, Hercus TRD et al. Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common \{beta\}-subunit. Blood 2010; 115: 3346-3353.
29. Hercus TR, Thomas D, Guthridge MA, Ekert PG, King-Scott J, Parker MW et al. The GMCSF receptor: linking its structure to cell signaling and its role in disease. Blood 2009; 114: 1289-1298.
30. Leis H, Sanchis A, Perez P. Deletion of the N-terminus of IKKgamma induces apoptosis in keratinocytes and impairs the AKT/PTEN signaling pathway. Exp Cell Res 2007; 313: 742-752. (Pubitemid 46206074)
31. Ekert PG, Read SH, Silke J, Marsden VS, Kaufmann H, Hawkins CJ et al. Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drugtreated cells die. J Cell Biol 2004; 165: 835-842. (Pubitemid 38821974)