JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

Journal of Biological Chemistry

Volumn 281, Issue 30, 2006, Pages 21256-21265

  Kim, Bong Jo ^a   Ryu, Seung Wook ^b   Song, Byoung Joon ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIODIVERSITY; CHEMICAL REACTIONS; ENZYME INHIBITION; ENZYMES; METABOLISM; PATIENT TREATMENT; RNA;

APOPTOSIS; HUMAN HEPATOMA HEPG2 CELLS; MITOCHONDRIAL TRANSLOCATION; PHOSPHORYLATION;

CELLS;

ETOPOSIDE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MUTANT PROTEIN; PHOSPHATE; PROTEIN BAX; SMALL INTERFERING RNA; STAUROSPORINE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; THREONINE;

APOPTOSIS; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG INHIBITION; GENE TRANSLOCATION; HEPATOMA CELL; HUMAN; HUMAN CELL; KIDNEY CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 8; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BIOSYNTHESIS; STAUROSPORINE; SWINE;

SUIDAE;

EID: 33746379603     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510644200     Document Type: Article

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